日本化学療法学会雑誌第53巻第S-1号
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- ほのか おえづか
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1 Doripenem II Doripenem II doripenem DRPM II DRPM DRPM mg mg mg mg GPT. GOT II DRPM Key words: carbapenem doripenem respiratory tract infection urinary tract infection early phase II clinical study Doripenem DRPM Stenotrophomonas maltophilia β β I DHP-I imipenem meropenem
2 Table. Clinical sites and investigators Sites Sapporo Hospital of Hokkaido Railway Company Sendai Kosei Hospital Fukushima Prefectural Aizu General Hospital Doai Memorial Hospital The Jikei University School of Medicine National Hospital Organization Utsunomiya National Hospital Toranomon Hospital School of Medicine, Kyorin University Kugayama Hospital National Hospital Organization Tokyo National Hospital Kanagawa Prefecture Midwives and Nurses Training School Hospital Kanagawa Prefectural Cardiovascular and Respiratory Disease Center Institute of Medical Science, St. Marianna University School of Medicine Niigata University, School of Medicine Shinrakuen Hospital Department of Medicine, Kawasaki Medical School Kawasaki Medical School, Kawasaki Hospital School of Medicine, Kurume University Nagasaki University School of Medicine Institute of Tropical Medicine, Nagasaki University Oita University Faculty of Medicine Faculty of Medicine, University of the Ryukyus Sapporo Medical University School of Medicine The Jikei University School of Medicine Faculty of Medicine, The University of Tokyo Tokyo Kyosai Hospital Tokai University, School of Medicine Tokai University Oiso Hospital Fujita Health University School of Medicine Hiratsuka City Hospital Gifu University School of Medicine Kobe University, School of Medicine Kawachi General Hospital Hyogo Prefectural Rehabilitation Center Okayama University Medical School Tottori City Hospital Jyuzen General Hospital Faculty of Medicine, Kyushu University Faculty of Medicine, Kagoshima University Wakayama Medical University, School of Medicine Kyoto Prefectural University of Medicine Department Respiratory Disease Allergy and Respiratory Disease Respiratory Disease Respiratory Disease Respiratory Disease Respiratory Diseases Surgery Obstetrics and Gynecology Investigators Yohmei Hiraga, Mitsuhide Ohmichi Yushi Nakai, Yoshihiro Honda, Satoshi Shoji, Hiroshi Takahashi Kazunao Niizuma Yasuyuki Sano, Chuhei Ogawa Osamu Sakai, Kohya Shiba Kazuhisa Okada, Yasushi Nakazawa Koichiro Nakata Hiroyuki Kobayashi Hiroshi Sugiura Harumi Shishido, Sachiko Tanoue, Kana Miyata Fumio Matsumoto Shigeki Odagiri, Kaneo Suzuki, Satoshi Inoue, Yuji Watanuki, Yoshihiro Hirai, Ishimaru Yuriko, Kenichi Takahashi Jingoro Shimada, Kazuo Ishida Masaaki Arakawa Nobuki Aoki Toshiharu Matsushima, Yoshihito Niki, Naoyuki Miyashita Niro Okimoto, Makoto Kimura Kotaro Oizumi, Nobuyuki Suzuki, Toru Rikimaru, Takashi Yoshizumi, Yasuko Kim, Tomomi Shimizu, Yoshiko Sueyasu, Seiji Ueda Shigeru Kohno, Hironobu Koga, Hiroaki Hazama, Kazunori Tomono, Kazuo Ohba Tsuyoshi Nagatake, Hideaki Amano, Misao Tao Masaru Nasu Atsushi Saito, Futoshi Higa, Masao Tateyama Taiji Tsukamoto, Takasi Sato Yukihiko Ohishi Kazuki Kawabe, Yasushi Saiko Isao Saito, Masahiko Yoshida Nobuo Kawamura, Yasuhisa Harashima Keishi Okada, Aiichiro Masuda Yorio Naide, Kiyotaka Hoshinaga, Masaki Horiba Keizo Suzuki Yukimichi Kawada, Shigehiko Ozeki Sadao Kamidono, Toshio Imai Shusou Den Atsushi Sengoku, Maki Kobayashi Hiroyuki Ohmori, Kouichi Monden Shunji Hayata Satoshi Uno Joichi Kumazawa, Yoshihumi Abe Yoshitada Ohi, Kazuya Kawahara Hiroshi Tanimura, Koichi Murakami, Hiroaki Nakai, Manabu Kawai, Shinji Yamazoe Hideo Honjo, Jinsuke Yasuda
3 Doripenem II Table. Exclusion criteria Subjects should not meet any of the following exclusion criteria:. Subjects who are suspected to indicate a bad prognosis due to severe symptoms. Subjects with severe cardiac disturbance, hepatic dysfunction, or renal dysfunction. Subjects where the assessment of efficacy and safety of antibiotics is difficult due to severe or progressive underlying diseases and/or complications. Subjects with a history of epilepsy or with central nervous system disorders. Subjects whose intracutaneous reaction to DRPM is Positive or Impossible to determine whether it is positive or negative. Subjects with a history of hypersensitivity to beta-lactam antibiotics carbapenems, cephems, penicillins, etc.. Subjects who are pregnant women, lactating women, or women suspected of being pregnant 8. Subjects where, prior to administration of DRPM, causative organisms are obviously resistant to DRPM S. maltophilia, Mycoplasma, fungi, etc. 9. Subjects who need diuretics bumetanide, furosemide, etc.. Subjects who have taken other investigational drugs just prior to administration of DRPM. Subjects who are getting better due to the treatment with other antibiotics prior to administration of DRPM. Aged subjects who have or may have disorders that might affect the assessment of efficacy of DRPM. Subjects who, in the opinion of the investigator, are otherwise unsuited for participation in this study I, mg, mg µ g ml mg DRPM 8 GCP I Table UTI Table DRPM mg DRPM mg DRPM µ g ml I mg mg mg I mg I erythromycin beclometasone dipropionate
4 CRP X UTI dip slide CFU ml PaO PaCO ph GOT GPT ALP γ -glutamyl transpeptidase γ -GTP lactate dehydrogenase LDH leucine aminopeptidase LAP BUN Cr Ccr β Na K Cl CRP CF IHA mg 8 Bioassay UTI
5 Doripenem II II Table Table 9. Table mg 9. mg mg 9 mg 9 Table UTI UTI UTI UTI 9.8 Table 9 9 Pseudomonas aeruginosa Table Table Table P. aeruginosa Enterococcus faecalis P. aeruginosa Table Haemophilus influenzae P. aeruginosa Escherichia coli Staphylococcus spp. Klebsiella pneumoniae P. aeruginosa 8. 9 Table.8
