ニトロトルエン

4-115

116

4-3 2 117

4- g/kg/day mg/kg/day 25 125 30 40 50 100 250 300 ( ) ( ) ( ) ( ) F1 42 10 118

ER 10-11 M 1% 10-11 10-4 M ER 10-4 M 3% 10-11 10-4 M E-screen 10-9 10-4 M AR ( ) 10-6 10-4 M AR ( ) 10-6 10-4 M AR IC50=7.710-4 M 10-5 10-3 M TR <10-4 M TR <10-4 M 119

120

2. F0 (mg/kg/day) 0 0.001 0.005 0.025 0.125 100 13 14 14 14 14 12 0/13 0/14 0/14 0/14 1/14 0/12 0/13 0/14 0/14 0/14 0/14 0/12 (g) 0 218 218 217 217 217 215 ± 17 16 14 16 18 19 7 243 246 243 246 243 237 ± 20 20 20 17 19 18 14 273 279 274 278 272 267 ± 22 21 21 19 20 18 20 332 344 334 345 334 323 ± 28 27 26 22 20 22 0 263 269 264 269 259 255 ± 24 18 21 19 25 18 7 286 289 281 289 280 277 ± 25 19 24 15 22 19 14 296 299 296 297 290 287 ± 27 18 16 16 20 18 21 280 290 287 284 277 284 ± 26 15 15 18 23 15 (g) 0-7 25 28 26 29 26 22 ± 5 7 7 5 4 3 0-14 54 62 57 61 56 52 ± 10 11 10 5 5 6 0-20 114 127 117 127 117 108 ± 22 16 17 9 10 13 0-7 23 21 17 19 21 23 ± 16 11 13 12 11 8 0-14 33 30 31 28 30 32 ± 18 9 7 9 10 8 0-21 17 21 23 15 18 29 ± 12 10 13 12 14 12 (g) 0-7 22.3 21.9 21.5 22.4 21.6 20.9 ± 2.0 1.6 2.3 2.3 2.2 1.1 7-14 24.0 24.2 23.9 24.5 23.6 23.1 ± 2.5 1.7 2.5 2.2 2.1 1.6 14-21 23.4 23.3 23.0 24.3 22.6 21.5 ± 2.0 1.7 2.3 2.4 2.5 1.5 0-7 34.9 34.7 33.7 34.3 34.1 34.4 ± 6.7 3.1 5.0 4.1 4.2 3.9 7-14 53.8 55.5 54.0 55.1 53.8 53.4 ± 12.1 2.5 3.8 3.6 4.1 5.7 14-21 65.2 66.6 65.4 64.5 62.9 66.5 ± 15.1 4.8 5.1 5.9 5.8 6.2 (%) 92.9 100 100 100 100 85.7 (%) 100 100 100 100 100 100 22.0 21.9 21.9 21.9 21.9 21.9 ± 0.4 0.3 0.3 0.4 0.3 0.3 12.2 12.8 12.3 12.8 12.4 12.0 ± 3.1 2.0 2.1 1.1 2.4 2.0 11.2 11.8 11.7 11.9 11.6 11.3 ± 3.6 2.2 2.2 1.3 2.3 2.4 (%) 89.7 92.1 95.2 92.6 94.0 93.8 ± 14.8 10.2 5.5 5.3 7.3 8.2 (p0.05) 121

2. F0 (mg/kg/day) 0 0.001 0.005 0.025 0.125 100 13 14 14 14 14 12 10 4 /mm 3 783 735 751 732 737 709 ± 37 30 32 37 48 35 g/dl 15.6 15.1 15.0 14.8 15.0 14.8 ± 0.6 0.5 0.5 0.6 0.9 0.4 (%) 46.1 43.9 43.7 42.8 43.6 43.0 ± 1.9 1.8 1.3 2.0 2.4 1.5 µ 3 59 60 58 59 59 61 ± 2 2 2 2 2 2 pg 19.9 20.5 20.0 20.3 20.3 20.8 ± 0.6 0.5 0.6 0.6 0.6 0.8 (%) 33.9 34.3 34.4 34.6 34.3 34.3 ± 0.6 0.6 0.5 0.9 0.6 0.6 10 2 /mm 3 72 63 60 62 60 62 ± 16 13 12 13 8 11 10 4 /mm 3 85.4 84.9 87.5 81.6 86.5 96.3 ± 10.8 9.9 9.7 13.1 11.4 8.4 (%) 0.2 0.1 0.4 0.3 0.4 0.3 ± 0.3 0.2 0.3 0.3 0.5 0.3 21.8 25.1 25.6 23.9 24.0 28.4 ± 8.9 7.1 6.0 6.9 7.3 7.2 76.1 73.6 73.1 74.7 74.5 70.0 ± 8.9 7.0 6.0 7.2 7.4 7.2 1.0 0.8 0.7 0.5 0.6 0.7 ± 0.7 0.6 0.6 0.5 0.6 0.7 0.8 0.4 0.3 0.6 0.5 0.5 ± 0.7 0.5 0.3 0.5 0.7 0.6 0.0 0.0 0.0 0.0 0.0 0.1 ± 0.1 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 ± 0.0 0.0 0.0 0.0 0.0 0.0 ( ) 26 24 24 20 22 28 ± 6 5 8 5 4 7 g 13.2 13.3 13.4 13.4 13.0 14.5 ( ) ± 1.9 0.8 0.9 1.0 1.8 1.0 mg 578 576 595 577 559 607 ± 77 60 74 62 61 80 mg 1969 2047 1963 2020 1998 2005 ± 163 120 155 142 239 117 mg 93.9 88.3 94.9 96.8 94.8 95.6 ± 15.0 5.7 6.8 12.7 12.3 7.5 mg 159 142 151 149 134 121 ± 67 48 52 58 62 44 mg 22.1 23.2 23.3 23.7 24.2 23.4 ± 3.2 3.5 4.0 4.8 6.2 4.8 mg 13.1 12.4 13.1 12.3 11.7 12.1 ± 1.4 1.7 1.3 1.7 1.4 1.3 mg 88.6 85.5 90.3 87.5 89.1 77.8 ± 12.7 8.7 14.6 11.9 12.7 13.5 mg 442 418 436 380 409 453 ± 137 115 144 83 110 173 (p0.05) ( p0.05 p0.01) 122

