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1 27

2 P4 276NPO 3BIOKYOWA P4 BIOKYOWA MR

3 , TEL: ,7563,644 PHARMACEUTICALS BIO-CHEMICALS , ,44 358, , , % 12.4% 25.4% 17.3% 33.9% 26 CHEMICALS FOOD ,89 1,17 8,485 25,535 12,694 26,836 3,698 33,57 16,273 17,932 5,756 5,8 5,96 6,294 6, % % % 13.4% % ,342 32,876 28,762 29,26 31,438 BIOKYOWA,INC. KYOWA HAKKO U.S.A., INC. KYOWA HAKKO EUROPE GMBH KYOWA HAKKO U.K. LTD. KYOWA ITALIANA FARMACEUTICI S.R.L. KYOWA HAKKO INDUSTRYSPTE LTD. KYOWA HAKKOMALAYSIASDN BHD. KYOWA PHARMACEUTICAL, INC. BIOWA, INC. KYOWA HAKKO U.K. LTD

4 No.1 C 197 IPCC Bios P14 P1522 IPCC

5 Pharmaceuticals POTELLIGENT POTELLIGENT BioWa, Inc. BioWaPOTELLIGENT POTELLIGENT COMPLEGENT TM BioWa BioWa2323 POTELLIGENT BioWa 274POTELLIGENT COMPLEGENT TM POTELLIGENT 2KW-761 BIW-84526KW-761 BIW-845 BIW-845I MedImmune POTELLIGENT BioWa GenentechBiogenIdec MedImmuneMedarex BioWa 2BioWa 92 POTELLIGENT ADCC CDCCOMPLEGENT TM KW KW-62FDA KW-62 KW-62A2A

6 Bio-Chemicals AHYP 1997 A B AHYP AHYP Q1 Q1 Q1 AHYP AHYP AHYP Q1 Q1 Q1 Q Q1 Q1 JHFAQ AHYP AHYP Q1 AHYP

7 Medical Representative MRMR=Medical Representative MR 51 7MR6 MR1 7 MR

8 & e 1e

9 34 (IR :Investor Relations) ( 26 ) & GMPISOHACCP 2,27, % 1.1% 3.5% 3, 2, 1, 1.7% 5,127 1,8 4.8% 1.8% , % 27,93 25, % % % 59, % % ,243,55561,

10 26P MAP PR 1URUOI TOEIC FA 22 P MAPMission&Action for the Progress PDS(Plan-Do-See) 254MAP &

11 11 P , KYT ( 2, ( 2, ,4 1, % % % % &

12 21 27 RC 5RC NGO RC & % E , WWF WWF1 NGO 6 WWF , 27 22

13 THE HAKKO BOOK HAKKO HAKKO THE HAKKO BOOK 21: No.1 HAKKO HAKKO CM CM 6DenimCM

14 ISO141 OSHMS ISO ISO

15 GHS GHS OECD GHS HPV MSDS 2 GHS 12 9 Japan GHS 3R Replacement ReductionRefinement

16 ISO141 8ISO141 ISO141 P26 27ISO141 4 P26 ISO141 OSHMS ISO141OSHMS P26 P19 85% 1% 1% P P CO2 21CO21996% 1% % % 9712% 12: % PRTR % : % CO21996% 71% % P34, 35 P34, 35 P38 P37 SOx NOx COD 2, % 577% 19.72% 54.42% 49923% 41253% 2.34% P36 P36 P36 P36 P36 P36 P36 P19 P2, % 95% 211% P35 P19 GOP 1% 2.3% 1% P34 1% %2311.8% 1%323 P34 277% 75% 277% P34 LCA- LCA LCA P31, 32, 33 CSR P16 P1 6 P2 P19 1 P41, 42 P36 EBM GHS Japan EBMEvidence Based Medicine P COD 24 CO2 CO HP SOxNOx HP HP COD HP / HP 2 : 3 26CO % 6 7 5%

