Pathology of drug-induced nephropathies Kensuke JOH and Hideyuki KOSUKEGAWA D 3 23 % 8 m

Size: px

Start display at page:

Download "Pathology of drug-induced nephropathies Kensuke JOH and Hideyuki KOSUKEGAWA D 3 23 % 8 m"

ひできたかひ
2 years ago
Views:

1 Pathology of drug-induced nephropathies Kensuke JOH and Hideyuki KOSUKEGAWA D 3 23 % 8 m

2 1 959 A a C 9,10 11 A 12 VEGF 13,14 15 b podocyte NSAIDs TNF 2 Collapsing focal segmental glomerulosclerosis 24 c 1 29 ARB HgCl ,26 27, MPO-ANCA 35 TNF 36 B 1 a 1 37 B 39 A 42, b 47,48 A 49,50 51, a NSAIDs A D b 58,59 60, Osmotic nephrosis ,66 diphenylmethan 5 6 a NSAIDs 18,78 84 b

3 960 thrombotic microangiopathy intratubular obstructive nephropathy 7, endothelium 1 54 PAS 2 VEGF 70 VEGF 1,500 C mitomycin C MMC MMC 8.5 % 9 PG I 2 10 MMC A CsA FK

anti-inflammatory drugs NSAIDs MCNS fenoprofen nephropathy 18 3

4 1 a b g % 3,000 HUS 12 VEGF 2 13, podocyte adriamycin puromycin minimal change nephrotic syndrome MCNS 16 podocalyxin glycocalyx 17 drug addict nephropathy nonsteroidal anti-inflammatory drugs NSAIDs MCNS fenoprofen nephropathy 18 3 NSAIDs COX IgG1 IgG2 IgG4 a 5,000 b IgG2 PG PGE 2 PGI 2 A 2 T 20 NSAIDs 18 TNF % ,26 27,

962 a b 5 Chlorphentermine 20,000 31 6 HgC1 2 32

34 MPO-ANCA 35 TNF MPO-ANCA 36 1 1 acute tubular

phospholipidosis 37 acute tubular necrosis Zebra body

5 962 a b 5 Chlorphentermine 20, HgC drug-induced lupus nephritis DNA DNA-histon in situ MPO-ANCA 35 TNF MPO-ANCA acute tubular necrosis 6 60 a b 4,800 B pinocytosis Na -K ATPase phospholipidosis 37 acute tubular necrosis Zebra body myelinoid body defecation bleb 38 5 N-acetylbeta-glucosaminidase 1ysozyme

1 963 7 40 5 Fu bizzare Masson 8 A 55 isometric vacuolization

CsA CsA CsA 44,45 isometric vacuolization 8 45 crystal

6 Fu bizzare Masson 8 A 55 isometric vacuolization Masson 39 6 carcinosis 39 bizzare A CsA 42,43 CsA CsA CsA 44,45 isometric vacuolization 8 45 crystal nephropathy 46 2 analgesic nephropathy 47 vasa recta 48 CsA CsA CsA 49

7 964 9 A striated interstitial fibrosis Masson 10 A 51 W striated interstitial fibrosis 9 CsA * * GFR GFR Chinese herb * PAS GFR 54 GFR 1 Na 55 NSAIDS Na

nephropathy ph 58 tumor lysis syndrome 13

8 Cr 5.95 mg dl HE 56 NSAIDs COX 1 COX 2 D mg dl GFR nephrocalcinosis GFR cast nephropathy intratubular obstructive nephropathy ph 58 tumor lysis syndrome mg dl 6.4 mg dl Masson 14 osmotic nephrosis 52 A Masson ,61

966 a b 15 a Masson b PAS PAS 16 NSAIDs 50 BUN

65 Bartter 66 5 drug-induced hypersensitivity

9 966 a b 15 a Masson b PAS PAS 16 NSAIDs 50 BUN PAS warfarin-related nephropathy osmotic nephrosis osmotic nephrosis 14 IVIG 63 viscosity 64 4 hypokalemic nephropathy PAS Bartter 66 5 drug-induced hypersensitivity nephritis DIHN NSAIDs COX % 73 DIHN 3 3 IgE 74

4 lymphocyte stimulation test 5 TBM DIHN

10 a b a PAS b HE 2 1 N NSAIDs MCNS 18,74,75 16 DIHN acute interstitial nephritis AIN tubulitis 17a hypersensitivity granuloma 17b 3 IgG C3 4 lymphocyte stimulation test 5 TBM DIHN 76 IgG C3 IgG 77 CD4 CD MHC Class HLA-DR DIHN 81, ABPC CTX 6 ABPC CTX DLST PAS mg dl PAS

