Chaptor 18
( ) ()
1. 2. 3. 4.
届 届
BSL BSL1 BSL2 P1 P2 BSL3 P3 BSL2 BSL4 P4 BSL3 BSL: Biosafety Level P: Physical Containment
BSL
P4施設
Rhabdoviridae, Filoviridae, Arenaviridae and Bunyaviridae (-)RNA +
Rhabdoviridae, Filoviridae, Arenaviridae and Bunyaviridae (-)RNA + ( )
Rhabdoviridae, Filoviridae, Arenaviridae and Bunyaviridae (* ) Filoviridae Ebola virus*, Marburg virus* Arenaviridae Lassa virus* Bunyaviridae Hantaan virus, Crimian-Congo Hemorrhagic fever virus* Flaviviridae Dengue virus, Yellow fever virus
(* )
Rhabdoviridae (Lyssavirus) (Vesiculovirus) (Ephemerovirus)
Rhabdoviridae 75nm 100~300nm (-) RNA 12,000
http://www.mhlw.go.jp/bunya/kenkou/kekkaku-kansenshou10/07.html http://idsc.nih.go.jp/iasr/28/325/inx325-j.html
1. 2. 3. 4. 5. 6.
() 0 3 7 14 28 90 10
Filoviridae Marburgvirus and Ebolavirus
Filoviridae (Marburgvirus) (Ebolavirus)
Filoviridae
BSL4,
Arenaviridae
Arenaviridae (Arenavirus) (Lassa virus; (Junin virus; (Machupovirus; (Guanaritovirus;
Arenaviridae 2 1 RNA
1969 Mastomys 5~21 1/3
Bunyaviridae
300 Bunyaviridae
SFTS
Bunyaviridae 3 1 RNA
1984
2 3 PCR
SFTS 20112012 2005 2005 24 10 201313 3
重症熱性 血小板減少症候群
SFTS STFS (97%) CDC WPRO
1~7 1. 38 2. ( ) 3. (10 /mm 3 ) 4. (4000/mm 3 ) 5. AST ALT LDH ( ) 6. 7. /
(CCHF) CCHF CCHF
(CCHF) 2 9