東洋医学雑誌

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1 Vol.61 No , 2010 a b c d Naoki OKADA ad Masaru NATSUAKI b Takashi NISHIMOTO ac Nishimoto Clinic, Koshienguchi, Nishinomiya, Hyogo , Japan Department of Dermatology, Hyogo College of Medicine, 1-1 Mukogawacho, Nishinomiya, Hyogo , Japan Department of General Internal Medicine, Kobe University School of Medicine, Kusunokicho, Chuo-ku, Kobe, Hyogo , Japan Emergency Department, Kobe University School of Medicine, Kusunokicho, Chuo-ku, Kobe, Hyogo , Japan Schamberg disease is a subtype of idiopathic pigmentary purpura, which manifests with petechiae. It is assumed to be caused by venous microcirculatory disturbance, or an immunological and allergic mechanism. We report a 55-year-old Japanese male with Schamberg disease successfully treated with keishibukuryogan prepared at a hospital pharmacy. The patient had purpuric eruptions in his both lower legs at first, and brownish pigmentation enlarged with purpura. A dermatologist had diagnosed this, from the clinical findings, as Schamberg disease. We administered keishibukuryogan to the patient because his pathological condition was considered as oketsu. In order to improve effectiveness, keishibukuryogan was manufactured according to our own modification. The eruptions have reduced gradually, and about four months later, have mostly resolved. A Kampo therapy utilizing unseiin has been reported to be effective against idiopathic pigmentary purpura in previous studies. We suggest that a Kampo treatment with keishibukuryogan seems to be effective against idiopathic pigmentary purpura through improvements of microcirculation and inflammation. idiopathic pigmentary purpura, Schamberg disease, oketsu, keishibukuryogan!!! Schamberg

2 Vol.61 No.7, 2010 X X B mm cm cmkg mmhg Schamberg B g

3 Vol.61 No.7, 2010 Schamberg $ # variant Schamberg Gougerot-Blum Majocchi lichen aureuslichen purpuricus# itching purpura Schamberg Schamberg # C K " $!

4 Vol.61 No.7, 2010 lichen aureus Schamberg " " " Schamberg " "! " " cinnamic aldehyde

5 Vol.61 No.7, 2010 paeoniflorine g g g g " " " cinnamic aldehyde paeoniflorine " " in vitro! " MB Derma Schamberg

6 Vol.61 No.7, 2010 lichen aureus!!!! Nozaki K, Goto H, Nakagawa T, Hikiami H, Koizumi K, Shibahara N, Shimada Y : Effects of Keishibukuryogan on Vascular Function in Adjuvant-Induced Arthritis Rats, Biol. Pharm. Bull.

8 The Bulletin of Meiji University of Integrative Medicine API II 61 ASO X 11 7 X-4 6 X m 5 X-2 4 X 3 9 X 11 7 API 0.84 ASO X 1 1 MR-angio

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