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11 1) von Essen, C. F. : Clinical radiation tolerance of the skin and upper aero - digestive tract. Front. Rad. Ther. Oncol., Vol.6, J. M. Vaeth (Ed.), pp , 1972, S. Karger, Basel 2) Meyneord, W. V. : Energy absorption. Brit. J. Radio!., 13, 235, ) Jones, H. E. and Cunningham, J. R. : The combination of radiation fields for clinical

12 use. The Physics of Radiology, 3rd Ed., pp , 1978, Charles C. Thomas, Springfield 6) Baker, S., Freed, B. R., et al. : An extension of the Memorial System for implant dosirnetry. Radiology, 87, , ) Mohan, R., Brewster, L. J. and Barest, G. D. : A technique for computing dose volume histograms for structure combinations. Med. Phys., 14, , ) ICRU: Dose Specification for Reporting External Beam Therapy with Photons and Electrons. ICRU Report 29, 1978, ICRUM, Bethesda 11) ICRU: Use of Computers in External Beam Radiotherapy Procedures with High Energy Photons and Electrons. ICRU Report 42, 1987, ICRUM, Bethesda 12) ICRU: Prescribing, Recording, and Reporting Photon Beam Therapy. ICRU Report 50, 1993, ICRUM, Bethesda 13) Anderson, L. L.: A "natural" volume dose histogram for brachytherapy. Med. Phys., 13, , ) Wu, A., thin, K. and Sternick, E. S.: A dose homogeneity index for evaluating '921r interstitial breast implants. Med. Phys., 15, , ) Hoshina, M., Shibuya, H., et al.: Discriminant analysis on the treatment results of interstitial radium tongue implants. Brit. J. 18) Shipley, W. U., Tepper, J. E., et al.: Proton radiation as boost therapy for localized prostatic carcinoma. JAMA, 241, , ) Chin, L. M., Kijewski, P. K., et al.: A computer controlled radiation therapy machine for pelvic and paraaortic nodal areas. Int.J. Radiat. Oncol. Biol. Phys., 7, 61-70, ) Goitein, M. and Miller, T.: Planning proton therapy of the eye. Med. Phys., 10, , ) Chen, G. T. Y., Austin Seymour, M., et al.: Dose volume histograms in treatment planning evaluation of carcinoma of the pancreas. Proc. of 8th ICCR, pp , 1984, IEEE Computer Press, Silver Springs 22) Austin Seymour, M. M., Chen, G. T. Y., et al.: Dose volume histogram analysis of liver radiation tolerance. Int. J. Rad. Oncol. Biol. Phys., 12, 31-35, ) Williamson, J. F.: The accuracy of the line and point source approximations in Ir-192 dosimetry. Int. J. Rad. Oncol. Biol. Phys., 12, , ) Mizoe, J.: Analysis of the dose volume histogram in uterine cervical cancer by diagnostic CT. Strahlenther. Onkol., 166, , ) Chen, G. T. Y., Pelizzari, C. A., et al.:

13 Evaluation of treatment plans using dose volume histograms. Front. Radiat. Ther. Oncol., Vol.21, J. M. Vaeth and J. Meyer(Eds.), pp.44 55, 1987, Karger, Basel 26) Orton, C. G. (Ed.) : Bioeffect dosimetry in radiation therapy. Radiation Dosimetry, Physical and Biological Aspects, pp.1 71, 1986, Plenum Press, New York 29) Gremmel, H., Hebbinghous, D. and Wendhausen, B.: An optimisation criterion for dose distributions, minimizing the radiation effect in healthy tissue. Proc.of fith ICCR, Rosenow, U.(Ed.), pp , 1977, Univ. Frauen klinik, Goettingen 30) Sakata, S., Nakano, M., et al.: Volume dependence of tolerance dose in interstitial radiation therapy of cancer of the tongue. Proc.of 7th ICCR, Umegaki, Y.(Ed.), pp , 1981, Jap. Radiol.Soc. Tokyo 33) Lyman, J. T.: Complication probability as assessed from dose - volume histograms. Radiat. Res., 104, S13-S19, ) Burman, C., Kutcher, G. J., et al.: Fitting of normal tissue tolerance data to an analytic function. hit. J. Rad. Oncol. Biol. Phys., 21, , ) Schultheiss, T. E., Orton, C. G. and Peck, R. A.: Models in radiotherapy: Volume effects. Med. Phys., 10, , ) Rubin, P.: Late effects of chemotherapy and radiation therapy: A new hypothesis. Int. J. Radiat. Oncol. Biol. Phys., 10, 5-34, ) Dritschilo, A., Chaffey, J. T., et al.: The complication probability factor: a method for selection of radiation treatment plans. Brit. J. Radiol., 51, , ) Wolbarst, A. B., Sternick, E. S., et al.: Optimized radiotherapy treatment planning using the complication probability factor (CPF). hit. J. Rad. Oncol. Biol. Phys., 6, , ) Wolbarst, A. B,: Optimization of radiation therapy : The critical - voxel model. Int.J. Rad. Oncol. Biol. Phys., 10, , ) Lyman, J. T. and Wolbarst, A. B.: Optimization of radiation therapy, N : A dose - volume histogram reduction algorithm. Int. J. Radiat. Oncol. Biol. Phys., 17: , ) Lyman, J. T. and Wolbarst, A. B.: Optimization of radiation therapy, HI : A method of assessing complication probabilities from dose volume histograms. hit. J. Rad. Oncol. Biol. Phys., 13, , ) Hamilton, C. S., Chan, L. Y., et al.: A practical evaluation of five dose - volume histogram reduction algorithms. Radiother. Oncol., 24, , ) Kutcher, G. J. and Burman, C.: Calculation of complication probability factors for non - uniform normal tissue irradiation : The effective volume method. Int. J.

14 Radiat. Oncol. Biol. Phys., 16, , ) Niemierko, A. and Goitein, M.: Calculation of normal tissue complication probability and dose volume histogram reduction schemes for tissues with a critical element architecture. Radiother. Oncol., 20, , ) Niemierko, A. and Goitein, M.: Modeling of normal tissue response to radiation : The critical volume model. Int.J. Rad. Oncol. Biol. Phys., 25, , ) Drzymala, R. E., Mohan, R., et al.: Dose volume histograms. Int. J. Rad. Oncol. Biol. Phys., 21, 71-78, ) Fowler, J. F.: The volume effect in

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