6 Table. Patients profiles Demographics Gender Age yr Dose Treatment days History of allergy Previous antibacterial drug Category number of patients Male Female Complicated cystitis Complicated pyelonephritis Others mg /day mg /day mg /day mg /day Yes No Yes No patients 8 8 Table. Patients assessed for efficacy and safety of DRPM patients Efficacy Number of patients Safety Safety Symptom Laboratory data Safety rate Usefulness Respiratory infection Chronic respiratory tract infection Secondary infection of chronic respiratory disease Other respiratory infection Urinary tract infection Complicated urinary tract infection Cystitis Pyelonephritis Other urinary tract infection number of patients Number of exceptional patients
7 Doripenem II Table. Correlation between diagnosis and clinical response patients Excellent Clinical evaluation Good Fair Poor Efficacy Chronic respiratory tract infection Secondary infection of chronic respiratory disease 9. Complicated urinary tract infection Cystitis Pyelonephritis Efficacy: Excellent Good / patients Table. Correlation between daily dose and clinical response mg Chronic respiratory tract infection / / Secondary infection of chronic respiratory disease / / Complicated urinary tract infection / Cystitis / Pyelonephritis 8/8 Excellent Good / patients Efficacy mg / / / / / / / / / / 9. Daily dose mg 9/9 / / / / / / / /. mg / / / / / / / Table. Overall clinical efficacy of DRPM in complicated UTI at end of treatment Pyuria Bacteriuria Eliminated Decreased Replaced Unchanged Effect on pyuria Excellent Moderate Poor Cleared Decreased.%.%.9% Unchanged.% Effect on bacteriuria 8 8. % % 9. %. % patients Overall effectiveness / 9.8% mg Table
8 Table 8. Correlation between isolated organism and clinical response Isolated organism patients Clinical efficacy Excellent Good Fair Poor Efficacy Monomicrobial infection Gram-positive bacteria Gram-negative bacteria Staphylococcus aureus Staphylococcus epidermidis Streptpcoccus pneumoniae Enterococcus faecalis Subtotal Branhamella catarrhalis Escherichia coli Klebsiella pneumoniae Enterobacter cloacae Proteus mirabilis Morganella morganii Pseudomonas aeruginosa Pseudomonas sp. Haemophilus influenzae Pasturella multocida 9 Subtotal 8. Polymicrobial infection Efficacy: Excellent Good / patients Table 9. Correlation between infection and bacteriological response Chronic respiratory tract infection a Disease group Bacterial effects Eradication patients Eliminated Decreased Replaced Unchanged 8. Complicated urinary tract infection b Eradication: Eliminated Replaced / patients Bacterial effects of complicated UTI diverted results of bacteriuria eliminated, decreased, replaced, unchanged. a,,, Pulmonary emphysema with infection b Cystitis, Pyelonephritis.8 Table GPT GOT mg. mg. Table GPT.. 9 ALP. 9 GOT.8 Table 98.
9 Doripenem II Table. Correlation between isolated organism and bacteriological response Isolated organism patients Eliminated Bacterial effects Decreased Replaced Unchanged Eradication Monomicrobial infection Gram-positive bacteria Gram-negative bacteria Staphylococcus aureus Staphylococcus epidermidis Streptococcus pneumoniae Enterococcus faecalis Subtotal Branhamella catarrhalis Escherichia coli Klebsiella pneumoniae Enterobacter cloacae Proteus mirabilis Morganella morganii Pseudomonas aeruginosa Pseudomonas sp. Haemophilus influenzae Pasturella multocida 9 8 Subtotal 9. Polymicrobial infection Eradication: Eliminated Replaced / patients Table. Eradication of isolated organism Isolated organism bacterial strains Bacterial efficacy Eliminated Persisted Eradication Gram-positive bacteria Staphylococcus aureus Staphylococcus epidermidis Coagulase negative Staphylococcus Streptococcus pneumoniae Streptococcus agalactiae Streptococcus constellatus Enterococcus faecalis Subtotal 9. Gram-negative bacteria Branhamella catarrhalis Escherichia coli Citrobacter freundii Klebsiella pneumoniae Enterobacter cloacae Proteus spp. Morganella morganii Pseudomonas aeruginosa Haemophilus influenzae other gram-negative rods 9 Subtotal Table mg. Table Table mg
10 Table. Isolated organisms after DRPM treatment Isolated organism Staphylococcus aureus -Streptococcus -non-streptococcus Enterococcus faecalis Enterococcus faecium Pseudomonas aeruginosa Flavobacterium sp. Stenotrophomonas maltophilia Fungi patients with organisms/ observed patients bacterial strains 9 /.% Table. Correlation between daily dose and adverse drug reaction symptoms Adverse drug reaction Daily dose symptom patients mg mg mg mg observed patients patients seen Appearance Eruption Tongue numbness Headache Table. Correlation between daily dose and adverse drug reaction abnormal laboratory findings Adverse drug reaction Daily dose laboratory data patients mg mg mg mg observed patients patients seen Appearance Table. Correlation between daily dose and adverse drug reaction abnormal laboratory findings by test item Adverse drug reaction laboratory findings mg Daily dose mg mg mg event observed patients Incidence Basophilia Eosinophilia Neutropenia Neutropenia Segmented Thrombocytosis GOT increased GPT increased ALP increased LDH increased -GTP increased LAP increased Serum potassium increased
11 Doripenem II Table. Correlation between diagnosis and DRPM safety profile patients Safe Safety evaluation Nearly safe Slightly uneasy Uneasy Safety Respiratory infection Secondary infection of chronic respiratory disease 9.. Diffuse panbronchiolitis Pneumonia Urinary tract infection 98. Complicated urinary tract infection Cystitis Pyelonephritis Prostatitis Safety: Safe Nearly safe / patients Table. Correlation between daily dose and DRPM safety profile Respiratory infection Secondary infection of chronic respiratory disease Diffuse panbronchiolitis Pneumonia Urinary tract infection Complicated urinary tract infection Cystitis Pyelonephritis Prostatitis Safe Nearly safe / patients Safety mg / / / / / / / /. mg / / / / / / / / / / / / / / / 9.8 Daily dose mg / / / / / / / / / / / /. mg / / / / / / / / / /.. Table 9 mg.. µ g g..9 Table Fig. III DHP-I P. aeruginosa DRPM II
