2001 4 5 8 21 14 17 Helicobacter hepaticus H.rodentium H.bilis Pasteurella multocida P.multocida Pasteurella multocida Rattus norvegicus 2 21 25 27 28 28 29 30 LABIO 21 JULY 2001 3
LABIO 21 JULY 2001 4 1 LEC 7 3 1,200 100 50 50 20 3 48 21 1 2001
TEXT 129 LABIO 21 JULY 2001 5
LABIO 21 JULY 2001 6 LIF Thomson 2, 3 4 5 LIF
MHC MHC MHC LABIO 21 JULY 2001 7
LABIO 21 JULY 2001 8 1945815 85 3 20005 550580180 25 10 21 50 2 20015 1 2 3 4 5
Hot Corner 30 1993 1968 LABIO 21 JULY 2001 9
LABIO 21 JULY 2001 10 25 1950 1945 54671998
Hot Corner 1998 28833 135 2338 1294 22 1997 LABIO 21 JULY 2001 11
LABIO 21 JULY 2001 12 20 1200 5060 1998 6000 21 1998
LABIO 21 JULY 2001 13 16 21 500 21 1 2 3 4 Hot Corner
SOT5000 2000 FDA San Francisco Moscone Convention Center 40 CRO in vitro in vivo in vivo 14 LABIO 21 JULY 2001
in vitro in vitro in vitro 1996 SOT Continuing Education Course Screening Pharmaco- /ToxicogenomicsCombinatorial ChemistryHigh-Throughput Screeningtoxicology Computational Toxicology FDA/CDER Dr. Contrera Bristol-Myers Squibb Dr. Durham IT Computer Quantitative Structure Activity Relationship: QSAR Computational Predictive Program LABIO 21 JULY 2001 15
CleavelandWashington D.C. San Francisco San Francisco California whole body 16 LABIO 21 JULY 2001
Information on Overseas Technology Information Helicobacter hepaticus, H. rodentium H. bilis H. rodentium2 6 102 H. rodentium H. H. bilis bilis PCR Tac:SWfBR H. IgG hepaticus 82%H. rodentium 17 PCR H. hepaticus, H. rodentium H. bilis PCR ELISA IgG 88% H. bilis 94% H. hepaticus 98%H. rodentium 86%H. bilis 95% 1 PCR 6 H. hepaticus H. rodentium IgG ELISA 98%100% 34% 44% H. hepaticus H. rodentium PCR Information on Overseas Technology 60%44% 17 3 945 H. hepaticus 43 H. hepaticus H. rodentium 14 100%81%H. 7058 bilis 4 keyword LABIO 21 JULY 2001 17
Information Pasteurella multocida P. multocida Information on Overseas Technology Pasteurella multocida PMT P. multocida CN PMT CN 24 PMT/CN PMT/CN PMT/CN PMT/CN Day 0 Day 14 28 42 Day 56 P. multocida Day 60 Day 7 21 35 49 keyword PMT/CN CN IgG IgM IgG IgAIgG 100 50 1g PMTCN PMT CN Information Pasteurella multocida Pasteurella multocida PMT PMTIPMT PMT IPMT IPMT 15 0.5 ml P. multocida BT 10 IPMTg 0714 21 PMT ELISA BT IPMT 14PMT IgG IgA PMT 18 LABIO 21 JULY 2001
Information on Overseas Technology BTIPMT 21 PMT 28g Information PMT IPMT BT keyword P. multocida PMT Information on Overseas Technology PCR DNA 9510 ph DNA DNA PCR 19 PCR 89 keyword LABIO 21 JULY 2001 19
Information on Overseas Technology Information (Rattus norvegicus) SHR QTL SHR F1 F1 SHR BC1 SHR F1 F1 F1 BC1 72 QTL BC1 72 200 2 D2Mit2 Fgg 2.3 7 3X3 1431311 SHR á keyword Information CO 2 10C57BL/6 n=40 CO 270% CO 2/30% O 270% CO 2/30% O 2 100% CO 2100% CO 2 100% CO 2 100% CO 2 70% CO 2/30% O 2 100% CO 2 MCV MCH CD8 + T CO 2 CO 2 / keyword 20 LABIO 21 JULY 2001
WHHL WHHLWatanabe Heritable HyperlipidemicRabbit origin 1973 1973 900 4000 5 52 300 2 1 Ch Ch 20 Ch Ch Ch 10 Mutant WHHL origin 1973 LABIO 21 JULY 2001 21
Mutant Mutant Ch 40 Ch Ch F3 3 1 WHHL 6 1979 44,000 WHHL 3 6 WHHL F Mutant Ch WHHL 22 LABIO 21 JULY 2001
WHHL Data Data 1976 l,2 Ch 6 give Up 1979 Ch Mutant 6 HLR WHLWatanabe Hyperlipidemic Suggestion Heterozygote WHL 1980 Atherosclerosis Atherosclerosis WHL Heritable WHHL WHHL 1982 6 WHHL 4050 Texas Goldstein LDL Pathway LDL FH Ch LDL Ch Ch Ch FamiliaI Hypercholesterolemia: FH Ch Homozygote 20 LDL WHHL LABIO 21 JULY 2001 23
WHHL LDL Goldstein WHHL 1985 WHHL 1990 41 60 NIH National Institute of Health WHHL WHHL WHHL WHHL 1990 WHHL WHHL 24 LABIO 21 JULY 2001
LABIO 21 JULY 2001 25
26 LABIO 21 JULY 2001
ELISA Parainfluenza virus Type 3 Sendai virus Clostridium piliforme Tyzzer Sendai virus HI IFA HI PCR PCR PCR LABIO 21 JULY 2001 27
Books Books Books Books Books Books Books Books Books Books Books Books Books Books Books Books Books Books Books Books Books 1 19007 8kgAdrenaline BOOK Epinephrine 1927 Adrenaline Adrenaline AdrenalineEpinephrine Adrenaline 719 28 LABIO 21 JULY 2001
LABIO 21 1352517 12 1381,011 62,549( 17 13. 3. 4 39 30 13. 3. 6 13 2001 13. 3. 16 136 1213 13 34 13. 3. 27 1213 13. 4. 10 13 13. 4. 17 LABIO 21 No.5No.6 13. 5. 16 13 35 13. 5. 25 17 17 13. 5. 25 1213 13. 7. 67 13. 8. 19 7 13. 9. 12 13. 9. 1014 13. 10. 1516 13. 10. 1819 13. 10. 26 13. 11. 18 17 13. 12. 2 17 LABIO 21 JULY 2001 29
13719721 1383091 http://hayato.med.osaka-u.ac.jp/index/ societies-j/alt/15.html 131068 http://square.umin.ac.jp/jsvs132/ 131110 20017710 20017813 Brisbane Australia www.uq.edu.au/ict9 200171418 Boston USA 2001823 St. Louis. cindy.m.hoorn@pharmacia.com 20019911 www.ki.se/gem2 2001102125 20011149 Sydney, Australia. www.zoo.nsw.gov.au? j 30 LABIO 21 JULY 2001
http://www.crj.co.jp