to
56 1981 18 2006 32 9,314 10 261.0 30.4 1981
cancer,carcinoma sarcoma
T3 T2 T1 M1 N 1 N2 N3 M1
DIC
DNA 10 9
65% 25%
3
65 1.29 1.29 2.07 QOL quality of life 17 19.6% 1 4 27 25.2% 1 3 62 32.3% 1 2 QOL quality of life
1895 X
Röntogen WC X (1895)
X X
1903 1896 Voigt 1900 Stenbeck ) 1904 Perthes 1913 Coolidge X 1964
1898
Malie Curie Irene
1905
I125
1901 St. Luis Ra 1903 Cleaves 1904 Abbe 1907 Dominici Ra 1934
http://www.kankyo-hoshano.go.jp/study_round.html
1 2 3 4 5
1 --- X --- radioactivity :
X
X
X
--- Gy Sv
X X /Kg) 1Kg ;Gy) 1Gy=1J/Kg ;Sv E Ht X 1 1Gy=1Sv ;Bq 1Bq=1 /sec
1905-1965 : Gy 1Gy 1kg 1J rad 1rad=0.01Gy or : Sv X 1Gy 1Sv 1896-1966 : Bq SI 1 1 1 1 Bq 370 Bq 370 1852-1908 1Bq 60cpm(count per minute) 1Bq
1. + +
e- e-
2.
DNA DNA DNA
DNA DNA DNA
(SH H H O DNA H 2 2 O + + e- H 2 O + + H 2 3 O + X << >>
DNA X X OH
53
DNA
(REPAIR)
56
3. FRAGMENT FRAGMENT
tricentric fragment dicentric
DNA G 1 S G 2 G 1 M
1 2 3
DNA
1, 2 3, 4 5 6 7 8
DNA --- --- ---
i)
- -137 30-60 5.3-198 2.7-125 59-90 28.8
HDR High-dose rate (HDR) Low-dose rate LDR)
Stereotactic irradiation)
Stereotactic Radio Surgery ; SRS ( ) 1
(Stereotactic RadioTherapy ; SRT) X X
4 10
IMRT( Intensity Modulated Radiotherapy
IMRT / MLC method (step and shoot) Intensity Map M L C