12 Table. Correlation between diagnosis and DRPM usefulness patients Extremely useful Usefulness Slightly Useful useful Not useful Usefulness Respiratory tract infection Secondary infection of chronic respiratory disease 8 9. Complicated urinary tract infection Cystitis Pyelonephritis Usefulness: Extremely useful Useful / patients Table 9. Correlation between daily dose and DRPM usefulness mg Respiratory tract infection / / Secondary infection of chronic respiratory disease / / Complicated urinary tract infection / Cystitis / Pyelonephritis 8/8 Extremely useful Useful / patients Usefulness mg 9/ / / / / / / / / / 88.9 Daily dose mg 9/9 / / / / / / / /. mg / / / / / / / 8/8 Table. Pharmacokinetic profiles in determining DRPM sputum level DRPM: mg, Infusion time: minutes Subject No. AUC a g h/ml CL b L/h T/ c h Cmaxserum d g/ml Cmaxsputum e g/g Cmax Ratio f Mean SD a AUC: calculated by trapezoidal method b CL clearance : calculated by dose/auc c T/ : half-life at phase d Cmaxserum: observed values at h e Cmaxsputum: obtained from observation f Cmax Ratio: Cmaxsputum/Cmaxserum
13 Doripenem II Serum concn g/ml or Sputum concn g/g.. 8 Time h mean serum concentration mean sputum concentration Fig.. DRPM concentration in serum and sputum DRPM: mg, Infusion time: minutes II.8.8 GPT. 98. mg. 9. I mg mg mg mg DRPM Doripenem in vitro Suppl :, β doripenem Suppl :, Doripenem dehydropeptidase-i Suppl :9 9, Doripenem I Suppl :, UTI UTI Chemotherapy : 8, 98 Chemotherapy 9: 8 89, 99
14 Early phase II study of doripenem, a new carbapenem antibiotic for injection Jingoro Shimada, Keizo Yamaguchi, Kohya Shiba, Atsushi Saito, Sadao Kamidono and Takeshi Inamatsu Institute of Medical Science, St. Marianna University School of Medicine, Sugao Miyamae-ku, Kawasaki, Kanagawa, Japan Department of Microbiology, Toho University School of Medicine Department of Department of Infection Control, Jikei University Faculty of Medicine, University of the Ryukyus Kobe University, School of Medicine Tokyo Metropolitan Geriatric Medical Center A multicenter prospective early phase II study was conducted at sites in Japan in patients with internal and urologic infection to evaluate the dosage and administration of doripenem DRPM, a new carbapenem antibiotic for injection, and to assess its safety and efficacy. Subjects numbered, of whom internal medicine:, urology: were evaluated for efficacy, for safety in abnormal laboratory test findings, and in abnormal symptoms. The usefulness of DRPM in was evaluated and DRPM concentration in the sputum determined in. DRPM was administered intravenously for to minutes at mg b. i. d., mg b. i. d., mg t. i. d., and mg b. i. d., with the following results: Efficacy was 9. 9 in internal medicine patients and 9. in urology patients, for an overall efficacy of 9.. Bacterial eradication was 8. 9 in internal medicine patients and 9. in urology patients, for an overall bacterial eradication of 9.9. In safety, adverse drug reactions symptoms observed in patients events: tongue numbness, headache, and rash were not serious and disappeared after completion of treatment. Adverse drug reactions abnormal laboratory test findings observed in patients events included increased GPT cases,got cases, and eosinophilia cases, all of which were slight and improved or returned to normal after completion of treatment. Overall safety was 98.. Of the patients evaluated for DRPM usefulness, usefulness rate in internal medicine patients and 9.9 in urology patients, for an overall usefulness of 9.. These results show that DRPM has the expected efficacy without adverse drug reactions that might raise clinical issues, so DRPM is expected to produce sufficient therapeutic effect in treating target infection.
CHEMOTHERAPY aureus 0.10, Enterococcus faecalis 3.13, Escherichia coli 0.20, Klebsiella pneumoniae, Enterobacter spp., Serratia marcescens 0.78, Prote
aureus 0.10, Enterococcus faecalis 3.13, Escherichia coli 0.20, Klebsiella pneumoniae, Enterobacter spp., Serratia marcescens 0.78, Proteus mirabilis 3.13, Proteus vulgaris 1.56, Citrobacter freundii 0.39,
Fig.2. Sensitivity distribution of clinical isolates of S. epidermidis (24 strains, 106 CFU/ml) Staphylococcus aureus Staphylococcus epider- midis Ent
Fig.2. Sensitivity distribution of clinical isolates of S. epidermidis (24 strains, 106 CFU/ml) Staphylococcus aureus Staphylococcus epider- midis Enterococcus faecalis Klebsiella pneumoniae, Morganella
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CHEMOTHERAPY VOL.41 S-2 Laboratory and clinical evaluation of teicoplanin CHEMOTHERAPY AUG. 1993 VOL.41 S-2 Laboratory and clinical evaluation of teicoplanin Table 1. Comparative in vitro activity of teicoplanin
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VOL.39 S-1 CHEMOTHERAPY FEB. 1981 Table 1. Activity of cefpirome and others against clinical isolates VOL.39 S-1 CHEMOTHERAPY FEB. 1991 72 M, 55.5 kg 66 F, 53 kg Chronic bronchitis Bronchopneumonia Peak
Table 1. Antibacterial activitiy of grepafloxacin and other antibiotics against clinical isolates
Table 1. Antibacterial activitiy of grepafloxacin and other antibiotics against clinical isolates Table 2-1. Summary of patients treated with grepafloxacin for respiratory infection 1) Out: outpatient,
Key words : 7432-S, Oral cephem, Urinary tract infection Fig. 1. Chemical structure of 7432-S.
