KEY FIGURES 19% 2% 214 CO % 214 PRTR CO2 NOxSOx CO22525% 22 CO % % NOx 75% SOx 6% 3% FUTURE OUTLOOK 3 22 EHS

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1 EHS EHS 197 EHS 215 EHS P.4 2EHS 49% 214 CO2 3 GHG CO2 -CO CO23 -CO CO2 CO2 CO2 214 CO2GHG m 3 1, 5, 6,161 4, P.46 P Takeda CSR Data Book 215

2 KEY FIGURES 19% 2% 214 CO % 214 PRTR CO2 NOxSOx CO22525% 22 CO % % NOx 75% SOx 6% 3% FUTURE OUTLOOK 3 22 EHS P.88 Takeda CSR Data Book

3 EHS 197 Takeda Environment Action Tree 212 Global One TakedaEHS EHS EHS 215 EHS 23 TEA Tree Message Patient TrustReputation Business E H S EHS EHS EHS215 CO % Shinji Honda 4 Takeda CSR Data Book 215

4 EHS 3 EHS EHS EHS 213EHS 214 EHS EHS EHS 214EHS Takeda CSR Data Book

5 P LIME CO2 SOx LIME 1 LIMELife-cycle Impact assessment Method based on Endpoint modeling ,8 Message & EHS 215 Safe Takeda GMSO Thomas Wozniewski 42 Takeda CSR Data Book 215

6 , 949 1, Co., Ltd. Pvt. Ltd. S.p.A. GmbH GmbH Pharma Ltda.ISO , ,199 ISO141 Co., Ltd. Pvt. Ltd. S.p.A. GmbH GmbH Pharma Ltda CDP SNAM SRI Takeda CSR Data Book

7 EHS EHS EHS 213EHS EHS Process Mass IntensityPMI 1 CMC PMI 2 1 1kg 2 Inc. S.p.A. Pvt. Ltd. AS Pharma Sp.z o.o. Pharma Ltda. Pharma S.A. 44 Takeda CSR Data Book 215

8 Takeda s Voice 22 Pharma Ltda Pharma Ltda. Luiz Antonio da Rocha Takeda CSR Data Book

9 CO21974 CO2 -CO CDP 1 1 CDP 19% 214 CO2 25 CO CO2 CO CO % CO % CO % 214CO % CIS P.38 CO kWh 2136 CO2 46 Takeda CSR Data Book 215

10 214 S.p.A. GmbH Pvt. Ltd. CII % % CO CO2 49% 214 CO2 3 GHG CO2 P.38 CO23 CO % 4% 2% 1-CO2 1 6% 29-CO2 9% 46-CO2 27% 144-CO2 3 49% 1 19% 2 32% 1: 2: 3: P.88 Takeda CSR Data Book

11 7 G l o b a l Water Tool WBCSD A B A C B C m 3 1, 5, 6,161 4, WET 2 P.88 2 WETWhole Effluent Toxicity 48 Takeda CSR Data Book 215

12 2.2% % 2.3% 2.2% ,82, P.54 Takeda CSR Data Book

13 5 Takeda CSR Data Book % % , ,869 17, ,475 6, , , ,43 8,218 1, ,855 5,333 9, , ,153 3,175 4,7 9, , ,83 5,164 5,851 8, , ,975 3,729 6,573 1, , , ,255 7,77 1, , ,643 2%

14 PRTR 6, 4,949 18% PRTR 21 PCB 3, , SDS OEL WET PRTR 214PRTR %2572% % % 214VOC PRTR , P.88 Takeda CSR Data Book

15 SOxNOx 4 SOx NOx COD 6 48 NOxSOx 3 COD 214 NOxSOx NOxSOx 22NOxSOx NOx22252% 214 SOx222575% 52 Takeda CSR Data Book 215

16 2154 Inc. Inc.TCAL ,15TCAL CSR 214 Takeda CSR Data Book

17 , Takeda CSR Data Book 215

18 8,387 MJ 216,381 kl 521,94 MWh 3,369 kl 595 kl 65,215 m 3 3,211 m 3 2,389 m 3 49 m 3 64 m 3 7 m 3 PRTR PRTR 4,949 7,624 13,81 CO2 SOx NOx PRTR VOC C O D PRTR 417 -CO ,89 m ,69 1,917 25,724 4,688 CO2 3,74 -CO2 23,81 2 CO2 5,883 -CO2 2 CO CO2PRTR 1 VOCVOC1n-11 P.88 Takeda CSR Data Book

19 MJ ,938 5,654 6,69 5,947 5,63 CIS 372 1,988 1,717 1,718 1, ,944 8,553 8,811 8,725 8,387 CO , ,81 31,79 325,38 319,88 CIS 17,427 81,936 5,949 5,3 54,992 6,159 8,846 8,31 7,955 34,993 34,929 33,559 35,134 34, , ,16 44, , ,492 m ,716 6,13 6,19 5,658 5,132 CIS ,93 7,15 7,29 6,673 6,161 SOx CIS Takeda CSR Data Book 215

20 NOx CIS ,29 22,77 24,239 25,839 26,818 CIS 1,994 11,539 13,289 14,142 15, ,27 1,251 1, ,773 35,75 39,58 42,2 43, PRTR Takeda CSR Data Book

21 T-EMS ISO141 EHS Pvt. Ltd. 3ISO141 CO % 214CO % 215 S.p.A % ReduceReuse Recycle3R RO PCB PCB 58 Takeda CSR Data Book 215

22 214 NOxSOx COD ABS Message EHS 22CO SOxNOx Takashi Fukushima Takeda CSR Data Book

Contents CEO GRI 4G COP CSR CSR CSR SDGs & At a Glance At a Glance CSR 2006

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