2. F0 (mg/kg/day) 0 0.001 0.005 0.025 0.125 100 13 14 14 14 14 12 4.69 4.59 4.68 4.73 4.68 5.11 (,%) ± 0.47 0.27 0.30 0.18 0.38 0.36 0.207 0.199 0.207 0.204 0.203 0.214 ± 0.030 0.020 0.025 0.023 0.025 0.027 0.705 0.707 0.684 0.712 0.722 0.706 ± 0.056 0.054 0.058 0.042 0.060 0.025 0.0335 0.0305 0.0331 0.0342 0.0344 0.0337 ± 0.0044 0.0022 0.0025 0.0046 0.0045 0.0025 0.0567 0.0488 0.0525 0.0523 0.0478 0.0427 ± 0.0236 0.0157 0.0176 0.0197 0.0188 0.0154 0.00791 0.00800 0.00815 0.00837 0.00875 0.00821 ± 0.00122 0.00117 0.00149 0.00179 0.00212 0.00147 0.00467 0.00425 0.00456 0.00432 0.00421 0.00428 ± 0.00033 0.00047 0.00039 0.00056 0.00040 0.00051 0.0317 0.0295 0.0315 0.0308 0.0323 0.0273 ± 0.0046 0.0026 0.0051 0.0038 0.0043 0.0044 0.159 0.144 0.152 0.134 0.148 0.160 ± 0.048 0.039 0.048 0.031 0.040 0.064 0/13 0/14 0/14 0/14 1/14 0/12 0/13 1/14 1/14 0/14 0/14 0/12 3/13 0/14 2/14 5/14 0/14 1/12 # - - - - 1/14 - - - - - 1/14-0/13 0/14 0/14 1/14 0/14 0/12 1/13 0/14 0/14 1/14 0/14 0/12 2/13 1/14 1/14 1/14 1/14 2/12 2/13 2/14 1/14 4/14 3/14 3/12 13/13 14/14 12/14 12/14 14/14 12/12 0/13 1/14 0/14 0/14 0/14 0/12 1/13 1/14 1/14 2/14 1/14 1/12 0/13 1/14 1/14 0/14 0/14 0/12 1/13 0/14 0/14 1/14 1/14 2/12 1/13 0/14 0/14 1/14 0/14 0/12 0/13 0/14 0/14 1/14 1/14 0/12 1/13 0/14 0/14 1/14 2/14 0/12 0/13 0/14 1/14 0/14 0/14 0/12 (p0.05) # 123

2. 3 F0 F1 0 (mg/kg/day) 0 0.001 0.005 0.025 0.125 100 12 14 14 14 14 12 13 14 14 14 14 12 F1 63 83 74 95 81 58 81 79 85 67 80 75 / 0.412 0.511 0.482 0.579 0.498 0.433 ± 0.185 0.146 0.218 0.103 0.113 0.148 * 0/12 0/14 1/14 0/14 0/14 0/12 0/63 0/83 1/74 0/95 0/81 0/58 0/13 0/14 1/14 0/14 0/14 0/12 0/81 0/79 2/85 0/67 0/80 0/75 (%) 4 98.1 97.6 97.8 98.1 98.5 97.3 ± 3.6 4.0 4.5 3.7 3.1 4.1 7 100.0 100.0 100.0 100.0 99.5 100.0 ± 0.0 0.0 0.0 0.0 1.9 0.0 14 100.0 100.0 100.0 100.0 99.5 100.0 ± 0.0 0.0 0.0 0.0 1.9 0.0 21 100.0 100.0 99.5 100.0 99.5 100.0 ± 0.0 0.0 2.1 0.0 1.9 0.0 (g) 0 5.9 6.1 5.8 5.9 6.0 5.5 ± 0.4 0.4 0.3 0.3 0.5 0.4 4 9.8 10.2 9.5 9.6 9.9 9.2 ± 0.9 0.9 1.1 0.6 1.8 1.1 7 14.2 14.5 13.6 13.7 14.3 13.5 ± 1.3 1.5 1.7 0.7 2.9 1.8 11 20.8 21.4 20.2 20.4 21.1 20.3 ± 2.1 2.4 2.5 1.1 4.6 3.1 14 26.0 26.7 25.4 25.4 26.2 25.4 ± 2.7 3.2 3.1 1.4 5.3 4.2 18 32.3 33.4 32.1 31.7 32.8 31.9 ± 3.7 4.7 4.0 2.0 6.9 5.3 21 42.3 43.0 41.2 40.8 42.1 40.2 ± 4.8 5.4 5.1 2.5 9.0 6.2 0 5.8 5.8 5.6 5.6 5.7 5.2 ± 0.5 0.4 0.3 0.4 0.6 0.3 4 9.7 9.8 9.2 9.2 9.5 8.8 ± 1.1 0.9 0.9 0.7 1.8 1.0 7 13.9 13.9 13.2 13.3 13.7 12.8 ± 1.8 1.5 1.6 1.1 2.9 1.6 11 20.6 20.7 19.8 19.9 20.3 19.4 ± 2.7 2.6 2.4 1.4 4.6 2.9 14 25.8 25.9 24.8 25.0 25.4 24.5 ± 3.7 3.5 3.1 1.7 5.6 3.8 18 32.1 32.3 31.4 30.9 31.7 30.6 ± 4.8 4.8 4.0 2.3 7.1 4.9 21 41.8 41.3 40.4 40.2 40.5 38.7 ± 5.9 5.8 5.2 2.9 9.3 5.8 ( p0.05 p0.01) * 124

2. 4 F0 F1 0 (mg/kg/day) 0 0.001 0.005 0.025 0.125 100 12 14 14 14 14 12 13 14 14 14 14 12 (mm) 4 4.48 4.59 4.48 4.46 4.51 4.37 ± 0.42 0.34 0.34 0.24 0.45 0.39 4 2.45 2.48 2.38 2.49 2.40 2.48 ± 0.22 0.21 0.29 0.21 0.22 0.19 (/BW 1/3 ) 4 2.09 2.12 2.12 2.10 2.11 2.09 ± 0.17 0.16 0.14 0.12 0.16 0.13 4 1.15 1.16 1.14 1.19 1.15 1.21 ± 0.09 0.08 0.12 0.09 0.09 0.09 () 3.0 3.0 3.1 3.1 2.8 2.9 ± 0.3 0.3 0.5 0.4 0.5 0.4 () 11.9 12.1 12.2 12.2 12.1 12.7 ± 0.6 0.7 0.5 0.7 0.6 0.8 () 14.6 14.3 14.6 14.4 14.4 14.7 ± 0.7 0.6 0.7 0.5 0.8 0.5 ( 11-13,%) 0.0 0.0 0.0 0.0 0.0 0.0 ± 0.0 0.0 0.0 0.0 0.0 0.0 () 2.9 2.9 3.0 3.0 2.9 2.9 ± 0.5 0.4 0.4 0.6 0.5 0.5 () 11.6 12.2 12.4 12.2 12.2 12.8 ± 0.8 0.6 0.7 0.7 0.7 0.9 () 14.3 14.2 14.5 14.1 14.3 14.6 ± 0.8 0.5 0.6 0.8 0.7 0.5 ( 11-13,%) 100.0 100.0 100.0 100.0 100.0 100.0 ± 0.0 0.0 0.0 0.0 0.0 0.0 (p0.01) 125