Key words : 7432-S, Oral cephem, Urinary tract infection Fig. 1. Chemical structure of 7432-S. Table 1. Clinical summary of acute uncomplicated cystitis patients treated with 7432-S UTI : Criteria by the
CHEMOTHERAPY APRIL 1992 Table 2. Concentration of meropenem in human prostatic fluid Table 1. Background of 21 chronic complicated UTI cases * NB + BPH, NB + Kidney tumor, NB + Kidney tuberculosis Table
Staphylococcus sp. K.pneumoniae P.mirabilis C.freundii E. cloacae Serratia sp. P. aeruginosa ml, Enterococcus avium >100ƒÊg/ml
CHEMOTHERAPY SEPT. 1992 cefoperazone ceftazidime (CAZ), imipenem (IPM) Staphylococcus sp., Enterococcus (CPZ), faecalis, Escherichia coli, Klebsiella pneumoniae, Citrobacter freundii, Enterobacter cloacae,
Fig. 1 Chemical structure of KW-1070
Fig. 1 Chemical structure of KW-1070 Fig. 2 Sensitivity distribution of clinical isolates Fig. 4 Sensitivity distribution of clinical isolates Fig. 3 Sensitivity distribution of clinical isolates Fig.
coccus aureus Corynebacterium sp, Haemophilus parainfluenzae Klebsiella pneumoniae Pseudornonas aeruginosa Pseudomonas sp., Xanthomonas maltophilia, F
VOL.43 S-1 coccus aureus Corynebacterium sp, Haemophilus parainfluenzae Klebsiella pneumoniae Pseudornonas aeruginosa Pseudomonas sp., Xanthomonas maltophilia, Flavobacter- Table 1. Concentration of grepafloxacin
VOL.35 S-2 CHEMOTHERAPY Table 1 Sex and age distribution Table 2 Applications of treatment with carumonam Table 3 Concentration of carumonam in human
CHEMOTHERAPY Fig. 1 Chemical structure of carumonam Disodium(+)-(Z)-CCE1-(2-amino-4-thiazoly1)-2-[[(2S, -(carbamoyloxymethyl)-4-oxo-1-sulfonato-3-azetidinyll -2-oxoethylidene] amino] oxy] acetate 3S)-2
pneumoniae 30, C. freundii 32, E. aerogenes 27, E. cloacae 32, P. mirabilis 31, P. vulgaris 34, M. morganii 32, S. marcescens 31, H. influenzae 27, P.
pneumoniae 30, C. freundii 32, E. aerogenes 27, E. cloacae 32, P. mirabilis 31, P. vulgaris 34, M. morganii 32, S. marcescens 31, H. influenzae 27, P. aeruginosa 30, P. maltophilia pyogenes 32, Escherichia
Fig. 1 Chemical structure of DL-8280
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VOL. 32 S-4 CHEMOTHERAPY Fig. 1 Chemical structure of sodium cefoperazone Fig. 2 Chemical structure of sodium cefoperazone CHEMOTHERAPY JUN. 1984 Citrobacter freundii 27, Enterobacter aerogenes 26, Enterobacter
epidermidis, Enterococcus faecalis, Enterococcus Klebsiella pneumoniae, Proteus mirabilis, indolepositive Proteus spp., Enterobacter spp., Serratia
epidermidis, Enterococcus faecalis, Enterococcus Klebsiella pneumoniae, Proteus mirabilis, indolepositive Proteus spp., Enterobacter spp., Serratia Table 3. Overall clinical efficacy of cefozopran in
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CHEMOTHERAPY JUNE 1993 Table 1. Background of patients in pharmacokinetic study VOL. 41 S 1 Table 2. Levels (Đg/ml or Đg/g) of S-1006 in serum, bile, and tissue (gallbladder) after oral administration
日本化学療法学会雑誌第59巻第5号
Streptococcus pneumoniae Haemophilus influenzae Moraxella catarrhalis S. pneumoniae H. influenzae M. catarrhalis S. pneumoniae H. influenzae M. catarrhalis S. pneumoniae H. influenzae M. catarrhalis S.
VOL. 23 NO. 3 CHEMOTHERAPY 1067 Table 2 Sensitivity of gram positive cocci isolated from various diagnostic materials Table 3 Sensitivity of gram nega
1066 CHEMOTHERAPY MAR. 1975 Table 1 Sensitivity of standard strains VOL. 23 NO. 3 CHEMOTHERAPY 1067 Table 2 Sensitivity of gram positive cocci isolated from various diagnostic materials Table 3 Sensitivity
CHEMOTHERAPY Table 1 Clinical effect of Sultamicillin
CHEMOTHERAPY CHEMOTHERAPY Table 1 Clinical effect of Sultamicillin CHEMOTHERAPY Fig. 1 MICs of sultamicillin against respiratory pathogenic Branhamella catarrhalis 62 strains, inoculum size 106CFU/m1 Fig.
Table 1. Antibacterial spectrum SBT ABPC ABPC CPZ : sulbactamiampicillin : ampicillin : cefoperazone
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Table 1. Influence of urine ph on MBCs of new quinolones against Escherichia coli NIHJ JC-2 and Pseudomonas aeruginosa 18S; MBCs in urine were compared with those in Miieller-Hinton broth. Table 2. Influence
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VOL.40 S-1 coagulase negative Staphylococcus sp, methicillin- resistant Staphylococcus aureus (MRSA), Enterococcus faecalis, Escherichia coli, Citrobacter freundii, Klebsiella pneumoniae, Enterobacter
04-c-„FŒ{›xŒ¾-4.01
544( 56 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 58 6 Dec. 25 2003 2. * * Dec. THE JAPANESE JOURNAL OF ANTIBIOTICS 58 6 545( 57 ) 9 5 2003 8 2004 714 565 719 50 20 39 0 9 70 79 44.4 91.7% Escherichia coli
VOL.42 S-1 methicillin-susceptible Staphylococcus aureus (MSSA), Staphylococcus epidermidis, Enterococcus faecalis, Escherichia coli, Klebsiella pneum
VOL.42 S-1 methicillin-susceptible Staphylococcus aureus (MSSA), Staphylococcus epidermidis, Enterococcus faecalis, Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae methicillin-resistant Staphylococcus
366 12 THE JAPANESE JOURNAL OF ANTIBIOTICS 65 6 Dec. 2012 1 8 DNA 2,3 16 12 20 171 2008 12 2010 11 2 3,558 4.44% 1.65% 1.17% 90% 9 Escherichia coli -
Dec. 2012 THE JAPANESE JOURNAL OF ANTIBIOTICS 65 6 365 11 sita oxacin 1 1 1 1 1 1 2 2 3 3 1 1 1 2 3 2012 9 14 sita oxacin STFX 50 mg 10% 2008 1 2008 12 2010 11 2 STFX 1,452 91.4% 1,235/1,351 95.9% 466/486
