同窓会(本間).indd
|
|
- ぜんぺい はにうだ
- 4 years ago
- Views:
Transcription
1 76 (4-5): (2017) 235 講 演 平成 28 年日本大学医学会秋季学術大会同窓会学術奨励賞受賞講演 -synucleinopathy Ⅰ.α-synucleinopathy? Ⅰ-1.α-synucleinopathy とは -synucleinopathy -synuclein (asyn) 1 Parkinson (Parkinson s disease, PD) (dementia with Lewy bodies, DLB) (Lewy body, LB) (multiple system atrophy) 1 LB (Fig 1a) asyn (Lewy neurite, LN) 1 asyn (Fig 1b) 1 asyn Ⅰ-2. 日本における α-synucleinopathy の現状 -synucleinopathy PD DLB LB MSA /10 PD MSA 8 3 synucleinopathy PD PD PD 4 (Fig 2) Alzheimer LB DLB 5 (Fig 3) -synucleinopathy LB PD PD Ⅱ.Parkinson 病の臨床と病理 Ⅱ-1.Parkinson 病の基本的な臨床像 1817 James Parkinson 6 PD An Essay on Shaking Palsy 6 7 Parkinson PD J.-M. Charcot maladie de Parkinson 6 Parkinson s disease Fig. 2 Trends in number of patient with Parkinson s disease in Japan Fig. 1 Lewy body and Lewy neurite in the tissue of a patient with Parkinson s disease (1a, phosphorylated alpha-synuclein), and intracytoplasmic inclusion and neuronal cytoplasmic inclusion in the tissue of a patient with multiple system atrophy (1b, phosphorylated alpha-synuclein). Fig. 3 Cause of dementia in Japan adapted from Asada
2 PD PD 8 Ⅱ-2.Parkinson 病病理の変遷 PD LB Braak Hawkes PD asyn LB LB 2 PD PD Uchihara 13 asyn LB Ⅲ.Parkinson 病の臨床病理学的検討 Parkinson PD 1 Ⅲ-1. ある Parkinson 病患者の病理解剖症例から LB LN PD PD (Fig 4a, b) LB (pituitary posterior lobe, PPL) (Fig 4c) asyn CA2/3 pasyn (CA2/3 phosphorylated asyn-neurite) (Fig 4d) (transentorhinal spongiform change, TER SpC) (Fig 4e) DLB 14 (argyrophilic grain, ArG) (Fig 4f) Fig. 4 Depigmented substantia nigra was observed in the midbrain of a patient with Parkinson s disease (4a). Microscopically, Lewy body was seen in the substantia nigra (4b, Hematoxylin & eosin). Sagittal section of the pituitary gland; PAL, pituitary anterior lobe; PPL, pituitary posterior lobe (4c-left, Hematoxylin & eosin). Phosphorylated alpha-synuclein-positive neurite (red arrow) and dots (yellow arrow) were in the PPL (4c-right, phosphorylated alpha-synuclein). Phosphorylated alpha-synuclein-positive neurite in the CA 2/3 (4d, phosphorylated alpha-synuclein), spongiform change of the transentorhinal cortex (4e, Hematoxylin & eosin), and argyrophiclic grain in the ambient gyrus (4f, Gallyas-Braak stain).
3 76 (4-5) synucleinopathy 237 (argyrophilic grain dementia, AGD) 15 PD asyn LB DLB AGD PD Ⅲ-2.Parkinson 病に関する病理学的 臨床病理学的検討 -2a PPL Lewy 16 PPL pasyn LB 60 PD, 23 ; DLB, 1 ; MSA, 9 ; 10 ;, 3 ; 1 ; AGD, 1 ; 1 ; 2 ; 5 ; 1 ; 1 ;, 1 ; 1 Hoehn-Yahr stage Braak PD stage 11 1 PPL pasyn 2 PPL paraventricular nucleus, PVN (supraoptic nucleus, SON) pasyn LB Table 1 LB pasyn PPL (95.8%) non-lb (8.3%) (P < ) alphasynucleinopathy PPL pasyn PD 95.7% PPL pasyn MSA 11.1% (P < ) asyn PPL pasyn PD DLB LB 88.5%; 97.1% PPL PVN SON pasyn (neuropil) LB asyn -2b. Parkinson 17 PD PD PD ArG TER SpC CA2/3 pasyn-neurite (PD with dementia, PDD) DLB 20 PD 8 PD without dementia (PDND), 8 ; PDD, 12 Braak PD stage Braak neurofibrillary tangle stage 18 Braak senile plaque stage 18 ArG TER SpC CA2/3-paSyn-neurite scoring system PD ArG TER SpC CA2/3 pasyn neurite Table 2 PD ArG (P=0.0021) PDND PDD SpC (P=0.0193) 3 ArG TER SpC CA2/3 pasyn neurite PDD 3 Table 1 Clinical and neuropathological data relating to the studied cases Table 1. Clinical and neuropathological data adapted relating from to Homma the studied T et al 16 cases Case No Male:Female ratio Age at death (years) Brain weight (g) Positive case of pasyn IHC in PPL (mean (SD)) (mean (SD)) (%) LB-related disorder 24 13: (5.21) 1255 (118.4) 23/24 (95.8) Non-LB-related disorder 36 24: (13.1) 1255 (148.8) 3/36 (8.3) pasyn, phosphorylated alpha-synuclein; IHC, immunohistochemistory; PPL, pituitary posterior lobe; LB, Lewy body
