Cmax AUCo-+on,l, fns/ml 76.468+ t'/.710 x x n=3
l1) Labroo,R.B.etal. : Drug Metab.Dispos. 1997; 25(9): 1072- r 080 l2) Schneider,E.et al. : Naunln Schmiedebergs Arch.Pharmacol.
B0T0X'ror injection
-0.09 t-o.35ot?l -0.46 f-0.?1.-0. ml -0. l5-0.3c 0. 08.l
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40mg
40mg 40 mg4; a 80 mg 57.g1os Q2/38 FtJ)
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CLr (ml/min/ 1.73m1
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20mg(n= 8 ) 40mg(n= 3.) Cma* (nglml-) --{F 40mg (n=3; --O- 20mg (n=8) mean t SD mean t SD 20mg(n= 8 ) 40me(n=11) mean a SD
l. 9 [-1. r], 8. 5l