CHEMOTHERAPY DEC (NFLX), ofloxacin (OFLX), ciprofloxacin (CPFX) Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Enterococcus faecali
CHEMOTHERAPY DEC. 1988 (NFLX), ofloxacin (OFLX), ciprofloxacin (CPFX) Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Enterococcus faecalis Pseudomonas aeruginosa, Serratia ma- Fig. 1. Chemical
日本化学療法学会雑誌第65巻第4号
Mycoplasma pneumoniae M. pneumoniae M. pneumoniae M. pneumoniae M. pneumoniae M. pneumoniae Key words Mycoplasma pneumoniae Mycoplasma pneumoniae M. pneumoniae I M. pneumoniae M. pneumoniae M. pneumoniae
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Fig. 1 Chemical structure of CXM-AX NOV. 1986 Fig. 2 Sensitivity distribution of clinical isolates organisms (106 cells/ml) a Smurcus 27 strains d) P.m irabilis 15 strains b Ecol i 27 strains 111.morganii
400 46 THE JAPANESE JOURNAL OF ANTIBIOTICS 65 6 Dec. 2012 LVFX 100 mg 3 / 7 150 mg 2 / 7 2 2006 2008 9 LVFX PK PD 2009 7 100 mg 1 3 500 mg 1 1 AUC/MIC
Dec. 2012 THE JAPANESE JOURNAL OF ANTIBIOTICS 65 6 399 45 2012 11 5 LVFX 500 mg 1 1 20 Chlamydia trachomatis C. trachomatismycoplasma genitalium M. genitalium LVFX 1 500 mg 1 1 7 22 22 C. trachomatis 17
Fig. 1 Chemical structure of norfioxacin (AM-715)
Fig. 1 Chemical structure of norfioxacin (AM-715) Table 1 Serum and biliary concentration of norfloxacin (AM-715) Table 2 Protocol for clinical evaluation of norfloxacin (AM-715) in the treatment of biliary
Table 1 Sensitivity distribution of clinical isolates 1. Escherichia coli Inoculum size: 106cells/ml 2. Klebsiella pneumoniae 3. Enterobacter cloacae 4. Serratia marcescens Inoculum size: 106cells/nil
VOL. 40 S- 1 Table 1. Susceptibility of methicillin-resistant Staphylococcus aureus to meropenem Table 2. Coagulase typing of methicillin-resistant St
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CHEMOTHERAPY CHEMOTHERAPY Table 1 Antibacterial activity of BRL 28500 against standard strains of bacteria Fig, 1 Sensitivity distribution of ABPC-resistant E. coli isolated from urinary tract Fig. 2 Sensitivity
VOL.42 S-1
CHEMOTHERAPY APR. 1994 VOL.42 S-1 CHEMOTHERAPY APR. 1994 Table 1. Criteria for evaluation of clinical efficacy by the Japanese Society of Oral and Maxillo-Facial Surgeons Grades of symptoms and numerical
1272 CHEMOTHERAPY MAR. 1975
1272 CHEMOTHERAPY MAR. 1975 VOL. 23 NO. 3 CHEMOTHERAPY 1273 Fig. 2 Minimal inhibitory concentration of aminoglycosides against 50 strains of Klebsiella Fig. 1 Minimal inhibitory concentration of aminoglycosides
VOL.32 S-7 CHEMOTHERAPY Table 1 MIC of standard strains of CTRX Fig. 2 Cumulative curves of MIC S. aureus (26 strains )
CHEMOTHERAPY OCT. 1984 Fig. I Chemical structure of CTRX VOL.32 S-7 CHEMOTHERAPY Table 1 MIC of standard strains of CTRX Fig. 2 Cumulative curves of MIC S. aureus (26 strains ) CHEMOTHERAPY Fig. 3 Cumulative
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VOL.33 S-5 CHEMOTHERAPY 381 Fig. 1 Chemical structure of HAPA-B Chemical name 1-N-[(2S)-3-Amino-2-hydroxypropiony1]-4-0-(6-amino- 6-deoxy-a-D-glucopyranosyl)-6-013-deoxy-4-C-methyl- 3-(methylamino)-ƒÀ-L-arabinopyranosyl]-2-deoxystreptamine
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Table 1 Classification of female patients with vesical irritating symptom by their signs : Urinary pain with or without other vesical irritability. s Vesical irritability without urinary Pain. Pyuria 10/
Fig. 1 Chemical structure of TE-031 Code number: TE-031 Chemical name: (-) (3R, 4S, 5S, 6R, 7R, 9R, 11R, 12R, 13S, 14R)-4-[(2, 6-dideoxy-3-C-methyl-3-
Fig. 1 Chemical structure of TE-031 Code number: TE-031 Chemical name: (-) (3R, 4S, 5S, 6R, 7R, 9R, 11R, 12R, 13S, 14R)-4-[(2, 6-dideoxy-3-C-methyl-3-O-methyl-a-L-ribo-hexopyranosyl) oxy]-14-ethyl-12,
Hisao Takayasu Department of Urology, Faculty of Medicine, University of Tokyo Masaaki Ohkoshi Department of Urology, Tokai University School of Medic
COMPARATIVE CLINICAL EFFECT OF AMIKACIN AND GENTAMICIN ON COMPLICATED URINARY TRACT INFECTIONS BY DOUBLE-BLIND METHOD Tsuneo Nishiura and Yukimichi Kawada Department of Urology, Gifu University School
VOL.30 S-1 CHEMOTHERAPY Table 1 Antibacterial activity of CTT against standard strains Table 2 Antibacterial activity of CTT against standard strains
CHEMOTHERAPY APR. 1982 Fig. 1 Chemical structure of cefotetan (CTT, YM09330) VOL.30 S-1 CHEMOTHERAPY Table 1 Antibacterial activity of CTT against standard strains Table 2 Antibacterial activity of CTT
CHEMOTHERAPY
CHEMOTHERAPY CHEMOTHERAPY Table 1 Antibacterial activity of Sulbactam/CPZ against standard strains MIC mg/ml Inoculum size 106 CFU/ml * Sulbactam/CPZ= 1: 1 ** Concentration of Sulbactam+ CPZ CHEMOTHERAPY
Fig.1 Chemical structure of BAY o 9867
Fig.1 Chemical structure of BAY o 9867 CHEMOTHERAPY 43 Table 3 Antibacterial spectrum of gram negative bacteria Medium:Heart infusion agar (Nissui) Method:Agar dilution (Streak) CHEMOTHERAPY DEC 1985
日本化学療法学会雑誌第55巻第S-1号
µ µ Key words Streptococcus pneu- moniae S. pneumoniae µ µ I γ H H C HN F F O N O CO H H C SO H H O Fig.. ChemicalstructureofGRNX. γ γ II Haemophilus influenzae Pseudomonas aeruginosa Streptococcus intermedius
THE JAPANESE JOURNAL OF ANTIBIOTICS 48-8 Enterococcus avium 5Š, Corynebacterium xerosis 10Š, Corynebacterium pseudodiphtheriticum 10Š, Corynebacterium