4 238 Table 2 Distribution and degree of argyrophilic grain, spongiform change of the transentorhinal cortex and phosphorylated alpha-synucleinpositive neurite in the CA2/3 among 20 PD cases adapted from Homma T et al 17 Table 2. Distribution and degree of argyrophilic grain, spongiform change of transentorhinal cortex and phosphorylated alpha-synuclein-positive neurite in CA2/3 among 20 PD cases ArG score in Medial temporal region TER SpC score CA2/3 pasyn neurite score Anterior Posterior Total Total ArG score Ant Post Case No Amy Amb ER TER ER TER Subic CA1 TER SpC score PDND PDD PDD-ArG PDD-TER SpC PDD-NOS PDND, Parkinson's disease without dementia; PDD, Parkinson's disease with dementia; ArG, argyrophilic grain; TER SpC, spongiform change in the transentorhinal cortex, NOS, not otherwise specified Amy, amygdala; Amb, ambient gyrus; ER, entorhinal gyrus; TER, transentorhinal gyrus; Subic, subiculum; ArG, argyrophilic grain; SpC, spongiform change; pasyn, phosphorylated alpha-synuclein ArG PDD (PDD-ArG) PDD (PDD-TER SpC) 2 PDD Ⅳ. まとめ - これまでの Parkinson 病研究で知り得た結果と今後の検討課題 - PD -2. PD DLB 1 LB PD 2 PD LB 3 PDD DLB DLB 10) 2007;25: ) Braak H, Del Tredici K, Rub U, de Vos RAI, Steur ENHJ, Braak E. Staging of brain pathology related to sporadic Parkinson s disease. Neurbiology of Aging 2003;24: ) Hawkes CH, Del Tredici K, Braak H. Parkinson s disease: The dual hit theory revisited. Ann N.Y. Acad Sci. 2009;1170: ) Uchihara T, Giasson BI, Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies. Acta Neuropathol. 2016;131: ) McKeith IG, Galasko D, Kosaka K et al. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the consortium on DLB international workshop. Neurology 1996;47: ) Tolnay M, Clavaguera F. Argyrophilic grain disease: A lateonset dementia with distinctive features among tauopathies. Neuropathology 2004;24: ) Homma T, Mochizuki Y, Mizutani T. Phosphorylated -synuclein immunoreactivity in the posterior pituitary lobe. Neuropathology. 2012;32: ) Homma T, Mochizuki Y, Takahashi K, Komori T. Medial temporal regional argyrophilic grain as a possible important factor affecting dementia in Parkinson s disease. Neuropathology. 2015;35: ) Braak H, Braak E. Neuropathological staging of Alzheimerrelated changes. Acta Neuropathol 1991;82: 文 献 1) 2015;33: ) 2009;98: ) 1989;29: ) 26 (2014) 5) : 2012;52: ) Donaldson IM. James Parkinson s essay on the shaking palsy. J R Coll Physicians Edinb. 2015;45: ) 100 Brain and Nerve 2012;64: ) 2016: p16-p21 9) 2007;25:43-45
5 76 (4-5) synucleinopathy 239
Parkinson disease : ,
1 2012 7 24 Parkinson disease :10 50 100, 65 10 200 tremor rigidity (pill rolling) Cogwheel rigidity Akinesia Bradykinesia Resting tremor in Parkinson disease Parkinson disease: camptocormia Parkinson's
More information118 Dementia Japan Vol. 31 No. 1 January 2017 表 1. DLB に対して mect を行った先行研究 Rasmussen K 2003 USA Japan Japan Japan Japan 1 2
Dementia Japan 31 : 117-124, 2017 117 症例報告 要旨 1. はじめに 70 1 modified electroconvulsive therapy ; mect mect Modified electroconvulsive therapy in dementia with Lewy bodies with drug - resistant psychiatric
More informationDiagnosis of Dementia: Update
10 C A 1 2 Normal SMI MCI Early Dementia B Moderate Dementia 3 Severe Dementia 4 5 D AD, VD, FTD, DLB, PDD Depression Dementia d/t GMC Modifiable risk factors and preventive factors for dementia 6-5 -
More informationTable 1. Numbers of Cancerous Pleurisy Cases According to Primary Site Table 2. Histological Type of Lung Carcinoma with Cancerous Pleurisy at Autopsy
Clinicopathological Studies on Cancerous Pleurisy, with Emphasis on Extra-Pulmonary Malignancy Table 1. Numbers of Cancerous Pleurisy Cases According to Primary Site Table 2. Histological Type of Lung
More informationTable 1 Muscle weight (g) and those ratio (%) in M. quadriceps femoris Table 2 Cross-sectional area (mm2) and those ratio (%) in M, quadriceps femoris
