1 3 1 10 2003 1 1 211
My obacterium leprae c 212
4 5 10 Cole 213
2 19 9 11 14 15 18 1807 97 1980 19 1817 20 1849 1853 O. G. Hoegh 1 1868 5 1851 1870 1 1858 1869 P. F. Mange,, Jpn. J. Leprosy, 63: 17-29, 1994 214
3 19 1970 1877 5 laegd laegd 1885 6 1866 500 1873 1889 19 2 1897 1 4 1 2 3 215
4 1906 59 1906 1909 5 5 1923 3 1920 1926 1927 1928 1930 3 14.4 8 1930 12 216
1 4 1931 3 19316 1920 30 1943 1 Public Health Reports 58:1729-1741, 1943 1950 1970 20 1970 1960 80 90 6 12 217
Waters, M.R.F., et al., Changes in the morphology of Mycobacterium leprae in patients under treatment.:internat. J. Leprosy 30: 266-277, 1962 40 218
1970 HLA HLA HLA 10 6 90 1960 1970 2001 Cole, S.T. et al, Massive gene decay in leprosy bacillus: Nature 409:1007-1011, 2001 330 4 3 219
2000 1 4 1000 1 401907 5 1931 6 1 220
1953 90 1994 1996 1998 7 1927 1976 1996 1 1930 1977 1996 221
1947 1932 5 2600 1 1936 8 1939 13 10,000 15,000 1942 17 1947 1995 1931 1 1951 2004 5 21 77 1931 1953 1961 1975 222
1947 1966 1968 41 1973 21 6 223
1974 1982 55 92 66 1994 67 95 1980 20 224
1953 1955 1990 53 FLA-ABS 1980 225
5 55 1992 1 20 DDS 1970 WHO 226
3500 1987 3 1 30 3 1 12 8 1 2 3 6 227
301955 3 1996 3 1963 83 20 3500 1 301955 228
7 1 1951 26 1958 33 4 19831991 1971 1989 19621969 1970 19811991 2 1909 42 191718 6 7 1942 1917 6 3 1 1937 12 1 51 1992 1931 6 1939 14 1931 6 60 8 1979 1940 15 14 1952 27 3 1989 1942 17 21 3 1936 11 1955 30 12 5 1985 1964 39 1977 1989 229
1960 35 100 5 40 3 30 5 30 1966 41 3 30 5 1971 20 1971 46 1983 58 20 195758 3233 1999 11 12 2003 3 1951 26 1942 17 21 1952 27 19 3 1956 31 1 1963 38 3 2 1972 47 1976 51 1976 1 2 1931 6 1 60 8 1960 35 5 5 40 230
8 1984 59 1996 61 2 1974 49 1931 6 1939 14 5 1960 35 5 1962 37 1966 41 3 5 30 1991 3 5 3 1998 10 50 30 195758 3233 1959 1 1981 1956 31 1964 39 1968 43 1 1909 42 1934 9 1952 27 1951 26 9 1956 31 1980 55 3 1946 21 2 2002 14 3 3 50 2004 16 10 31 21 1955 30 231
4 2000 12 1 1988 63 1940 15 1991 3 1 4 5 12 1964 0.79 0.2 65 2 32.5 21.7 1932 7 1960 35 232
5 233
2003 1 2 1942 17 1938 13 1 10 2 5 2000 13 234
1 2 1909 0 1 190910 159.5 1911 0 0 0 0 0 191115 0 1916 0 0 1 0 0 191620 25.7 1921 2 1 1 0 0 192125 81.8 1926 1 0 1 0 2 192630 28.7 1931 1 3.5 2.5 2.5 0.5 193135 98.9 1936 2.5 2.5 4.5 5.5 2.5 193640 54.1 1941 5.5 6.5 2.5 6.5 4.5 194145 52.0 1946 0.5 4.5 2.5 2.5 4.5 194650 35.9 1951 2.5 3.5 3.8 3.8 4.8 195155 38.8 1956 1.8 2.8 3.8 2.8 2.8 195660 28.4 1961 4.8 2.8 4.4 4.4 0.4 196165 36.4 1966 3.4 3.4 2.4 7.4 3.4 196670 48.4 1971 1.4 3.5 0.5 0.5 0.5 197175 22.4 1976 0.5 3.5 3.5 2.5 2.5 197680 29.8 1981 2.5 3.7 2.7 3.7 4.7 198185 52.7 1986 3.7 4.7 2.7 2.7 0.7 198690 51.2 1991 1.7 1.4 2.4 1.4 0.4 199195 29.4 1996 2.4 1.4 2.4 1.4 2.4 199699 45.2 1 235