11 968 TNF b WHO JAPIC 6 Perazella MA, Moeckel GW. Nephrotoxicity from chemotherapeutic agents clinical manifestations, pathobiology, and prevention therapy. Semin Nephrol Fillaster JP, Goldin M. Drug-induced nephropathy. Cameron S, et al eds Oxford Textbook of Clinical Nephrology. Oxford Oxford Medical Publication, Valavaara R, Nordman, E. Renal complication of Mitomycin C therapy. Special reference to the total dose. Cancer Mistry B, Kimmel PL, Hetzel PC, Phillips TM, Braden GL. The role of circulating immune complexes and biocompatibility of staphylococcal protein A immunoadsorption in mitomycin C-induced hemolytic uremic syndrome. Am J Kidney Dis e Pham PT, Peng A, Wilkinson AH, Gritsch HA, Lassman C, Pham PC, Danovitch GM. Cyclosporine and tacrolimus-associated thrombotic microangiopathy. Am J Kidney Dis Fung MC, Storniolo AM, Nguyen B, Arning M, Brookfield W, Vigil J. A review of hemolytic uremic syndrome in patients treated with gemcitabine therapy. Cancer VEGF Eremina V, Jefferson JA, Kowalewska J, Hochster H, Haas M, Weisstuch J, Richardson C, Kopp JB, Kabir MG, Backx PH, Gerber HP, Ferrara N, Barisoni L, Alpers CE, Quaggin SE. VEGF inhibition and renal thrombotic microangiopathy. N Engl J Med Grond J, Weening JJ, Elema JD. Glomerular sclerosis in nephrotic rats. Comparison of the long-term effects of adriamycin and aminonucleoside. Lab Invest Kerjaschki D, Vernillo AT, Farquhar MG. Reduced sialylation of podocalyxin. The major sialoprotein of the rat kidney glomerulus in aminonucleoside nephrosis. Am J Pathol Finkelstein A, Fraley DS, Stachura I, Feldman HA, Gandy DR, Bourke E. Fenoprofen nephropathy Lipoid nephrosis and interstitial nephritis. A possible T lymphocyte disorder. Am J Med Bennett WM, Henrich WL, Stoff JS. The renal effects of nonsteroidal anti-inflammatory drugs summary and recommendations. Am J Kidney Dis Suppl 1 S56 S Porile JL, Bakris GL, Garella S. Acute interstitial nephritis with glomerulopathy due to nonsteroidal anti-inflammatory agents a review of its clinical spectrum and effects of steroid therapy. J Clin Pharmacol