17 JLCA-LCA 24 2LCA-Environmental load of 4 social stocks CO2 4 LCA CO22 3 CO2 67 SOx 11 NOx ,3 BOD ,4 5,7 2 CO21% CO2 1 9,7 COD 27 T-N 14 T-P 2 64 CO2 49 SOx 1 NOx , , 9,6 CO2 91 1, , ,5 COD 13 T-N 1 T-P 1 CO2 16 SOx 51 NOx CO , 1, ,7 COD 14 T-N 4 T-P 1 CO2 3 SOx 4 NOx ,3 CO , COD 44 T-N 39 T-P CO2 177 SOx 74 NOx , CO ,2 45, CO2 71 SOx 79 NOx , COD 49 T-N 41 T-P , 1 17, 54, ,17 7, CO2 17 CO ,1 3 CO239 CO236 CO254 3 LCA CO2 3 CO2

18 KEP CO CODNP 4 SOxNOx CO2 21CO21996% 1% 271% GOP ,851 1,37 4, , , , , ,29 4 1, ,658 1,141 5, ,253 13,237 32,536 33, ,327 1,317 1% 1% % GOP GOP GOP3 2 GOP

19 CO2199 6% 71% % CO2199 6% % CO2 1 SOx 2,595 NOx COD SOx 8. 4% NOx 57. 7% % COD % % 2.3 4% SOx NOx COD CO2 1 5% 2 5% 6% ,483k114, ,268% , % CO % % SOx SOx98% COD 2611 SOXNOX SOx NOx COD 1,5 1,293 1, , , , SOX NOX COD 1,5 1,244 1, , , COD k

20 % % PRTR % VOC % 275% % PRTR 1 1 PRTR PRTR PRTR PRTR , , , N,N ,5,5--1-1, , , , , mg-teq) VOC VOC4182 VOC 26 14,883257% , 245,39 2,271 23,874 2, 1, ,57 15, 1,48 158,11 127, ,546 1, 14, , ,5 2, 1,5 1, 5 PCB PCB ,883 14,531 64,634 25, ,441 PCB ,437 11,

21 ISO ,m ISO ,m SOx NOx COD SOx NOx COD % % % % 18 12% % % 1 146% 62,255 77% 11 33% % 4.1 9% %.4 2% 23 1% % 71 14% 8 87% 6, % 2 4% 441 ISO ,m ISO ,m ISO141 SOx NOx COD SOx NOx COD %.5 158% %.22 18%.6 122% %.6 45%.5 54% 1,17 97% %.3 15% 3 75% % % 18 9% %.6 67% % 43 86% 1188 ISO ,m ISO141 m 2 SOx NOx COD %.1 3% 3. 43% % % % %.25 5% 63 96% 23 ISO ,m ISO141 SOx NOx COD %.4 25% % % % % 2.4 3% % 32,377 13% 21 51% ( 1153 ISO ,m ISO141 m 2 SOx NOx COD %.5 82% % %.5 271%.1 17% % 5 59% ISO ,m SOx NOx COD %.59 23% %.12 52%.8 87%.4 2% % 85%

22 KYOWA HAKKO KYOWA HAKKO FOOD SPECIALTIES REIZO FRZ CO2 CO2 REIZO FRZ REIZOFRZ 199 KYOWA HAKKO CHEMICAL HFC HCFCR HCFC R-47CR-41A 2512,26 4, CO ISO

23 ISO141 CSR ISO141 win-win 28ISO ISO ISO ISO141 ISO141 ISO141 ISO141 ISO141 ISO141 ISO

24 CSR 1 IPCC 6G CSR CSR CSR ISO26 ISO CO2 CO2 6 CSR 15

25 TEL FAX

KEY FIGURES 19% 2% 214 CO2 25 214 21 18% 214 PRTR 21 127 214 22 22CO2 NOxSOx CO22525% 22 CO2 25 25% 22 25 2% NOx 75% SOx 6% 3% FUTURE OUTLOOK 3 22 EHS

KEY FIGURES 19% 2% 214 CO2 25 214 21 18% 214 PRTR 21 127 214 22 22CO2 NOxSOx CO22525% 22 CO2 25 25% 22 25 2% NOx 75% SOx 6% 3% FUTURE OUTLOOK 3 22 EHS EHS EHS 197 EHS 215 EHS P.4 2EHS 49% 214 CO2 3 GHG CO2 -CO2 6 3 417 CO23 -CO2 75 15 1 13 14 13 14 13 14 13 14 13 14 144 1 23 1 29 32 46 7.5 215 5 1 11 12 13 14 15 CO2 CO2 CO2 214 CO2GHG m 3 1, 5, 6,161

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