2009 H20.8 2009 5 23 ()
2 2 3 9 12 GLP-1 15 17 Cookie Test 26 32 1
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DM(ROS) DM DM 64 1 7 2 516 Free Radical Analytical System diacron Reactive Oxygen Metabolites test(d-roms ) ROS Biological Antioxidant Potential test(bap ) 12 DM HbA1c8.1 ROM U.CARR37873 ROM 32244 (p<0.01) BAP M2258359 BAP 2152353 1 DM HbA1c7.5 ROM U.CARR34981BAP M2365437 22 DM HbA1c 5.86.46.57.98.0 9.910 ROM U.CARR 37278*37479*36358* 41561***p<005**p<0.01 3DM ROM HbA1c TGHDL-C LDL-CBMIHbA1c r=0.27r=0.28r=0.32p<0.05 4DM ROM 39473U.CARR ROM 35671U.CARR(p<0.05) 5DM HbA1c7.0 ROM U.CARR 380 82 (p<0.05) ROM 34595 6 TG 120 ROM 15 p<0.05 BAP 7 150mg HbA1c6.4 6.1ROM 5(p<0.05) 3
2 DM ROM HbA1c 1. (O 2, HO, 1 O 2 *, H 2 O 2 ) 2. ( O 2 3. R-OOH Fe/Cu 4. R-O / R-OO 5.) 1 4
ROM)BAP) ROM BAP p<0.01 n.s. n.s. n.s. (n=16) (n=7) (n=57) (n=16) (n=7) (n=57) (n=16) (n=10) (n=24) (n=13) (n=10) 5
(n=64) ROM 6
p<0.05 vs (n=4) (n=5) d-rom *p<0.05 n.s. n.s. (n=4) (n=5) 7
150mg d-rom *P<0.05 3 (n=5) 8
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1 LDL120HDL40 49% + 51% TG 22
Met S Met S n=) Met ( ) Met 31% ( ) 44% Met (+) (+) 56% 69% Met S 56 ( TG % 90 80 70 60 50 40 30 20 10 0 56 6 25 31 63 50 6 25 81 23
<0.01 Paired tteat vs. (SE) 2454 1817 1000 1200 1400 1600 1800 2000 2200 2400 2600 2800 3 4 kcal 81.8 67.5 333.7 59.3 43.8 254.8 0 50 100 150 200 250 300 350 400 3 4 11.9 10 12.3 7.2 5 6 7 8 9 10 11 12 13 14 g 3 4 24
n=2) % 90 80 70 60 50 40 30 20 10 0 75 25 0 17 33 25 8 8 67 25 33 17 0 17 0 0 83 50 25 0 25
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(mg/dl) 350 300 250 200 150 100 50 () 250 200 150 100 50 0 2 IGT 2 10 5 0 5 10 15 20 25 30 Int. Textbook of Diabetes Mellitus, third edition: John Wiley & Sons; 2004;995-1015 18200697 29
0 20 40 60 80 100 120 140 NGT Pre-Borderlin mg/dl NGT) IFG IGT DM P<0.001 P<0.00 1 P<0.001 P<0.001 N.S. N.S. n=179 n=41 n=22 n=61 n=59 UMI(mg/gCr) WHO(75gGTT) (UMI) UMI NGTCPR 8 0 3 30 NGT 1 2 2 3 1 2 2 4 IGT 1 1 1 3 2hCPR 75g/gCr 2h 100mg/dl UMI 10mg/gCr * * 75gOGTT 30
100mg/dL125mg/dL 5.2% HbA1c6.0% UMI10mg/gCr 75g 2007 31
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50% 10 20 33
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TEL: 072-700-1135 () TEL: 06-4706-6081 E-mail: Cookie-test@saraya.com 35
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