2. 5 F0 F13 (mg/kg/day) 0 0.001 0.005 0.025 0.125 100 12 14 14 14 14 12 (10 4 /mm 3 ) 459 464 464 456 460 468 ± 16 17 24 16 13 22 (g/dl) 9.6 9.6 9.6 9.4 9.6 9.9 ± 0.4 0.4 0.4 0.4 0.3 0.4 (%) 29.9 29.9 29.6 29.1 29.8 30.4 ± 1.3 1.0 1.3 1.3 0.9 1.1 (µ 3 ) 65 65 64 64 65 65 ± 2 1 1 1 3 3 pg 20.9 20.6 20.6 20.6 20.9 21.2 ± 0.7 0.7 0.5 0.6 0.7 0.9 (%) 32.1 31.9 32.2 32.2 32.2 32.7 ± 0.8 0.7 0.5 0.9 0.6 1.0 (10 2 /mm 3 ) 103 118 104 99 85 70 ± 32 56 47 42 38 20 (10 4 /mm 3 ) 75.2 85.9 84.6 85.3 81.4 81.2 ± 15.7 11.8 8.5 13.9 8.3 8.1 (%) 0.6 0.5 0.3 0.6 0.6 0.5 ± 0.5 0.4 0.3 0.4 0.5 0.4 22.1 22.1 22.6 21.9 22.7 23.9 ± 6.6 4.6 5.2 4.8 6.6 6.0 76.0 75.6 75.7 75.9 74.8 74.2 ± 7.2 5.0 5.3 5.3 7.4 6.4 0.9 1.1 0.7 1.0 1.0 0.9 ± 0.3 0.5 0.4 0.7 0.4 0.6 0.5 0.7 0.7 0.6 1.1 0.7 ± 0.3 0.5 0.6 0.4 0.5 0.4 0.1 0.0 0.0 0.1 0.0 0.1 ± 0.1 0.1 0.1 0.2 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 ± 0.0 0.0 0.0 0.0 0.0 0.0 ( ) 136 134 126 119 117 112 ± 19 21 25 15 25 22 (p0.05) 126

2. 6 F0 F13 (mg/kg/day) 0 0.001 0.005 0.025 0.125 100 13 14 14 14 14 12 (10 4 /mm 3 ) 465 467 467 465 473 475 ± 21 15 17 16 26 20 (g/dl) 9.7 9.7 9.8 9.7 9.9 10.1 ± 0.4 0.4 0.3 0.5 0.5 0.3 (%) 30.4 30.3 30.2 30.0 30.9 31.0 ± 1.3 1.1 1.0 1.0 1.7 1.0 (µ3) 66 65 65 65 66 66 ± 2 2 2 2 2 3 pg 20.8 20.7 20.9 20.7 21.0 21.3 ± 0.8 0.6 0.7 0.6 0.5 0.9 (%) 31.8 31.9 32.3 32.2 32.2 32.5 ± 0.6 0.7 0.7 1.0 0.4 0.9 (10 2 /mm 3 ) 99 85 81 96 71 54 ± 33 38 40 32 35 14 (10 4 /mm 3 ) 74.8 78.8 78.0 82.7 75.4 79.6 ± 12.9 8.0 8.2 8.2 6.4 5.7 (%) 0.5 0.6 0.3 0.6 0.6 0.8 ± 0.4 0.5 0.3 0.5 0.3 0.6 18.8 19.8 19.6 20.0 20.6 21.7 ± 5.9 5.0 6.1 4.6 4.9 6.5 78.9 78.3 78.5 78.2 77.4 76.5 ± 5.9 5.1 6.3 5.2 5.4 6.9 0.8 0.7 0.8 0.7 0.8 0.7 ± 0.4 0.5 0.5 0.4 0.5 0.3 1.0 0.7 0.8 0.6 0.8 0.5 ± 0.5 0.4 0.5 0.5 0.4 0.3 0.1 0.0 0.0 0.0 0.0 0.1 ± 0.1 0.1 0.1 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 ± 0.0 0.0 0.0 0.0 0.0 0.0 ( ) 134 121 120 123 112 108 ± 21 19 20 20 23 10 (p0.05) ( p0.05 p0.01) 127

2. 7 F0 F13 (mg/kg/day) 0 0.001 0.005 0.025 0.125 100 12 14 14 14 14 12 13 14 14 14 14 12 g1.47 1.54 1.47 1.38 1.45 1.38 ( ) ± 0.20 0.29 0.21 0.13 0.37 0.24 mg 176 192 170 162 173 158 ± 39 60 40 31 65 49 mg 428 455 430 420 437 396 ± 52 67 65 46 88 72 mg 13.6 13.9 13.2 13.3 13.2 13.2 ± 1.5 2.0 2.1 1.6 2.4 2.9 mg 147 156 165 157 160 156 ± 25 31 29 16 43 40 mg 201.6 203.3 201.0 187.3 200.9 193.3 ± 25.6 22.6 28.9 14.7 40.0 29.6 mg26.4 27.2 30.8 26.9 29.2 28.6 ± 3.3 5.3 4.0 4.7 7.2 7.5 (mg) 31.7 32.8 32.9 31.0 32.3 31.2 ± 3.7 1.9 2.9 3.8 4.9 3.5 mg 9.4 10.0 10.5 9.9 9.7 9.1 ± 1.4 1.8 2.1 1.9 1.6 1.9 g 1.51 1.51 1.43 1.42 1.40 1.34 ± 0.25 0.25 0.23 0.13 0.39 0.20 mg 183 184 171 181 163 160 ± 44 48 42 27 59 48 mg 456 464 435 440 430 409 ± 70 60 69 44 103 64 mg 14.2 14.6 13.8 13.7 13.6 13.4 ± 2.7 1.8 1.8 1.1 3.0 2.6 mg 163 163 172 166 157 158 ± 41 33 22 21 44 39 mg 14.3 13.6 13.8 13.1 13.4 11.5 ± 2.3 2.4 3.1 1.6 4.1 1.9 mg 32.1 32.2 32.8 34.2 31.4 30.9 ± 4.6 4.4 5.7 3.7 5.3 4.0 128

