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- あおい しどり
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2 21 +
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4 TC : Toatal Choelesterol TGtriglyceride CE : cholesterol ester VLDLvery low density lipoprotein IDLintermediate density lipoprotein LDL low density lipoprotein HDL high density lipoprotein FFAfree fatty acid NEFA Lp(a): lipoprotein(a) (a) LPLlipoprotein lipase HTGLhepatic triglyceride lipase TG CETP:cholesteryl ester transfer protein CE FHfamilial hypercholesterolemia TC
5 Chol (mg/dl) TG 0 C>B>A <0.96 VLDL 630 C>B>E ~1.006 LDL HDL B A >C ~1.063 ~1.125 VLDL LDL HDL
6
7
8
9 LDL- LDL-C LDL-CFriedewald Friedewald400mg/dl Friedewald LDL-CHDL-C
10 220mg/dL LDL HDL LDL HDL 140mg/dL 40mg/dL 150mg/dL
11
12
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14
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16 WHO β
17
18
19 β
20
21 TG 83% 52.2% 49.3% b 32.4% a 16.9% n= %,78,115,1990.
22 TG FFA TG TG= VLDL LPL LPL HDL VLDLsmall dense LDL
23 2
24 TGHDL-C LDL small dense LDL LDL LDL RLP-C
25
26
27 220mg/dL LDL HDL LDL HDL 140mg/dL 40mg/dL 150mg/dL
28 mg/dl LDL-C TC LDL-C HDL- C TG A B1 B2 B3 B C
29 B3B4 200 LDL120 HDL (120) C 180 LDL100 mg/dl
30
31 LDL-CHDL-CTG
32
33
34
35 * /3
36 1 2 III
37 LDL-C TC TG HDL-C
38 ll a ll b 700mg/dl EPA
39 HMG-CoA LDLC TG HDLC. CYP A C A Medical View Points 22(10)2001
40
41 pleiotropic effects
42 LDL JAMA 2001;285:
43 cm cm mgdl HDL mgdl mmhg mg mgdl Diabetes & Endocrine Division, Kawasaki Medical School
44 CT
45 p p p for linear trend p = p for linear trend p =
46 Diabetes & Endocrine Division, Department of Medicine, Kawasaki Medical School
47 Diabetes & Endocrine Division, Department of Medicine, Kawasaki Medical School
48
49 µ µ µ µ Diabetes & Endocrine Division, Department of Medicine, Kawasaki Medical School
50 Diabetes & Endocrine Division, Department of Medicine, Kawasaki Medical School
51 62mm 48mm Diabetes & Endocrine Division, Kawasaki Medical School
52 LDLCFH atorvastatin 20mg, probcol 1000mg LDL mg/dl Diabetes & Endocrine Division, Kawasaki Medical School
53 Diabetes & Endocrine Division, Department of Medicine, Kawasaki Medical School
54 Diabetes & Endocrine Division, Department of Medicine, Kawasaki Medical School
55 PAGE Diabetes & Endocrine Division, Department of Medicine, Kawasaki Medical School
56 Diabetes & Endocrine Division, Department of Medicine, Kawasaki Medical School
57 LPL Diabetes & Endocrine Division, Department of Medicine, Kawasaki Medical School
58 LPL C 2
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20 121 150 1 20 121 1 HbA1C 1 2 2 HbA1C 3 2 4 5 HbA1C 1 HbA1C -NH2 -CHO HbA1C 1 1 HbA1C HbA1C HbA1C HbA1C HbA1C 120 HbA1C HbA1C 1 2 2 HbA1C 120 10 10 10 3 β β 1 1 GAD ICA 2 4 HbA1C 2 1 2 5 2 20 121 150
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1 2 3 TG T-cho 4 TG 10 Triglyceride (mg/dl) 400 350 300 250 200 150 T-cho 100 50 B 0 B B B Pre 2 4 6 8 10 12 After feeding (hr) B B B 5 HPLC 6 HPLC 152-0034 1-5-22-201 Tel. 03-5731-3630 / Fax. 03-5731-3631
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