Table 1 Muscle weight (g) and those ratio (%) in M. quadriceps femoris Table 2 Cross-sectional area (mm2) and those ratio (%) in M, quadriceps femoris Fig. 1 Comparison of cross-sectional area in human
More information2017 年 10 月 高齢総合医学ハイライト 図 蛋白の構造と機能 一部 4R 型には進行性核上性麻痺 大脳皮質基底 たアミロイド β 蛋白がタウ蛋白に影響し最終的に神 核変性症 嗜銀顆粒性認知症などがある アルツハ 経細胞死を引き起こすとする説である アミロイド イマー病
420 754: 420-425, 2017 No. 1 14-3 - 3 Neurodegenerative diseases characterized by conformation change of protein and 14-3 - 3 proteins : Department of Geriatric Medicine, Tokyo Medical University : Takahiko
More information若年認知症支援ハンドブック_H19
64 18 18 19 203 50 65 1) - 1 - 18 64 40 64 65 18 3064 10 54 4564 98 35 15 18 2) 45 64 10 6781 3) 1996 10 32 25600 34 10 70008000 4, 5) 10 5) 30 5 2 2) 58 42 2) 2:1 4) - 2 - 1 24, 6) Harvey 3064 185
More informationRecurrent Vertigo with Unilateral or Bilateral Sensorineural Hearing Loss of Unkown Etiology. Tsutomu Yamazaki, Sachie Watanabe, Hideo Kozaki and Taka
Recurrent Vertigo with Unilateral or Bilateral Sensorineural Hearing Loss of Unkown Etiology. Tsutomu Yamazaki, Sachie Watanabe, Hideo Kozaki and Takao Abe (Sapporo General Hosp.) Kazuo Yamamoto (Tomakomai)
More informationBUN, CRP K mg/ cm, 49.6 kg, BMI /72 mmhg, 92/ Hb 6.7 g/dl PT-INR CT 1 MRI 2a, b T1 T2 T1 MRI
20 2 2015 1 2 3 85 K CT Abstract A case of renal subcapsular hematoma resulting from trigger point injection under excessive effect of anticoagulant YAMANE Tateki, UMEDA Akira and SHIMAO Hitoshi An 85-year-old
More informationInfluences of mortality from main causes of death on life expectancy. \ An observation for the past 25 years, 1950-1975, in Japan \ Takao SHIGEMATSU* and Zenji NANJO** With the Keyfitz-Nanjo method an
More informationII Key words : RBD RBD % REM RBD PSG PSG RBD RBD RBD PD DLB RBD MIBG PD DLB RBD PD RBD rapid eye movement sleep behavior disorder, RBD R
II 1 2 1 3 Key words : RBD RBD 50 0.5% REM RBD PSG PSG RBD RBD RBD PDDLB RBD MIBG PD DLB RBD PD RBD rapid eye movement sleep behavior disorder, RBD RBD Parkinson s disease, PD multiple system atrophy,
More information脳の形態学的 な正常 と異常 Fig.11神 経 細 胞 体 内 の リ ポ フ ス チ ン(矢 印,K-B 染 色) 脊 髄 前 角 細 胞. Fig.12ア ミ ロ イ ド 小 体corpora LPH染 色> PAS陽 性. Fig.13Alzheimer神 amylacea(矢 印, 経 原 線 維 変 化(Bielschowsky 平 野 変 法 染 色) 583 Fig.14瀰 漫 性
More informationFig. 1 Clinical Appearance on the Left Leg before Therapy Fig. 2 Clinical Appearance after Therapy Fig. 3 Histopathological Features of the Skin Lesio
Ryoji KANDA, M.D. and Seiichiro HATA, M.D. Fig. 1 Clinical Appearance on the Left Leg before Therapy Fig. 2 Clinical Appearance after Therapy Fig. 3 Histopathological Features of the Skin Lesion, Showing
More informationFig Table 1 SCA3 Machado Joseph disease MJD SCA6 SCA31 Dentate rubro pallido luysian atrophy DRPLA SCA2 SCA1 Ataxin 3 Calcium channel
Review Opinion for Spine Surgeons Key words spinocerebellar degeneration multiple system atrophy progressive supranuclear palsy Parkinson disease spinal cord disease Spinal Surgery 26 3 278 283 2012 Parkinson
More informationMicrosoft PowerPoint UTNP.ppt
Neuropathology Shigeo Murayama 2007.05.21 Department of Neuropathology (Brain Bank) Tokyo Metropolitan Institute of Gerontology Today s Themes A. General consideration Hierarchy of the nervous system Dynamic
More information認知症診療ガイドライン2017_100_第1章.indd
1 CQ 1 1 10 ICD 10 /Alzheimer National Institute on Aging Alz heimer s Association workgroup NIA AA 5 DSM 5 ICD 10 1993 1 1 NIA AA 2011 Alzheimer 2 2 DSM 5 2013 neurocognitive disorders dementia major
More information特集・総説・報告(44行)/P045-055_報告 日本肝移植研究会
45 Liver Transplantation in Japan in 2006 Part 2 Registry by the The Summary Four thousand three hundred thirty liver transplants have been performed as of December 31, 2006 in 59 institutions in Japan.
