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1 氏名所属職位学位 高木明医療科学部臨床検査学科教授博士 ( 医学 ) 資 格 臨床検査技師 主な著書 原著論文年度タイトル ( 出版元又は掲載誌 ) ( 著書 ) 平成 12 年度 Part 1 総論 1. 血液学の基礎知識 3) 凝固 線溶因子とその調節機構 e) 血管内皮の機能 ( 医学書院検査と技術増刊号血液検査実践マニュアル p ) 平成 25 年度 2 章血栓止血関連検査 15 血液凝固因子 ( 中外医学社臨床に直結する血栓止血学 p.67 69) 平成 27 年度第 5 章血栓 止血検査 III. 血液凝固系の検査 IV. 線溶系の検査 V. 血栓 止血の分子マーカー VI. 血栓性素因の検査 ( 金原出版株式会社臨床検査法提要改訂第 34 版 p ) 平成 30 年度 2 章血栓止血関連検査 26 血液凝固因子 ( 中外医学社臨床に直結する血栓止血学改訂第 2 版 p ) ( 原著論文 ) 平成 5 年度平成 8 年度平成 12 年度平成 12 年度 Rapid detection of plasma glycocalicin by a latex agglutination test. A useful adjust in the diffetential diagnosis of thrombocytopenia : Kunishima S, Kobayashi S, Takagi A, Naoe T, Ohno R American Journal of Clinical Pathology 100 巻 5 号 Structural Organiqation and Promoter Activiter of Human Ryudocan Gene : Takagi A, Kojima T, Tsuzuki S, Katsumi A, Yamazaki T, Sugiura I, Hamaguchi M, Saito H Journal of Biochemistry 119 巻 5 号 Long-PCR 法を用いた血液凝固第 VIII 因子遺伝子の逆位解析 : 山田貴之 高木明 中出祐介 村手隆 柳田正光 中山享之 山本晃士 松下正 高松純樹 齋藤英彦 小嶋哲人日本血栓止血学会誌 12 巻 3 号 Complete antithrombin deficiency in mice results in embryonic lethality : Ishiguro K, Kojima T, Kadomatsu K, Nakayama Y, Takagi A, Suzuki M, Takeda N, Ito M, Yamamoto K, Matsushita T, Kusugami K, Muramatsu T, Saito H Journal of Clinical Investigation 106 巻 7 号

2 平成 13 年度平成 14 年度平成 15 年度平成 15 年度平成 15 年度平成 16 年度平成 16 年度平成 17 年度平成 18 年度 Plasma levels of syndecan-4 (ryudocan) are elevated in patients with acute myocardial infarction : Kojima T, Takagi A, Maeda M, Segawa T, Shimizu A, Yamamoto K, Matsushita T, Saito H. Thrombosis and Haemostasis 85 巻 5 号 793~799 発現ベクターを用いた抗マウスアンチトロンビン抗体の作製 : 中出祐介 山田貴之 太田明伸 高木明 村手隆 小嶋哲人愛知県臨床検査技師会誌らぼ 53 巻 17~22 Involvement of caspase 3 mediated apoptosis in hematopoietic cytotoxicity of metabolites of ethylene glycol monomethyl ether : Takagi A, Yamada T, Hayashi K, Nakade Y, Kojima T, Takamatsu J, Shibata E, Ichihara G, Takeuchi Y, Murate T. Industrial Health 40 巻 4 号 371~374 Enzyme immunoassay for measurement of murine plasminogen activator inhibitor-1, employing a specific antibody produced by the DNA vaccine method : Yamada T, Takagi A, Takeshita K, Yamamoto K, Ito M, Matsushita T, Murate T, Saito H, Kojima T. Thrombosis Research 111 巻 4-5 号 285~291 Compound heterozygosity for two novel mutations in a severe factor XI deficiency : Tsukahara A, Yamada T, Takagi A, Murate T, Matsushita T, Saito H, Kojima T. American Journal of Haematology 73 巻 4 号 279~284 Identification of protein Sa gene mutations including four novel mutations in eight unrelated patients with protein S deficiency. : Okada H, Takagi A, Murate T, Adachi T, Yamamoto K, Matsushita T, Takamatsu J, Sugita K, Sugimoto M, Yoshioka A, Yamazaki T, Saito H, Kojima T. British Journal of Haematology 126 巻 2 号 219~225 Targeted disruption of mouse