THE JAPANESE JOURNAL OF ANTIBIOTICS 48-8 Enterococcus avium 5Š, Corynebacterium xerosis 10Š, Corynebacterium pseudodiphtheriticum 10Š, Corynebacterium

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1 THE JAPANESE JOURNAL OF ANTIBIOTICS 48-8 Enterobacter spp., Serratia spp., Burkholderia cepacia, Flavobacterium spp., Alcaligenes spp.

2 THE JAPANESE JOURNAL OF ANTIBIOTICS 48-8 Enterococcus avium 5Š, Corynebacterium xerosis 10Š, Corynebacterium pseudodiphtheriticum 10Š, Corynebacterium jeikeium 10Š, Bacillus cereus 15Š, Bacillus sp. 15Š, Klebsiella pneumoniae subsp. pneumoniae 40Š, Klebsiella oxytoca 20Š, Enterobacter aerogenes 10Š, Enterobacter cloacae 20Š, Serratia marcescens 25Š, Serratia liquefaciens 5Š, Proteus mirabilis 10Š, Proteus vulgaris 5Š, Morganella morganii 5Š, Providencia alcalifaciens 5Š, Providencia stuartii 5Š, Pseudomonas aeruginosa 30Š, Pseudomonas putida 10Š, Pseudomonas fluorescens 5Š, Burkholderia cepacia 10Š, Stenotrohomonas maltophilia 5Š, Flavobacterium indologenes 10Š, Flavobacterium meningosepticum 10Š, Flavobacterium odoratum 10Š, Acinetobacter baumannii 15Š, Acinetobacter lwoffii 10Š, Acinetobacter junii 5Š, Alcaligenes faecalis 15Š, Alcaligenes xylosoxidans subsp. xylosoxidans 15Š, Moraxella subgenus Moraxella lacunata

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4 THE JAPANESE JOURNAL OF ANTIBIOTICS 48-8 (4) Streptococcus spp. S. pyogenes, S. agalactiae, S. dysgalactiae, S. anginosus, S. canis, S. oralis, S. sanguis, S. mitis, S. saliva-

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17 THE JAPANESE JOURNAL OF ANTIBIOTICS 48-8 ANTIMICROBIAL ACTIVITIES OF NORFLOXACIN AGAINST CLINICAL ISOLATES FROM OCULAR INFECTIONS MASAMI KOGUCHI, YUMIKO SUZUKI, SETSUKO TANAKA, SHIGEMI FUKAYAMA, RIKA ISHIHARA and KOICHI DEGUCHI Section of Studies, Tokyo Clinical Research Center SEIJI ODA and YUTAKA NAKANE Clinical Laboratory, The Second Department, (Department of Microbiology) ToRAO FUKUMOTO Adachi-ku Doctors Association Tokyo Clinical Research Center In order to evaluate antimicrobial activity of norfloxacin (NFLX), minimum inhibitory concentration (MICs) of NFLX and control drugs were determined against clinical isolates from ocular infections that were obtained in our laboratory from July, 1993 to December, The results are summarized as follows; 1. Compared to MIC distributions of NFLX against clinical isolates from ocular infections studied in 1986 and 1987, the MICK) of NFLX against Corynebacterium spp., Enterobacter spp., Serratia spp., Burkholderia cepacia, Flavobacterium spp., Alcaligenes spp. increased 8 times. Almost all of NFLX-resistant strains among them were ofloxacin (OFLX)-resistant, new quinolones resistant strains, and a part of them were aminoglycosides, js-lactams-resistant as well, thus all of these strains were multiple drug resistant. 2. MIC of NFLX against Pseudomonas aeruginosa were lower than that of OFLX. 3. NFLX showed strong antimicrobial activities against so-called "particular bacteria" including Staphylococcus aureus subsp. aureus, Moraxella spp., Haemophilus spp., and P. aeruginosa from ocular infections. And MIC80 of NFLX against these bacteria was ƒÊg/ml. We observed that NFLX eye drops was administered so that concentrations above the MIC against these clinical isolates were maintained.

1.Streptococcus pneumoniae, Streptococcus pyogenes JC-1,S.aureus Smith,methicillin (DMPPC)- susceptible S. aureus subsp. aureus (MSSA) TR101, DMPPC-resistant S. aureus subsp. aureus (MRSA) TR102, Staphylococcus

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