More informationA Nutritional Study of Anemia in Pregnancy Hematologic Characteristics in Pregnancy (Part 1) Keizo Shiraki, Fumiko Hisaoka Department of Nutrition, Sc
A Nutritional Study of Anemia in Pregnancy Hematologic Characteristics in Pregnancy (Part 1) Keizo Shiraki, Fumiko Hisaoka Department of Nutrition, School of Medicine, Tokushima University, Tokushima Fetal
More informationEVALUATION OF NOCTURNAL PENILE TUMESCENCE (NPT) IN THE DIFFERENTIAL DIAGNOSIS OF IMPOTENCE Masaharu Aoki, Yoshiaki Kumamoto, Kazutomi Mohri and Kazunori Ohno Department of Urology, Sapporo Medical College
More informationWeb Stamps 96 KJ Stamps Web Vol 8, No 1, 2004
The Journal of the Japan Academy of Nursing Administration and Policies Vol 8, No 1, pp 43 _ 57, 2004 The Literature Review of the Japanese Nurses Job Satisfaction Research Which the Stamps-Ozaki Scale
More information28 1 1a 1b 2 MRI T2 3 CT C3 N95 N95 6ml 90
2015 28 1 89 93 CT C3 Tb PCR XP WBC 7 600/mm 3 CRP 4 08mg/dl MRI MRI CT MRI WBC 9 700/mm 3 CRP 6 09mg/dl CT C3 C2 C7 low density area CT 89 28 1 1a 1b 2 MRI T2 3 CT C3 N95 N95 6ml 90 28 1 4 CT C2 C7 low
More informationTFT 2F 1000 OD ALS SMA 2 TFT 2F 500 OD TFT 2F 300 OD TFT 9F OD CIDP 5 TFT 9F 906 OD
1 11 23 1 TFT 2F 1000 11 10 12 10 AOD1 1 01 06 1 AOD1 1 07 11 2 2 TFT 2F 500 11 10 12 10 AOM1 2 01 04 1 AOM1 2 05 08 2 3 TFT 2F 300 11 10 12 10 OD1 3 01 06 OD1 3 07 11 1 4 TFT 9F 904+905 11 10 12 10 OD1
More informationJ Kanazawa Med Univ , 2017 要約 :( ) ( ) magnetic resonance imaging (MRI) Hasegawa s dementia scale-revised (HDS-R) 11 7 (WAIS-III) MRI
J Kanazawa Med Univ 42 17 23, 2017 要約 :( ) ( ) 24 9 1.5 magnetic resonance imaging (MRI) Hasegawa s dementia scale-revised (HDS-R) 11 7 (WAIS-III) MRI voxel-based specific regional analysis system for
More information606 Dementia Japan Vol. 29 No. 4 October 2015 Table 1. The day care for people with severe dementia Outline Subjects Personal distribution Medical man
Dementia Japan 29 : 605-614, 2015 605 原著 要旨 1. はじめに 1 26 4.2 80 2 3 A survey of daycare facilities for dementia people in Japan Tohmi Osaki, Kiyoshi Maeda 1 650-0017 7-5 - 2 Medical Center for Dementia,
More information幻覚が特徴的であるが 統合失調症と異なる点として 年齢 幻覚がある程度理解可能 幻覚に対して淡々としている等の点が挙げられる 幻視について 自ら話さないこともある ときにパーキンソン様の症状を認めるが tremor がはっきりせず 手首 肘などの固縮が目立つこともある 抑うつ症状を 3~4 割くらい
レビー小体型認知症 Dementia with Lewy bodies : DLB(070803 110225) 110225 参考文献 5 を復習して追加記載 治療に関する論文のリンクを張った レビー小体型認知症の患者を診察する期会があったので その基本について復習してみる こ の疾患はアルツハイマー型認知症とパーキンソン病の特徴を併せ持つような疾患で 典型的なア ルツハイマー型認知症と思っても
More informationuntitled
239 10 3 14 00 14 50 1 : 10 2 10 30 11 30 1 : 10 4 13 00 14 00 1 : 10 2 13 00 14 00 1 : Peter St. George - Hyslop University of Toronto 10 2 14 10 15 10 1 : Randall Bateman Neurology at Washington University
More informationCHEMOTHERAPY Fig. 1 Body weight changes of pregnant mice treated orally with AM- 715 Day of sestation
CHEMOTHERAPY CHEMOTHERAPY Fig. 1 Body weight changes of pregnant mice treated orally with AM- 715 Day of sestation CHEMOTHERAPY Table 1 Preliminaly test of AM- 715 1): Mean } SD *: Significant difference
More information( ) fnirs ( ) An analysis of the brain activity during playing video games: comparing master with not master Shingo Hattahara, 1 Nobuto Fuji
1 1 2 3 4 ( ) fnirs () An analysis of the brain activity during playing video games: comparing master with not master Shingo Hattahara, 1 Nobuto Fujii, 1 Shinpei Nagae, 2 Koji Kazai 3 and Haruhiro Katayose
More informationx [1] Palmer Jeffrey, B. and M. Hiiemae Karen, (propulsion). (1343-8441), 1997. 1(1): p. 15-30. [2] Saitoh, E., et al., Chewing and food consistency: effects on bolus transport and swallow initiation.