ortholog of the human MYH9 responsible for macrothrombocytopenia with different organ involvement: hematological, nephrological, and otological studies of heterozygous KO mice. : Matsushita T, Hayashi H, Kunishima S, Hayashi M, Ikejiri M, Takeshita K, Yuzawa Y, Adachi T, Hirashima K, Sone M, Yamamoto K, Takagi A, Katsumi A, Kawai K, Nezu T, Takahashi M, Nakashima T, Naoe T, Kojima T, Saito H. Biochemical Biophysical Research Communications 325 巻 4 号 1163~1171 A case of coagulation factor V deficiency caused by compound heterozygous mutations in the factor V gene. : Yamakage N, Ikejiri M, Okumura K, Takagi A, Murate T, Matushita T, Naoe T, Yamamoto K, Takamatsu J, Yamazaki T, Hamaguchi M, Kojima T. Haemophilia 12 巻 2 号 172~178 In vitro characterization of missense mutations associated with quantitative protein S deficiency. : Okada H, Yamazaki T, Takagi A, Murate T, Yamamoto K, Takamatsu J,

3 平成 19 年度平成 20 年度平成 20 年度平成 21 年度平成 22 年度平成 22 年度平成 23 年度 Matsushita T, Naoe T, Kunishima S, Hamaguchi M, Saito H, Kojima T Journal of Thrombosis and Haemostasis 4 巻 9 号 2003~2009 An Sp1 binding site mutation of the PROS1 promoter in a patient with protein S deficiency. : SANDA Naomi, FUJIMORI Yuta, KASHIWAGI Takahiro, TAKAGI Akira, MURSTE Takashi, MIZUTANI Emi, MATSUSHITA Tadashi, NAOE Tomoki, KOJIMA Tetsuhito British Journal of Haematology 138 巻 5 号 663~ 665 A neonate with homozygous protein C deficiency with a homozygous Arg178Trp mutation. : Ferda Ozlu, Mayu Kyotani, Erdal Taskin, Kenan Ozcan, Tetsuhito Kojima, Tadashi Matsushita, Hacer Yapicioglu, Akira Takagi, Ilgen Saşmaz, Mehmet Satar, Nejat Narli Journal of Pediatric Hematology/Oncology 30 巻 8 号 608~611 Skewed X chromosome inactivation in fraternal female twins results in moderately severe and mild haemophilia B. : Kaoru Okumura, Yuta Fujimori, Akira Takagi, Takashi Murate, Mitio Ozeki, Koji Yamamoto, Akira Katsumi, Tadashi Mstsushita, Tomoki Naoe, Tetsuhito Kojima Haemophilia 14 巻 5 号 1088~1093 Definite diagnosis in Japanese patients with protein C deficiency by identification of causative PROC mutations. : Akira Takagi, Ryoko Tanaka, Daisuke Nakashima, Yuta Fujimori, Takayuki Yamada, Kaoru Okumura, Takashi Murate, Midori Yamada, Yasuo Horikoshi, Koji Yamamoto, Akira Katsumi, Tadashi Matsushita, Tomoki Naoe and Tetsuhito Kojima International Journal of Hematology 89 巻 4 号 555~557 Down-regulation of PROS1 gene expression by 17beta-estradiol via estrogen receptor alpha (ERalpha)-Sp1 interaction recruiting receptor-interacting protein 140 and the corepressor-hdac3 complex. : SUZUKI Atsuo, SANDA Naomi, MIYAWAKI Yuri, FUJIMORI Yuta, YAMADA Takayuki, TAKAGI Akira, MURATE Takashi, SAITO Hidehiko, KOJIMA Tetsuhito The Journal of Biological Chemistry 285 巻 18 号 13444~13453 Severe hemophilia A in a Japanese female