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1 CoQ10 CoQ10 CoQ10 CoQ10 CoQ10 (A CoQ10 CoQ10 B CoQ10 CoQ10 C CoQ10 CoQ10 CoQ10 QOL CoQ10 QOL CoQ10 CoQ10 CoQ10 CoQ10 14 還元型 CoQ10 の摂取はインフルエンザウイルス感染に対する予防効果を示す
2 CoQ1050CoQ10 CoQ1080CoQ10 Åberg et al., Arch Biochem Biopys 295: 230, 1992 CoQ1080% (Okamoto et al., Int J Vit Nutr Res 59: 288, 1989) CoQ10 % (Åberg et al., Arch Biochem Biopys 295: 230, 1992)
3 CoQ10CoQ10 CoQ10 CoQ10 2CoQ10 CoQ10 CoQ10 CoQ10 CoQ10 (Mohr et al. Redox Report 4:79, 1999 )
4 CoQ10 CoQ ~ ~ CoQ10 (%) Wada, H., et al JAGS () Vol. 55, No.7
5 CoQ10CoQ10A CoQ10CoQ (MeanSD, n=4) ** Plasma QH ratio (%) Co Q CoQ10 CoQ QH CoQ10 (w.o.) CoQ10 CoQ10 Dose 100 mg/kg, Sampling 8 hours after dosing DeterminationHPLC with ECD ** p<0.01 U test
6 CoQ10CoQ10B CoQ10DTdiaphorase (NQ01) (López-Lluch et al., AGE 27:153, 2005) (Shih et al., Biogerontl 8:71, 2007) ~70
7 CoQ10CoQ10C NQ01 CoQ10NADPH % 60% 36% Parihar MS et al, J Neurosci Res 86, 2339, 2008
8 CoQ10 CoQ10 (1) Lim et al., Diabet Med 23:1344, 2006 a p=0.001 (mmol/l) 5.5 (n=60) (n=63) 7.0 (n=69) CoQ10(%) a a a a + CoQ10 (2) Lim et al., Atherosclerosis 196: 966, 2008 CoQ10 (n=40) (n=40) CoQ10(%) CoQ10 (1) n=40coq10200mg12 (2) CoQ10CoQ10 CoQ10CoQ10
9 ( (n=20 ): CoQ10(%) A (n=10) B (n=10) CoQ CoQ CoQ10CoQ10 100mg3CoQ10 CoQ10COQ10 CoQ10CoQ10 *p<0.01 (Yamamoto et al., BioFactors 9: 241, 1999) (n=16) (n=28) (n=16) (n=20) CoQ10 (%) * * *
10 (sals) *p<0.01 (Sohmiya et al., J. Neurol Sci 228: 49, 2005) (n=20) sals (n=20) CoQ10 (%) * *p<0.01 (Sohmiya et al., J. Neurol Sci 223: 161, 2004) (n=29) (n=36) CoQ10 (%) *
11 CoQ10CoQ10 CoQ10CoQ10 P< P=0.010 P< (Trisomy 21) CoQ mg/30kg CoQ10 CoQ10 CoQ10 CoQ10 Miles et al., Pediatr Neurol 37: 398, 2007
12 QOL CoQ10QOL CoQ10 CoQ10QOL QOL 100 * 6 12 (n=6meansd) * * CoQ10100 QOLSF ** 40 () () CoQ10QOL ( 24:233, 2008 Food style21 12:82, 2008
13 CoQ10 CoQ10 Yan, J., et al Exp. Gerontology 41, : Senescence Accelerated Mouse P1 (SAMP1) : Control CE-2 CoQ10 0.2% (w/w) CoQ10 ( mg/kg ) CoQ10 0.2% (w/w) CoQ10( mg/kg ) 2 : (( )SAM* * : The Council for SAM Research:
14 Control 15 (n=10 12, Mean SD) Control 0.2% CoQ10 QH 0.2% CoQ10 Grading Score 10 CoQ10 5 * ** ** * * ** CoQ Month old Yan, J., et al Exp. Gerontology 41,
15 CoQ10 CoQ * / Prolonged time (s) () CoQ10 CoQ10 () Control Ubiquinol Ubiquinone 300mg/kg 300mg/kg SD n=7 CoQ10300 mg/kg 2 3 CoQ10 CoQ10 * p<0.05 U test
