100 100 100 1990 127
DNA DNA DNA DNA hybridization DNA RNA DNA DNA 128
12 µδγαε 129
300 1,200 500 50012 4 24,000 1,20024,000 2.910 7 10 8 rejection major histocompatibility complex MHC MHC MHC 130
MHC MHC MHC HLAhuman leucocyte antigen MHC MHC 131
cytotoxic T cell MHC 132
MHC CD8 cluster of differentiation CD8 T 1985 α β Ig 133
Ig α β α β Ig MHC MHC 134
G0 135
MHC TCR MHC Scicence http://sage.bact.wisc.edu/~forest/bact568/humans/tcr.pdf 136
helper T cellcd4 CD CD4 MHC MHC 137
CD4 T IL 138
MHC MHC IL IL IL 139
secondary response primary response IL MHC IL interleukin IL leucocyte cytokine 140
MHC 141
MHC 95 CDclusters of differentiation CD4 CD8 CD4 immunological self tolerance autoimmune disease β 142
SLE MHC CD4CD8 70110 β dimer 143
144