110 12 2001 1 31 I. 2000 9 17 11 19 126 10 1 8 10 60 41 E - 1 -
II. 9/17 9/24 10/1 10/8 10/15 10/22 10/29 11/5 11/12 11/19 19 10 11 9 5 6 10 10 9 6 95 19 20 30 40 50 60 70 (%) 7.7 11.5 15.4 5.8 19.2 21.2 19.2 % 39 (41%). 4 11 4 9 4 6 3 4 11 95 10 5 3 64 38 C 1,2 C 3-8 18 T1-12 13 6 4 3 10-2 -
51 3 1 5 10 20 20 6 8 23 6 2 6 N 29 13 43 9 30 5 17 2 10 43 45 52 55 95-3 -
- 4 - III. 70 10 J 65 20 L2-4 O C5 70 75 T
- 5-71 2 T11 1 76 T3 77 1 C3 5 MRI 61 27 2 36 C
C 10 63 4 11 62 10 C 12 62 2 13 21 T 14 64 15 PSA 0.3 0.7 11 2 0.1 9 PSA 0.4-6 -
17 16 27 2 C 17 18 16 6 C 3 24 MSW - 7 -
19 C 20 26 1-8 -
21 65 22 3 23 C 24 41 T12 500cc 25 31 7 26 20-9 -
10 27 41 3 T12 28 60 12 25 29 30 3 30 30 10 31-10 -
32 58 1 C 33 50 34 71 8 35 64 5 T11 65 36 52 10-11 -
37 30 10 C 38 30 15 C 39 61 40 30 41 30 C4 CAD K CAD 42 70 30 T 43 18 1999 3 1 T12 3 16 4-12 -
44 70 3 50 25 165,000 7-13 -
- 14 - deaf-ferentation pain neuropathic pain NSAID 64 55 21
~ 1 ( ) 1. ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) =GABA GABA ( ) ( ) ( ) GABA ( ) ( ) GABA - 15 -
2. (TENS) 2 30~70Hz 3 2 1990 3. ( ) ( ) ( ) (2) 4. ( ) ( ) ( ) ( ) (3) - 16 -
( ) (2) 1 100 NMDA NMDA NMDA NMDA NMDA - 17 -
á- GABA á- GABA NMDA GABA - 18 -
- 19 - QOL QOL
Wise Young Wise Wire 2000 1999 Sidall 100 40 36 19 64 55 21 Millan ATP NO pro-nociceptive NMDA NMDA - 20 -
- 21 - Basbaum 10 P PPK C PKC Polgar PKC PKC Vilim NPFF NPAF NPSF 1999 Colburn â Ignatowski TNFá á â P GABA Dickinson Fleetwood-Walker VIP PACAP Fisher Hagen
- 22 - Huang Simpson c-fos Munglani 20 Laffey Seaman Cleaveland Kontinen