More information366 12 THE JAPANESE JOURNAL OF ANTIBIOTICS 65 6 Dec. 2012 1 8 DNA 2,3 16 12 20 171 2008 12 2010 11 2 3,558 4.44% 1.65% 1.17% 90% 9 Escherichia coli -
Dec. 2012 THE JAPANESE JOURNAL OF ANTIBIOTICS 65 6 365 11 sita oxacin 1 1 1 1 1 1 2 2 3 3 1 1 1 2 3 2012 9 14 sita oxacin STFX 50 mg 10% 2008 1 2008 12 2010 11 2 STFX 1,452 91.4% 1,235/1,351 95.9% 466/486
More informationKey words: Antibodies to Leptospira, Tokyo, Uveitis
Key words: Antibodies to Leptospira, Tokyo, Uveitis Fig. 1 Distribution of Antibody Titers in Age Decade Fig. 3 Distribution of Antibody Titers in each Strain Fig. 2 Correlation between Antibody Titers
More informationTitle 生活年令による学級の等質化に関する研究 (1) - 生活年令と学業成績について - Author(s) 与那嶺, 松助 ; 東江, 康治 Citation 研究集録 (5): 33-47 Issue Date 1961-12 URL http://hdl.handle.net/20.500.12000/ Rights 46 STUDIES ON HOMOGENEOUS
More information日本消化器外科学会雑誌第25巻第11号
Key words: intestinal nerve plexus, hypoxic perfusion, immunohistochemistry, 5-100 protein Table I (A) Sroo staining reactivity of nerve tissue normal partly mildly declined all mildly declined partly
More informationFig. 1 Trends of TB incidence rates for all forms and smear-positive pulmonary TB in Kawasaki City and Japan. Incidence=newly notified cases of all fo
Kekkaku Vol. 79, No. 1: 17-24, 2004 17 (Received 21 Aug. 2003/Accepted 18 Nov. 2003) Fig. 1 Trends of TB incidence rates for all forms and smear-positive pulmonary TB in Kawasaki City and Japan. Incidence=newly
More informationFig. 1 Chest X-ray on admission, with infiltrative shadow in the right upper lung field. Fig. 2 Chest CT scan shows an infiltrative shadow, multiple b
congenital bronchial atresia, obstructive pneumonia Fig. 1 Chest X-ray on admission, with infiltrative shadow in the right upper lung field. Fig. 2 Chest CT scan shows an infiltrative shadow, multiple
More information臨床神経学雑誌第48巻第1号
meta parkin α α α meta parkin Fig.1 パーキンソン病および類縁疾患における H/M 比の比較検討 ( 早期像 ). PD: パーキンソン病,PAF: 純粋自律神経不全症,DLB: レビー小体型認知症,MSA: 多系統萎縮症,PSP: 進行性核上性麻痺,BD: 大脳皮質基底核変性症,ET: 本態性振戦,AD: アルツハイマー病,: コントロール ( 織茂智之 : 内科
More information423 昭 和60年6,月28日 Fig. Panel 4.3, are œ; A B as SO and after follows; (slow B 1 are Microphotographs processed preincubation FG twitch for at (fast twitch oxidative a ph 4.0. cross ATPase Panel glycolitic
More informationVol.0 No. 0 図 Montreal Cognitive AssessmentMoCA orientation visuospatial attention orientation 4 visuospatial executive MMSE MoCA language language me
Parkinson 病の認知機能障害を MMSE と MoCA により評価した多施設共同研究 : 慶應 PD データベース Cognitive impairment in Parkinson s disease patients evaluated by the Montreal Cognitive Assessment and the Mini-Mental State Examination.
More information013858,繊維学会誌ファイバー1月/報文-02-古金谷
Development of Non-Contact Measuring Method for Final Twist Number of Double Ply Staple Yarn Keizo Koganeya 1, Youichi Yukishita 1, Hirotaka Fujisaki 1, Yasunori Jintoku 2, Hironori Okuno 2, and Motoharu
More informationSpecial IssueDiagnoses and therapeutic agents for age-related diseases Reviews Original Case reports β Medicinal drugs affecting on clinical laboratory blood test results and adverse effects of them
More information原著・報告・記録(44行)/P261~274_報告 肝移植症例登録
261 Liver Transplantation in Japan Registry by the Japanese Liver Transplantation Society The Japanese Liver Transplantation Society Summary As of December 31, 2013, a total of 7,474 liver transplants
More informationStabilometry-Significance of Locus Length per Unit Area (L/A) in Patients with Equilibrium Disturbances- Tsuyoshi Okawa, Takashi Tokita, Yasunari Shib
Stabilometry-Significance of Locus Length per Unit Area (L/A) in Patients with Equilibrium Disturbances- Tsuyoshi Okawa, Takashi Tokita, Yasunari Shibata Tetsuya Ogawa, Hideo Miyata 1) Department of Otolaryngology,
More informationMicrosoft PowerPoint - LITA-noreflow_English.pptx
A case of no-reflow phenomenon during PCI to LIMA graft Iwatsuki-Minami hospital, Saitama, Japan Koichi Sano, Masaki Tsukagoshi, Yasunari Ueno, Seiichi Fukuda, Takayoshi Sato, Yasuyuki Maruyama 77 y.o.
More information, PDD ASD p.,.,..,..,.,..,.,..,.,.,.,, 146
Study on the System of the Chinese Autistic in Japan Xiaotong Ro abstract This study note is mainly introduced the research of China s autistic child treatment in Japan. There is not very much research
More informationKittipong
1. Aoki R, Srivatanakul K, Hirayama A, A vein of the foramen caecum observed on angiography, Eur J Ana 21(4): 305-307, 2017 2. Hui Han & Wei Tao & Ming Zhang, The dural entrance of cerebral bridging veins
More informationArthroscopic Subacromial Decompression for Impingement Syndrome by E. Shimozaki, K. Kitaoka, T. Matsumoto, H. Itokawa, T. Kobayashi and K. Tomita Depa
Arthroscopic Subacromial Decompression for Impingement Syndrome by E. Shimozaki, K. Kitaoka, T. Matsumoto, H. Itokawa, T. Kobayashi and K. Tomita Department of Orthopaedic Surgery, School of Medicine,
More informationTable 1.Concentration of gatifloxacin (Middle-ear) Table 2.Concentration of gatifloxacin (Paranasal sinuses) Table 3.Concentration of gatifloxacin (Tonsil) Table 4.No.of patients studied Table 5.Background
More information日本化学療法学会雑誌第59巻第5号
Streptococcus pneumoniae Haemophilus influenzae Moraxella catarrhalis S. pneumoniae H. influenzae M. catarrhalis S. pneumoniae H. influenzae M. catarrhalis S. pneumoniae H. influenzae M. catarrhalis S.