12 Kumasaka R, Nakamura N, Shirato K, Fujita T, Murakami R, Shimada M, Nakamura M, Osawa H, Yamabe H, Okumura K. Nephrotic syndrome associated with interferon-beta 1b therapy for multiple sclerosis. Clin Exp Nephrol Stokes MB, Foster K, Markowitz GS, Ebrahimi F, Hines W, Kaufman D, Moore B, Wolde D, D Agati VD. Development of glomerulonephritis during anti-tnf-alpha therapy for rheumatoid arthritis. Nephrol Dial Transplant Abramowicz D, Meyer M, Florquin S, Goldman M. OKT3 DeBroe ME, Porter GA, Bennett WM, Verpooten GA eds, Markowitz GS, Appel GB, Fine PL, Fenves AZ, Loon NR, Jagannath S, Kuhn JA, Dratch AD, D Agati VD. Collapsing focal segmental glomerulosclerosis following treatment with high-dose pamidronate. J Am Soc Nephrol Plaza JJ, Herrero G, Barat A, Loutaif JJ, Hernando L, Vallado P, Oliva H. Membranous glomerulonephritis as a complication of oral gold therapy. Ann Int Med Hall CL, Fothergill NJ, Blackwell MM, Harrison PR, MacKenzie JC, MacIver AG. The natural course of gold nephropathy long term study of 21 patients. Br Med J Clin Res Ed Ross JH, McGinty F, Brewer DG. Penicillamine nephropathy. Nephron Nagahama K, Matsushita H, Hara M, Ubara Y, Hara S, Yamada A. Bucillamine induces membranous glomerulonephritis. Am J Kidney Dis Sturgill BC, Shealock KT. Membranous glomerulopathy and nephrotic syndrome after captopril therapy. JAMA Nakano M, Ueno M, Nishi S, Shimada H, Hasegawa H, Watanabe T, Kuroda T, Sato T, Maruyama Y, Arakawa M. Analysis of renal pathology and drug history in 158 Japanese patients with rheumatoid arthritis. Clin Nephrol Druet P, Bernard A, Hirsch F. Weening JJ, Gengoux P, Mahieu P, Birkeland S. Immunologically mediated glomerulonephritis induced by heavy metals. Arch Toxicol Hirsch F, Coudere J, Sapin C, Fournie G, Druet P. Polyclonal effect of HgCl 2 in the rat, its possible role in an experimental autoimmune disease. Eur J Immunol Eldredge NT, Robertson WB, van MillerJJ. The interaction of lupus inducting drugs with deoxyribonucleic acid. Clin Immunol Immunopathol Zimmerman SW, Groehler K, Beirne GJ. Hydrocarbon exposure and chronic glomerulonephritis. Lancet Kudoh Y, Kuroda S, Shimamoto K, Iimura O. Propylthiouracilinduced rapidly progressive glomerulonephritis associated with anti-neutrophil cytoplasmic autoantibodies. Clin Nephrol Doulton TW, Tucker B, Reardon J, Velasco N. Antineutrophil cytoplasmic antibody-associated necrotizing crescentic glomerulonephritis in a patient receiving treatment with etanercept for severe rheumatoid arthritis. Clin Nephrol Kaloyanides GK, Pastoriza-Munoz E. Aminoglycoside nephrotoxicity. Kidney Int Joh K, Furusato M, Aizawa S. Shibasaki T, Ishimoto F, Miyahara T. Clinical and pathological study on drug induced nephropathies in biopsy cases. Jikeikai Med J Joh K, Furusato M, Aizawa S, Shibasaki T, Ishimoto F, Miyahara T. Clinical and pathological study on drug induced nephropathies in autopsy cases. Jikeikai Med J Array I, Safirstein RL. Cisplatin nephrotoxicity. Semin Nephrol Garofeanu CG, Weir M, Rosas-Arellano MP, et al. Causes of reversible nephrogenic diabetes insipidus a systematic review. Am J Kidney Dis Mihatsch MJ, Antonovych T, Bohman SO, Habib R, Helmchen U, Noel LH, Olsen S, Sibley RK, Kemény E, Feutren G. Cyclosporin A nephropathy standardization of the evaluation of kidney biopsies. Clin Nephrol Mihatsch MJ, Thiel G, Basler V, Ryffel B, Landmann J, von Overbeck J, Zollinger HU. Morphologic patterns in cyclosporine A treated renal transplant recipients. Transplant Proc Suppl 1 S101 S Burdmann EA, Yu L, Andoh TF, Perico N, Bennett WM. DeBroe ME, Porter GA, Bennett WM, Verpooten GA eds, Izzedine H, Launay-Vacher V, Deray G. Antiviral drug-induced nephrotoxicity. Am J Kidney Dis Nanra RS, Chirawong P, Kincaid-Smith P. Medullary ischemia in experimental analgesic nephropathy The pathogenesis of renal papillary necrosis. Aust NZJ Med Mihatsch MJ, Hofer HO, Gudat F, Knüsli C, Torhorst J, Zollinger HU. Capillary sclerosis of the urinary tract and analgesic nephropaty. Clin Nephrol Mihatsch MJ, Morozumi K, Strøm EH, Ryffel B, Gudat F, Thiel G. Renal transplant, morphology after long-term therapy with cyclosporine. Transplant Proc Mihatsch MJ, Kyo M, Morozumi K, Yamaguchi Y, Nickeleit V, Ryffel B. The side effects of ciclosporine-a and tacrolimus. Clin Nephrol