THE JAPANESE JOURNAL OF ANTIBIOTICS 48-8 Enterobacter spp., Serratia spp., Burkholderia cepacia, Flavobacterium spp., Alcaligenes spp. THE JAPANESE JOURNAL OF ANTIBIOTICS 48-8 Enterococcus avium 5Š, Corynebacterium
日本化学療法学会雑誌第57巻第6号
Streptococcus pneumoniae Haemophilus influenzae Moraxella catarrhalis S. pneumoniae S. pneumoniae β β H. influenzae S. pneumoniae H. influenzae M. catarrhalis Key words Otalgia Fever Item Crying,Iritation,
Table 1.Concentration of gatifloxacin (Middle-ear) Table 2.Concentration of gatifloxacin (Paranasal sinuses) Table 3.Concentration of gatifloxacin (Tonsil) Table 4.No.of patients studied Table 5.Background
日本化学療法学会雑誌第60巻第4号
Streptococcus pneumoniae Haemophilus influenzae S. pneumoniae H. influenzae Key words β Streptococcus pneumoniae Haemophilus influenzae S. pneumoniae H. influenzae μ μ S. pneumoniae H. influenzae S. pneumoniae
CHEMOTHERAPY Table 1 Urinary excretion of mezlocillin Fig. 4 Urinary excretion of mezlocillin Fig. 3 Blood levels of mezlocillin
CHEMOTHERAPY Fig. 2 Urinary excretion of mezlocillin Fig. 1 Blood levels of mezlocillin CHEMOTHERAPY Table 1 Urinary excretion of mezlocillin Fig. 4 Urinary excretion of mezlocillin Fig. 3 Blood levels
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Escherichia coli Enterococcus faecalisstreptococcus agalactiae Klebsiella pneumoniae Staphylococcus epidermidis E. colie. faecalispseudomonas aeruginosa K. pneumoniae S. agalactiae E. coli E. coli μ p
988 CHEMOTHERAPY NOV. 1971
988 CHEMOTHERAPY NOV. 1971 VOL. 19 NO. 8 CHEMOTHERAPY 989 Effect of medium-ph and inoculum size on activity of SB-PC heart infusion agar, mcg/ml Sensitivity distribution of Staphylococci to SB-PC in surgical
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β β β β β Streptococcus pneumoniaehaemophilus influenzaemoraxella catarrhalismycoplasma pneumoniaechlamydia pneumoniae β Key wordsβ mys nilc laci ngis Table. Assessmentschedule Parameters Patientcharacteristics
Table 1. Antibacterial activity of cefdinir, cefixime, cefteram, cefuroxime, cefaclor and amoxicillin against standard strains Inoculum size: 108 cells/ml CFDN: cefdinir, CFIX: cefixime, CFTM: cefteram,
Feb THE JAPANESE JOURNAL OF ANTIBIOTICS Tebipenem pivoxil 1 1, Meiji Seika 2 Meiji Seika G 3 Meiji Seika Tebipen
Feb. 2016 THE JAPANESE JOURNAL OF ANTIBIOTICS 69 1 53 53 Tebipenem pivoxil 1 1, 3 2 2 1 1 Meiji Seika 2 Meiji Seika G 3 Meiji Seika 2015 12 15 Tebipenem pivoxil 10% 2010 4 2013 3 3,547 3,540 3,540 3,331
CHEMOTHERAPY MAY. 1988
CHEMOTHERAPY MAY. 1988 CHEMOTHERAPY Fig. 1 Chemical structure CHEMOTHERAPY MAY. 1988 VOL.36 5-1 CHEMOTHERAPY CHEMOTHERAPY MAY. 1988 VOL.36 S-1 CHEMOTHERAPY CHEMOTHERAPY MAY. 1988 VOL.36 S-1 CHEMOTHERAPY
Staphylococcus aureus (MSSA), Streptococcus pneumoniae, Enterococcus faecalis Pseudomonas aeru- ginosa, Enterobacter cloacae, Citrobacter freun- Fig.
Key words : cefluprenam, seven days therapy, respiratory tract infection Staphylococcus aureus (MSSA), Streptococcus pneumoniae, Enterococcus faecalis Pseudomonas aeru- ginosa, Enterobacter cloacae, Citrobacter
VOL.39 S-3
VOL.39 S-3 CHEMOTHERAPY SEPT.1991 Table 1. Background of characteristics and allocation of 5 healthy male volunteers in a multiple-dose study on panipenem/betamipron Day 1 Fig. 1. Schedule of multiple-dose
CHEMOTHERAPY APRIL 1992 Acinetobacter calcoaceticus Staphylococcus aureus, Escherichia coli P. aeruginosa E. eoli, Klebsiella pneumoniae Serratia marc
APRIL 1992 Acinetobacter calcoaceticus Staphylococcus aureus, Escherichia coli P. aeruginosa E. eoli, Klebsiella pneumoniae Serratia marcescens P. aeruginosa P. aeruginosa Streptococcus pyogenes Streptococcus
CHEMOTHERAPY Methicillin-resistant S.aureus(MRSA) coccus epidermidis 105 Streptococcus pyogenes E.faecali senterococcus avium Enterococcus faecium Str
cefaclor(ccl),cefuroxime(cxm),cefixime (CFIX),cefteram(CFTM),cefdinir(CFDN) pneumoniae,streptococcus pyogenes Moraxella catarrhalis,haemophilus influenzae,escherichia coli, Klebsiella pneumoniae,proteus
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β Moraxella catarrhalis Escherichia coli Citrobacter Klebsiella pneumoniae Enterobacter cloacae Serratia marcescens Proteus Pseudomonas aeruginosa Acinetobacter Bacteroides fragilis β Haemophilus influenzae
Fig. 1 Clinical findings and extent of inflammation area in female urethrocystitis Fig. 2 Classification and distribution of female patients with blad
Key words: Female with bladder irritability, Subjective symptoms, Pyuria, Bacteriuria Fig. 1 Clinical findings and extent of inflammation area in female urethrocystitis Fig. 2 Classification and distribution
CHEMOTHERAPY OCT Fig. 1 Chemical structure of CVA-K
OCT. 1986 Fig. 1 Chemical structure of CVA-K VOL.34 S-4 heart infusion broth (Difco) 37.0 g, Resazurin 0.1% alcoholic solution (Wako) 1.0 ml, L-Cystein-HCl H2O (Wako) 0.5 g, Bact agar (Difco) 1.0 g, Deionized
CHEMOTHERAPY APR Fig. 2 The inactivation of aminoglycoside antibiotics by PC-904 Fig. 3 Serum concentration of PC-904 (1) Fig. 4 Urinary recover
VOL.26 S-2 CHEMOTHERAPY Gentamicin (GM), Dibekacin (DKB), Tobramycin Fig. 1 Protein concentration and protein binding rate Table 2 Protein binding rate of PC-904 in serum of healthy adults, and patients
CHEMOTHERAPY Silver sulfadiazine (T 107) CHEMOTHERAPY Fig. 1 Item of patients Table 1 Criteria of bacteriological efficacy by the Committee xcellent: E Score of infection becomes to 0% at the end of medication.