More informationJ. Smooth Muscle Res. (Jap. Section) 5: J-59--J-67, 2001 URODYNAMIC STUDY IN DIAGNOSIS OF DIABETIC DYSURIA Minoru SATO First Department of Urology, To
J. Smooth Muscle Res. (Jap. Section) 5: J-59--J-67, 2001 URODYNAMIC STUDY IN DIAGNOSIS OF DIABETIC DYSURIA Minoru SATO First Department of Urology, Toho University School of Medicine, 6-11-1 Omori-nishi,
More information食道がん化学放射線療法後のsalvage手術
2006 2 17 52 Daly JM, et al. J Am Coll Surg 2000;190:562-573 Esophageal Cancer: Results of an American College of Surgeons Patient Care Evaluation Study Daly JM, et al. J Am Coll Surg 2000;190:562-573
More information051
Aug. THE JAPANESE JOURNAL OF ANTIBIOTICS 58 4 389( 15 ) 1. MDS collagenase 2. 1 3. 4. / 390( 16 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 58 4 Aug. 4 4 2004 10 2 1 NTT Aug. THE JAPANESE JOURNAL OF ANTIBIOTICS
More informationTable 1. Antibacterial activitiy of grepafloxacin and other antibiotics against clinical isolates
Table 1. Antibacterial activitiy of grepafloxacin and other antibiotics against clinical isolates Table 2-1. Summary of patients treated with grepafloxacin for respiratory infection 1) Out: outpatient,
More informationKey words : candidemia, endotoxin, D-arabinitol, Candida antigen, serological examination
Key words : candidemia, endotoxin, D-arabinitol, Candida antigen, serological examination Fig. 1 The value of fungal index and D- arabinitol/creatinine. Fungal index was mesured by Endotoxin D and Endospecy
More informationTable 1 ICHs in young adults Table 2 Five cases of undetermined etiology
Table 1 ICHs in young adults Table 2 Five cases of undetermined etiology 神 1 1. left : in the right ted MRI, callosum. parietal. right : ICH in 保 洋 之 他 ICHs 4 Ti-weighthe 1. left: rrhagic corpus infarction
More informationTable 1 Patients with various renal function * Ccr, Creatinine clearance ml/min per 1. 48 m2 ** C.V.D., Cerebral vascular disease ; C.R F., Chronic renal failure ; H.D., Hemoclialysis ; D., Dialyzer ;
More informationExperimental and Clinical Studies of Pregnant Hypertension Takashi SHIMAZU Department of Obstetrics and Gynecology, Osaka City University Medical Scho
Experimental and Clinical Studies of Pregnant Hypertension Takashi SHIMAZU Department of Obstetrics and Gynecology, Osaka City University Medical School While the problem of late pregnant hypertension
More informationi152.j
Case 1 THE IMAGING CASES Case 2 THE IMAGING CASES Case 3 THE IMAGING CASES Case 4 THE IMAGING CASES Case 1 Reading & Diagnosis THE IMAGING CASES Case 2 Reading & Diagnosis THE IMAGING CASES Case
More informationArthroscopic Treatment for Painful Bennett Lesions of the Shoulder in Baseball Players by M. Yoneda and K. Hayashida Department of Orthopaedic Surgery
Arthroscopic Treatment for Painful Bennett Lesions of the Shoulder in Baseball Players by M. Yoneda and K. Hayashida Department of Orthopaedic Surgery, Osaka Kosei-Nenkin Hospital K. Izawa and S. Wakitani
More information原著・報告・記録(44行)/P156~169_報告 肝移植症例登録
156 Vol. 50, No. 23 Liver Transplantation in Japan Registry by the Japanese Liver Transplantation Society The Japanese Liver Transplantation Society Summary As of December 31, 2014, a total of 7,937 liver
More informationTable 1 Characteristics of the study participants in Imari municipal hospital
Key words: tuberculosis, booster phenomenon, two-step tuberculin test Table 1 Characteristics of the study participants in Imari municipal hospital Fig. 1 Frequency distributions of size of the first tuberculin
More information1) Richter, C. P.: Ann. Rev. Physiol., 4, 561 (1942) 2) A. L. Fox: Proc. Nat. Acad. Sci., Wash., 18, 115(1931) 4) Hansen, R. u. W. Langer: Klin. Wschr, 9) Katsch, G. u. H. Pickert: Handb. d. Inn. Med.
More information,,,, : - i -
2017 Future University Hakodate 2017 System Information Science Practice Group Report Project Name Manga engineering Group Name Literacy Manga /Project No. 19 /Project Leader 1015131 Kiyomasa Murakami
More informationCHEMOTHERAPY APR. 1984
VOL.32 S-3 CHEMOTHERAPY dihydro-4-oxo-7-(1-piperazinyl)-1, 8-naphthyridine- CHEMOTHERAPY APR. 1984 VOL.32 S-3 CHEMOTHERAPY Table 1 Implantation rates and post- implantation survival rates in females mated
More information8 The Bulletin of Meiji University of Integrative Medicine API II 61 ASO X 11 7 X-4 6 X m 5 X-2 4 X 3 9 X 11 7 API 0.84 ASO X 1 1 MR-angio
7-14 2010 1 1 1 2 1 1 1 2 Fontaine II ASO61 3 API ASO ASO ASO API API KKKKKKKKKK ASO Fontaine II API Received April 14, 2009; Accepted July 16, 2009 I arteriosclerosis obliterans: ASO ASO 50 70 1,2 Fontaine
More informationToshiya CHIHARA,M.D. and Takakazu SHIBATA, M.D.