2. 8 F0 F13 (mg/kg/day) 0 0.001 0.005 0.025 0.125 100 12 14 14 14 14 12 13 14 14 14 14 12 F1 23 28 28 28 28 23 26 28 27 28 28 24 3.48 3.52 3.53 3.39 3.40 3.42 (,%) ± 0.19 0.32 0.14 0.17 0.20 0.19 0.412 0.436 0.404 0.397 0.399 0.382 ± 0.056 0.093 0.056 0.057 0.083 0.064 1.015 1.046 1.034 1.034 1.037 0.976 ± 0.057 0.060 0.047 0.069 0.051 0.043 0.0323 0.0320 0.0316 0.0326 0.0315 0.0324 ± 0.0032 0.0023 0.0026 0.0027 0.0032 0.0039 0.349 0.358 0.395 0.387 0.378 0.382 ± 0.048 0.036 0.050 0.025 0.041 0.051 0.478 0.470 0.483 0.462 0.477 0.479 ± 0.024 0.027 0.020 0.023 0.027 0.034 0.0630 0.0629 0.0744 0.0666 0.0690 0.0705 ± 0.0063 0.0108 0.0086 0.0122 0.0102 0.0151 0.0757 0.0768 0.0799 0.0765 0.0781 0.0778 ± 0.0079 0.0107 0.0111 0.0085 0.0121 0.0086 0.0224 0.0233 0.0256 0.0242 0.0235 0.0225 ± 0.0033 0.0044 0.0061 0.0043 0.0049 0.0035 3.55 3.61 3.51 3.51 3.48 3.46 ± 0.19 0.20 0.15 0.14 0.19 0.15 0.425 0.437 0.418 0.447 0.397 0.407 ± 0.057 0.065 0.058 0.051 0.072 0.067 1.076 1.118 1.069 1.090 1.075 1.061 ± 0.046 0.046 0.044 0.059 0.047 0.030 0.0334 0.0353 0.0340 0.0340 0.0342 0.0348 ± 0.0030 0.0037 0.0025 0.0022 0.0036 0.0042 0.381 0.389 0.426 0.410 0.389 0.407 ± 0.050 0.041 0.040 0.035 0.039 0.049 0.0339 0.0329 0.0338 0.0325 0.0333 0.0299 ± 0.0022 0.0054 0.0039 0.0034 0.0058 0.0023 0.0770 0.0784 0.0815 0.0846 0.0809 0.0808 ± 0.0012 0.0085 0.0119 0.0064 0.0131 0.0065 * 1/12 0/14 0/14 0/14 0/14 0/12 1/23 0/28 0/28 0/28 0/28 0/23 0/12 1/14 0/14 0/14 2/14 1/12 0/23 1/28 0/28 0/28 2/28 1/23 0/12 0/14 0/14 1/14 0/14 0/12 0/23 0/28 0/28 1/28 0/28 0/23 0/12 0/14 0/14 1/14 0/14 0/12 0/23 0/28 0/28 1/28 0/28 0/23 2/13 3/14 1/14 2/14 0/14 1/12 2/26 3/28 1/27 2/28 0/28 2/24 (p0.05) * 129

2. 9 F0 F13 (mg/kg/day) 0 0.001 0.005 0.025 0.125 100 12 14 14 14 14 12 F1 23 28 28 28 28 23 * 12/12 14/14 14/14 14/14 14/14 12/12 23/23 28/28 28/28 28/28 28/28 23/23 1/12 0/14 0/14 0/14 0/14 0/12 1/23 0/28 0/28 0/28 0/28 0/23 0/12 1/14 0/14 0/14 0/14 0/12 0/23 1/28 0/28 0/28 0/28 0/23 0/12 1/14 0/14 0/14 0/14 0/12 0/23 1/28 0/28 0/28 0/28 0/23 1/12 1/14 0/14 0/14 0/14 1/12 1/23 1/28 0/28 0/28 0/28 1/23 0/12 2/14 1/14 0/14 0/14 1/12 0/23 2/28 1/28 0/28 0/28 1/23 0/12 0/14 0/14 0/14 0/14 1/12 0/23 0/28 0/28 0/28 0/28 1/23 0/12 0/14 0/14 0/14 1/14 1/12 0/23 0/28 0/28 0/28 1/28 1/23 0/12 1/14 0/14 0/14 2/14 1/12 0/23 1/28 0/28 0/28 2/28 1/23 0/12 0/14 0/14 0/14 1/14 1/12 0/23 0/28 0/28 0/28 1/28 1/23 0/12 1/14 0/14 0/14 0/14 0/12 0/23 1/28 0/28 0/28 0/28 0/23 0/12 0/14 0/14 1/14 0/14 0/12 0/23 0/28 0/28 1/28 0/28 0/23 1/12 1/14 1/14 1/14 0/14 0/12 1/23 1/28 1/28 1/28 0/28 0/23 0/12 0/14 1/14 2/14 3/14 0/12 0/23 0/28 2/28 2/28 4/28 0/23 0/12 1/14 3/14 1/14 3/14 2/12 0/23 1/28 3/28 1/28 3/28 2/23 1/12 1/14 0/14 0/14 1/14 0/12 1/23 1/28 0/28 0/28 1/28 0/23 * 130

2. 10 F0 F13 (mg/kg/day) 0 0.001 0.005 0.025 0.125 100 13 14 14 14 14 12 F1 26 28 27 28 28 24 * 13/13 14/14 14/14 14/14 14/14 12/12 26/26 28/28 27/27 28/28 28/28 24/24 1/13 0/14 0/14 1/14 1/14 0/12 1/26 0/28 0/27 1/28 1/28 0/24 0/13 0/14 1/14 1/14 1/14 0/12 0/26 0/28 1/27 1/28 1/28 0/24 0/13 0/14 0/14 3/14 0/14 0/12 0/26 0/28 0/27 3/28 0/28 0/24 1/13 0/14 0/14 0/14 0/14 0/12 1/26 0/28 0/27 0/28 0/28 0/24 1/13 1/14 0/14 0/14 0/14 0/12 1/26 1/28 0/27 0/28 0/28 0/24 2/13 4/14 2/14 2/14 0/14 1/12 2/26 5/28 2/27 2/28 0/28 2/24 0/13 0/14 1/14 0/14 0/14 0/12 0/26 0/28 1/27 0/28 0/28 0/24 1/13 0/14 0/14 0/14 0/14 0/12 1/26 0/28 0/27 0/28 0/28 0/24 1/13 0/14 0/14 0/14 0/14 0/12 1/26 0/28 0/27 0/28 0/28 0/24 0/13 0/14 0/14 0/14 1/14 0/12 0/26 0/28 0/27 0/28 1/28 0/24 1/13 0/14 0/14 0/14 1/14 0/12 1/26 0/28 0/27 0/28 1/28 0/24 0/13 0/14 1/14 2/14 3/14 0/12 0/26 0/28 1/27 3/28 3/28 0/24 1/13 3/14 1/14 4/14 2/14 2/12 1/26 4/28 1/27 4/28 3/28 2/24 0/13 1/14 0/14 0/14 1/14 0/12 0/26 1/28 0/27 0/28 1/28 0/24 0/13 0/14 1/14 0/14 0/14 1/12 0/26 0/28 1/27 0/28 0/28 1/24 * 131

2. 11 F0 F13-12 (mg/kg/day) 0 0.001 0.005 0.025 0.125 100 11 13 14 14 13 10 12 14 12 14 13 12 F1 40 55 46 67 53 35 55 51 57 39 52 51 0/40 0/55 0/46 0/67 0/53 0/35 0/55 0/51 0/57 0/39 0/52 0/51 * 1/11 0/13 0/14 0/14 0/13 0/10 1/40 0/55 0/46 0/67 0/53 0/35 0/11 1/13 0/14 0/14 0/13 0/10 0/40 1/55 0/46 0/67 0/53 0/35 0/11 1/13 1/14 0/14 0/13 0/10 0/40 1/55 1/46 0/67 0/53 0/35 0/11 0/13 1/14 0/14 0/13 0/10 0/40 0/55 1/46 0/67 0/53 0/35 0/11 0/13 0/14 0/14 1/13 0/10 0/40 0/55 0/46 0/67 1/53 0/35 0/11 0/13 0/14 0/14 1/13 0/10 0/40 0/55 0/46 0/67 1/53 0/35 0/12 1/14 0/12 0/14 0/13 0/12 0/55 1/51 0/57 0/39 0/52 0/51 0/12 1/14 0/12 0/14 0/13 0/12 0/55 1/51 0/57 0/39 0/52 0/51 0/12 1/14 0/12 0/14 0/13 0/12 0/55 2/51 0/57 0/39 0/52 0/51 0/12 0/14 0/12 1/14 0/13 0/12 0/55 0/51 0/57 1/39 0/52 0/51 0/12 0/14 1/12 0/14 0/13 0/12 0/55 0/51 2/57 0/39 0/52 0/51 * 132