1917 191144 2 1912 1 2 19132 0 19143 1 4 62.4 3 20 19674214.2 1998 10 200315 34,427 10 1 1 2,761 9 27.0 23,000 196136 1970 40 198156 4 1959 1 7 1981 195732-1958331 1 58 10 1948-1957 1 16 1932-1947 2.1 10 10 Folia Psychiatrica et Neurologica Japonica 1 2.1 1932-1947 34 1948-1957 10 195758 1948-57 2 195025 41 18 236
230 160 20 14 55 44 33 1 195530-19755020 13 8 42.9 1 3 1 1966 1973 5 13 5 8 68-86 2 13 13 3 1 1 1 3 1 13 6 6 3 1 1 1 1 6 1 1 1 1 1 237
6 613 77 12.6 52 21.2 11 1945 1951 1944 295 42.3 337 48.4 9 65 9.3 1972 3 1957 1948 1952 1955 10 1993 1959 30 DDS 1952 238
1962 50 1951 1940 1955 1959 195 7 23 2 1 3 3 239
1 2 1 2 LSIK LSIK QOL 240
LSIK 9 3 QOL 2002 2003 13 5 357 14 5 1 653 11 208 44 481 171 315 175 204 758 1,861 StatView 5.0.1 SAS institute 3 409 317 74.08.9 20.98.6 50.211.1 65 650 LSIK 2.31.92 65-69 70-75 75-79 80 F3=3.04 3 377 49.7 78 10.3 42 5.5 36 4.7 24 3.2 21 2.8 19 2.5 11 15. 9 12. 128 16.9 98 12.9 197 26.0 223 29.4 277 36.5 485 64.0 486 64.1 78 10.3 66 8.7 235 31.0 266 35.1 162 21.4 34 4.5 31 4.1 517 68.2 225 29.7 371 48.9 371 48.9 437 57.7 184 24.3 157 20.7 223 29.4 184 24.3 148 19.5 199 26.3 241
29 3.8 27 3.6 36 4.7 659 86.9 208 27.4 9 1.2 8 1.1 218 28.8 80 10.6 224 29.6 28 3.7 40 5.3 40 5.3 50 6.6 50 6.6 161 21.3 522 68.9 93 12.3 LSIK LSIK 0 147 19.4LSIK LISK 70 70 80 80 3 45 45 60 60 3 15 15 25 25 3 1945 1945 1955 1955 3 49 13 OR95 95%CI 4 OR=1.7, 95%CI=1.2~2.3 OR=1.5, 95%CI=1.1~2.0 3 1 2 2002 2003 13 242
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3 KLSIK p 65-69 2.01.9 55 4.82.3 290 <0.001 70-75 2.31.9 103 4.62.1 218 <0.001 75-79 2.22.0 91 4.42.2 118 <0.001 80 2.61.9 117 4.72.4 80 <0.001 65 2.31.9 366 4.72.2 706 <0.001 65-69 1.91.7 44 4.72.2 342 <0.001 70-75 2.31.9 54 4.52.3 283 <0.001 75-79 2.31.7 74 4.42.2 190 <0.001 80 2.62.1 95 4.52.2 130 <0.001 65 2.31.9 267 4.62.2 945 <0.001 65-69 2.01.8 102 4.82.2 632 <0.001 70-75 2.31.9 163 4.62.2 501 <0.001 75-79 2.31.9 168 4.42.2 308 <0.001 80 2.62.0 217 4.62.3 210 <0.001 65 2.31.9 650 4.62.2 1651 <0.001 Koyano W, Shibata H. Development of a measure of subjective well-being in Japan. Facts and Research in Gerontology, 8 suppl: 181-187, 1994. 4 LSIK 0 LSIK 0 OR 95CI OR 95CI 326 122 37.4 432 200 46.3 1.4 1.1-1.9* 575 224 39.0 183 98 53.6 1.8 1.3-2.5** 603 238 39.5 155 84 54.2 1.8 1.3-2.6** 538 207 38.5 220 115 52.2 1.8 1.3-2.4** 250