Toshiya CHIHARA,M.D. and Takakazu SHIBATA, M.D. Fig. 1 Clinical Appearrance on the Head and Face of Case 1 on the First Arrival Fig. 2 Clinical Appearrance on the Shoulder and Arm of Case 1 on the First
More information日本職業・災害医学会会誌第54巻第6号
Reprint request: A CASE OF PRESENTED VARIOUS FUNCTIONAL DISTURBANCES AFTER AN INJURY Taketoshi NOGAKI, Nobusuke HOUCHI, Tomoko SUGIUCHI, Naohiko WATANABE and Hiroyuki ZUSHO Department of Otolaryngology,
More informationsemen quality or those without WBC in semen. In the patients with azoospermia and normal FSH levels (normogonadotropic azzospermia), the antibody (IgG
CLINICAL STUDIES OF UROGENITAL INFECTIONS WITH CHLAMYDIA TRACHOMA TIS Report 2. The Epidemiology of Chlamydial Infections in Okayama District in Japan and Detection of Antibodies to Chlamydiae in the Sera
More informationFig. 1. Chest X-ray film on admission showed a mass in the left middle lung field and multiple nodular densities in the bilateral lung fields. Fig. 3.
A Case of Slow-growing Mucous-producing Adenocarcioma of the Lung Key words: Mucous-producing lung adenocarcinoma, Slow-growing, Bronchial gland cell type adenocarcinoma, Adenoid cystic carcinoma Table
More information) 5 Lawton QOL 4 4 QOL Lawton 4) Philadelphia Geriatric Center Affect Rating ScaleARS ARS QOL 5) HDS R
Vol. 12 No. 2 2002 389 397 Λ1 Λ2 16 10 30 1 2 Lawton Philadelphia Geriatric Center Affect Rating ScaleARS Lawton ARS + ARS 6 2 ARS 2 12:00 15:0017:00 11:30 16:00 1 2 ARS 1 2 ARS QOL QOL QOL 1) QOL QOL
More information01津行篤士ほか.indd
Biosphere Sci. 55 1-6 (2016) 耳石 Sr:Ca 比によって推定した利根川産大型ヤマメの回遊履歴 1) 2) 3) 1) * 1) 739 8528 1-4-4 2) 375-0011 3) 371-0036 13 要旨 8 Sr:Ca 3 5 4 243km キーワード : Sr:Ca 緒 言 Oncorhynchus masou masou 1980 2014 4 2014
More informationmm mm , ,000 Fig. 1 Locality map of the investigation area NE SW Fi
5 Report on the Landslide Disaster in the Upper Part of the Abukuma River, Fukushima Prefecture, Due to Heavy Rainfall in August 1998 By Takashi INOKUCHI National Research Institute for Earth Science and
More information評論・社会科学 85号(よこ)(P)/3.佐分
well-being well-being well-being well-being QOL well-being satisfaction appraisal 69 well-being 2025 520 http : //www.mhlw.go.jp/ 2000 2004 2005 well-being 1 Walker 1996 ; Picot 1997 2003 2004 Zarit 1980
More information北海道水産試験場研究報告
Sci.Rep.Hokkaido Fish.Res.Inst. Age determination of Japanese flounder Paralichthys olivaceus, caught from Ishikari Bay, using cross sections of otoliths NOBORU HOSHINO Central Fisheries Research Institute,
More information& Vol.2 No (Mar. 2012) 1,a) , Bluetooth A Health Management Service by Cell Phones and Its Us
1,a) 1 1 1 1 2 2 2011 8 10, 2011 12 2 1 Bluetooth 36 2 3 10 70 34 A Health Management Service by Cell Phones and Its Usability Evaluation Naofumi Yoshida 1,a) Daigo Matsubara 1 Naoki Ishibashi 1 Nobuo
More informationClinical Characteristics in Multiple Endocrine Neoplasia Type 1 in Japan: A review of 106 patients Katsuhiko YOSHIMOTO 1,2, Shiro SAITO 1 1. The First Department of Internal Medicine 2. Otsuka Department
More informationMechanism of painful breast induced by cold stimulus Yoshinori ITOH (Nagoya) Dept. of Physiol., Nagoya Univ, Sch, of Med., Nagoya, Japan Abstract Cold colic pain response was first mentioned in Kinkiyoryaku,
More information1) Asa, S. L., et al.: Immunohistochemical localization of neuron-specific enolase in the human hypophysis and pituitary adenoma, Arch. Pathol. Lab. Med., 108: 40 `43, 1984. 2) Chi, B. H. and Kim, R. C.:
More information顔面神経麻痺を来したMPO―ANCA 陽性の中耳炎2症例
11367 : MPOANCA MPO ANCA MPOANCA 134EU MPO ANCA 67EU MPOANCA ANCA : MPOANCAANCA antineutrophil cytoplasmic antibody ; ANCA Davies IgG ANCA PR3proteinase3ANCA MPOmyeloperoxidaseANCA Wegener PR3ANCA MPO
More information研究報告37号
Bathymetric distribution and phenology of Ecklonia kurome in the western Wakasa Bay, the Sea of Japan. Tomokazu Nishigaki and Akio Douke Bathymetric distribution of large brown algae, and temporal variation
More informationAuthor Workshop 20111124 Henry Cavendish 1731-1810 Biot-Savart 26 (1) (2) (3) (4) (5) (6) Priority Proceeding Impact factor Full paper impact factor Peter Drucker 1890-1971 1903-1989 Title) Abstract