208 ( 2 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 63 _ 3 June 2010 Cefditoren pivoxil (CDTR-PI) MS MS 10%
207 ( 1 ) Cefditoren pivoxil G 2010 2 2 2006 3 Cefditoren pivoxil CDTR-PI MS 10% CDTR-PI 305 2,144 2,006 1,958 1.79% 36 2,006 26 (1.30%) CDTR-PI CDTR-PI (9 mg/kg/day) 1.5 2 (2.70%) 2 (1.92%) 93.5% 1,831
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piperacillin piperacillin PIPC. g Cmax CL PIPC CL CLR CLNR CL PIPC g g Cmax PIPC Key words: piperacillin Piperacillin PIPC PIPC g g PIPC Cmax g g ml g g ml g g ml T T T PIPC g g T Ccr ml min AUCCmax PIPC
Key words: E. coli O 157: H7, fosfomycin, verotoxin, mouse infection
Key words: E. coli O 157: H7, fosfomycin, verotoxin, mouse infection Table 1. Bacterial cell counts in feces of mice infected with Esclwrichia coli O 157: H7 NK2 before and during oral dosing with fosfomycin
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β β Moraxella catarrhalisescherichia colicitrobacter Klebsiella pneumoniaeenterobacter cloacaeserratia marcescens Proteus Providencia Pseudomonas aeruginosaacinetobacter Bacteroides fragilis β β E. colik.
VOL. 34 S-2 CHEMOTH8RAPY 913
VOL. 34 S-2 CHEMOTH8RAPY 913 914 CHEMOTHERAPY APR. 1986 Fig. 1 Chemical structure of T-2588 and T-2525 T- 2588 pivaloyloxymethyl (+ )- (6 R, 7 R)-7-[(Z)-2- (2-amino- 4-thiazolyl)-2-methox yiminoacetamido]-3-[(
Takeji NISHIKAWA, M. D.*, Takashi HARADA, M. D.** and Tatsuya IZUML M. D. Toshiyuki SUGI, M. D. Hiroshi HANYAKU, M. D. Shun-ichi MIYAKAWA, M. D. and Masaru TANAKA, M. D. Nobuko INAMOTO, M. D. and Hironori
JUNE 2000
VOL.48 NO.6 JUNE 2000 VOL.48 NO.6 Fig. 1. Chemical structure of pazufloxacin and pazufloxacin mesilate. JUNE 2000 VOL.48 NO.6 JUNE 2000 Table 1. Items and schedule of laboratory tests VOL.48 NO.6 Table
VOL.27 S-5 CHEMOTHERAPY Table 1 Clinical evaluations of cefamandole on UTI (1) Benign prostatic hypertrophy (2) Transurethral resection of bladder tum
CHEMOTHERAPY JUNE 1972 Fig. 1 Chemical structure of cefamandole E. coil, Klebsiella Proteus vulgaris indole positive Proteus sp., Enterobacter, Citrobacter, Serratia marcescens Chemical name: 7-D-mandelamido-3-
Dec. THE JAPANESE JOURNAL OF ANTIBIOTICS XXXVII (45)
Dec. THE JAPANESE JOURNAL OF ANTIBIOTICS XXXVII-12 2305(45) 2306(46) THE JAPANESE JOURNAL OF ANTIBIOTICS XXXVII-12 Dec. Dec. THE JAPANESE JOURNAL OF ANTIBIOTICS XXXVII-12 2307(47) 2308(48) THE JAPANESE
VOL. 17 NO. 7 CHEMOTHERAPY 1305 1) W. BRumFirr et al. : Clinical and laboratory studies with carbenicillin. Lancet 1: 1289~ 1293, 1967 2) E. T. KNUDSEN et al. : A new semisynthetic penicillin active against
Table 1 Classification of female patients with vealcal irritating symptom by their signs Urination pain with other vesical irritability or not Table 2 Serum levels of DL-8280 after a single oral administration
CHEMOTHERAPY Table 2 Clinical response of 6059-S by infection Table 3 Effect of 6059-S on blood chemistry *Normal range : S-GOT 20 `60 mu/ml, S-GPT 5 `25 IU/L, Al-Pase 30 `85 mu/ml In oilier cases : S-GOT
b) Gram-negative bacteria Fig. 2 Sensitivity distribution of clinical isolates : E. coli Fig. 3 Sensitivity distribution of clinical isolates : Pseudomonas Fig. 1 Sensitivity distribution of clinical isolates
Table 1 Survival rates of infected mice given antibiotic doses producing peak serum a) S. aurcus Smith Challenge dose :7 ~10 (5% mucin) CFU/mouse. LD50: 1 ~103 (5% mucin) CFU/mouse. Table 2 Survival rates
VOL. 43 NO. 4
VOL. 43 NO. 4 Fig. 1. Frequency of Enterococcus species from complicated UTI, 1988-1992. the number * of Enterococcus species/the number of cases with complicated UTI. Fig. 3 Epidemiologic characteristics
CHEMOTHERAPY JAN Fig. 1 Structure of cephradine
VOL. 23 NO. 1 CHEMOTHERAPY 409 CHEMOTHERAPY JAN. 1975 Fig. 1 Structure of cephradine VOL. 23 NO. 1 CHEMOTHERAPY 411 Table 1 Reason for drop-out 412 CHEMOTHERAPY JAN. 1975 VOl. 23 NO. 1 CHEMOTHERAPY 413
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in vitro Key words Streptococcus pneumoniae β Haemophilus influenzae Escherichia coli I Table. Antibacteriallevofloxacinactivityagainstclinicalisolates Organism Year Susceptibility(%)(Numberofstrains)
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β Key words Candida albicans albicans Candida C. albicans Candida glabrata Candida krusei albicans Candida C. glabrata C. albicans albicans Candida β in vitro in vivo C. glabrata C. krusei I β γ µ Candida
