橡アジポニトリル.PDF

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1 ( ) CAS ( ) 1,4- NC(CH 2 ) 4 CN C 6 H 8 N ) ) 1 2) 295 2) 159(c.c.) 3) 550 3) vol % ( ) 3) d ) 3.73 ( = 1) Pa (0.002 mmhg) (20) 2) log Pow-0.32 ( ) 2) m/z41 (, 1.0 )68 (0.54)54 (0.43) 4) Koc g/l (20) 2) 2) 1 ppm = 4.49 mg/m 3 (, 20) 1 mg/m 3 = 0.223ppm 3)

2 ,118 t( 0 t 8,118 t) 5) 2 1) 3. 1) 6) ( ) mg/l 30 mg/l BOD 3543% (NO 2 ) 5366% (NH 3 ) TOC 86% GC 96% OH = cm 3 /sec( 25) 7) OH /cm ) 8 3) () 55 ppb ppm ppm B/A B/A B/A B/A ( ) ( ) ( ) ( ) 0/21 0/21 (10) (0.10.3) B/A

3 3 4. LC 50(mg/L) EC 50 (mg/l) : *9) Daphnia magna 10) ( ) Lepomis 720 (96-h) macrochirus 10) ( ) Poecilia 775 (96-h) reticulata 10) ( ) Pimephales 820 (96-h) promelas 10) ( ) * OECD 445 (24-h): ( ) 5. 2, 11, 12, 13, 14, 15, 16) 1) LD mg/kg mg/kg mg/kg LC ppm (4h) LD 50 > 2,000 mg/kg 2,134-2,290 mg/kg LD mg/kg LD mg/kg 17) ppm (250-3,030 mg/m 3 )4 160 ppm (710 mg/m 3 ) LC ppm(1,710 mg/m 3 ) 13) 2) 0.5 ml 24 14) 3) ( ) 14)

4 4) (1) ppm ppm 2, 14) (2) ppm( mg/l)6 / 5 / ppm 21.5 ppm 60.6 ppm 2, 14 14) ppm ( mg/m 3 )6 / 5 / ppm 111 ppm 2, ) ppm ( mg/m 3 )6 / 5 / ppm NOAEL , ppm 14,18) 5) in vitro in vivo * TA97TA98TA100 TA1535TA1537S9 mix (+/-) 12) TA98TA1535TA1537 TA1538S9 mix (+/-)100-10,000 µg/plate 14) L5178YS9 mix (+/-) 5µL/mL 14) DNA S9 mix (+/-) -2,500 µl/ml 14) SD * 6) ,15)

5 7) (1) mg/kg/day ,14) (2) ppm ( mg/m 3 )6 / 22 ( )) 14, 19) ppm ( mg/m 3 )6 / 5 / 74 (53 ) ( 14, )) 20) 6. 1) 15) 2, 14, 18 ml 2, 14) 2) 21, 22, 23) 3) EPA (1999 ) D EU 2000 NTP 2000 IARC 2000 ACGIH , 23) 4) ACGIH (2000 ) 2 ppm (8.8 mg/m 3 ) (2000 )

6 % 5 14,15) 50 mg/kg 79% 12, 14, 15,16) 5.75 mg/kg 80%6% 9 14) 8. (OECD ) * 9) * OECD OECD 9. 1) in vitro in vivo OH

7 2) (1) 7 (2) (3) (4) 13 10

8 8 1) () (2001). 2) Hazardous Substances Data Bank (HSDB), U.S. National Library of Medicine (2001). 3) IPCS, International Chemical Safety Cards (1995). 4) NIST Library of 54K Compounds. 5) 10, (1999). 6),,, (1992). 7) AOPWIN ver1.86 (Syracuse Research Corporation). 8) (2000). 9) OECD, Harmonised Integrated Classification System for Human Health and Environmental Hazards of Chemical Substances and Mixtures. OECD Series on Testing and Assessment No. 33 (2001). 10) AQUIRE (US EPA, ECOTOX Database System). 11) Registry of Toxic Effects of Chemical Substances (RTECS), US NIOSH (1998). 12) Sharat Gangolli, The Dictionary of Substances and their Effects, 2nd. Ed., The Royal Society of Chemistry (1999). 13) Ladd W. Smith, Inhalation toxicity of adiponitrile in rats, Toxicology and Applied Pharmacology, 65, (1982). 14) IUCLID (International Uniform Chemical Information Data Base) Data Sheet, EU (1995). 15) OECD/UNEP/WHO/ILO, Screening Information Data Set (SIDS), 5(1), (1998). 16),,,, (1994). 17) O. L. Dashiell, The effects of fasting on the acute oral toxicity of nine chemicals in the rat, Journal of Applied Toxicology, 4(6), (1984). 18) R. D. Short, 13-Week inhalation toxicity study and fertility assessment in rats exposed to atmospheres containing adiponitrile, Journal of Toxicology and Environmental Health, 30, (1990). 19) EPA/OTS Doc#: , Monsanto Co., Female Fertility study of Sprague-Dawley rats exposed by the inhalation route to adiponitrile with attachments (Final report) (1983). 20) EPA/OTS Doc#: , Monsanto Co., Male Fertility study of Sprague-Dawley rats exposed by inhalation to adiponitrile (Final report) with cover letter dated (1987). 21) JETOC,,, 4 (1999). 22) ACGIH, Booklet of the Threshold Limit Values and Biological Exposure Indices (2000). 23),, 42, (2000).

9 9 1) 2)

10 (mg/l) 1000 甲殻類魚類オオミシンコフルーキルクッヒーファットヘットミノー (96-h) (96-h) (96-h) 445 (24-h) 100 LC50 EC ) AQUIRE (US EPA, ECOTOX Database System).

11 ( アジポニトリル ) 急毒反復生殖発生許容濃度 4 h 6 h/d 5 d/w 2 w 6 h/d 5 d/w 4 w 6 h/d 5 d/w 13 w 6 h/d 1000 ppm 386 LC 痙攣嗜眠流涎血糖値増加赤血球白血球減少心臓脾臓精巣重量増加 21.5 尿素窒素増加好酸球比率減少 111 赤血球減少ヘモグロビン濃度減少死亡 25.8 ヘモグロビン減少髄外造血 14.5 影響なし 22.4 赤血球減少ヘマトクリット値減少ヘモグロビン減少 ( 雌 22d 暴露 ) 影響なし ( 雄 74d 暴露 ) 影響なし 7.01 不整呼吸流涎 6.92 NOAEL 2 ACGIH 1

CAS NC(CH 2 ) 4 CN 1,4- C 6 H 8 N c.c d = Pa

CAS NC(CH 2 ) 4 CN 1,4- C 6 H 8 N c.c d = Pa 1 200117 21512 CAS 111693 110 NC(CH 2 ) 4 CN 1,4- C 6 H 8 N 2 108.14 1 99 2-1. 2 1 295 159 c.c. 550 3 1.7-4.9 20 d 0.965 4 3.73 = 1 0.3 Pa 0.002 mmhg20 2 log Pow-0.32 m/z 41, 1.0 68 0.54 54 0.43 4 Koc9-16

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橡アジポニトリル.PDF