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1 SETTLE FOR NOTHING LESS VALIANT CAPTIVIA

2 BARE STENT TYPE FREEFLO VALIANT Captivia FREEFLOはチップキャプチャーシステムにより ショートネック症例において正確な位置決めを可能にします 1. ZONE-2 and Short Neck 独自のベアステント構造 外骨格 シーリング サポート ステントにより ショートネック症例への留置を実現 2. 高い中枢シーリング 中枢側の 8ピークFREEFLOにより ラジアルフォースを均一に分散 シーリング サポート ステントにより 血管壁への高い密着性を実現 3. チップ キャプチャーシステム コントロールされた正確な位置決めと 展開が可能 4. 高い経験と実績 15年にわたる胸部ステントグラフトの経験と 50,000 症例を超える植込実績 改良に基くデザイン 2 VA L I A N T T H O R A C I C ST E N T G R A F T W I T H T H E C A P T I V I A D E L I V E RY SYST E M

3 NON BARE STENT TYPE CLOSED WEB VALIANT CLOSED WEB Non-Bare Non-Barb 1. Non Bare Stent nd Type3 3

4 CLINICAL DATA VALIANT VALOR II 5-YEAR RESULTS VALIANT 5 TEVAR FOR AORTIC ANEURYSM Cumulative clinical results: year 0 through year 5 Key VALOR II five-year follow-up findings include: 100% 80% 60% 40% 20% 0% 94.8% freedom from aneurysm related mortality 1.3% rupture rate 6.9% required secondary procedures 0.6% 1/160 conversion to open surgery rate 89.3% of patients had stable or decreased aneurysm size 0% migration reported (defined as > 10mm from the 1-month follow-up) 0% loss of integrity reported 0 Source:Conrad M.F.,NESVS VALIANT THORACIC STENT GRAFT WITH THE CAPTIVIA DELIVERY SYSTEM

5 MEDTRONIC DISSECTION IDE 30-DAY AND 1-YEAR RESULTS VALIANTB 301 MEDTRONIC U.S. DISSECTION TRIAL Demonstrates positive Aortic remodeling of stented segment 100% 80% 15% 85% 6% 94% 97% 100% Decrease Increase Stable 60% 40% 20% 0% 3% 6 months 12 months 6 months 12 months False Lumen Volume True Lumen Volume *Prospective, multi-center, single-arm trial (N=50) % 301 Source: Medtronic Dissection Trial Results, Clinical Study Report 5

6 VALIANT Captivia PROXIMAL FREEFLO STRAIGHT CLOSED WEB STRAIGHT VAMF C 100 TJ VAMF C 100 TJ VAMF C 100 TJ VAMF C 100 TJ VAMF C 100 TJ VAMF C 100 TJ VAMF C 100 TJ VAMF C 100 TJ VAMF C 100 TJ VAMF C 100 TJ VAMF C 100 TJ VAMF C 100 TJ VAMF C 100 TJ VAMF C 150 TJ VAMF C 150 TJ VAMF C 150 TJ VAMF C 150 TJ VAMF C 150 TJ VAMF C 150 TJ VAMF C 150 TJ VAMF C 150 TJ VAMF C 150 TJ VAMF C 150 TJ VAMF C 150 TJ VAMF C 150 TJ VAMF C 150 TJ VAMF C 200 TJ VAMF C 200 TJ VAMF C 200 TJ VAMF C 200 TJ VAMF C 200 TJ VAMF C 200 TJ VAMF C 200 TJ VAMF C 200 TJ VAMF C 200 TJ PROXIMAL FREEFLO TAPERED VAMC C 100 TJ VAMC C 100 TJ VAMC C 100 TJ VAMC C 100 TJ VAMC C 100 TJ VAMC C 100 TJ VAMC C 100 TJ VAMC C 100 TJ VAMC C 100 TJ VAMC C 100 TJ VAMC C 100 TJ VAMC C 100 TJ VAMC C 100 TJ VAMC C 150 TJ VAMC C 150 TJ VAMC C 150 TJ VAMC C 150 TJ VAMC C 150 TJ VAMC C 150 TJ VAMC C 150 TJ VAMC C 150 TJ VAMC C 150 TJ VAMC C 150 TJ VAMC C 150 TJ VAMC C 150 TJ VAMC C 150 TJ VAMC C 200 TJ VAMC C 200 TJ VAMC C 200 TJ VAMC C 200 TJ VAMC C 200 TJ VAMC C 200 TJ VAMC C 200 TJ VAMC C 200 TJ VAMC C 200 TJ CLOSED WEB TAPERED VAMF C 150 TJ VAMF C 150 TJ VAMF C 150 TJ VAMF C 150 TJ VAMF C 150 TJ VAMF C 150 TJ VAMF C 150 TJ VAMF C 150 TJ VAMF C 150 TJ VAMF C 150 TJ VAMF C 150 TJ VAMC C 150 TJ VAMC C 150 TJ VAMC C 150 TJ VAMC C 150 TJ VAMC C 150 TJ VAMC C 150 TJ VAMC C 150 TJ VAMC C 150 TJ VAMC C 150 TJ VAMC C 150 TJ VAMC C 150 TJ DISTAL BARE SPRING STRAIGHT VAMC B 100 TJ VAMC B 100 TJ VAMC B 100 TJ VAMC B 100 TJ VAMC B 100 TJ VAMC B 100 TJ VAMC B 100 TJ VAMC B 100 TJ VAMC B 100 TJ VAMC B 100 TJ VAMC B 100 TJ VAMC B 100 TJ VAMC B 100 TJ VALIANT THORACIC STENT GRAFT WITH THE CAPTIVIA DELIVERY SYSTEM

7 OVER SIZING VALIANT , 30 3, 5 32, , 32 3, 5 34, , 34 3, 5 36, , 36 3, 5 38, VALIANT , 44 2, , 46 2,

8 日本メドトロニック株式会社 ストラクチャラルハート & エンドバスキュラー事業部 東京都港区港南 Tel: medtronic.co.jp 製造販売元 : 日本メドトロニック株式会社一般的名称 : 大動脈用ステントグラフト販売名 :VALIANT 胸部ステントグラフトシステム医療機器承認番号 :22400BZX 特定保険医療材料区分 :146 大動脈用ステントグラフト (3) 胸部大動脈用ステントグラフト ( メイン部分 ) 1 標準型 2016 Medtronic, Inc. All rights reserved. Printed in JAPAN.Trademarks are the property of their respective owners. UC JA EV442_SP_SP_01

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