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6 1 69 3 18 59 15 58 6 43 5 4 3 2 2 1 A 4 1 236 B 4 1 46 33 2 43 18 19 7 1 15 5 15 1 11 82 11 7 5 9 5 5 172 14 6 1 1 5 5 510 1 2 3 4 5 6 252
7 60 5 3 60.0 0 0.0 0 0.0 2 40.0 4 80.0 0 0.0 60-70 32 3 9.4 4 12.5 0 0.0 16 50.0 23 71.9 0 0.0 70-80 110 7 6.4 12 10.9 8 7.3 45 40.9 79 71.8 0 0.0 80-90 94 19 20.2 13 13.8 5 5.3 47 50.0 70 74.5 4 4.3 90 15 1 6.7 1 6.7 0 0.0 8 53.3 10 66.7 1 6.7 256 33 12.9 30 11.7 13 5.1 118 46.1 186 72.7 5 2.0 465 33 7.1 30 6.5 13 2.8 118 25.4 186 40.0 5 1.1 8 60 5 3 60.0 0 0.0 0 0.0 2 40.0 0 0.0 60-70 32 3 9.4 3 9.4 0 0.0 14 43.8 12 37.5 70-80 110 7 6.4 10 9.1 8 7.3 51 46.4 34 30.9 80-90 94 20 21.3 6 6.4 2 2.1 39 41.5 27 28.7 90 15 2 13.3 1 6.7 0 0.0 6 40.0 6 40.0 256 35 13.7 20 7.8 10 3.9 112 43.8 79 30.9 465 35 7.5 20 4.3 10 2.2 112 24.1 79 17.0 253
1 254
8 1 195025 9 1872 1874 1875 1882 1879 1889 1892 255
1893 1894 1895 1897 1898 1899 1900 1901 1902 1903 1905 1907 1909 5 1914 1915 1916 1918 1919 1922 1927 1928 1930 1931 1933 256
1932 1933 1934 1935 1936 1938 1939 1940 1941 5 1942 1943 1945 1946 1947 1948 1950 1951 1952 1953 1954 1955 1956 1957 1958 7 1960 257
1963 8 1964 1965 1979 1984 1987 1988 1994 1995 1996 1997 1998 2001 2002 2003 18692 18725 11 15 240 1872 5 3 23 258
1898 31 1901 34 1909 42 1908 41 1875 8 5 1879 12 7 1 525 71 2 2 3 1940 15 1879 12 7 2 1919 8 1875 8 1882 15 1878 11 4 10 259
1 2030 10 1 3 1 1 3 1875 1880 1885 1890 1895 1900 1905 1910 1915 1920 1925 1930 1935 0.01 0.10 0.15 0.18 0.27 0.37 0.54 0.62 0.82 1.06 1.22 1.82 2.40 100 54.3 41.4 45.2 37.7 33.7 23.7 20.6 18.9 13.6 20.8 19.4 18.4 100 91.4 93.1 95.8 95.5 94.8 91.5 87.3 76.2 67.5 59.0 57.0 51.1 0 77.4 58.6 71.1 56.0 61.2 68.5 67.9 55.8 48.3 37.1 30.5 27.3 260
1900 33 1892 25 1964 1900 33 7 1 29 1903 36 1901 34 1904 261
32 1013 1918 1919 8 1929 4 1951 26 1897 30 1905 38 21 6 23 1907 40 3 1909 42 5 5 4 1 1910 43 1914 3 1874 7 13 1933 8 2 1887 20 2 2 1904 1925 14 9 1938 13 262
10 10 1941 1918 7 5 1917 6 6 30 59,930 5,004 1919 8 41 1 2 4 7 50 3 1 1945 20 1920 1926 263
1929 1931 1931 1932 1937 1945 8 1950 25 1940 15 4 19 7 2001 13 4 10 1 50 9 2003 1,646,797 32.6 357,385 11.0 1916 5 1930 5 1932 7 1931 6 3 1931 6 59 1915 4 1940 15 264
