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- まれあ あくや
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2 Data cleaning Original datan=8479 NCC/ptkgN=7958 NCC10x10E NCC/kgPage 1-2) Covariate cleaningcovariate Page Page5-8
3 Kaplan-Meier method, Log-rank, Cox hazard model Overall survival Cumulative incidence method, Gray test, Competing hazard regression model PltRet /GVHD Logistic model PltRet
4 Patient characteristics (n=8139) NCC/kg Total Adult 1,134 2,775 2, ,763 Child ,376 Total 1,253 3, 080 2,677 1,129 8,139 Frequency Adult ( , med2.81) NCC/Pt kg Excel) Frequency Child ( , med3.51) NCC/Pt kg
5 Neu500 Adult Cumulative incidence (n=5020) Probability P< % d % d % d % d Days
6 Neu500 Adult Cumulative incidence (n=4981) Benign (n=206) Malignancy (n=4775) % d 93.0% d 97.1% d 100 % d % d 97.5% d 99.1% d 99.2 % d
7 Neu500 Child Cumulative incidence (n=1320) Probability P= % d % d % d % d Days
8 Neu500 Child Cumulative incidence (n=1320) Benign (n=245) Malignancy (n=1075) % d % d % d % d16 P= % d % d % d % d17 P= Days Days
9 Plt5 Adult Cumulative incidence (n=5039) Probability P< % d % d % d % d Days
10 Plt5 Child Cumulative incidence (n=1323) Probability P< % d % d % d % d Days
11 Ret1 Adult Cumulative incidence (n=5039) Probability P< % d % d % d % d Days
12 Ret1 Child Cumulative incidence (n=1323) Probability P< % d % d % d % d Days
13 OS (n=314) Adult/ Benign (n=19) Child/ Benign (n=9) Adult/ Malignancy (n=251) Child/ Malignancy (n=35) Days after SCT
14 Adult Overall survival (N=5096) Kaplan-Meier survival estimates P= analysis time cd cd cd cd
15 Adult Overall survival (N=4868) cd = /H cd = /H cd = /H cd = /H cd = /S cd = /S cd = /S cd = /S Months after SCT
16 Adult Overall survival Benign disease (n=209) Malignant disease (n=4859) cd = cd = cd = cd = cd = /H cd = /H cd = /H cd = /H cd = /S cd = /S cd = /S cd = /S Months after SCT Months after SCT
17 Children Overall survival (N=1332) Kaplan-Meier survival estimates P= analysis time cd cd cd cd
18 Children Overall survival (N=1245) cd = /H cd = /H cd = /H cd = /H cd = /S cd = /S cd = /S cd = /S Months after SCT
19 Children Overall survival Benign disease (n=247) Malignant disease (n=1067) cd = /H cd = /S cd = cd = cd = cd = Months after SCT cd = /H cd = /S cd = /H cd = /S cd = /H cd = /S Months after SCT
20 NRM & Relapse Adult Cumulative incidence (n=4836) Probability Months after SCT NRM Relapse 43% 23% 39% 21% 42% 19% 33% 18% NRM (P=0.024) Relapse (P=0.10)
21 Probability NRM Child Cumulative incidence (n=1273) Months after SCT NRM 37% 25% 23% 21% NRM (P=0.013)
22 Relapse Child Cumulative incidence (n=1273) Probability Relapse 22% 20% 22% 19% Relapse (P=0.83) Months after SCT
23 agvhdi Adult Cumulative incidence (n=4741) Probability P= (Gray test) 65.4% 67.9% 69.0% 70.8% Months after SCT
24 agvhdii Adult Cumulative incidence (n=4741) Probability % 43.8% 43.1% 43.0% P=0.808 (Gray test) Months after SCT
25 agvhdiii Adult Cumulative incidence (n=4741) Probability P=0.466 (Gray test) 17.0% 18.0% 19.4% 18.4% Months after SCT
26 agvhdi Child Cumulative incidence (n=1261) Probability P= (Gray test) 62.4% 70.4% 74.4% 68.4% Months after SCT
27 agvhdii Child Cumulative incidence (n=1261) Probability % 50.0% 45.2% 46.0% P= (Gray test) Months after SCT
28 agvhdiii Child Cumulative incidence (n=1261) Probability % 20.1% 22.8% 22.6% P=0.760 (Gray test) Months after SCT
29 cgvhd(lm+ex) Adult Cumulative incidence (n=3725) Probability % 44.0% 43.0% 46.7% P=0.45 (Gray test) Months after day100
30 cgvhd(lm/ex) Adult Cumulative incidence (n=3725) Probability LM EX LM EX 16.7% 29.5% 16.1% 27.9% 14.0% 29.0% 15.1% 31.7% P=0.31 P=0.54 (Gray test) Months after day100
31 cgvhd(lm+ex) Child Cumulative incidence (n=1075) Probability % 32.2% 33.6% 33.4% P=0.99 (Gray test) Months after day100
32 cgvhd(lm/ex) Child Cumulative incidence (n=1075) Probability LM EX LM EX 15.8% 18.2% 15.5% 16.7% 13.0% 20.6% 14.9% 18.5% P=0.81 P=0.72 (Gray test) Months after day100
33 30Early death Adult P=0.626) Children P=0.194)
34 Ret NRM (Cox Grade IGVHDHR 1.061)Grade II-IV, III-IV GVHD 30 NRM GVHDaGVHD 4x10 8 /kggvhd GVHD Competing hazardcox
35 TBIFK MinorMajorTCD) HLAGVHD -2 Logistic model TBI HLA rejection
36 TBI HLARejection FK Ret HLA
37 FK HLA Rejection NRM FK HLA Rejection HLAGVHD VPFK Cox
38 Grade IGVHD HLAGVHDTBI RISTFK Grade II-IVGVHD HLAGVHD Grade III-IVGVHD HLA GVHD FK GVHDLM+EX) DnPtTBIGradeI agvhdgradeiiagvhd
39 11. HLAGVHD 12. HLAGVHD 13. HLAGVHD DnPt TBI FK 14. T HLAGVHD RIST FK THLAGVHD
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訪問看護ステーションにおける安全性及び安定的なサービス提供の確保に関する調査研究事業報告書
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