2013
: : BSC - - :
- -
58 30 9 70 3 3 1
Association of genetic variants of the α kinase1 gene with myocardial infarction in community dwelling individuals Abstract. ALPK1 ALPK1 AG ALPK1 Correspondence to: Key words: Introduction ALPK1 ALPK1 Materials and methods Study population.
et alalpk1 Genotyping of polymorphisms. Statistical analysis.
ALPK1 ALPK1 GG GA AA ALPK1 AA AG GG ALPK1, ALPK1 ALPK1 ALPK1 ALPK1 Results Study population. Genotype distribution and allele frequencies. Multivariable logistic regression analysis and stepwise forward selection procedure. A G
et alalpk1 ALPK1 ALPK1 Haplotype analysis. ALPK1 Discussion ALPK1 A G ALPK1 ALPK1 A G A G ALPK1 ALPK1 ALPK1 ALPK1ALPK1, ;
ALPK1 ALPK1 Acknowledgements References et al et al et al et al et al et al; et al et al et al et al et al et al et al et al et al et al et al
A 3
J o h a n s s o n ( 2 0 0 0 ) 7 5 6 5 2 0 7. 3 2 4 9. 7 5 % 1 2 0 8 0 1 2 5 4 1 2 5 9 2 A 5 0 2 5 3 F I M 11 5
A D L I A D L F I M 1 2 1 3 1. 1 1 2 3 4 5 6 7 8 9 1 0 11 1 2 1 3 1 4 1 5..
5 0 A A
1 2 1 2 1 9-1 1, 2 0 1 3 2 3 1 1 2 1 5 7-6 5, 2 0 1 2.
A 3
NS CW ADL 1 2 25 3 1 25 9 30 20 N S 12 CW 8 7 OT 5 ST 2 2 3 1 1 1OTST 15 2 2 2
1 2 3 3 1 1 2 3 4 4 1 1 5 2 100 100 1 60 40
2 81 19 3 63 37 4 89 11 5 100. 89
. ADL 1,,p 15,H24 2012,,p77,H25 2013
) 1.5% 2 B C 1 25 4 9 124 4 6 62 186 7 9 62 372 2 3
62 66.1% 41.9% 12.9% 62 45.0% 35.0% 15.0% 10.0% 5.0% 0% () 186 75 40.3% 372 7 1.9% 100% 30.4% 1 46.8% 1 2 76.2% 2 100% 2 100% 25% 25% 22%
100% 2 200526 248251 200171518519
80.00% 60.00% 40.00% 20.00% 0.00% 1 2 22 0% 50% 100%
25 17 18 14 BSC
1
25
1 KYT
25 6 7 1 4 1 1 17 25 25 5 1
1 1 2 3 4 24 10 2
3 4 24 365 12 12 26
25 () BSC
FAX 1
25 2 1 BSC 49 1
S BSC
25 H25 PT15 OT7 ST3 5 30 5S 5S 25 BSC BSC 31 A2FA3F 1) PTOT 9 S S S PTOT S PDF PDF 2
S SP-kine No. 2)A2F 6 3 IC 10 PT 10 3 30.5 25.8 IC IC IC 91 PTOTST 6
3)A3F 14 2 26 3 NsCW 3 20 BSC S BSC
S S 3 BSC
BSC 2
25 S S CPAP CBC Dr BOX S
CT
25 2 NST S 2 S S BSC
1 60 50 40 30 20 10 0 H24.4H26.3 61 61 60 57 53 49 42 42 43 38 29 18 14 12 14 10 8 7 4 3 0 0 1 2 1 2
25 () S S BSC PDCA KPI PR
と と
25 2 CT UGI BSC PFC 5S
25 1,200 1,000 800 600 400 200 0 4 5 6 7 8 9 10 11 12 1 2 3 848 998 751 715 766 684 775 748 757 786 808 916 645 766 564 577 630 571 622 615 545 655 626 698 159 185 110 138 136 113 153 133 154 133 131 150 1 25 1 OPE 160 140 120 25CT 100 80 60 40 20 0 1 2 3 4 5 6 7 8 9 10 11 12 125 151 110 111 127 102 115 140 143 148 122 129 50 46 26 31 45 31 36 49 44 57 51 53 75 105 84 80 82 71 79 91 99 91 77 76 2 25 CT 2 CT CT
CT
25 BSC S
BSC BSC
25 4 5S 5S 34 1
23 1 2
25 5 25 5S 1 LAN 26 NO
25 2 84.6 H25.11.22
25 10 25 1. 25 2. 1 2 1 3. 1 2 3 1 1 4.
5.26
25 27 2 28 30 24 12 S 26 6