FANCD

PIG-A PIG-A

é

íá ñ

ü

de novo

JAK2

AML1-EVI1NUP98-HOXD13 DEK-NUP214 FLT3 FMS RAS AML1 RUNX1 p53 RAS

p15 INK4b TET2 RPS14TET2 RPS14

ë

World Health Organization Classification of Tumors Pathology and genetics Tumor of Haematopoietic and lymphoid tissues WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues WHO histological classification of myelodysplastic syndromes in World Health Organization Classification of Tumours Pathology and Genetics of Tumour of Haematopoietic and Lymphoid Tissues Myelodysplastic syndromes/neoplasms overviewwho Classification of Tumours of Haematopoietic and Lymphoid Tissues http //www jslh com/mds pdf

SHCT monograph vol 18

Clinical Practice Guidelines in Oncology Myelodysplastic syndromes V 2

PIG-A

PIG-A

ü PIG-A

phosphatidylinositolglycan-classa(pig-a) PIG-A

PIG-A Pig-a PIG-A PIG-A

PIG-A WT1

early growth response factor 1 EGR-1TAX-responsive enhancer element binding protein TAXREB107 human A1 hhr23b Mcl-1 RhoA HMGA2 EGR-1HMGA2RhoA

PIG-A

PIG-A PIG-A PIG-A PIG-A PIG-A

é é

é é é

é ö

Treponema pallidum RHD RHCE

ü ö

ä

JAK2 MPL JAK2 AK2JAK2 MPL TET2 TET2 TET2 C-CBL C-CBL ASXL1 ASXL1 ASXL1 ASXL1 EZH2 EZH2

EZH2 BCR-ABL JAK2 MPL JAK2 MPL JAK2 MPL

JAK2 JAK2

JAK2 JAK2 JAK2 JAK2 JAK2 JAK2 TET2JAK2 JAK2 JAK2JAK2 JAK2 JAK2

JAK2

é

DKC

DKC TERC TERT NOP NHP TINF

RPS RPS RPL RPLRPL a

RPS

é

ALAS2 ALAS2 ALAS2

ALAS2 ALAS2 SLC25 A38 PUS1 SLC25 A38 PUS1 ABCB7 GLRX5 SLC19A2 SLC19A2 SLC19A2

GLRX5 GLRX5 ABCB7PUS1

Glutaredoxin5 ABCB7 SLC25A38SLC25A38 ALAS2 SCL19A2 Pseudouridyate synthase 1 gene PUS1

PUS1