caused by an F8-intron 22 inversion associated with skewed X chromosome inactivation. : MIYAWAKI Yuri, SUZUKI Atsushi, FUJIMORI Yuta, TAKAGI Akira, MURATE Takashi, SUZUKI N, KATSUMI Akira, NAOE Tomoki, YAMAMOTO Koji, MATSUSHITA Tadashi, TAKAMATSU Junki, KOJIMA Tetshuhito International Journal of Hematology 92 巻 2 号 405~408 Sphingosine kinase 1/S1P pathway involvement in the GDNF-induced GAP43 transcription : MURAKAMI Masashi, ITO Hiromi, HAGIRAWA Kazumi,

4 平成 24 年度平成 24 年度平成 25 年度平成 25 年度平成 25 年度平成 26 年度平成 27 年度平成 27 年度 KOBAYASHI Misa, HOSHIKAWA Asuka, TAKAGI Akira, KOJIMA Tetsuhito, TAMIYA=KOIZUMI Keiko, SOBUE Sayaka, ICHIHARA Masatoshi, SUZUKI Motoshi, BANNNO Yoshiko, NOZAWA Yoshinori, MURATE Takashi Journal of Cellular Biochemistry 112 巻 11 号 3449~3458 Thrombosis from a prothrombin mutation conveying antithrombin resistance. : Yuhri Miyawaki, Atsuo Suzuki, Junko Fujita, Asuka Maki, Eriko Okuyama, Moe Murata, Akira Takagi, Takashi Murate, Shinji Kunishima, Michio Sakai, Kohji Okamoto, Tadashi Matsushita, Tomoki Naoe, Hidehiko Saito, Tetsuhito Kojima The New England Journal of Medicine 366 巻 25 号 2390~2396 Ribavirin-induced intracellular GTP depletion activates transcription elongation in coagulation factor VII gene expression. : Atsuo Suzuki, Yuhri Miyawaki, Eriko Okuyama, Moe Murata, Yumi Ando, Io Kato, Yuki Takagi, Akira Takagi, Takashi Murate, Hidehiko Saito Biochemical Journal 449 巻 1 号 231~239 Molecular mechanisms of syndecan-4 upregulation by TNF-α in the endothelium-like EAhy926 cells. : Okuyama E, Suzuki A, Murata M, Ando Y, Kato I, Takagi Y, Takagi A, Murate T, Saito H, Kojima T. The Journal of Biochemistry 154 巻 1 号 41~50 A novel prothrombin mutation in two families with prominent thrombophilia- the first cases of antithrombin resistance in a Caucasian population : Djordjevic V, Kovac M, Miljic P, Murata M, Takagi A, Pruner I, Francuski D, Kojima T, Radojkovic D Journal of Thrombosis and Haemostasis 11 巻 10 号 1936~1939 Development of a new laboratory test to evaluate antithrombin resistance in plasma. : Murata M, Takagi A, Suzuki A, Okuyama E, Takagi Y, Ando Y, Kato I, Nakamura Y, Murate T, Matsushita T, Saito H, Kojima T. Thrombosis Research 133 巻 2 号 293~298 Antithrombin -resistant prothrombin Yukuhashi mutation also causes thrombomodulin resistance in fibrinogen clotting but not in protein C activation. : Yuki Takagi, Io Kato, Yumi Ando, Yuki Nakamura, Moe Murata, Akira Takagi, Takashi Murate, Tetsuhito Kojima Thrombosis Research 134 巻 4 号 914~917 High prophylactic LMWH dose successfully suppressed hemostatic activation in pregnant woman with a new prothrombin c.1787g>a mutation. : Kovac M, Elezovic I, Mikovic Z, Mandic V, Djordjevic V, Radojkovic D, Lalic-Cosic S, Murata M, Takagi A, Kojima T. Thrombosis Research 135 巻 420~422 The first case of antithrombin-resistant prothrombin Belgrade mutation in Japanese. : Kishimoto M, Suzuki N, Murata M, Ogawa M, Kanematsu T, Takagi A, Kiyoi H, Kojima T, Matsushita T. Annals hematology 95 巻 3 号 541~542