2. 12 F0 F13-12 (mg/kg/day) 0 0.001 0.005 0.025 0.125 100 11 13 14 14 13 10 12 14 12 14 13 12 (g) 42 42 41 41 41 39 ± 5 5 5 3 9 6 75 75 72 73 73 69 ± 7 6 7 4 12 7 122 122 117 117 117 112 ± 12 8 8 5 17 9 169 169 162 162 161 155 ± 16 10 10 6 22 12 215 216 206 206 204 196 ± 21 12 12 6 25 14 262 259 250 250 246 239 ± 25 17 14 9 29 16 299 295 285 284 280 272 ± 30 17 16 11 31 17 10 329 324 314 313 308 301 ± 33 19 19 12 33 19 11 354 349 339 339 332 324 ± 36 18 21 15 36 22 12 378 372 360 360 354 346 ± 38 21 23 16 39 24 41 41 40 40 39 39 ± 5 6 4 3 7 6 69 70 67 69 67 66 ± 6 8 4 5 10 7 104 106 102 104 100 100 ± 8 12 6 7 12 9 133 134 128 130 125 126 ± 8 12 6 9 12 10 152 156 148 150 144 146 ± 8 12 7 10 12 12 172 175 168 171 163 164 ± 10 12 8 11 12 12 187 191 183 188 180 180 ± 9 12 8 11 13 12 10 201 205 194 200 191 193 ± 10 14 9 12 12 12 11 211 214 206 211 200 203 ± 10 14 9 12 12 14 12 219 223 216 220 209 211 ± 10 15 10 12 12 15 (p0.05) 133

2. 13 F0 F13-12 (mg/kg/day) 0 0.001 0.005 0.025 0.125 100 11 13 14 14 13 10 12 14 12 14 13 12 (g) 3-4 32 33 31 32 32 30 ± 3 2 3 2 3 2 3-5 80 80 76 76 76 73 ± 7 4 5 4 8 5 3-6 126 127 121 121 120 117 ± 12 7 6 5 13 7 3-7 173 173 165 165 163 157 ± 17 9 10 6 16 10 3-8 220 216 210 209 205 200 ± 21 14 12 8 22 13 3-9 257 253 244 243 239 233 ± 26 14 13 11 25 14 3-10 287 282 273 272 267 262 ± 29 16 16 12 26 16 3-11 312 306 298 298 291 285 ± 32 15 18 15 29 19 3-12 336 330 319 319 313 307 ± 35 18 20 16 32 21 3-4 28 29 28 28 28 27 ± 2 3 1 3 3 1 3-5 64 65 62 63 61 61 ± 4 7 3 6 5 4 3-6 92 93 89 90 86 87 ± 4 8 5 8 6 5 3-7 111 114 109 110 105 107 ± 5 8 6 9 6 6 3-8 132 134 129 131 124 125 ± 7 8 7 11 7 7 3-9 147 150 143 147 141 142 ± 7 10 8 11 7 8 3-10 160 163 155 160 152 154 ± 8 11 9 12 7 9 3-11 171 172 166 171 161 164 ± 8 11 8 12 7 10 3-12 179 182 176 180 170 172 ± 8 12 10 12 7 11 44.7 43.8 44.2 44.1 43.9 44.3 ± 1.6 1.2 1.2 1.4 1.5 1.6 (g) 187 181 176 175 172 168 ± 19 9 10 9 18 16 32.0 31.3 32.5 33.3 31.6 31.7 ± 1.2 1.7 1.5 1.4 1.7 1.4 (kg) 89 87 89 95 84 85 ± 10 10 7 11 8 9 4.5 4.4 4.5 4.4 4.6 4.4 ± 0.2 0.2 0.2 0.1 0.2 0.1 (p0.05) 134

2. 14 F0 F112 (mg/kg/day) 0 0.001 0.005 0.025 0.125 100 11 13 14 14 13 10 (10 4 /mm 3 ) 796 804 815 795 800 802 ± 15 27 27 22 21 29 (g/dl) 15.3 15.4 15.4 15.2 15.1 15.2 ± 0.4 0.5 0.3 0.4 0.3 0.4 (%) 44.4 45.2 45.5 44.7 44.5 44.9 ± 1.3 1.4 0.8 1.0 1.0 1.5 (µ 3 ) 56 57 56 56 56 56 ± 1 1 2 1 1 1 pg 19.2 19.2 19.0 19.1 18.9 19.0 ± 0.5 0.5 0.5 0.4 0.4 0.4 (%) 34.4 34.2 34.0 34.0 33.9 33.9 ± 0.7 0.5 0.4 0.3 0.4 0.3 (10 2 /mm 3 ) 81 76 76 69 70 70 ± 14 15 12 10 10 11 (10 4 /mm 3 ) 77.5 80.5 80.9 78.6 80.1 81.6 ± 6.3 6.8 7.7 7.4 4.5 4.7 (%) 0.5 0.3 0.3 0.2 0.3 0.4 ± 0.4 0.3 0.3 0.2 0.3 0.2 10.5 9.0 10.7 9.3 10.3 9.8 ± 4.2 2.5 4.1 3.7 3.7 4.6 87.8 89.6 87.7 89.5 88.2 88.8 ± 4.7 2.8 4.6 3.9 4.0 4.9 0.3 0.3 0.3 0.4 0.4 0.5 ± 0.3 0.3 0.3 0.3 0.3 0.3 1.0 0.8 1.0 0.7 0.9 0.6 ± 0.5 0.7 0.7 0.4 0.5 0.3 0.1 0.0 0.1 0.0 0.1 0.0 ± 0.1 0.0 0.2 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 ± 0.0 0.0 0.0 0.0 0.0 0.0 ( ) 11 9 11 8 9 9 ± 2 2 3 2 2 3 135