VOL.30 NO.10 CHEMOTHERAPY 1123 Fig,1 Group B case 6 hepatolithiasis,e.k.66 y.0.,f.45kg Postoperative wound infection Fig.2 Group B case 15 gastric cancer,k.k.60 y.o.,m. Postoperative peritonitis Fig.3
2108 CHEMOTHERAPY SEPT Table 1 Antimicrobial spectrum Fig. 1
2108 CHEMOTHERAPY SEPT. 1977 Table 1 Antimicrobial spectrum Fig. 1 VOL. 25 NO. 7 CHEM 014 HERAPY 2109 Table 2 Susceptibility distribution of Staphylococcus aureus to aminoglycosides (54 strains) Table
Table 1 Patients with various renal function * Ccr, Creatinine clearance ml/min per 1. 48 m2 ** C.V.D., Cerebral vascular disease ; C.R F., Chronic renal failure ; H.D., Hemoclialysis ; D., Dialyzer ;
CHEMOTHERAPY SEPT. 1991
CHEMOTHERAPY SEPT. 1991 VOL. 39 S-3 Table 1. Background of characteristics and allocation of 9 healthy male volunteers in a single-dose study on betamipron Table 2. Background of characteristics and allocation
VOL.48 NO.7 lase negative staphylococci, Escherichia coli, Klebsiella spp., Citrobacter freundii, Enterobacter spp., indole-positive Proteus, Serratia
ceftazidime, cefpirome, cefepime, cefoperazone/sulbactam (2: 1), imipenem Staphylococcus aureus oxacillin coagulase negative staphylococci Escherichia coli piperacillin Klebsiellac spp. Citrobacter Pseudomonas
CHEMOTHERAPY Proteus mirabilis GN-79 Escherichia coli No. 35 Proteus vulgaris GN-76 Pseudomonas aeruginosa No. 11 Escherichia coli ML-1410 RGN-823 Kle
VOL. 29 NO.8 CHEMOTHERAPY 865 CHEMOTHERAPY Proteus mirabilis GN-79 Escherichia coli No. 35 Proteus vulgaris GN-76 Pseudomonas aeruginosa No. 11 Escherichia coli ML-1410 RGN-823 Klebsiella pneumoniae GN-69
400 CHEMOTHERAPY JAN Table 1 Cases of drop outs
VOL. 23 NO. 1 CHEMOTHERAPY 399 Fig. 1 Stracture of cephradine Chemical name : 7-CD(-)-2-amino-2-(1,4-cyclohexadien-1-y1) -acetamido) -3-methyl-8-oxo-5-thia-1-aza- -bicyclo [4. 2. 0] oct-2-ene-2-carboxylic
VOL. 23 NO. 3 CHEMOTHERAPY 1379 Table 1 Susceptibility of clinical isolated strains to Tobramycin
VOL. 23 NO. 3 CHEMOTHERAPY 1379 Table 1 Susceptibility of clinical isolated strains to Tobramycin 1380 CHEMOTHERAPY MAR. 1975 Table 2 Susceptibility of isolated Pseudomonas aeruginosa to various antibiotics
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Key words Streptococcus pneumoniae µ µ H F Cl H H N N H N F COOH O Fig.1. Sitafloxacinstructure. I γ S. pneumoniae Haemophilus influenzae Table1. Observationandtestschedule Observation/Tests Informedconsent
CHEMOTHERAPY AUG. 1982 VOL. 30 NO. 8 CHEMOTHERAPY Fig.1 Relation between various-closis of cefazolin and detection rate of organisms in heart blood of dying mice with E. coli and P. aeruginosa infection
Key words : R-plasmid, Urinary tract infection, E. coli Fig. 1. MIC distribution against E. coli isolated from urinary tract (366 strains) and isolation - frequencies of drug-resistant strains Table 1.
Table1MIC of BAY o 9867 against standard strains
Table1MIC of BAY o 9867 against standard strains Fig.2Cumulative and Distribution Curves of MIC (S.aureus 54 strains) 106cfu/ml Fig.3Correlogram of MIC (S.aureus 54 strains) CHEMOTHERAPY 451 Fig.4Cumulative
CHEMOTHERAPY JUNE 1987 Table1 Media used *BHIB, brain heart infusion broth (Difco); /3 -NAD, S -nicotinamidoadeninedinucleotide (Sigma Chemical Co.);
VOL.35 S-2 CHEMOTHERAPY Fig.1 Chemical structure of carumonam CHEMOTHERAPY JUNE 1987 Table1 Media used *BHIB, brain heart infusion broth (Difco); /3 -NAD, S -nicotinamidoadeninedinucleotide (Sigma Chemical
2.7 臨床概要
2.7 臨床概要 A/G Al-P ALT AST AT- AUC AZM BIPM BP BUN CEZ CFPN-PI CFU CLcr Cmax CNS COPD CPFX CRP CS CYP CVA DBT DHP-I DIC DRPM DRPM-DC FAS γ-gtp GCP GNB GNF-GNR GPB HAM - Staphylococcus C P450 -I Full Analysis
Fig. 1 Chemical structure of norfloxacin Table 1. Institutes attended to the study The Department of Dermatology, Defense Medical College The Department of Dermatology, School of Medicine, Teikyo University
Key words : candidemia, endotoxin, D-arabinitol, Candida antigen, serological examination
Key words : candidemia, endotoxin, D-arabinitol, Candida antigen, serological examination Fig. 1 The value of fungal index and D- arabinitol/creatinine. Fungal index was mesured by Endotoxin D and Endospecy
Mueller-Hinton broth), Streptococcus pneumoniae (S. pneumoniae), Streptococcus faecalis (S. faecalis)
Fig. 1 Chemical structure of TA-058 (2S, 5R, 6R)-6- k2r-2- (2R-2- amino-3-n- methyl carbamoylpropionamido) -2- (4- hydroxyphenyl) acetamido l-3, 3-dimethy1-7-oxo- 4-thia-1- azabicycio k3.2,0 l heptane-2-carboxylic