25 1 H25.11.20 1. 2. 3. 4. 5. 1 2 1
4 2 10 4 10 22 5 8 3 3 1. 2. 3. 4. 4 2
1. 2. 3., 4. 5 1. 1 2. 1 6 3
434 365 600 100 25 5 15 7 1 4200 8 4
9 ADI = ND 10 5
11 - NOEL NOAEL ADI 12 6
DNA 10 100 1 10-5 10-6 WHO : 10-5 FDA: 10-6 VSD 13 DNA DNA DNA 14 7
NOAEL 1/100 1/10 1/10 ADI 15 ADI A B C ADI 80% D E F,etc 16 8
1976-2000 7 1 17 5,000 15,000 18 9
(mg/ ) ADI,mg/kg 2 0.006 0.5 25 0.02 4 0.469 7.5 375 0.13 0.154 0.7 35 0.44 13.56 25 1250 1.08 5.853 40 2000 0.29 K 0.736 15 750 0.10 Na 0.648 5 250 0.28 70.098 (mg/ ) ADI (%) 1052.95 19 14 15 ADI (kg) (kg) (mg/ / mg/ / 200,000 160,000 3.46 2,000 0.17 2 1,950 1,560 0.034 25 0.14 102 30,000 23,940 0.516 200 0.26 280,000 224,500 4.81 250 1.92 2,034,400 1,627,600 34.8 1,250 2.78 BHT 20,000 16,000 0.34 15 2.27 BHA 10,000 8,000 0.17 25 0.68 OPP 0 0 0 10 ADI (% ) 17 3 31 20 10
A B 47 80 120mg/ 80 120mg/ 160 9.26g/ 2.30g/ = 9.26g-6.86g=2.30g 2, 54 (1995), 5, 178 (1998) 21 1890 1953 1955 1957 1962 = 5 1965 1968PCB 1969DDT BHC 1975 1996 22 11
1956 Minamata Disease 23 Rachel-Carson Silent Spring, 1962) (EPA) DDT 24 12
1975 1931 1984 25 26 13
1948.1.1 1966.41 101 1966.7 74,5 1,2 1,2,3 1968.7 1969.10Na 1974.9 AF2 1976.2 2FDAJECFA = EU 2OPPK BHA 27 1 28 14
( 2 (A) Ca (B) (C) 29 NOEL NOAEL ADI 30 15
/ 352,000 228,900 31,560 20,513 5,740 3,730 1,159 753 * 850 552 * 815 509 ** 450 292 * 6 3.9 * 12 7.8 100, * 10**21 6-8 31 (%) 32 16
(10) (%) 33 Risk Benefit 34 17