PTP D AMX AMZ MALT MALT PC CYPC ACYPA ph ph ph ph
ALTGPT ASTGOT LDH AlP X ToxicEpidermalecrolysisTE StevensJohnson BU CKCPK ASTGOT ALTGPT AlPGTP LDH BU TSH CK CPK ALTGPT ASTGOT GTP AlPLDH PTPPTP PTP C C tmax
MeanSDn Cmax tmax AUC t MeanSDn Cmax tmax AUCt t EM PM EM PM EM PM MeanSDtmaxMedianMinMaxEMnPMn PCCYPC EMextensivemetabolizerCYPC CYPC CYPC PMpoormetabolizerCYPC CYPC CYPC Cmax tmax AUC t EM n PM n MeanSD PCCYPC ACYPA P CCYPC R PACYP A ZollingerEllison H gradea gradeb gradec graded KaplanMeier c a P b P P akaplanmeierblogrankc KaplanMeier H K ATPaseSH ph ph EM PM EM PM EM PM in vitro H K ATPase AMPin vitro
ph RabeprazoleSodium MonosodiumRSmethoxypropoxy methylpyridinylmethylsulfinylh benzoimidazolide CHaOS ph KinoshitaYetalAmJGastroenterol PRT KinoshitaYetalAlimentPharmacolTher PRT IwakiriRetalAlimentPharmacolTher PRT KuwayamaHetalAlimentPharmacolTher PRT IsomotoHetalAlimentPharmacolTher PRT PRT PRT PRT MoriiMetalBiochemPharmacol PRT FujisakiHetalBiochemPharmacol PRT FujisakiHetalDrugInvest PRT GIResearch PRT GIResearch PRT GIResearch PRT EffectofRabeprazoleSodiumonAspirininduced GastricMucosalLesioninRats PRT EA PTPPTPT PTPPTPT PTPTPTP PTPT YasudaSetalIntJClinPharmacolTher PRT E PRT YasudaSetalClinPharmacolTher PRT IshizakiTetalClinPharmacolTher PRT IshizakiTetalAlimentPharmacolTher Suppl PRT ModernPhysician PRT ModernPhysician PRT ModernPhysician PRT ModernPhysician PRT ModernPhysician PRT ModernPhysician PRT ModernPhysician PRT ModernPhysician PRT ModernPhysician PRT A
D AMZ PC CYPC ACYPA ph ph ph ph ALTGPT ASTGOTLDH AlP X Toxic Epidermal ecrolysiste StevensJohnson BU CKCPK ASTGOT ALTGPT AlPGTP LDH BU TSH CK CPK
PTPPTP PTP tmax MeanSDn Cmax tmax AUC t MeanSDn Cmax tmax AUCt t EM PM EM PM EM PM MeanSDtmaxMedianMinMaxEMnPMn PCCYPC EMextensivemetabolizerCYPC CYPC CYPC PMpoormetabolizerCYPC CYPC CYPC PCCYPC ACYPA P CCYPC R PACYP A ZollingerEllison gradea gradeb gradec graded ph H K ATPaseSH ph ph EM PM EM PM EM PM in vitro H K ATPase AMPin vitro RabeprazoleSodium MonosodiumRSmethoxypropoxy methylpyridinylmethylsulfinylh benzoimidazolide CHaOS ph A PTPPTPT PTP YasudaSetalIntJClinPharmacolTher PRT E PRT YasudaSetalClinPharmacolTher PRT IshizakiTetalClinPharmacolTher PRT IshizakiTetalAlimentPharmacolTher Supple PRT ModernPhysician PRT ModernPhysician PRT ModernPhysician PRT ModernPhysician PRT ModernPhysician PRT ModernPhysician PRT ModernPhysician PRT ModernPhysician PRT ModernPhysician PRT KinoshitaYetalAmJGastroenterol PRT PRT PRT PRT MoriiMetalBiochemPharmacol PRT FujisakiHetalBiochemPharmacol PRT FujisakiHetalDrugInvest PRT GIRes PRT GIRes PRT GIRes PRT EffectofRabeprazoleSodiumonAspirininduced GastricMucosalLesioninRats PRT EA
1.
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65.1% Grade AB 87.1% 79.5% 25.0% Grade CD 35.3% 64.7%
6. 7.
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EM PM 1.
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3. 4. H H CH3 O S CH2 O S CH3 CH2 O O OCH3 OCH3 H a S CH3 O S CH2 CH3 CH2 O O OH OCH3 H H S CH2 CH CH3 O S CH2 O HCOCH3 COOH OH CH3 O COOH S CH2 H 5. H H3C O S CH2 OCH2CH2CH2OCH3 S CH 3 H OCH 2 CH 2 CH 2 OCH 3 H H HS-X O S CH 3 OCH 2 CH 2 CH 2 OCH 3 H X XH K ATPase S S CH 2 CH 3 OCH 2 CH 2 CH 2 OCH 3
1. 2. 3.
4.
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100PTP140PTP14T10 100PTP140PTP14T10 280PTP14T20500PTP700PTP14T50 100PTP140PTP14T10500PTP
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