a a a b a: - - b:.5% 5 B- A- B- A- B- A- Lot.No.997261 B- Lot.No.34192 Pharmatose DCL11 DMV INTERNATIONAL Lot.No. 3628 1 Mesh Lactose Monohydrate DMV INTERNATIONAL Lot.No. 15289 VIVAPUR 12P Microcrystalline cellulose J.R.S. Lot.No. 5612127 85 2mm 1.4mm
B- A- A- B- B- A- 1% :24.31 4. 5.% B- DCL11 1Mesh VIVAPUR 12P 1 1 1 1 (%) 8 6 4 8 6 4 (%) (%) 8 6 4 8 6 4 (%) 2 2 2 2.1.5 1 5 1 5 1 (µm).1.5 1 5 1 5 1 (µm) A- B-
A- B- 45rpm.5% 1 3 5 1 15 3 1.2ml
19. 1 1 1mL 1 2mL 1mL 1mg/L 1mL 1.38 1 ml 1 6% 2 ml 15 1 2 ml 1 ml Absorbance 1.5 1.5 (mg/l) 2 1 1 2 3 Concentration(mg/L).1.2.3.4.5 B--st (wt%) B-
a -st (wt%).6.5.4.3 a CV(%) 5 4 3 2 1 b c d e -st (wt%) -st (wt%) -st (wt%) -st (wt%).2 1 2 3 (min).6.5.4.3.2 1 2 3 (min).6.5.4.3.2 1 2 3 (min).6.5.4.3.2 1 2 3 (min).6.5.4.3 b c d e CV(%) CV(%) CV(%) CV(%) 1 2 3 (min) 3 2 1 1 2 3 (min) 3 2 1 1 2 3 (min) 3 2 1 1 2 3 (min) 3 2 1.2 1 2 3 (min) 1 2 3 (min) -st adcl11 b 1Mesh c VIVAPUR 12P a DCL11 b 1Mesh c VIVAPUR12P d e d e
1 B- A- A- A- B- A- 18 pp17 173 1971 PHARM TECH JAPAN 9 1139 1993 33 676 1996 PHARM TECH JAPAN 15 895 97 1999 12 pp9 2