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3 Special IssueManagement principles in the critically ill - Review Case reports
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8 et al et al et al et al
9 Nutritional management in critically ill patients Akiko Mano, Emiko Nakataki, Harutaka Yamaguchi, Daisuke Inui, Jun Oto, Hideaki Imanaka, and Masaji Nishimura Emergency and Critical Care Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School, Tokushima, Japan
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14 Blood glucose control in critically Ill patients Moritoki Egi Department of Intensive Care, Okayama University Hospital, Okayama, Japan
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22 Oral health care for severe human cases encountered in Intensive Care Unit -professional oral care at Tokushima University Hospital Intensive Care Unit- Masami Yoshioka, Masaaki Yokoyama, and Tetsuo Ichikawa Department of Oral Health Care Education, Institute of Health Biosciences, the University of Tokushima Graduate School, and Oral Health Management Center, Tokushima University Medical and Dental Hospital, Tokushima, Japan
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25 2 2 近 藤 和 也 a a b b 図2 胸腺における未分化な T リンパ球と樹状細胞の分布 胸腺組織において CD1a 抗体を使用し 未分化な T リンパ球 を染色している 2 a S 1 0 0 beta 抗体を使用し 樹状細胞を染 めている 2 b c 癌抑制遺伝子 p5 3の蛋白発現の程度を免疫染色にて検 討すると 非浸潤型胸腺腫は8例の内1例も p5 3の発現 を認めなかった 浸潤型胸腺腫は1/9例 1 1 に発 現を認め 胸腺癌は1 4/1 9例 7 4 に発現を認め う ち5例は強発現であった 図4 p5 3の発現の高い胸 腺癌に対して PCR-SSCP 法および sequencing 法にて 点突然変異を検索すると1例にexon6のcodon222に C-T の塩基置換を認めた 胸腺腫では癌遺伝子 p5 3蛋白の発 図3 type B1胸腺腫における未分化な T リンパ球と樹状細胞の 分布 type B1胸腺腫の medullary differentiation の領域である 3 a CD1a 抗体を使用し 未分化な T リンパ球を染色している 3 b S 1 00beta 抗体を使用し 樹状細胞を染めている 3 c 現はまれであるが 胸腺癌は高頻度であるが p5 3の点 突然変異はまれである10 胸腺癌では 癌関連遺伝子の DNA のメチル化が高頻 度に認められるのに対して胸腺腫では頻度が少ない 癌 non-invasive thymoma n=8 positive case 関連遺伝子 DAP-K p-1 6 MGMT HPP1 の DNA メチル化を検討すると その頻度は胸腺腫では2 9 に対 して 胸腺癌では8 6 と高頻度に認めた 図5 胸腺 highly positive case invasive Thymoma n=9 癌の6 0 が複数の癌関連遺伝子のメチル化を認めた11 腫瘍の機能的な見地 genetic および epigenetic な見 11% 26% thymic ca n=19 74% 地からみると 胸腺腫と胸腺癌には 生物学的な違いが あり 異なる疾患単位とみるべきである 図4 胸腺腫と胸腺癌における癌抑制遺伝子 p5 3蛋白の発現
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28 Therapeutic strategy for mediastinal tumors Kazuya Kondo Department of Oncological Medical Services, Institute of Health Biosciences, the University of Tokushima Graduate School, Tokushima, Japan
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32 A case of descending colon cancer complicated with a left psoas abscess Mitsutoshi Fukuyama, Sadahiro Yoshida, Takeshi Kuroda, Michiaki Imatomi, and Tsuneo Saitoh Department of Surgery, Oe Kyodo Hospital, Tokushima, Japan
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36 Six cases of splenic artery aneurysms Mitsutoshi Fukuyama, Sadahiro Yoshida, Takeshi Kuroda, Michiaki Imatomi, and Tsuneo Saitoh Department of Surgery, Oe Kyodo Hospital, Tokushima, Japan
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41 Two cases of abdominal emergencies in patients of advanced age over ninety Mitsutoshi Fukuyama, Takeshi Kuroda, Takafumi Kinoshita, Masahiro Iuchi, Yoh Fukuda Yoshinori Aoki, and Kunio Ogasahara Department of Surgery, Takamatsu Municipal Hospital, Kagawa, Japan
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62 Editor-in-Chief Editors Published by Tokushima Medical Association in
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