CAS H 3 C C CH 2 C 9 H tert d = hpa

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おきまさかつもと
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1 CAS H 3 C C CH 2 C 9 H tert d = hpa 1.9 mmhg log Pow m/z 118, Koc1351, ppm = 4.91 mg/m 3, 20 1 mg/m 3 = ppm

2 ,753 t 22,753 t 0 6 ABS mg/l 30 mg/l BOD mg/l 30 mg/l BOD 100 OH = cm 3 / sec 25 9 OH /cm 3 48 = cm 3 / sec /cm nm mg/l mg/l 12113

3 ppb ppm ppm B/A B/A B/A B/A 0/3 0/ / / B/A 4 LC 50 mg/l EC 50 mg/l : *11 Selenastrum h: 2 capricornutum 12 Daphnia magna 12 Daphnia magna 12 Oryzias latipes 12 Oryzias latipes h: d: NOEC h 2 > d d: NOEC * OECD 5. 2, 13, 14 1 LD 50 4,500 mg/kg 4,900-5,603 mg/kg LC 50 LD 50

4 4 13 3,4486,89613,792 mg/kg 3,448 mg/kg 1 6,896 mg/kg ,792 mg/kg ,896 mg/kg 4/5 13,792 mg/kg 5/5 14 SD 7,94010,00012,60015,800 mg/kg 10,000 mg/kg 1/5 12,600 mg/kg 2/5 15,800 mg/kg 2/5 7,940 mg/kg 10,000 mg/kg ,500 ppm, /6 14 6,89613,792 mg/kg 6,896 mg /kg 13,792 mg/kg 13,792 mg/kg 3/7 14 3,1605,0107,940 mg/kg 7,940 mg/kg 1/1 5,010 mg/kg 7,940 mg/kg ml , ml

5 SD ,000 mg/kg/day ,000 mg/kg/day mg/kg/day ALT 1,000 mg/kg/day 17 NOEL 40 mg/kg/day 17 2 B6C3F ,000 ppm 6 / 5 / ppm 6 1/ ppm 56 10/18 1,000 ppm 21 5/ ppm 18 3,000 ppm F344 NBR ppm 6 / 5 / ppm F F ,000 ppm 6 / 5 / ppm ppm 7 / 5 / 27 19, ppm 7 / 5 2, 16, / * in vitro S9-20 TA98TA100TA1535 TA1537 WP2uvrA µg/plate S9 -/+ 17

6 6 * TA97TA98TA100 TA µg/plate S9 -/+ 21 in vitro 1-2 mms9 -/ , µmol/l S9 19 CHO S9 19 CHO S9 * SD ,000 mg/kg/day ,000 mg/kg/day 2/8 4 NOEL 1,000 mg/kg/day 200 mg/kg/day SD 250 mg/kg/day , ppm 200 ppm 2, 16, 600 ppm ,

7 7 3.9 Drop and compression 25 26, 27, 28 3 EPA 1999 EU 1999 NTP 1999 IARC 1999 ACGIH , 28 4 ACGIH ppm mg/cm mg/cm OECD * 5 2 * OECD OECD

8 in vitro OH

9 Hazardous Substances Data Bank HSDB, U.S. National Library of Medicine IPCS, International Chemical Safety Cards KowWin ver 01.66, Syracuse Research Corporation NIST Library of 54K Compounds , , , AOPWIN ver1.86, Syracuse Research Corporation , OECD, Harmonised integrated Classification System for Human Health and Environmental Hazards of Chemical Substances and Mixtures. OECD Series on Testing and Assessment No , US NIOSH, Registry of Toxic Effects of Chemical Substances RTECS EPA/OTS , Range Finding Toxicity Studies of α-methylstyrene EPA/OTS , Initial Submission : Toxicological Investugatuib of Alpha Methyl Styrene with Cover Letter dated S. Gangolli, The Dictionary of Substances and their Effects, 2nd. Ed., The Royal Society of Chemistry ,, D. L. Morgan, Toxicological Sciences, 47, ACGIH, Documentation of the Threshold Limit Values and Biological Exposure Indices H. Norppa, J. Scand., Work environ. Health, 9, E. Zeiger, Environmental Molecular Mutagenesis, 19 Suppl 21, H. Norppa, Basic Life Science, 29B, H. Norppa, Mutation Research, 116, EPA/OTS Testing of Selected Workplace Chemicals for Teratogenic Potential EPA/OTS , Toxic Control Act Substantial Risk Reporting on Alpha-Methyl Styrene : Dermal Sensitization with Attachments and Cover Letter Dated Sanitized JETOC,,, ACGIH, Booklet of the Threshold Limit Values and Biological Exposure Indices ,,, 43,

10 10 29 The Alkyl Benzenes, Metabolism of Alkyl Benzenes,

11 11 mg/l h h d h LC 50 EC , 1997.

12 12 6h/d 5d/w 12d 3-4d 6h/d 5d/w 12d 6h/d 5d/w 9d 7h/d 5d/w 27d 7h/d 5d/w 5-6month ppm 10,000 3,000 1, , ,

CAS NC(CH 2 ) 4 CN 1,4- C 6 H 8 N c.c d = Pa

CAS NC(CH 2 ) 4 CN 1,4- C 6 H 8 N c.c d = Pa 1 200117 21512 CAS 111693 110 NC(CH 2 ) 4 CN 1,4- C 6 H 8 N 2 108.14 1 99 2-1. 2 1 295 159 c.c. 550 3 1.7-4.9 20 d 0.965 4 3.73 = 1 0.3 Pa 0.002 mmhg20 2 log Pow-0.32 m/z 41, 1.0 68 0.54 54 0.43 4 Koc9-16