[ a ( :2-4)] [ ( :2-4)] [ ( :2-4)] 1955( 30) 1972( 47) 10 1974( 49) 10 1985() 1996( 8) [ ( :2-4)] 1998( 10) 1992( 4) 2001( 13) 1996( 8) 2000( 12) 23
[ a] [ ] 1993 5 12 3 2003( 15) 2005( 17) 2006( 18) [ ( )] [ b] 1996( 8) 1998( 10) 2003( 15) 2006( 18) [ c] [ ] 24
[ b] [ ] 37(10) 109 1990 1990 2 1 1/5 1/3 8 [ ] 5(2) 117-122 2001 1998 1999 8 10 8.8 2.5 3.3 1.2 p<0.01 25
p<0.1 [ ] 3(1) 38-45 2001 1999 67 48.6 38.7 1 228 85.688 41.2 13.5 10 77 Cronbach 0.86 96 38.7 18.4 28 3 30.8 16.5 r=-0.25 p 0.057 r=-0.24 p 0.098 1 r=-0.32 p 0.05 [ a] Quality of Life 5(3) 47-53 2002 [ a] 61 58.4 7.8 47 14 88.1 63.2 1 26 51.0 39.8 1 19 1 5 22 6 7 39 2 21 40 2 28.8 11.8 5 51 Cronbach 0.88 p<0.1 r=0.25 p=0.08 [ b] 26
ALS - 6(2) 153-156 2002 2000 4 9 176 135 35 6 60.2 40 2 110 66 6 9 10 29 20 10 135 1992 1996 30.6 1992 19.8 2000 69.4 76.710 19.0 22.2% 6.9 43.2 40.0 56.0%18.0 40.3% p<0.01 p<0.05 44.2 25.0 [ a] 6(3) 51-58 2002 [ a] 5 51 55 24 10 48 53 24 62 57 14 9 53 53 11 5 36 61 63 5 3 6 6 24 [ b] 27
5(1) 34-41 2001 2000 8 423 328 12 1 4 3 39.2 2.5 2.9 3.3 1.4 56.7 10.9 243 55.0 10.8 85 62.0 9.3 273 184 p<0.01 60 p<0.01p<0.05 p<0.05 [] 36(5) 363-373 2003 2001 8 2002 9 12 10 2 8 4 30 2 40 4 50 1 60 4 70 1 11 1 9 3 1 3 4 2 [ ] 13(6) 494-498 2008 2003 5 8 25 18 (72 ) 7 (28 ) 75.2 11.1 11.1 6.8 6.2 4.5 6 (24 ) 19 (76 ) 21 (84 ) 59.6 9.6 24 12 (48%) 24 28
3 (12%) 10 (40%) 25 (100%) 13 52% [ 2008] 23() 553 2004 2003 8 22 278 203 138 65 62.0 8.8 73 15 769 8 8555 33 17 131 69 Zarit 42.8 18.8 37.3 15.948.0 17.1 40.0 18.1 p<0.05 [ ] 50(6) 412-414 2010 2008 4 2009 7 20 10 10 20 60.0 12.4 45.6 34.2 ALSFRS 3 9 11 ALSFRS 14 14 5 15 56.9 12.0 12 ALSFRS J-ZBI r=-0.661 p 0.027 SF-36 ALSFRS p=0.01 [ ] 29
[ a] [ ] [ b] - 6(2) 153-156 2002 2000 9 176 135 35 6 135 46 26 26 24 [ a( )] 64(12) 865-868 2000 30
2000 10 4082 1929 1447 86 14 55 19 81 [ ] ( ) 1(1) 168-182 2003 3 1(1) 185-195 2003 352 2001 3 249 219 1996 [ a] ( ) [ b] ( ) 12(2) 156-164 2007 57(4) 298-304 2010 2003 10 31 250 31
[ b] 100% [ c] 5 89-101 2010 2004 6 172 148 7 2 2 3 [ ] 8(3) 304-313 2004 2003 6 1 5 5 1 1 [ ( )] 10(3) 218-223 2007 1 1 4 32
1 2 3 4 [ ] [ ] [ ] 2012 33
34
35
[ ] [ ] [ ] [ ] [ ( :2-4)] [ ( )] [] [ ] [ ] [ ( :1-1)] [] [ ] 36
[ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] 37
[ a] 8(4) 306-312 2003 [ ] 8(3) 304-313 2004 [ ] 51(4) 280-286 2004 [ ] 154-160 2009 [ a] 140-153 2009 [ ] Modern Physician 28(5) 764-767 2008 [ b] 83-94 2009 [ c] 27-32 2009 [ ] 64(12) 869-874 2000 [ b] 8(1) 41 2003 [ ] 8(4) 326-329 2003 [ ] 37(10) 109 1990 [ ] 5(2) 117-122 2001 [ a] 3(1) 38-45 2001 [ b] Quality of Life 5(3) 47-53 2002 [ a] ALS - 6(2) 153-156 2002 [ b] ALS 6(3) 51-58 2002 [] 38
5(1) 34-41 2001 [ ] 36(5) 363-373 2003 [ a] ALS 13(6) 494-498 2008 [ ] 23() 553 2004 [ ] QOL 50(6) 412-414 2010 [ a] ALS 10(3) 224-230 2006 [ ] 9(1) 73 2004 [ b] 9(3) 194-199 2005 [ a] [ ] 64(12) 865-868 2000 [ a] 1(1) 168-182 2003 [ b] 3 1(1) 185-195 2003 [ b] 12(2) 156-164 2007 [ c] 57(4) 298-304 2010 [ ] 5 89-101 2010 [ ] [ ] 10(3) 218-223 2007 [ ] 5(6) 48-56 2003 [ ] 14(10) 19-22 2009 39
[ ] Medical Rehabilitation 113 55-60 2009 [ ] 38 103-105 2007 [ ] 3(1) 14-16 2003 [ ] 38 176-178 2007 [] 29(1) 31-35 2006 [ ] 18(9) 837-841 2009 [ ] 9(4) 256-263 2004 [ ] Medical Rehabilitation 113 37-45 2009 [] 46(1) 52-57 2009 [ ] 11 55-58 2007 [ ] 29 101-102 2002 [ ] 64(12) 856-860 2000 [ ] ALS Modern Physician 22(5) 671-674 2002 [ ] 33( 2) 254-256 2006 [ ] 18(1) 56-59 2006 [ ] ALS 9(1) 78 2004 [ ] 18(10) 927-932 2009 [ ] 18(11) 1030-1036 2009 [ ] 50(1) 73 2005 [ ] 11 27 3 623-625 2000 40