第6回クッキーテスト研究会研究報告集(PDF)

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1 2009 H ()

2 GLP Cookie Test

3 2

4 DM(ROS) DM DM Free Radical Analytical System diacron Reactive Oxygen Metabolites test(d-roms ) ROS Biological Antioxidant Potential test(bap ) 12 DM HbA1c8.1 ROM U.CARR37873 ROM (p<0.01) BAP M BAP DM HbA1c7.5 ROM U.CARR34981BAP M DM HbA1c ROM U.CARR 37278*37479*36358* 41561***p<005**p<0.01 3DM ROM HbA1c TGHDL-C LDL-CBMIHbA1c r=0.27r=0.28r=0.32p<0.05 4DM ROM 39473U.CARR ROM 35671U.CARR(p<0.05) 5DM HbA1c7.0 ROM U.CARR (p<0.05) ROM TG 120 ROM 15 p<0.05 BAP 7 150mg HbA1c ROM 5(p<0.05) 3

5 2 DM ROM HbA1c 1. (O 2, HO, 1 O 2 *, H 2 O 2 ) 2. ( O 2 3. R-OOH Fe/Cu 4. R-O / R-OO 5.) 1 4

6 ROM)BAP) ROM BAP p<0.01 n.s. n.s. n.s. (n=16) (n=7) (n=57) (n=16) (n=7) (n=57) (n=16) (n=10) (n=24) (n=13) (n=10) 5

7 (n=64) ROM 6

8 p<0.05 vs (n=4) (n=5) d-rom *p<0.05 n.s. n.s. (n=4) (n=5) 7

9 150mg d-rom *P< (n=5) 8

10 9

11 10

12 11

13 12

14 # 13

15 # 14

16 15

17 16

18 17

19 Cookie Test 18

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21

22 1 21

23 1 LDL120HDL40 49% + 51% TG 22

24 Met S Met S n=) Met ( ) Met 31% ( ) 44% Met (+) (+) 56% 69% Met S 56 ( TG %

25 <0.01 Paired tteat vs. (SE) kcal g

26 n=2) %

27 26

28 27

29 28

30 (mg/dl) () IGT Int. Textbook of Diabetes Mellitus, third edition: John Wiley & Sons; 2004;

31 NGT Pre-Borderlin mg/dl NGT) IFG IGT DM P<0.001 P< P<0.001 P<0.001 N.S. N.S. n=179 n=41 n=22 n=61 n=59 UMI(mg/gCr) WHO(75gGTT) (UMI) UMI NGTCPR NGT IGT hCPR 75g/gCr 2h 100mg/dl UMI 10mg/gCr * * 75gOGTT 30

32 100mg/dL125mg/dL 5.2% HbA1c6.0% UMI10mg/gCr 75g

33 32

34 50%

35 34

36 TEL: () TEL:

37 36

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