Daiichi College of Pharmaceutical Sciences 22-1 Tamagawa-cho, Minami-ku,Fukuoka 815-8511, Japan 1. B 10 14 2 2.
1. 2. 3.
G. Edelman 3. H (heavy chain) L (light chain) 2 4 S-S
R. Porter papain) N Fab(Fragment antigen binding) C Fc(Fragment crystallizable) Fab Fc Fab N Fc C 4.
60 110 S-S110 5.
Complemetarity-determining region, CDR) 6.
antigenic determinant epitope (88-58) (85-31) 10 15 (89-33) (83-58)
6. V C Fc 7.
H H 8. 5 IgG 12 80 23 28 II III Rh IgG IgM 10 5 ABO
IgM IgA 80 I A I A IgA IgA IgA IgA J IgA Sc IgA Sc IgA IgA IgA IgASc 390,000
IgA 170,000 IgA2 J IgE IgD B 9.
1 1 Fab 2 Fab Fab400 10. 11.
11.1 VH CH 100 90AA/110AA AA/110AA IgM IgD IgG AA/110AA IgE IgA L( 90AA/110AA AA/110AA
2 3 11.2 Ig) IgM IgG IgD IgE IgA IgM IgMIgG IgM IgG IgD IgE IgA IgD
H TGF- BIgA IL-4 IFN-IL-4 BIgE ex) IL4 IgM IgE INF IgM IgG M)E) 2. a. b. c. IgG d.(monoclonal) (polyclonal)
2. a. b. c. IgG d.(monoclonal) (polyclonal) 3. a. H b. L c. IgE d. IgA 3. a. H b. L c. IgE d. IgA 4. a IgE b IgG c IgA d IgM 4. a IgE b IgG c IgA d IgM 2007
121 a HL 2 1 b Fab Fc c 5H d Fc FabFab 1 2 3 4 5 6 121 a HL 2 1 b Fab Fc c 5H d Fc FabFab 1 2 3 4 5 6 122 a B b H c IgM d IgA 1 2 3 4 5 6 122 a B b H c IgM d IgA 1 2 3 4 5 6 58 92 a IgM b IgE c IgG IgM d IgA Ig e IgMIgA -1 1 (a b c) 2 (a b d) 3 (a b e) 4 (b c d) 5 (b c e) 6 (c d e) 58 92 a IgM b IgE c IgG IgM d IgA Ig e IgMIgA -1 1 (a b c) 2 (a b d) 3 (a b e) 4 (b c d) 5 (b c e) 6 (c d e)