13 Vanherweghem JL, Depierreux M, Tielemans C, Abramowicz D, Dratwa M, Jadoul M, Richard C, Vandervelde D, Verbeelen D, Vanhaelen-Fastre R, et al. Rapidly progressive interstitial fibrosis in young women. Association with slimming regimen including Chinese herbs. Lancet Tanaka A, Nishida R, Yoshida T, Koshikawa M, Goto M, Kuwahara T. Outbreak of Chinese herb nephropathy in Japan. Are there any differences from Belgium? Intern Med Gonick HC. Nephrotoxicity of cadmium & lead. Indian J Med Res Bakris GL, Weir MR. Angiotensin-converting enzyme inhibitor-associated elevations in serum creatinine is this a cause for concern? Arch Intern Med Shah M, Jenis EH, Mookerjee BK, Schriber JR, Baer MR, Herzig GP, Wetzler M. Interferon-alpha-associated focal segmental glomerulosclerosis with massive proteinuria in patients with chronic myeloid leukemia following high dose chemotherapy. Cancer Murray MD, Black PK, Kuzmik DD, Haag KM, Manatunga AK, Mullin MA, Hall SD, Brater DC. Acute and chronic effects of nonsteroidal antiinflammatory drugs on glomerular filtration rate in elderly patients. Am J Med Sci Kintzel RE, Dorr RT. Anticancer drug renal toxicity and elimination dosing guidelines for altered renal function. Cancer Treat Rev Coiffier B, Altman A, Pui CH, Younes A, Cairo MS. Guidelines for the management of pediatric and adult tumor lysis syndrome an evidence-based review. J Clin Oncol Eiser AR, Neff MS, Slifkin RF. Acute myoglobinuric renal failure. A consequence of the neuroleptic malignant syndrome. Arch Intern Med Khosla U, Ruel KS, Hunt DP. Antihistamine-induced rhabdomyolysis. South Med J Brodsky SV, Nadasdy T, Rovin BH, Satoskar AA, Nadasdy GM, Wu HM, Bhatt UY, Hebert LA. Warfarin-related nephropathy occurs in patients with and without chronic kidney disease and is associated with an increased mortality rate. Kidney Int Dickenmann M, Oettl T, Mihatsch MJ. Osmotic nephrosis Acute kidney injury with accumulation of proximal tubular lysosomes due to administration of exogenous solutes. Am J Kidney Dis Rudnick MR, Berns JS, Cohen RM, Goldfarb S. Nephrotoxic risks of renal angiography contrast media-associated nephrotoxicity and atheroembolism a critical review. Am J Kidney Dis Riemenschneider Th. Drug-associated nephropathy, part Tubulo-interstitial lesions B hypokalemic alterations. In Grundmann E ed Drug-Induced Pathology vol 69, Current Topics in Pathology Kim YG, Kim B, Kim MK, Chung SJ, Han HJ, Ryu JA, Lee YH, Lee KB, Lee JY, Huh W, Oh HY. Medullary nephrocalcinosis associated with long-term furosemide abuse in adults. Nephrol Dial Transplant Laberke HG, Bohle A. Acute interstitial nephritis correlation between clinical and morphological findings. Clin Nephrol Toto RD. Acute tubulointerstitial nephritis Review. Am J Med Sci Rossert J. Drug-induced acute interstitial nephritis. Kidney Int Henao J, Hisamuddin I, Nzerue CM, Vasandani G, Hewan- Lowe K. Celecoxib-induced acute interstitial nephritis. Am J Kidney Dis Smith WR, Neill J, Cushman WC, Butkus DE. Captopril-associated acute interstitial nephritis. Am J Nephrol Sakai N, Wada T, Shimizu M, Segawa C, Furuichi K, Kobayashi K, Yokoyama H. Tubulointerstitial nephritis with antineutrophil cytoplasmic antibody following indomethacin treatment. Nephrol Dial Transplant Praga M, Gonzalez E. Acute interstitial nephritis. Kidney Int Joh K, Aizawa S, Yamaguchi Y, Inomata I, Shibasaki T, Sakai O, Hamaguchi K. Drug-induced hypersensitivity nephritic Lymphocyte stimulation testing and renal biopsy in 10 cases. Am J Nephrol Kleinknecht D, Landais P, Goldfarb B. Pathophysiology and clinical aspects of drug-induced tubular necrosis in man. Contr Nephrol Joh K. Cationic antigen a possible role in the pathogenesis of allergic tubulointerstitial nephritis. Jikeikai Med J Border WA, Lehman DH, Egan JD, Sass HJ, Glode JE, Wilson CB. Anti-tubular basement membrane antibodies in methilcillin-associated interstitial nephritis. N Engl J Med Stachura I, Jayakumar S, Bourke E. T and B lymphocyte subset in fenoprofen nephropathy. Am J Med Husby G, Tung KSK, Williams RC Jr. Characterization of renal tissue lymphocytes in patients with interstitial nephritis. Am J Med Boucher A, Droz D, Adafer E, Noël LH. Characterization of mononuclear cell subsets in renal cellular interstitial infiltrates. Kidney Int Cheng HF, Nolasco F, Cameron JS, Hildreth G, Neild GH, Hartley B. HLA-DR display by renal tubular epithelium and phenotype of infiltrate in interstitial nephritis. Nephrol Dial Trans-

14 1 971 plant Neilson EG. Pathogenesis and therapy of interstitial nephritis. Kidney Int Tadic M, Grgurevic I, Scukanec-Spoljar M, Bozic B, Marusic S, Horvatic I, Galesic K. Acute interstitial nephritis due to mesalazine. Nephrology calton Thomson AB, Sauve MD, Kassam N, Kamitakahara H. Safety of the long-term use of proton pump inhibitors. World J Gastroenterol Hishida A. Determinants for the prognosis of acute renal disorders that developed during or after treatment with edaravone. Clin Exp Nephrol

Juntendo Medical Journal

Juntendo Medical Journal Recent progress in nephrology Key words: rapid high elf icency dialysis, phosphate transport, plasma membrane Na+ transport, cytokine, extracellular matrix 5) Nagasawa M, Koide H, Ohsawa K, Hoshi