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1 HEART'S Original A case of Brugada syndrome with a high defibrillation threshold in which defibrillation was successful by Active Can off defibrillation Keisuke Kawachi, Yukei Higashi, Yuuki Honda, Kouhei Wakabayashi, Hisa Shimojima, Hiroshi Suzuki, Youichi Takeyama Division of Cardiology, Department of Internal Medicine, Showa University Fujigaoka Hospital Ke words

2

3 HEART's Oriqinal

4 1) A comparison of antiarrhythmic-drug therapy with implantable defibrillators in patients resuscitated from near-fatal ventricular arrhythmias. The Antiarrhythmics versus Implantable Defibrillators (AVID) Investigators. N Engl J Med 1997 ; 337 : ) Gold MR, Olsovsky MR, Pelini MA, et al: Comparison of single- and dual-coil active pectoral defibrillation lead systems. J Am Coll Cardiol 1998 ; 31 : ) Rinaldi CA, Simon RD, Geelen P, et al : A randomized

5 HEART's Original prospective study of single coil versus dual coil defibrillation in patients with ventricular arrhythmias undergoing implantable cardioverter defibrillator therapy. Pacing Clin Electrophysiol 2003 ; 26 : ) Gold MR, Olsovsky MR, DeGroot PJ, et al : Optimization of transvenous coil position for active can defibrillation thresholds. J Cardiovasc Electrophysiol 2000 ; 11 : ) Bardy GH, Dolack GL, Kudenchuk PJ, et al : Prospective, randomized comparison in humans of a unipolar defibrillation system with that using an additional superior vena cava electrode. Circulation 1994 ; 89 : ) Manolis AS, Chiladakis J, Maounis TN, et al : Two-coil versus single-coil transvenous cardioverter defibrillator systems : comparative data. Pacing Clin Electrophysiol 2000 ; 23 : ) Strickberger SA, Man KC, Daoud E, et al : Effect of first-phase polarity of biphasic shocks on defibrillation threshold with a single transvenous lead system. J Am Coll Cardiol 1995 ; 25 : ) Natale A, Sra J, Dhala A, et al : Effects of initial polarity on defibrillation threshold with biphasic pulses. Pacing Clin Electrophysiol 1995 ; 18 : ) Coronel R, Casini S, Koopmann TT, et al : Right ventricular fibrosis and conduction delay in a patient with clinical signs of Brugada syndrome : a combined electrophysiological, genetic, histopathologic, and computational study. Circulation 2005 ; 112 : ) Hermida JS, Denjoy I, Clerc J, et al : Hydroquinidine therapy in Brugada syndrome. J Am Coll Cardiol 2004 ; 43 : ) Belhassen B, Glick A, Viskin S : Efficacy of quinidine in high-risk patients with Brugada syndrome. Circulation 2004 ; 110 : ) Tsuchiya T, Ashikaga K, Honda T, Arita M : Prevention of ventricular fibrillation by cilostazol, an oral phosphodiesterase inhibitor, in a patient with Brugada syndrome. J Cardiovasc Electrophysiol 2002 ; 13 : ) Kroll M, Tchou P : Testing of implantable defibrillator functions at implantation. In Ellenbogen K, Kay GN, Wilkoff BL(eds). Clinical cardiac pacing and defibrillation. Philadelphia : WB Saunders ; p ) Corrado D, Basso C, Buja G, et al : Right bundle branch block, right precordial st-segment elevation, and sudden death in young people. Circulation 2001 ; 103 :

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