16 CoQ10 CoQ10 CoQ10 : NYHA IV (n=7) CoQ10 : 450 mg/day 580 mg/day10 EF (Ejection Fraction) 22% 39% NYHA IV II (2 IV I) CoQ10 (1.6 µg/ml 6.5 µg/ml) (Langsjoen PH et al., Biofactors 32119, 2008) **NYHA (New York Heart Association) I II III IV
17 No. CoQ10 CoQ10 (mg/day) * (%) NYHA ** CoQ10 (µg/ml) # IV I # IV III # IV III # IV I # IV II # IV II # IV III Average *CoQ10 ( **NYHA (New York Heart Association) I IV II II III IV (Langsjoen PH et al., Biofactors 32119, 2008)
18 CoQ10 CoQ CoQ1011 CoQ mg/day 4 POMS* *POMS Profile of Mood States 6 59 No LBY-26)
19 CoQ10 Method: 10s P 2min Rest 10s P 2min Rest 10s P P: full power pedaling Power (Mean) Power (Peak) 0 0w 4w 4 0w 4w 0 4 CoQ10 Placebo CoQ10 Placebo CoQ10 59 No LBY-26)
20 CoQ10 *POMS Profile of Mood States 6 POMS 59 No LBY-26) 0 week 4 weeks
21 CoQ10 59No LBY-26)
22 研究情報 14 還元型 CoQ10 の摂取はインフルエンザウイルス感染に対する予防効果を示す マウスでのインフルエンザウイルス感染防御効果方法 マウス入荷 :BALB/c, 5 weeks (n=5) A 型インフルエンザウイルス H1N1 亜型 (2X10 4 PFU/mouse) 経鼻感染 剖検 : 感染後 3 日目気道内洗浄液中ウイルス量 -Day 7 -Day 3 Day 0 Day 3 試料投与 ( 経口 ) 試料投与量タミフル :12.5mg/kg/day 還元型 CoQ10(QH): 100mg/kg/day, 300mg/kg/day ラブレ菌 ( 殺菌体 ):10 6 個 /mouse/day
23 気道洗浄液中のウイルス量 量 ( 10 3 PFU/10 00mL) *** *** * * *** ウイルス Control タミフル *p<0.05, ***p<0.001 vs control 備考 : 気道はウイルスの主要な増殖部位 Q H 300 Q H 100 ラブレ殺菌体 10E6 QH ラブレ殺菌体 10E6 還元型 CoQ10+ ラブレ殺菌体の併用により 各試料の単独投与に比べて より効果的なウイルス感染防御を期待できる
24 補足資料 ( ラブレ生菌体との併用 ) 気道洗浄液中のウイルス量 ウイルス量 ( 1 103PFU/ ml) Control *** タミフル *p<0.05, p, ***p<0.001 p vs control *** QH 300 * QH 100 *** ブレ生菌体 10E6 *** QH ラブレ生菌体 10E6 ラ 備考 : 気道はウイルスの主要な増殖部位 還元型 CoQ10+ ラブレ生菌体の併用により 各試料の単独投与に比べて より効果的なウイルス感染防御を期待できる
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1 CoQ10 50 CoQ10 CoQ10 80 CoQ10 Åberg et al., Arch Biochem Biopys 295: 230, 1992 CoQ10 80% (Okamoto et al., Int J Vit Nutr Res 59: 288, 1989) CoQ10 %
1 CoQ10 50 CoQ10 CoQ10 80 CoQ10 Åberg et al., Arch Biochem Biopys 295: 230, 1992 CoQ10 80% (Okamoto et al., Int J Vit Nutr Res 59: 288, 1989) CoQ10 % (Åberg et al., Arch Biochem Biopys 295: 230, 1992 )
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NIHSS score14 1 400 1 p149 1 25 20 NIHSS score14 15 10 5 2 p149 4 p151 0 0.8 g ml 0.8 g ml D 1 D NIH NIHSS 14 D 0.8 g ml 1 2 148 149 3 2 3 A B C 4 D 2 A B C A C 1 Ogata T et al J Neurol Sci 272 83 86 2008
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