１．放射線治療概論
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- よりお みねむら
- 9 years ago
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10 cancer,carcinoma sarcoma
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14 T3 T2 T1 M1 N 1 N2 N3 M1
15 DIC
16 DNA 10 9
17
18 65% 25%
19 3
20 QOL quality of life % % % 1 2 QOL quality of life
21 1895 X
22 Röntogen WC X (1895)
23
24
25 X X
26 Voigt 1900 Stenbeck ) 1904 Perthes 1913 Coolidge X 1964
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28 1898
29
30 Malie Curie Irene
31 1905
32 I125
33 1901 St. Luis Ra 1903 Cleaves 1904 Abbe 1907 Dominici Ra 1934
34
35
36
37 1 --- X --- radioactivity :
38 X
39 X
40 X
41 --- Gy Sv
42 X X /Kg) 1Kg ;Gy) 1Gy=1J/Kg ;Sv E Ht X 1 1Gy=1Sv ;Bq 1Bq=1 /sec
43 : Gy 1Gy 1kg 1J rad 1rad=0.01Gy or : Sv X 1Gy 1Sv : Bq SI Bq 370 Bq Bq 60cpm(count per minute) 1Bq
44
45 1. + +
46 e- e-
47 2.
48
49 DNA DNA DNA
50 DNA DNA DNA
51 (SH H H O DNA H 2 2 O + + e- H 2 O + + H 2 3 O + X << >>
52 DNA X X OH
53 53
54 DNA
55 (REPAIR)
56 56
57 3. FRAGMENT FRAGMENT
58 tricentric fragment dicentric
59
60 DNA G 1 S G 2 G 1 M
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62 1 2 3
63
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67 DNA
68 1, 2 3,
69
70 DNA
71
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81 i)
82
83
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85 HDR High-dose rate (HDR) Low-dose rate LDR)
86 Stereotactic irradiation)
87
88 Stereotactic Radio Surgery ; SRS ( ) 1
89 (Stereotactic RadioTherapy ; SRT) X X
90 4 10
91
92 IMRT( Intensity Modulated Radiotherapy
93 IMRT / MLC method (step and shoot) Intensity Map M L C
94
95
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放射線の人体に対する影響
DNA Bergonie-Toribondeau 1, 2 3, 4 5 6 7 8 (msv) 100 250 1,000 2,000 5% 4,000 30 50% 6,000 2 90% 7,000 100% X 3 ( msv Bq msv/bq ICRP Publ.72 Sv/Bq Sv/Bq I-129 1570 1.1 10-7 3.6 10-8 I-131
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学習内容と日常生活との関連性の研究－第１部－第３章
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放射線照射事故とその背景－現況と展望－
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