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96 E-mail mizumi@tokyo-med.ac.jpmed.ac.jp 2008.6.28

1. 2. 3. 4. vs. 5. 6.

12,

Poroma /

vs.

1. decapitation secretion apocrine snout apical snout pinching-off fringe 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. scalloping

Cuticular cells Poroid cells Cuticular cells Poroid cells!

Poroid cell Cuticular cell poroid cell Poroma poroid cells

Eccrine poroma Syringocystadenoma papilliferum Syringoma Mixed tumor

Poroma

A. 1. Hidrocystoma (Cystadenoma) 2. Apocrine tubular adenoma 3. Hidradenoma 4. Clear cell hidradenoma 5. Hidradenoma papilliferum 6. Syringocystadenoma papilliferum 7. Mixed tumor B. 1. Apocrine carcinoma Mucinous carcinomas Cerminous adenoma/carcinoma 2. Extramammary Paget s s disease

C. 1. (Eccrine mixed tumor) 2. Syringoma 3. Spiradenoma 4. Cylindroma 5. Poroma Hidracanthoma simplex Eccrine poroma Dermal duct tumor Poroid hidradenoma clonal type 6. Eccrine spiradenoma D. 1. Porocarcinoma de novo developed in poroma 2. Malignant spiradenoma Eccrine spiradenocarcinoma 3. Eccrine carcinoma (syringomatous carcinoma) Microcystic adnexal tumor Digital papillary adenocarcinoma

1. Hidrocystoma (Cystadenoma) 2. Apocrine tubular adenoma 3. Syringoma 4. Poroma Hidracanthoma simplex Eccrine poroma Dermal duct tumor Poroid hidradenoma Clonal type 5. Porocarcinoma 6. Hidradenoma 7. Clear cell hidradenoma 8. Hidradenoma papilliferum 9. Syringocystadenoma papilliferum 10. Spiradenoma 11. Cylindroma 12. Mixed tumor 13. Apocrine carcinoma Mucinous carcinomas Cerminous adenoma/carcinoma 14. Extramammary Paget s s disease 15. Microcystic adnexal tumor

Hidrocystoma Cystadenoma

Apocrine hidrocystoma Apocrine cystadenoma ( ) Median raphe cysts

Apocrine hidrocystoma

Apocrine tubular adenoma

Apocrine tubular adenoma Papillary tubular adenoma DX DX HPV

Apocrine tubular adenoma

Syringoma 2/3 2/3

Syringoma

Poroma 1. 2. 3. 1. Hidracanthoma simplex 2. Eccrine poroma poroma 3. Dermal duct tumor 4. Poroid hidradenoma

Poroma

Poroma Hidracanthoma simplex A B Eccrine poroma C D Dermal duct tumor Poroid hidradenoma Abenoza P and Ackerman AB Neoplasm s with eccrine differentiation

Hidracanthoma simplex

Eccrine Poroma

Dermal duct tumor

Poroid hidradenoma

Poroma Hidradenoma simplex Eccrine poroma Dermal duct tumor Poroid hidradenoma

Poroma

Poroma, clonal type Poroma

Poroid cell poroid cell

1. 2. 3. 4. 5. 6. 1. 2. 3. 4. 5.

+ Poroid cell + cuticular cells

Porocarcinoma /de novo ++ ++ 1. 1. 2. 3.

Porocarcinoma

Porocarcinoma de novo

Porocarcinoma (de novo)

Porocarcinoma

Porocarcinoma SCC

Hidro- : Hidradenoma Poroid hidradenoma Clear cell hidradenoma clear cell myoepithelioma, nodular hidradenoma, eccrine sweat gland adenoma of clear cell type, solid and cystic hidradenoma, eccrine acrospiroma Clear cell hidradenoma solid- (nodular-), cystic-, solid & cysticapocrine-, eccrine-

Poroid hidradenoma Poroma

Clear cell hidradenoma

Hidradenoma

Hidradenoma papilliferum 1. 2. 3.

Hidradenoma papilliferum

Syringocystadenoma papilliferum 1. 2. 3.

Syringocystadenoma papilliferum

Spiradenoma

Spiradenoma 1. 2. N/C 3. 4. 5.

Spiradenoma

Spiradenocarcinoma 1) >> 2) de novo 1) 2) N/C N/C

Spiradenocarcinoma

spiradenocarcinoma

Spiradenocarcinoma

Cylindroma 1. 2. N/C N/C 3. 4. 5.

Cylindroma 66

Cylindroma

Mixed tumor

Eccrine mixed tumor Mixed tumor 10 10 20

Apocrine carcinoma

Apocrine carcinoma ceruminous gland Moll gland GCDFP-15 (+)

Apocrine carcinoma

Apocrine carcinomas

Apocrine carcinoma GCDFP-15

Extramammary Paget s s disease

Extramammary Paget s disease

Extramammary Paget s carcinoma

Extramammary Paget s disease

Microcystic adnexal carcinoma Sclerosing sweat duct carcinoma, Syringomatous carcinoma

Microcystic adnexal carcinoma

MAC syringoid eccrine ca. eccrine epithelioma, basal cell epithelioma with eccrine differentiation, eccrine ca. with syringomatous feature, sweat gland ca. with syringomatous feature, malignant syringoma, eccrine basalioma Ackerman AB Syringomatous carcinoma - well - moderately - poorly

ABC ABC (*^_^*)