5 平成 28 年度平成 28 年度平成 29 年度平成 30 年度平成 30 年度平成 30 年度令和元年度令和元年度 Progestin isoforms provide different levels of protein S expression in HepG2 cells. : Kozuka T, Tamura S, Kawamura N, Nakata Y, Hasebe R, Makiyama A, Takagi Y, Murata M, Mizutani N, Takagi A, Kojima T. Thrombosis Research 145 巻 40~45 Missense mutations in the gene encoding prothrombin corresponding to Arg596 cause antithrombin resistance and thrombomodulin resistance. : Takagi Y, Murata M, Kozuka T, Nakata Y, Hasebe R, Tamura S, Takagi A, Matsushita T, Saito H, Kojima T. Thrombosis and Haemostasis 116 巻 6 号 1022~1031 Clinical and biochemical characterization of the prothrombin Belgrade mutation in a large Serbian pedigree: new insights into the antithrombin resistance mechanism. : Miljic P, Gvozdenov M, Takagi Y, Takagi A, Pruner I, Dragojevic M, Tomic B, Bodrozic J, Kojima T, Radojkovic D, Djordjevic V. Journal of Thrombosis and Haemostasis 15 巻 4 号 670~677 Optimisation of antithrombin resistance assay as a practical clinical laboratory test: Development of prothrombin activator using factors Xa/Va and automation of assay. : Tamura S, Suga Y, Tanamura M, Murata-Kawakami M, Takagi Y, Hottori Y, Kakihara M, Suzuki S, Takagi A, Kojima T. International Journal of Laboratory Hematology 40 巻 3 号 312~319 Familial pulmonary thromboembolism with a prothrombin mutation and antithrombin resistance : Ritsu Yoshida, Shingo Seki, Jun Hasegawa, Tatsuya Koyama, Koji Yamazaki, Akira Takagi, Tetsuhito Kojima, Michihiro Yoshimura Journal of Cardiology Cases 17 巻 6 号 197~199 アンチトロンビン抵抗性の診断 検査法を中心に : 高木明 田村彰吾 小嶋哲人日本検査血液学会誌 19 巻 3 号 Apparent synonymous mutation F9 c.87a>g causes secretion failure by in-frame mutation with aberrant splicing. : Odaira K, Tamura S, Suzuki N, Kakihara M, Hattori Y, Tokoro M, Suzuki S, Takagi A, Katsumi A, Hayakawa F, Okamoto S, Suzuki A, Kanematsu T, Matsushita T, Kojima T. Thrombosis Research 179 巻 7 号 95~103 先天性血液凝固異常症の遺伝子解析 解析の Strategy と Pitfall : 田村彰吾 高木明 早川文彦 小嶋哲人日本検査血液学会誌 21 巻 1 号 所属学会日本検査血液学会 ( 功労会員 ) 日本血栓止血学会日本血液学会日本臨床検査医学会日本分子生物学会

6 主な社会的活動 年度 活 動 内 容 昭和 55 年 4 月昭和 57 年 4 月昭和 57 年 4 月平成 16 年 7 月平成 18 年 9 月平成 25 年 4 月 愛知県臨床衛生検査技師会学術部血液検査研究班副班長 ( 昭和 57 年 3 月まで ) 愛知県臨床衛生検査技師会学術部血液検査研究班班長 ( 昭和 59 年 3 月まで ) 日本臨床衛生検査技師会学術部血液検査研究班全国委員 ( 昭和 59 年 3 月まで ) 東海 KOAG 研究会幹事 ( 平成 18 年 8 月まで ) 東海 KOAG 研究会代表幹事 ( 平成 30 年 9 月まで ) 第 17 回東海 KOAG 研究会講演 静脈血栓塞栓症 - 新たに発見された危険因 子とその検査法 平成 26 年 3 月 第 73 回山梨血液研究会講演 新規静脈血栓症リスク アンチトロンビン抵 平成 30 年 10 月 抗性とその解析法 第 14 回名古屋大学ホームカミングデイ平成 30 年度 市民公開講座講演 大幸キャンパスで最近発見した新規静脈血栓症リスクとその検査法

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