More information総 説 6 6 PIMs P S J 7
2018 10 1-6 総 説 2018 P S J 1 2018 10 7-13 総 説 6 6 PIMs P S J 7 2018 10 19-29 誌上シンポジウム JASDS DSM 1997 2012 15 DSM DSSP JASDS DSM DSSP P S J 19 2018 10 30-34 誌上シンポジウム ADME 30 Pharmacy Society of Japan 2018
More information1) Delbet P: Retrocissement du choledoque. Cholecysto-duodenostomie. Bull Mem Soc Nat Chir 50: 1144-1146, 1924 2) Wiesner RH, LaRusso NF: Clinicopathologic Features of the Syndrome of Primary Sclerosing
More information66-1 石郷岡 愛.pwd
eating disorders ED ED ED ED ED ED ED ED anorexia nervosa AN bulimia nervosa BN Eating disorder not otherwise specified EDNOS DSM 5 EDNOS BN binge eating disorder BED feeding and eating disorders ED AN
More informationMicrosoft Word - mitomi_v06.doc
MSS mitomi@edm.bosai.go.jp matsuoka@edm.bosai.go.jp yamazaki@edm.bosai.go.jp taniguchi@manage.nitech.ac.jp 1 MSS MSS 2 2 1 m MSS CCT CCT Fig.1 CCT b02-b0 b0-b0b-b b-b1 CCT Landsat/TM MSS S/N 21x21 21x21
More informationVol.16 No.2 July 2012 報 告 パーキンソン病の歩行障害症状に変化をもたらすリズム刺激の方法および選曲等の嗜好反映の影響 音楽療法実践についての文献レビュー 1) 稲井晴子 抄 録 目的 方法 A B Web Version5.0 PubMed PsycINF
報 告 パーキンソン病の歩行障害症状に変化をもたらすリズム刺激の方法および選曲等の嗜好反映の影響 音楽療法実践についての文献レビュー 1) 稲井晴子 抄 録 目的 方法 AB20002011 Web Version5.0PubMedPsycINFOMEDLINECINAHLThe Cochrane Library ABUPDRS 分析 m/ cm/ / UPDRS 結果 109 RCT 3.820.722.65.1
More informationKey words: bacterial meningitis, Haemophilus influenzae type b, Streptococcus pneumoniae, rapid diagnosis, childhood
Key words: bacterial meningitis, Haemophilus influenzae type b, Streptococcus pneumoniae, rapid diagnosis, childhood Fig.1 Distribution of the cases with bacterial meningitis by age and pathogens Chiba
More information本文/依頼2_和気先生(4C) ☆
Ann Jpn Prosthodont Soc 4 : 256-266, 2012 Historical Changes of Psychosomatic Therapy for Patients with Temporomandibular Disorders Hiroyuki Wake, PhD, DDS a, and Osamu Komiyama, PhD, DDS b 256 257 258
More information202
201 Presenteeism 202 203 204 Table 1. Name Elements of Work Productivity Targeted Populations Measurement items of Presenteeism (Number of Items) Reliability Validity α α 205 α ä 206 Table 2. Factors of
More information第4回企画展 わたしたちの脳
"The Wisdom of the Body" The Structure of Brain Peripheral Nervous System Localization of Brain Function Homeostasis The Brain Difference between Humans and Other Mammals The history of brain research
More information1
1 2 3 4 . 5 6 7 8 9 10 11 12 .. 13 .. 14 15 16 17 18 19 20 .. 223 ( ) 218 1 21 1 225 72 63 154 141 54 24 40 274 186 226 197 507 22 23 24 25 26 27 28 29 .... 30 SPC 31 32 33 34 35 36 . 37 38 39 .......
More information36:378 第 38 回日本脳卒中学会講演シンポジウム 原著 36: , 要旨 TIA 2 t-pa Key words: stroke registry, stroke subtype, onset-visi
36:378 第 38 回日本脳卒中学会講演シンポジウム 原著 36: 378 384, 2014 1 2 要旨 1999 2012 10 31 29 26 80 30 TIA 2 t-pa Key words: stroke registry, stroke subtype, onset-visit time, chronological change はじめに 4 12 23 27 1 Japan
More informationTable 1 Isolated venous thrombi in soleal muscle by ultrasonography US finding Acute Chronic Total No. Early stage non-retracted slightl
Online publication October 8, 2010 原 著 第 50 回総会座長推薦論文 孤立性ひらめ筋内静脈血栓と抗核抗体との関連 1 2 要旨 : 89 116 D 3 30 70 63 26 100 J Jpn Coll Angiol, 2010, 50: 417 422 Key words: isolated soleal venous thrombi, recurrent
More information56 pp , 2005 * ******* *** ** CA CAMA
Title 成人知的障害者の加齢に伴う外観的変化に関する研究 : 知的障害者用外観的老化微候測定法を用いた検討 Author(s) 春日井, 宏彰 ; 菅野, 敦 ; 橋本, 創一 ; 桜井, 和典 ; 片瀬, Citation 東京学芸大学紀要. 第 1 部門, 教育科学, 56: 415-425 Issue Date 2005-03-00 URL http://hdl.handle.net/2309/2097
More information原著・報告・記録(44行)/P134~147_報告 肝移植症例登録
134 Vol. 52, No. 23 Liver transplantation in Japan. Registry by the Japanese Liver Transplantation Society The Japanese Liver Transplantation Society Summary As of December 31, 2016, a total of 8,825 liver
More information88(88) 日呼 外 会誌 chondromyxoid 瘍 の1彩 fibromaの 以 下 と比 較 的 稀 で,男 に 多 く,30歳 図5 切 図6 病 理 組 織像 発 生 頻 度 は 全 骨腫 女 比 はや や 男性 ま で の 若 年 者 に 多 く見 ら れ る3-7). 除 標 第3巻1号 (平成 元 年3.月) 本 発 生 部位 と して は長 幹 骨 の 末 端 に 発生 す
More information