Helicobacter pylori 19 J. Warren B. Marshall 1984 7 Marshall 10 Warren Marshall 1984 Campylobacter pyloridis pylorus C. pylori Campylobacter 1989 Goodwin Helicobacter H. pylori Herical: Pylori: Helicobacter pylori Helicobacter pylorih.pylori 3µm 47 H.pylori H.pylori
1 H.pylori H.pylori H.pylori H.pylori H.pylori 17 H.pylori H.pylori CAM H.pylori CAM MTZ PPIAMOXMTZ 3
MALToma H.pylori H.pylori WHO H.pyloridefinite carcinogen H.pylori H.pylori - H.pylori -- - H.pylori not culturable state:vnc coccoid VNC coccoid H.pylori H.pylori H.pylori H.pylori H.heilmannii Helicobacter H.pylori H.pylori
H.pylori ph ph H.pylori H.pylori PCR 1 2 1 2 H.pylori H.pylori H.pylori H&E H.pylori H.pylori H.pylori coccoid form
100 CO2 H.pylori CO2 NH3 CO2 CO2 2.5 13 C H.pylori 20 8 PPI 1) 13 C- 2) 13 C- 1 13 C- 100mg 100ml 3) 23 13 C 4) 5 5) 13 C- 20 6) 13 CO2 13 CO2/ 12 CO2 13 C 13 C2.5 H.pylori H.pylori H.pylori H.pylori 1 H.pylori
Helicobacter pylori MIC g/mlnccls Doc. M100-S10(M2) FDA 5% Mueller Hinton medium 2.0 110 7 110 8 CFU/ml 72 1 13uL 35 3 Helicobacter pylori ATCC R 43504 / MICug/m S I R A 0.25 0.5 1.0 H2 ( ) H.pylori BactNo.14 JULY,1998
H.pylori NA 30g CET 30g 47 PCR H.pylori 13 Helicobacter mustelae H.pylori H.pylori 2000 11 2000 10 27 H.pylori H.pylori 116 H.pylori H.pylori
11 1 H.pylori 1 2 12 3 4 5 3 1 1 4 3 7 5 1 4 3 2 180 2000 11 1 70 133 LA 70 133 EIA ELISA 70 138 70 138
1 2 1 30mg 1 750mg 1 200mg 3 1 2 7 1 400mg 1 2 PPI PPI-based 3 triple therapy 1 2 LPZAMOX CAM 1 3 2000 11 H.pylori H.pylori 1 PPI AMOXCAM1 3 PPI PPI MACH2 study PPICA MNZ PPI CAMAMOXCAMMNZCAMAMOX 4 PPICAMAMOX 9495 PPI PPI ph PPI H.pylori H2
H.pylori AMOX CAM MTZ PPIAMOXCAM3 AMOX 2 PPIAMOXCAM 3 CAM 2 2 AMOXCAM 3 2 CAM MTZ 3 PPIAMOX 2 MTZ H.pylori AMOX CAM PPI 1 2 3 PPIOPZ LPZ AMOXCAM1 MTZ H.pylori MTZ PPIAMOXCAM3
1 94.3 98.7 European Journal of Gastroenterogy Hepatology 2 116 8 3 3 87.4 90.7 4 1 (1)H 2025 (2) 2.02.6 1997 5 20 13 20 23 30 32 40 53 50 63 60 70 70 73 911 2(Suppl):1-12, 2000 BactNo.14 JULY,1998 50 7,2001 Vol.17 No.3,2001 http://www.takeda.co.jp/pharm/jap/seikatu/pylori/ http://www.mbcl.co.jp/index.htm Home Page