CHEMOTHERAPY DEC phvlococcus aureus Staphylococcus Enterococcus faecalis Escherichia Klebsiella pneumoniae Serratia marcescens Pseudomonas cepac

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1 CHEMOTHERAPY DEC phvlococcus aureus Staphylococcus Enterococcus faecalis Escherichia Klebsiella pneumoniae Serratia marcescens Pseudomonas cepacia 1 Bacteroides bivius Propionibacterium granulosum erythromycin (EM), Josamycin (JM), rokita- norfloxacin (NFLX), ofloxacin (OFLX), enoxacin cline (DOXY), minocycline (MINO) ampicillin (ABPC), amoxicillin (AMPC), bacampicillin (BAPC) cephalexin (CEX), cefadroxil (CDX), cefaclor

2 VOL.3 6 S-9 Fig. 1. Chemical structure of T rolidinyl)-6-fluoro-1-(2, 4-difluoropheny1)-1, 4-dihydro-4-oxo-1, 8-naphthyridine-3-carboxylic acid-pto- Staphylococcus aureus, Strepto-

3 CHEMOTHERAPY DEC. 1988

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11 CHEMOTHERAPY DEC. 1988

12 VOL.36 S-9 Enterococcus faecalis Propionibacterium granulosum Staphylococcus saprophyticus

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14 B. bivius P. granulosum S. aureus S. aureus S. aureus E. faecalis E. coli Staphylococ- K. pneu- S. marcescens P. cepacia

15 CHEMOTHERAPY DEC E. faecalis 0. 78,ug/ml, P. aeruginosa 1.56 aug/ml, B. fragilis gem', S. marcescens itiginil

16 VOL. 36 S-9 MIKAMI J, BEKKI E: Bacampicillin concentration in various tissues of patients. Chemotherapy 27 (Suppl. 4): 202 `205, ) NAKAMURA T, HASHIMOTO I, SAWADA Y, MIKAMI J, NAKANISHI M, KASAI Y, SAHA- SHI Y: Cefmetazole concentration in infected tissues from patients after intravenous administration and clinical effect for patients with cholecystitis and peritonitis. Current Chemoth. Inf. Dis., Proc. 11 th ICC and 19 th ICAAC, Amer. Soc. Microb., Vol.I: , Oct. 1 `5, 1979 (Boston) 10) NAKAMURA T, HASHIMOTO I, SAWADA Y, MIKAMI J, BEKKI E, HIRASAWA S, ABE H, WATANABE Y: Cefoperazone concentration in bile and gall bladder wall after intravenous 7) NAKAMURA T, HASHIMOTO I, SAWADA Y, MIKAMI J, BEKKI B: Dibekacin concentration in various tissues of patients. Chemotherapy 26: 377 `378, ) NAKAMURA T, HASHIMOTO I, SAWADAY, administration. Antimicr. Agents and Chemoth. 18: 980 `982, ) HASIMOTO I, SAWADA Y, NAKAMURA T, MIKAMI J, BEKKI E, FUJITA H, SAITOH M, NISHINDAI H, NAKANISHI Y, KASAI Y: Cefmenoxime concentration in infected tissues from patients after intramuscular or intravenous administration and clinical effect for patients with cholecystitis and peritonitis. Current Chemoth. & Immunoth. Proc. 12 th ICC, Amer. Soc. Microb. Vol. I: , July 19 `24, 1981 (Florence) 13) NAKAMURA T, HASHIMOTO I, SAWADA Y, MIKAMI J, BEKKI E, FUJITA H, SAITOH M, NISHINDAI H, NAKANISHI Y, KASAI Y Dibekacin concentration in infected tissues from patients after intramuscular injection and intravenous drip infusion. Current Chomoth. & Immunoth. Proc. 12 th ICC, Amer. Soc. Microb. Vol. II: 815 `817, July 19 `24, 1981 (Florence) 14) BEKKI E, SAIT01-1 M, TSUJISAKI M, SAWADA Y, HASHIMOTO I, NAKAMURA T, MIKAMI: Ceftazidime concentration in infected tissues and body fluids from patients following intravenous administration. Proc. 13 th Internat. Congr. Chemoth. Part 101, PS 4. 2/4 `9, Aug. 28-Sept. 2, 1893 (Vienna) 15) NAKAMURA T, HASHIMOTO I, SAWADA Y, MIKAMI J, SAITOH M, BEKKI E, TSUJISAKI M: Tissue concentration and clinical efficacy of MT-141 on acute peritonitis and biliary tract infection following intravenous administration. Proc. 13 th Internat. Congr. Chemoth. Pat 58, SE 4. 2/5 `6, Aug. 28-Sept.

17 CHEMOTHERAPY DEC CLINICAL STUDIES ON T-3262 IN THE SURGICAL FIELD TAKASHI NAKAMURA, IKUO HASHIMOTO and YASUO SAWADA Department of Surgery, Tenshi General Hospital (Franciscan Missionaries of Mary) Kita 12, Higashi 3-31, Higashi-ku, Sapporo-shi 065, Japan KUKIO SHIMIZU Department of Surgery, Hokuoh Hospital T-3262, a newly synthesized antimicrobial drug for oral administration, derived from pyridonecarboxylic acid, has a broad spectrum of antibacterial activity against various species, including Enterococcus faecalis and Pseudomonas aeruginosa. It was administered orally in a dose of 150 mg 2 or 3 times a day for 5-11 days to 30 patients with surgical infections. They were 9 cases of biliary tract infection, 4 of periproctitis and periproctal abscess, 11 of skin and soft tissue infection and 6 of acute mastitis. The clinical response was rated excellent in 10 cases, good in 18, fair in 1 and poor in 1, the efficacy rate being 93. 3%. No adverse effects were observed. Thirty-one strains of organisms were isolated from 25 cases. They included 12 strains of Staphylococcus aureus, 4 of the Staphylococcus group, 2 of E. faecalis, 7 of Escherichi a coli, 2 of Klebsiella pneumoniae and 1 each of Serratia marcescens, Pseudomonas cepacia, Bacteroides bivius and Propionibacterium granulosum. The MICs of T-3262 were pg/mi with an inoculum size of 106 cells/mi. In 3 cases, T-3262 concentrations in purulent milk and healthy milk were measured by paper disc bioassay with E. coli Kp as the test organism. The T-3262 concentration ranged from O fig' ml (mean }0. 21 pg/ml) in healthy milk 90 min after 150 mg p. o. and from itg/m1 (mean }0. 55 pg/m1) in purulent milk. T-3262 concentration in purulent milk was higher than in healthy milk and was also higher than the MICs of T-3262 against isolated organisms. In conclusion, We consider T-3262 a very useful drug against surgical infections.

CHEMOTHERAPY Fig. 1 Chemical structure of CXM-AX

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