* 1EE +8EE neants. D. +lee + 8 EEI meants. D. 2. 0 (1. 5-4. 0) AUCo in (ne' hrlml) 1436013887 /r'
200ne,/ lne
Precedex' i v.6.l iral +*lrr
-osg- - - - - - :!99:5!g'g - >50m8 >0mg-'50mg >50ms
ttz(hr) trtzlllr) /wrfttr-tv >omg-50mg iel Phase >Omg-50m9
7, e 7, /-I, [Aripiprazole(JAU. INN)) 7-14- 14- (2,3- dichlorophenyl) -l-piperazinylj butoxyl -3,4- dihydro-2 ( I Il) -quinolinone
a Otsuko
I'tr7v<,,nffirfr,o.1o/o
li<-lvil1 llt 25mg @rzz Orzs
100mg 50mg 100mg 18 (39.1) 10 (6b.e)
4> V z7-7 18 mg
CnENCIIA syrrnge FoR s.c. rnjecron
Cmax " (ue/ml-) ACR20 (%) b
acelio@lntravenous lnjection 1000mg
AUC!g.hrlmL)
OrenuMo'
5mg/kg 25 (mglml) 7 5mg/kg l0mgn{g l5mg/kg
i.+l* F'lt /\Jf- IV F'
/\+I* f* *
@oz'ttu->
0.5 ms m 607
l+s.s) o/19 xx i50.5) o1g** 128.3) o/18 ** i30.e) 66t327 00.2) '.1s.4) 43132s03.2)
AUC0-r2h (ns'h/ml,) Tmax (h) AUCO - (ns'h/ml) r max \n/ Cmax(nglml-)
Cmax Cmax nslml)
1.5 mg
D**=Dtox125/C$ D**: Dru x 7.5 / C' )**=Dro x 7.5/C-"er