239 10 3 14 00 14 50 1 : 10 2 10 30 11 30 1 : 10 4 13 00 14 00 1 : 10 2 13 00 14 00 1 : Peter St. George - Hyslop University of Toronto 10 2 14 10 15 10 1 : Randall Bateman Neurology at Washington University School of Medicine 21
240 Dementia Japan Vol. 29 No. 3 September 2015 10 2 15 10 16 10 1 : Reisa Sperling Harvard University, Brigham and Women s Hospital, Massachusetts General Hospital 10 3 9 30 10 30 1 : Steven G. Younkin Department of Neuroscience, MAYO clinic Jacksonville, Florida 10 3 10 30 11 30 1 : Todd E. Golde Director, Center for Translational Research in Neurodegenerative Disease Professor, Department of Neuroscience, College of Medicine University of Florida 10 3 15 00 16 00 1 : Eric M. Reiman Banner Alzheimer s Institute and Banner Research, University of Arizona, Arizona State University, Translational Genomics Research Institute, and Arizona Alzheimer s Consortium 10 4 10 30 11 30 3 : β Thierry Bussiére Biogen, Cambridge, Massachusetts 02142, USA 22
241 Jeffrey J. Sevigny Biogen Idec Inc, Cambridge, MA, USA 10 3 15 00 16 00 2 1 2 : 10 3 15 00 16 00 3 : 10 4 10 30 11 30 5 4 : 10 3 16 00 17 00 1 : 10 4 8 30 14 30 6 : 23
242 Dementia Japan Vol. 29 No. 3 September 2015 10 2 9 30 11 30 2 1 2 : : 1. 2. 3. 4. Tau imaging with PET in Tohoku University 10 2 13 00 15 00 2 1 2 : 1. 2. 3. 4. 10 2 9 30 11 30 3 : 4 1. 2. 24
243 3. : NanoSomiX 4. β 5. 10 2 13 00 15 00 3 : 1. 2. 3. 4. 10 2 9 30 11 30 4 1 : 1. 2. HDLS 3. Alexander : 4. Neuronal Intranuclear Inclusion disease NIID 5. Vanishing white matter disease VWMD 10 2 13 00 15 00 4 1 : 1 1. 2. 25
244 Dementia Japan Vol. 29 No. 3 September 2015 3. NHO 4. NCSE 10 2 9 30 11 30 5 4 : 1. AD 2. 3. 4. 10 3 9 30 11 30 2 1 2 : 1. PET 2. plasma biomarker 3. 4. 10 3 9 30 11 30 3 : 1. 2. 3. 4. 26
245 5. 10 3 9 30 11 30 4 1 : 1. 2. 3. 4. Aβ immunotherapy for Alzheimer s disease : effects on apoe and vasculopathy Clinical Neurosciences, University of Southampton Kenji Sakai 10 3 15 00 17 00 4 1 : 1. 2. MRI Time - SLIP 3. VSRAD MRS 4. VSRAD 5. MRI 10 3 9 30 11 30 5 4 : 1. 2. 3. 4. 27
246 Dementia Japan Vol. 29 No. 3 September 2015 5. 10 4 9 30 11 30 1 : 1. 2. 3. : 4. : 10 4 9 30 11 30 2 1 2 : ips 1. ips ips CiRA 2. ips γ 3. ips 4. ips ips β 10 4 9 30 11 30 4 1 : 1. Aβ 2. Aβ 3. Aβ KLK7 4. β 28
247 10 4 13 00 15 00 4 1 : 1. PSP CBD 2. PSP CBD 3. PSP 4. PSP CBD : 5. CBD PSP 6. 10 4 13 00 15 00 5 4 : 1. 2. Aβ oligomer 3. 4. 10 4 13 00 15 00 2 1 2 : 1. 2. 3. 4. 29
248 Dementia Japan Vol. 29 No. 3 September 2015 5. 6. 10 4 13 00 15 00 3 : 1. Aβ 2. Osaka mutation Aβ 3. 4 10 4 14 00 15 00 1 : 35 1. 2. 3. 10 4 9 00 10 30 5 4 : 1. 1 2 2. 30
249 3. 10 3 15 00 17 00 5 4 : 10 4 15 15 16 45 7 : 1. 2. 10 3 17 10 19 00 1 : 1. 700 2. 3. 4. 10 3 8 30 9 30 2 1 2 : : : & 31
250 Dementia Japan Vol. 29 No. 3 September 2015 10 2 11 50 12 50 2 1 2 : : : 10 2 11 50 12 50 3 : : : 1999 2011 10 2 11 50 12 50 4 1 : RI : 1. : 2. : 32
251 10 2 11 50 12 50 5 4 : 1. : : BPSD 2. : 10 3 11 50 12 50 2 1 2 : : : Reisa Sperling Harvard University, Brigham and Women s Hospital, Massachusetts General Hospital 10 3 11 50 12 50 3 : : : 33
252 Dementia Japan Vol. 29 No. 3 September 2015 NMDA NMDA NMDA enmdar enmdar enmdar β 10 3 11 50 12 50 4 1 : : : Paulo Fontoura Vice President, Global Head Clinical Development Neuroscience F. Hoffmann - La Roche Ltd : 10 3 11 50 12 50 5 4 : : 1. : ChE AChE BuChE 2. : 10 3 11 50 12 50 3F A B : : : 1. DLB : 34
253 DLB AD DAT DLB DAT 2014 1 MIBG DAT DLB AD DAT MIBG 2. : MRI MIBG (DAT) DAT 10 4 11 50 12 50 3 : : : BPSD 2000 McKeith BPSD AchEIs AchEIs Iwasaki BPSD evidence BPSD 10 4 11 50 12 50 4 1 : : : PD ADL QOL PD PD 35
254 Dementia Japan Vol. 29 No. 3 September 2015 10 4 11 50 12 50 5 4 : : : AD AChE NMDA AChE nachr BPSD nachr AD AD nachr 10 4 11 50 12 50 : : : MIBG 10 2 15 10 16 10 2 1 2 : : : 10 2 15 10 16 10 3 : : : 36
255 4 10 2 15 10 16 10 4 4 : : : Treatable Dementia inph inph L - P L - P inph LP Lancet Neurology SINPHONI - 2 10 3 16 00 17 00 2 1 2 : : : 1864-1915 20 19 20 10 3 16 00 17 00 3 : : : AD 6 QOL AD DLB 37
256 Dementia Japan Vol. 29 No. 3 September 2015 10 3 17 00 18 00 4 1 : : / : Lewy 38