ONO L 0.03mg/kg/min 1min 0.01mg/kg/min 10min M 0.03mg/kg/min 1min 0.02mg/kg/min 10min H 0.06mg/kg/min 1min 0.04mg/kg/min 10min 3 1) LSD p=0.000

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1 ONO L 0.03mg/kg/min1min0.01mg/kg/min10minM 0.03mg/kg/min1min0.02mg/kg/min 10minH 0.06mg/kg/min1min0.04mg/kg/min10min 3 1) LSD p=0.0001) 30 2) FACCFSVcfc LVESWS EDA DT MH LSD p<0.05)peak E peak A E/A 3) LMH RR LSD L p=0.0021mh p=0.0001)pq QRS QT ST 4) ONO-1101 ONO-1101 ONO-1101 ONO

2 100 / Hypovolemia 4 160/95 mmhgwho ONO ) 20 ONO mg/ mg/kg/min 0.01mg/kg/min mg/ kg/min 0.02mg/kg/min 0.06mg/kg/min 0.04mg/kg/min

3 1 50mg 5mL 1 ml/min mg 5mL 10 ml/min nifedipinenicardipinenilvadipine Ca FAC( )CFS( )Vcfc( )EDA( )LVESWS( )peak E( E )peak A( A )E/A( E / A ) DT(E ) 502

4 % 2 20% 3 20% 4 10% % 3 (20% 4 10% 5 10%

5 (RR PQ QRS QT ST ) (FAC, CFS, Vcfc) (LVESWS) (peak E, peak A, ) (LSD) 5% 1) T.Ryan, A.Timoney, A.J.Cunningham : Use of transoesophageal echocardiography to manage beta-adrenoceptor block and assess left ventricular function In a patient with pheaeochromocytoma. Br.J.Anaeth. 70: , ) Christopher J.O., David M.R., Jeffrer S.S. et al. : The effect of esmolol pretreatment on the incidence of regional wall motion abnomrmalities during electroconvulsive therapy. Anaeth.Analg. 82: ,

6 0.03mg/kg/min mg/kg/min L )0.06mg/kg/min mg/kg/min M )0.125mg/kg/min mg/kg/min H ) %90.7% ONO-1101 L M H /95mmHg / 4 85 / 505

7 506

8 LSD p=0.0001)h 30 LSD 30 p= p=0.0012) ANOVA : p= E1 507

9 85.7% 508

10 (mmhg) ANOVA : N.S. (FAC) (CFS) (Vcfc) (EDA) (LVESWS) peak E (peak E)peak A (peak A)peak E /peak A (E/A) E (DT) M H LSD p<0.05) DT 30 FAC (%) CFS (%) Vcfc (circ/sec) (ANOVA) 509

11 EDA (cm 2 ) LVESWS (g/cm 2 ) (ANOVA) peak E (cm/sec) peak A (cm/sec) E/A DT (cm/sec) (ANOVA) RR LSD L p=0.0021mh p=0.0001)pq QRS QT ST 510

12 ONO-1101 DT 1 DT 30 ONO ) Mantero A, Gentile F, Gualtierotti C, et al. : Left ventricular diastolic parameters in 288 normal subjects from 20 to 80 years old. Eur Heart J 16:94-105,

13 ONO %(17/28) ) mg/kg/min ONO-1101 ONO mg/kg/min mg/kg/min 10 ONO ASAAmerican Society of Anesthesiologist

14 ONO ONO mg/ 0.125mg/kg/min1 0.04mg/kg/min mg/kg/min 1 50mg 5mL 1 ml/min mg 5mL 10 ml/min nifedipinenicardipinenilvadipine Ca

15 / / 115 / / 130 / /

16 (RR PQ QRS QT ST ) t 5% mg/kg/min mg/kg/min 10 L ) 0.06mg/kg/min mg/kg/min 10 M ) 0.125mg/kg/min mg/kg/min 10 H )3 3 H 0.04mg/kg/min mg/kg/min 515

17 30 ECG

18 / 60.7% 517

19 / / / / 31.0%(9/29) 518

20 / GPT 519

21 72.4% 520

22 53.6% mmHg mmHg mmHg mmHg mmHg mmHg mmHg mmHg RPP bpmmmHg bpmmmHg bpmmmHg bpmmmHg 521

23 ONO-1101 ONO ng/mL ng/mL 0.04mg/kg/min 1000ng/mL ng/mL pg/mL pg/mL pg/mL pg/mL paired t p= p= p=0.0001) pg/mL pg/mL pg/mL paired t p= p=0.0213) pg/mL / / 50 / /) / mmhg mmHg

24 ONO % ONO % 523

25 RR QT paired t p=0.0001)qrs QTc PQ 524

26 ONO /51mmHg /74mmHg 8 76/53mmHg 9 60 /

27 526

28 1 ONO / 60.7% 1 RPP bpm mmhg bpmmmHg ONO

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