24 RS 24 RSRespiratory Syncytial Virus RS BPD24 24CHD RS RS BPD CHD

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1 Immunocompromised Children 24 RS24

2 24 RS 24 RSRespiratory Syncytial Virus RS BPD24 24CHD RS RS BPD CHD

3 RS [1] [1.1] RS 24 RS T DiGeorge Wiskott- Aldrich HIV T T PHA T TT HIV [1.2] RS 24 RS RS24 RS RS [1.3] 1224 RS 1 #1 2 #2, #3 #2 #1 0.5mg/kg/ 4 #2 #3 RS 3

4 RS RS RSBPDCLD RS , 2 BPDRS 60 3 CHD RS 4, 5 RS 6 8 RS RS 1RS R S CHD HIV Medicaid 3 1,0001Hall CB : Contemporary Pediatrics: , 1993November. 2Cunningham CK, et al : Pediatrics, 88 : , Groothuis JR, et al : Pediatrics, 82 : , McDonald NE, et al : N Engl J Med, 307 : , :, 86 : 2076, Hall CB, et al : N Engl J Med, 315 : 77-81, Meissner HC : Pediatr Infect Dis J, 222 Suppl: S40-44; discussion S44-45, Kristensen K, et al : Clin Infect Dis, 54 : , Boyce TG, et al : J Pediatr, 137 : ,

5 Drug Information CHD BPD mg/kg g/mL g/mL S.D.CHD BPD RS CHD BPD g/ml S.D. CHD BPD g/mL n=28 NA g/mL n=26 NA NA g/mL n= g/mL n= g/mL n= g/mL n= g/mL n= g/mL n= g/mL n= g/mL n=37 g/ml 0.5 mg/kg/ S.D g/mL g/mL n=4 n= g/mL g/mL n=5 n= g/mL g/mL n=8 n= g/mL g/mL n=4 n= g/mL n= g/mL n= g/mL n= g/mL n= g/mL n= g/mL n= /28 5

6 BPD 1, CHD % 1.4%1.2% RS RS ,500 5,000 4,500 4,000 3, ,000 2,500 2,000 1,500 1,

7 RS 1 RS 15mg/kg 1 1 RS 1kg15mgRS1 1mL 1 1mL kg15mg/kg 100mg/mL 2RS RS 31 RS RS RS RS RSIDWR , , RS 7

8 A187B

Synagis RS RSRespiratory Syncytial Virus RSBPD CHDRS RS RS BPD CHD 50mg100mg RS20138 RS Respiratory Syncytial Virus RS

Synagis RS RSRespiratory Syncytial Virus RSBPD CHDRS RS RS BPD CHD 50mg100mg RS20138 RS Respiratory Syncytial Virus RS RS Synagis RS RSRespiratory Syncytial Virus RSBPD CHDRS RS RS1998 7020021BPD 200510CHD 50mg100mg2012 812 RS20138 RS Respiratory Syncytial Virus RS 28 12 29 35 6 6BPD24 24CHD 24 24 28 2935 RS 12 6 RS BPD

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