CAS O C O * DOP* DEHP 2- C O O * n- C 24 H 38 O CH 2 CH 2 CH 2 CH 3 CH (CH 2 ) % 2- A BHT , 4

Size: px

Start display at page:

Download "CAS O C O * DOP* DEHP 2- C O O * n- C 24 H 38 O CH 2 CH 2 CH 2 CH 3 CH (CH 2 ) % 2- A BHT , 4"

きみのしんちとく
4 years ago
Views:

1 CAS O C O * DOP* DEHP 2- C O O * n- C 24 H 38 O CH 2 CH 2 CH 2 CH 3 CH (CH 2 ) % 2- ABHT , % d Pa mmhg kpa 1.2 mmhg200 3 log Pow m/z mg/l ppm = mg/m 3, 20 1 mg/m 3 = ppm CH CH 2 (CH 2 ) 3 CH 3 CH 3 CH 3

2 ,338 t 318,228 t 18,110 t mg/l 30 mg/l BOD 69% HPLC 89% 11, 12 = mg/l mg/l ppb ppm ppm 69 / / / / ppb / 4 6,300 ppb 50

3 ppb ppm ppm 58 / / / / ng/m LC 50 mg/l EC 50 mg/l OECD : Daphnia magna h harmful Daphnia pulex 12 Pimephales 12, 15 promelas h Lepomis 12, 15 macrochirus 12, 15 Ictalurus punctatus Oncorhynchus 12, 15 mykiss >10 96-h >10 96-h >10 96-h >10 96-h Entosiphon sulcatum 15 Pseudomonas putida 15 EC 0 :19 72-h EC 0 : h Bufo fowlen d Rana pipiens d OECD very toxic harmful harmful harmful

4 2-4 OECD OECD 5. 12, 16, 17, 18, 19 1 LD 50 25,000-34,000 mg/kg 26,000-49,000 mg/kg 24,750-30,600 mg/kg 26,300 mg/kg LC 50 LD 50 25,000 mg/kg 10,000 mg/kg , ,000 mg/kg/day 5 96% 2,000 mg/kg/day 7 50%15 100% 2,000 mg/kg/day 15 40% 50 mg/kg/day 9 2,000 mg/kg/day 15 2,000 mg/kg/day 7 P-450 MFO Mixed Function Oxidase 390 mg/kg/day mg/kg/day 5 palmitoyl CoA oxidase carnitine acetyl transferase 50 mg/kg/day mg/kg/day 9 P-450 2,000 mg/kg/day mg/kg/day 14

5 ,000 mg/m 3 6 / 5 / 4 1,000 mg/m 3 6 / 5 / 4 12, 20, 16, 17, 18 5 In vitro TA100 UDS µg/ml µg/ml In vivo g/kg ICR g/kg g/kg/day F344 12, 15, 16, 17, 18, 19, 21, 22, 23, 24 6 EPA 1994 B2 EU 1996 NTP 1994 IARC B ACGIH A3 2B 1 B6C3F ,325 mg/kg/day 7991,821 mg/kg/day 103 1,325 mg/kg/day 799 mg/kg/day

6 2-6 F mg/kg/day mg/kg/day mg/kg/day 12, 17, ,0002,000 mg/kg/day mg/kg/day 130 mg/kg/day 166 1,000 mg/kg 7 3,000 mg/kg/day 20,000 mg/kg 7 12,500 mg/kg 90 6,000 mg/kg 2 1,700 mg/kg/day 4,882 mg/kg 9,756 mg/kg 12 2,000 mg/kg/day mg/kg/day mg/kg/day 2,000 mg/kg ,800 mg/kg 2,000 mg/kg/day mg/kg/day 5 30% 4,930 mg/kg/day 9,860 mg/kg/day ,860 mg/kg/day mg/kg/day , 23, 17, ,000 mg 10,000 mg

7 MEHP MEHP mg/m 3 4 ACGIH mg/m mg/m 3 12, DEHP 2- MEHP DEHP MEHP MEHP MEHP DEHP DEHP MEHP OECD harmfulvery toxic

8 2-8 harmful 9. 1 In vivo DNA OECD harmful very toxic harmful

9 ,, ,, ,, Richardson, M.L. et.al., The Dictionary of Substances and their Effects, Royal Society of Chemistry IPCS, International Chemical Safety Cards C Log P. 8 NIST Library of 54K Compounds ) (), Hazardous Substance Data Bank HSDB, National Library of Medicine, IPCS, Environment Health Criteria ,, , BUA Report ACGIH, Documentation of the Threshold Limit Values and Biological Exposure Indices ATSDR, Toxicological profile for DEHP IARC, Monographs on the Evaluation of Carcinogenic Risks of Chemicals to Humans, 29, NTP, Technical Report on the Carcinogenesis Bioassay of DEHP in F344 Rats and B6C3F1 Mice BUA Report JETOC,,, IARC, Monographs on the Evaluation of Carcinogenic Risks of Chemicals to Humans, List of IARC Evaluations ACGIH, Booklet of the Threshold Limit Values and Biological Exposure Indices , 38,

10 2-10 mg/ l h h 96-h 96-h 96-h 1 LC h 1 IPCS, Environmental Health Criteria BUA Report 4, 1986.

11 2-11 mg/kg/day , , ,000 1,000-2,

12 2-12 B6C3F ,325 mg/kg/day ,821 mg/kg/day mg/kg/day , , /50 11/48 10/50 1/50 5/50 1/50 9/50 14/48 19/50 0/50 7/50 17/50 F mg/kg/day mg/kg/day mg/kg/day /50 5/49 7/49 0/50 4/49 5/50 1/50 1/49 5/49 0/50 2/49 8/50 1 ACGIH, Documentation of the Threshold Limit Values and Biological Exposure Indices ATSDR, Toxicological Profile for DEHP IARC, Monographs on the Evaluation of Carcinogenic Risks of Chemicals to Humans, IPCS, Environment Health Criteria BUA Report NTP, Technical Report on the Carcinogenesis Bioassay of DEHP in F344 Rats and B6C3F1 Mice 1982.

橡フタル酸ブチルベンジル.PDF

橡フタル酸ブチルベンジル.PDF 1 97 7 3 1312 CAS 85 68 7 O BBP 1, 2- C 19 H 20 O 4 312.4 C C O O O (CH 2 ) 3 1 99.9 % 1. 2-35 3 2, 3 370 3, 4 199 d 25 4 1.117 2 10.8 = 1 5 1.15 10-3 Pa 8.6 10-6 mmhg 20 5 253 Pa 1.9 mmhg 200 5 log Pow