2. 15 F0 F112 (mg/kg/day) 0 0.001 0.005 0.025 0.125 100 12 14 12 14 13 12 (10 4 /mm 3 ) 751 760 768 758 756 758 ± 27 25 28 21 26 24 (g/dl) 14.6 14.8 14.8 14.8 14.6 14.9 ± 0.4 0.5 0.5 0.4 0.5 0.5 (%) 42.4 42.8 43.2 42.7 42.4 43.1 ± 1.2 1.3 1.4 1.1 1.6 1.7 (µ 3 ) 57 57 56 57 56 57 ± 1 1 2 1 2 2 pg 19.5 19.5 19.3 19.5 19.3 19.6 ± 0.4 0.4 0.6 0.5 0.5 0.6 (%) 34.5 34.5 34.3 34.6 34.4 34.6 ± 0.5 0.4 0.6 0.5 0.5 0.5 (10 2 /mm 3 ) 58 51 49 49 47 48 ± 13 11 6 6 13 8 (10 4 /mm 3 ) 79.8 80.2 80.3 82.2 81.6 86.6 ± 6.9 7.3 4.6 4.5 7.8 4.9 (%) 0.5 0.3 0.5 0.6 1.1 1.0 ± 0.3 0.3 0.3 0.4 0.6 0.6 10.4 10.2 10.4 11.7 12.0 12.1 ± 2.5 3.8 3.8 3.7 4.1 5.1 87.7 87.9 87.9 86.2 85.3 85.2 ± 3.0 4.2 3.7 4.1 4.5 5.8 0.4 0.6 0.4 0.6 0.6 0.7 ± 0.4 0.4 0.3 0.4 0.3 0.4 1.1 1.1 1.0 1.1 1.1 1.1 ± 0.8 0.8 0.5 0.7 0.8 0.6 0.1 0.0 0.0 0.0 0.0 0.0 ± 0.2 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 ± 0.0 0.0 0.0 0.0 0.0 0.0 ( ) 11 12 12 13 12 12 ± 3 3 3 3 3 3 136

2. 16 F0 F112 (mg/kg/day) 0 0.001 0.005 0.025 0.125 100 11 13 14 14 13 10 12 14 12 14 13 12 g14.4 14.3 13.5 13.3 13.1 12.5 ( ) ± 1.6 1.5 1.3 1.2 2.0 1.1 mg 683 708 666 665 657 647 ± 74 56 81 43 66 42 mg 2396 2453 2264 2272 2207 2136 ± 287 202 204 184 236 85 mg 73.3 72.0 67.2 64.0 66.1 63.0 ± 8.6 6.4 7.8 5.6 8.4 5.8 mg 448 475 474 490 480 458 ± 64 47 41 95 90 67 mg 29.8 29.6 29.3 30.0 31.1 27.4 ± 2.2 3.0 4.4 6.3 5.3 2.6 mg 9.9 9.9 9.9 9.1 9.6 8.9 ± 0.6 1.1 1.0 0.8 0.9 0.6 mg 3316 3365 3310 3283 3202 3080 ± 183 210 230 213 621 172 mg 602 576 595 537 552 516 ± 93 70 97 58 68 75 (mg) 1058 1080 1101 1062 1025 1026 ± 65 76 99 102 163 78 mg 1008 1075 1156 999 987 961 ± 153 214 184 132 173 104 g 7.54 7.81 7.50 7.67 7.08 7.03 ± 0.67 0.87 0.54 0.76 0.47 0.63 mg 486 509 482 489 468 464 ± 62 56 54 39 41 66 mg 1501 1571 1456 1559 1439 1426 ± 117 189 81 138 78 118 mg 78.6 76.1 74.9 76.2 77.5 70.3 ± 9.6 9.4 8.4 9.4 6.6 11.0 mg 379 388 405 408 366 391 ± 33 58 46 45 51 53 mg 25.7 24.8 25.2 27.0 27.1 25.0 ± 3.4 3.9 2.8 3.7 5.7 4.5 mg 11.2 11.2 11.3 11.1 11.1 10.7 ± 1.4 1.3 0.9 1.3 1.5 1.3 mg 88.0 90.3 87.3 85.8 82.3 82.6 ± 12.7 12.3 13.8 8.6 8.8 10.9 mg 708 743 675 696 696 728 ± 183 101 81 105 90 76 (p0.05) 137

2. 17 F0 F112 (mg/kg/day) 0 0.001 0.005 0.025 0.125 100 11 13 14 14 13 10 12 14 12 14 13 12 F1 21 25 23 28 26 19 23 27 23 27 26 23 3.803.76 3.76 3.70 3.63 3.62 (,) ± 0.12 0.19 0.17 0.18 0.21 0.18 0.181 0.187 0.187 0.186 0.184 0.189 ± 0.016 0.012 0.022 0.009 0.021 0.011 0.632 0.647 0.634 0.636 0.616 0.622 ± 0.029 0.033 0.034 0.042 0.018 0.024 0.0194 0.0190 0.0189 0.0180 0.0185 0.0184 ± 0.0018 0.0014 0.0022 0.0020 0.0018 0.0017 0.119 0.125 0.134 0.137 0.134 0.133 ± 0.014 0.012 0.016 0.024 0.023 0.014 0.00794 0.00782 0.00821 0.00839 0.00870 0.00797 ± 0.00077 0.00089 0.00111 0.00164 0.00146 0.00062 0.00263 0.00261 0.00276 0.00253 0.00267 0.00257 ± 0.00025 0.00023 0.00024 0.00014 0.00016 0.00013 0.881 0.886 0.928 0.921 0.893 0.899 ± 0.060 0.051 0.047 0.060 0.159 0.070 0.159 0.152 0.166 0.151 0.154 0.150 ± 0.013 0.016 0.022 0.018 0.014 0.018 0.281 0.285 0.309 0.298 0.286 0.300 ± 0.021 0.026 0.028 0.023 0.046 0.030 0.270 0.284 0.325 0.280 0.276 0.280 ± 0.052 0.053 0.058 0.038 0.046 0.035 3.45 3.47 3.49 3.45 3.35 3.34 ± 0.16 0.21 0.15 0.17 0.12 0.15 0.223 0.227 0.225 0.220 0.223 0.219 ± 0.023 0.013 0.026 0.015 0.019 0.020 0.690 0.699 0.678 0.702 0.683 0.677 ± 0.049 0.052 0.021 0.045 0.029 0.038 0.0361 0.0340 0.0350 0.0344 0.0368 0.0334 ± 0.0037 0.0036 0.0045 0.0034 0.0037 0.0050 0.174 0.173 0.189 0.184 0.174 0.186 ± 0.018 0.023 0.023 0.018 0.024 0.025 0.0118 0.0111 0.0117 0.0122 0.0129 0.0119 ± 0.0011 0.0015 0.0010 0.0018 0.0026 0.0022 0.00512 0.00498 0.00524 0.00500 0.00524 0.00505 ± 0.00053 0.00048 0.00055 0.00056 0.00063 0.00054 0.0404 0.0403 0.0406 0.0387 0.0392 0.0392 ± 0.0054 0.0052 0.0061 0.0031 0.0055 0.0046 0.329 0.334 0.315 0.314 0.331 0.346 ± 0.093 0.057 0.040 0.051 0.045 0.034 (p0.05) 138