1936 12 23 1941 1914 3 1936 11 1927 2 1931 6 1931 6 25 1902 35 3 1933 8 1 1941 16 5 1945 20 1941 16 1942 17 1 1938 13 2001 13 2 59 10 31 32 2003 1892 1903 5 7 6 20 265
2 4 4 (38 ) 1984 59 1987 62 1997 9 6 1941 16 266
2 3 1 267
1927 2 5 7 5 1974 49 1984 59 1996 8 1929 1929 1928 3 1 11 113 64 46 7 4 1922 11 5 1941 16 1947 22 1945 20 1945 140 94 110 268
23 1941 1947 1975 1942171946 21 191144 12.3 9 1918715.2 6.7 1947 228.8 1951 26 1 1941 47 11 11 1941 1942 1943 1944 1945 1946 1947 3.9 7.6 6.7 7.1 10.6 3.9 5.3 3.0 4.0 4.5 3.6 6.4 5.2 3.8 5.1 6.4 6.5 6.4 9.1 9.6 4.6 6.1 9.2 6.9 8.0 9.6 8.4 4.6 1945 0 0 0.7 4.6 5.6 5.5 9.7 18.1 8.9 7.1 6.8 7.9 7.4 11.3 17.1 10.1 8.2 6.6 9.3 8.5 12.9 7.8 7.5 5.7 7.9 8.6 8.9 9.0 10.3 6.9 5.2 5.6 6.5 4.3 6.7 11.4 4.6 3.2 1943 0 7.3 4.5 8.7 4.1 4.8 2.3 3.3 6.1 26.4 4.4 2.6 1.4 4.0 5.2 11.9 31.9 8.1 3.0 194520 194217 194342194419 194621 1945 20 2 194520 7 2 1945 1000 194116 15.71942 15.81943 269
16.819441946 1947 14.6 1941 47 12 12 1941 1942 1943 1944 1945 1946 1947 0 0 0.6 2.3 8.3 9.3 13.6 1941 1943 17.6 13.3 13.6 31.2 40.9 20.4 13.5 19.0 22.0 21.2 38.8 52.5 25.0 11.4 6.6 13.1 8.0 20.2 31.4 19.6 12.1 16.5 19.7 27.5 28.1 40.3 27.8 12.8 22.6 31.5 42.8 51.9 62.3 38.9 23.0 1945 6 40.0 31.5 28.6 14.1? 26.9 22.5 51.0 31.4 23.0 9.3 4.7 5.4 11.1 9.5 31.9 17.2 15.3 11.3 9.3 11.0 26.1 46.1 26.5 1945 20 1946 21 194520 2 3 2 1945 76 73 1919 8 25.1 4 1914 3 1918715.2 1000 1918 26.919209 25.4 270
1947 22 19423 178 1951 26 24 1947 22 1947 1 271
195126 1953 28 19305 195631 195833 7 196338 8 1954 29 2 1957 32 600 25 1960351 1950 200 350 1955 500 600 1960 500 705 1965 850 2075 1970 1200 4296 1970 45 197247 1 195328 40 1965 1967 42 1970 45 1948 23 195833 1960 35 11 Yoshiko Ikeda: AnEpidemicofEmotional Disturbance Among Leprosarium Nurses in a Setting of Low Morale and Social Change.Psychiatry Vol.29 No.2,1966 198863 1953 272
28 1963 38 1994 6 1996 8 1947 22 1950 25 3 5 48 2 29 1978 53 93.5 1970 45 252,524 76,532 30.3 3 1 3 2 1954 29 273
70 1949 24 1958 3 1 3 2 2001 111 112 150 1986 61 1 2 10 1 1 1970 45 274
196035 195429600 1957 600 400 1960 705 400 1965 2,085 1,400 1970 4,295 3,405 1974 7,920 12 1964 39 19 124 28 100 200113 12 WHO 4 9 1 2000 1984 59 275
33 1987 62 22 3 1987 62 1995 1 28.2 2002 14 2003 15 1 2002 276
1910 43 10 1937 12 1919 16,261 1917 64,934 6 277
1951 26 1954 29 1979 54 1989 1947 22 2001 13 1 1970 45 30.3 1961 36 1995 7 2030 278
279
1 1 1 2 1984 59 32 2 4 4 280
3 4 5 6 1 7 2002 281
282