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1 Compatibility of Ophthalmic Solutions õ1 MUTSUMI END0 õ2, NOBUHIRO YASUNO õ2, KAORI TANAGAM1 õ2, ASAKA ONDA õ2, MIHO IMOT0 õ2, NAOMI IIDA õ2, YUKO SEKINE õ2, NORIO MIYAZAKI õ2, SHIGEKAZU WATANABE õ2, YUKO NAKAMURA õ2, YOSUKE KUROKAWA õ2, MASAO TSUCHIYA õ2, YOSHIHIRO ARAKAWA õ2 and HIDEKI ONO õ3 Department of Pharmacy, University of Tokyo Branch Hospital õ2 Department of Pharmacology, Faculty of Pharmaceutical Sciences, Science University of Tokyo õ3 Received October 24, 1997 Accepted February 14, 1998 We studied the compatibility in mixing any two of eight kinds of ophthalmic solutions which are frequently used in operations for glaucoma or cataract. Changes in the appearance, ph value, osmotic pressure and viscosity were checked immediately after mixing, both 1 hour and 24 hours after mixing and keeping in a dark place at room temperature. In some combinations, the mixture became turbid probably due to some of antiseptics to other ingredients. Regarding Noflo Ophthalmic Solution, white needle crystals were generated when mixed with some other drugs. These crystals were identified as norfloxacin (a principal ingredient of Noflo Ophthalmic Solution) by high-performance liquid chromatography and were found to be formed by the increase of ph. From these results, close attention should be paid to the order and intervals in the successive administration of various many ophthalmic solutions while taking into account not only any incompatibility of the antiseptics as well as any changes in the ph values. Key words-ophthalmic solution, compatibility, glaucoma, cataracts, antiseptic, norfloxacin, ph

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