2. 18 F0 F112 (mg/kg/day) 0 0.001 0.005 0.025 0.125 100 11 13 14 14 13 10 12 14 12 14 13 12 F1 21 25 23 28 26 19 23 27 23 27 26 23 * 0/11 0/13 1/14 0/14 0/13 0/10 0/21 0/25 1/23 0/28 0/26 0/19 0/11 0/13 0/14 1/14 0/13 0/10 0/21 0/25 0/23 1/28 0/26 0/19 0/11 1/13 0/14 0/14 0/13 0/10 0/21 1/25 0/23 0/28 0/26 0/19 1/11 2/13 3/14 2/14 0/13 0/10 1/21 2/25 3/23 2/28 0/26 0/19 0/11 0/13 1/14 0/14 0/13 0/10 0/21 0/25 1/23 0/28 0/26 0/19 0/11 0/13 0/14 0/14 1/13 0/10 0/21 0/25 0/23 0/28 2/26 0/19 0/11 1/13 1/14 0/14 0/13 0/10 0/21 1/25 1/23 0/28 0/26 0/19 0/12 0/14 0/12 0/14 0/13 1/12 0/23 0/27 0/23 0/27 0/26 1/23 0/12 0/14 0/12 0/14 0/13 1/12 0/23 0/27 0/23 0/27 0/26 1/23 1/12 2/14 1/12 1/14 0/13 1/12 1/23 3/27 1/23 1/27 0/26 2/23 0/12 0/14 0/12 1/14 0/13 0/12 0/23 0/27 0/23 1/27 0/26 0/23 /12 0/14 0/12 0/14 0/13 0/12 /23 0/27 0/23 0/27 0/26 0/23 /12 0/14 0/12 0/14 0/13 0/12 /23 0/27 0/23 0/27 0/26 0/23 /12 0/14 0/12 0/14 0/13 0/12 /23 0/27 0/23 0/27 0/26 0/23 0/12 0/14 0/12 1/14 0/13 0/12 0/23 0/27 0/23 1/27 0/26 0/23 * 139

2. 19 F0 F112 (mg/kg/day) 0 0.001 0.005 0.025 0.125 100 11 13 14 14 13 10 F1 21 25 23 28 26 19 * 2/11 2/13 0/14 0/14 0/13 0/10 2/21 2/25 0/23 0/28 0/26 0/19 0/11 0/13 0/14 1/14 0/13 0/10 0/21 0/25 0/23 1/28 0/26 0/19 0/11 1/13 0/14 0/14 0/13 0/10 0/21 1/25 0/23 0/28 0/26 0/19 0/11 0/13 0/14 1/14 0/13 0/10 0/21 0/25 0/23 1/28 0/26 0/19 0/11 1/13 0/14 0/14 0/13 0/10 0/21 1/25 0/23 0/28 0/26 0/19 0/11 1/13 0/14 0/14 0/13 0/10 0/21 1/25 0/23 0/28 0/26 0/19 0/11 1/13 0/14 0/14 0/13 0/10 0/21 1/25 0/23 0/28 0/26 0/19 0/11 0/13 0/14 1/14 0/13 0/10 0/21 0/25 0/23 1/28 0/26 0/19 4/11 1/13 1/14 4/14 3/13 1/10 4/21 1/25 1/23 4/28 3/26 1/19 0/11 0/13 1/14 0/14 0/13 0/10 0/21 0/25 1/23 0/28 0/26 0/19 2/11 1/13 0/14 0/14 0/13 2/10 2/21 2/25 0/23 0/28 0/26 2/19 0/11 0/13 0/14 2/14 0/13 0/10 0/21 0/25 0/23 3/28 0/26 0/19 1/11 2/13 3/14 2/14 0/13 0/10 1/21 2/25 3/23 2/28 0/26 0/19 0/11 1/13 1/14 0/14 0/13 0/10 0/21 1/25 1/23 0/28 0/26 0/19 0/11 0/13 0/14 0/14 1/13 0/10 0/21 0/25 0/23 0/28 1/26 0/19 0/11 0/13 1/14 0/14 1/13 0/10 0/21 0/25 1/23 0/28 2/26 0/19 6/11 5/13 10/14 7/14 7/13 5/10 6/21 5/25 10/23 9/28 9/26 6/19 # - 1/1 1/1 - - - - 1/1 1/1 - - - 2/11 0/13 1/14 1/14 0/13 0/10 2/21 0/25 1/23 1/28 0/26 0/19 0/11 0/13 1/14 1/14 2/13 0/10 0/21 0/25 1/23 2/28 2/26 0/19 0/11 2/13 1/14 1/14 1/13 2/10 0/21 2/25 1/23 1/28 1/26 2/19 1/11 0/13 0/14 0/14 2/13 0/10 1/21 0/25 0/23 0/28 2/26 0/19 0/11 0/13 1/14 0/14 0/13 0/10 0/21 0/25 1/23 0/28 0/26 0/19 0/11 1/13 0/14 0/14 0/13 0/10 0/21 1/25 0/23 0/28 0/26 0/19 # 140

2. 20 F0 F112 (mg/kg/day) 0 0.001 0.005 0.025 0.125 100 12 14 12 14 13 12 F1 23 27 23 27 26 23 * 4/12 2/14 1/12 0/14 1/13 1/12 5/23 2/27 1/23 0/27 1/26 1/23 4/12 4/14 1/12 3/14 2/13 1/12 4/24 5/27 1/23 3/27 2/26 1/23 0/12 0/14 0/12 1/14 0/13 0/12 0/23 1/27 0/23 1/27 0/26 0/23 3/12 1/14 1/12 4/14 4/13 2/12 3/23 1/27 1/23 4/27 5/26 2/23 9/12 11/14 9/12 10/14 13/13 9/12 14/23 16/27 12/23 16/27 20/26 14/23 0/12 0/14 0/12 1/14 1/13 0/12 0/23 0/27 0/23 1/27 1/26 0/23 2/12 0/14 1/12 1/14 0/13 0/12 2/23 0/27 1/23 1/27 0/26 0/23 1/12 4/14 1/12 1/14 0/13 2/12 1/23 6/27 1/23 1/27 0/26 3/23 0/12 0/14 0/12 0/14 0/13 1/12 0/23 0/27 0/23 0/27 0/26 1/23 0/12 0/14 0/12 1/14 0/13 0/12 0/23 0/27 0/23 1/27 0/26 0/23 2/12 0/14 1/12 1/14 0/13 0/12 2/23 0/27 1/23 1/27 0/26 0/23 # 1/1 - - - - - 1/1 - - - - - 1/1 - - - - - 1/1 - - - - - 1/1 - - - - - 1/1 - - - - - 1/1 - - - - - 1/1 - - - - - 1/1 - - - - - 1/1 - - - - - 0/12 0/14 0/12 1/14 1/13 0/12 0/23 0/27 0/23 1/27 1/26 0/23 # - - - 1/1 - - - - - 1/1 - - - - - 1/1 - - - - - 1/1 - - 0/12 0/14 2/12 2/14 1/13 1/12 0/23 0/27 2/23 2/27 1/26 1/23 0/12 0/14 0/12 2/14 4/13 0/12 0/23 0/27 0/23 3/27 5/26 0/23 3/12 2/14 2/12 2/14 2/13 1/12 3/23 3/27 2/23 2/27 2/26 2/23 1/12 1/14 0/12 2/14 0/13 2/12 1/23 1/27 0/23 2/27 0/26 2/23 (p0.05) # 141

