1 40 53 13 42 22 15 51 43 21 40 79 26 63 37 32 44 14 40 33 53 41 48 24 39 49 38 28 51 32 30 59 17 35 63 100 100 100
2 80 57 1 28 16 2 35 31 3 37 62 3 5 35 21 6 37 67 6 50 27 7 48 32 8 10
3
O157:H7 O139 VRSA H5N1) Nipah SARS prairie dog Chikungunya 4
H H A B B H C D 5
6
1 1 1. I.U.WHOCDC 7
MMWR VERO 8
100%92.3% 86.3% 40 % 50%12.5% 2.5% 30.8% 2005 9
1(1) 26(19) 2(2) 1(1) 30(23) 0 24(18) 4(3) 2(1) 30(22) 0 75(21) 5(4) 0 80(25) 0 16(14) 2(2) 2(2) 20(18) 1(1) 13(11) 3(3) 1(1) 18(16) 0 12 1 3 16 0 12 3 0 15 0 13 4 1 18 ( ) Nalidixic Acid () H H H 10
11
, 12
A 13
151216181540 14
15
16
17
( 250mg/ 100mg/ 18
19
20
21
GabonCongo Leroy, EM et al, Nature 2005;438:575-6 EV) Vesicular Stomatitis Virus (VSV)EV EV Plos Pathog. 2007;3(1):e2. 22
Mr. U.G 1 23
Child: Secondary lesions 5/27/03, adjacent to primary inoculation site on left hand. Marshfield Clinic Monkeypox lesions at a finger bitten by a prairie dog Marshfield Clinic 2006.10 / 0/0 0/0 0/0 8/58/5 0/0 0/0 4/4 2/2 6/6 1/1 0/0 8/5 12/8 21/14 0/0 0/0 0/0 1/0 1/0 0/0 0/0 0/0 15/6 15/6 0/0 0/0 19/12 50/40 69/52 0/0 0/0 0/0 3/2 3/2 0/0 17/12 5/2 3/3 8/5 0/0 0/0 0/0 12/4 12/4 3/3 29/20 61/19 0/0 93/42 4/4 46/32 97/42 106/ 70 253/148 24
in vitro 25
26
27
28
29
Prevention important B A () 1
A8,000 * 2
A 0 2 20023 ProMED 4/12.2004 3
0 38 1968 4
B 0 0-7-210-14-28 5
0 6
1970 7
* 8
9