2. 21 F1 (mg/kg/day) 0 0.001 0.005 0.025 0.125 100 9 11 8 13 12 6 10 8 10 7 11 11 F1 19 30 23 39 27 16 27 19 30 12 25 28 0/19 0/30 0/23 0/39 0/27 0/16 0/27 0/19 0/30 0/12 0/25 0/28 * 1/9 0/11 0/8 0/13 0/12 0/6 1/19 0/30 0/23 0/39 0/27 0/16 0/9 1/11 0/8 0/13 0/12 0/6 0/19 1/30 0/23 0/39 0/27 0/16 0/9 0/11 0/8 0/13 1/12 0/6 0/19 0/30 0/23 0/39 1/27 0/16 0/10 1/8 0/10 0/7 0/11 0/11 0/27 1/19 0/30 0/12 0/25 0/28 0/10 0/8 0/10 0/7 1/11 0/11 0/27 0/19 0/30 0/12 1/25 0/28 0/10 0/8 1/10 0/7 0/11 1/11 0/27 0/19 2/30 0/12 0/25 1/28 (g) 0 222 232 223 222 214 223 ± 13 12 6 16 14 19 7 248 257 245 242 235 245 ± 14 15 6 19 14 21 14 274 286 270 268 260 271 ± 15 18 6 20 16 22 (g) 0-7 25 26 22 20 21 22 ± 2 7 3 5 4 4 0-14 51 55 47 47 47 47 ± 3 12 4 8 5 6 (x10e6) 256 253 266 254 252 254 ± 29 20 13 22 22 38 g (x10e6/g) 146 143 150 146 149 150 ± 15 10 7 9 12 17 (x10e6) 86 90 95 94 75 104 ± 27 22 16 23 18 19 g (x10e6/g) 384 410 416 426 365 465 ± 107 83 72 88 86 72 (%) 89.5 87.3 90.8 87.9 85.5 89.9 ± 8.2 4.8 2.6 2.7 9.6 2.5 (%) 3.3 1.7 1.0 1.0 1.7 1.0 ± 7.2 1.2 0.6 0.7 0.9 0.6 * 142

2. 22 * F1 (mg/kg/day) 0 0.001 0.005 0.025 0.125 100 11 10 10 7 12 11 F1 32 24 34 12 26 28 11 9 10 7 12 11 F1 32 23 34 12 26 28 10 8 10 7 11 11 F1 27 19 30 12 25 28 * 11/11 9/10 10/10 7/7 12/12 11/11 (100.0%) (90.0%) (100.0%) (100.0%) (100.0%) (100.0%) % 100.0 90.0 100.0 100.0 100.0 100.0 ± 0.0 31.6 0.0 0.0 0.0 0.0 32/32 23/24 34/34 12/12 26/26 28/28 (100.0%) (95.8%) (100.0%) (100.0%) (100.0%) (100.0%) * 10/11 8/9 10/10 7/7 11/12 11/11 (90.9%) (88.9%) (100.0%) (100.0%) (91.7%) (100.0%) % 80.3 72.2 88.3 100.0 91.7 100.0 ± 31.2 40.0 15.8 0.0 28.9 0.0 27/32 19/23 30/34 12/12 25/26 28/28 (84.4%) (82.6%) (88.2%) (100.0%) (96.2%) (100.0%) (%) 86.0 79.8 88.5 88.8 89.5 89.3 ± 13.8 25.3 7.4 12.9 11.6 10.2 (%) 94.2 94.8 95.3 90.1 90.5 88.7 ± 6.1 5.8 3.8 14.1 4.6 9.6 143

2. 23 F1 (mg/kg/day) 0 0.001 0.005 0.025 0.125 100 9 11 8 13 12 6 11 10 10 7 12 11 F1 19 30 23 39 27 16 32 24 34 12 26 28 * 0/9 0/11 0/8 0/13 1/12 0/6 0/19 0/30 0/23 0/39 1/27 0/16 0/9 1/11 0/8 0/13 0/12 0/6 0/19 1/30 0/23 0/39 0/27 0/16 1/9 4/11 2/8 3/13 4/12 1/6 2/19 4/30 4/23 5/39 4/27 1/16 0/9 2/11 0/8 0/13 0/12 0/6 0/19 2/30 0/23 0/39 0/27 0/16 1/9 0/11 0/8 0/13 0/12 0/6 1/19 0/30 0/23 0/39 0/27 0/16 0/9 0/11 0/8 0/13 0/12 1/6 0/19 0/30 0/23 0/39 0/27 1/16 0/9 0/11 0/8 0/13 0/12 1/6 0/19 0/30 0/23 0/39 0/27 1/16 0/9 1/11 0/8 0/13 0/12 0/6 0/19 1/30 0/23 0/39 0/27 0/16 0/11 0/10 0/10 0/7 1/12 0/11 0/32 0/24 0/34 0/12 1/26 0/28 0/11 0/10 0/10 0/7 1/12 0/11 0/32 0/24 0/34 0/12 1/26 0/28 0/11 1/10 0/10 0/7 0/12 0/11 0/32 1/24 0/34 0/12 0/26 0/28 0/11 1/10 0/10 1/7 2/12 1/11 0/32 1/24 0/34 1/12 2/26 3/28 0/11 1/10 0/10 0/7 0/12 0/11 0/32 1/24 0/34 0/12 0/26 0/28 0/11 1/10 0/10 0/7 0/12 0/11 0/32 1/24 0/34 0/12 0/26 0/28 1/11 0/10 0/10 0/7 0/12 0/11 1/32 0/24 0/34 0/12 0/26 0/28 0/11 1/10 0/10 0/7 0/12 0/11 0/32 1/24 0/34 0/12 0/26 0/28 0/11 1/10 0/10 0/7 0/12 0/11 0/32 1/24 0/34 0/12 0/26 0/28 0/11 0/10 0/10 0/7 0/12 1/11 0/32 0/24 0/34 0/12 0/26 1/28 0/11 0/10 1/10 0/7 0/12 0/11 0/32 0/24 2/34 0/12 0/26 0/28 0/11 1/10 0/10 0/7 0/12 0/11 0/32 1/24 0/34 0/12 0/26 0/28 * 144

2. 24 F1 (mg/kg/day) 0 0.001 0.005 0.025 0.125 100 * - - - - - 1/1 - - - - - 1/1 1/1 - - - - - 1/1 - - - - - 1/1 - - - - - 1/1 - - - - - 1/1 - - - - - 1/1 - - - - - 1/1 - - - - - 1/1 - - - - - - - - - 1/1 - - - - - 1/1 - - 1/1 - - - - - 1/1 - - - - - 1/1 - - - - - 1/1 - - - - - 1/1 - - - - - 1/1 - - - - - 1/1 - - - - - 1/1 - - - - - 1/1 - - - - - 1/1 - - - - - 1/1 - - - - - 1/1 - - - - - 1/1 - - - - - 1/1 - - - - - 1/1 - - - - - 1/1 - - - - - 1/1 - - - - - 1/1 - - - - - 1/1 - - - - - 1/1 - - - - - 1/1 - - - - - 1/1 - - - - - 1/1 - - - - - 1/1 - - - - # 3 2 145

146