THE JAPANESE JOURNAL OF ANTIBIOTICS 65 6 Dec LVFX 100 mg 3 / mg 2 / LVFX PK PD mg mg 1 1 AUC/MIC

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1 Dec THE JAPANESE JOURNAL OF ANTIBIOTICS LVFX 500 mg Chlamydia trachomatis C. trachomatismycoplasma genitalium M. genitalium LVFX mg C. trachomatis 17 M. genitalium 4 C. trachomatis M. genitalium % 19/22 C. trachomatis M. genitalium C. trachomatis M. genitalium 94.1% 16/ % 2/4 100% 1/ % 20/22 C. trachomatis M. genitalium C. trachomatis M. genitalium 100% 17/ % 2/4 100% 1/1 M. genitalium P LVFX 500 mg

2 THE JAPANESE JOURNAL OF ANTIBIOTICS 65 6 Dec LVFX 100 mg 3 / mg 2 / LVFX PK PD mg mg 1 1 AUC/MIC Cmax/MIC 1 AUC Cmax LVFX 500 mg1 1 Mycoplasma genitalium LVFX 500 mg 1 1 2,3 LVFX 500 mg I C. trachomatis M. genitalium 1 2 mg/dl mg LVFX 500 mg 250 mg LVFX 250 mg mg mg 2 1 1

3 Dec THE JAPANESE JOURNAL OF ANTIBIOTICS G-CSF NSAID 2 5. Fig. 1 1 STI Fig. 1.

4 THE JAPANESE JOURNAL OF ANTIBIOTICS 65 6 Dec C. trachomatis TMA, SDA, PCR Neisseria gonorrhoeae, M. genitalium PCR 4 5 AST GOT ALT GPT -GTP LDH ALPCK CPK BUN Na, K, Cl CRP C. trachomatis M. genitalium 2

5 Table 1. Dec THE JAPANESE JOURNAL OF ANTIBIOTICS

6 THE JAPANESE JOURNAL OF ANTIBIOTICS 65 6 Dec C. trachomatis M. genitalium C. trachomatis M. genitalium % II C. trachomatis M. genitalium Table 1 22 C. trachomatis 17 M. genitalium 4 C. trachomatis M. genitalium STI /hpf 1000 Table 2.

7 Dec THE JAPANESE JOURNAL OF ANTIBIOTICS /hpf 1000 C. trachomatis M. genitalium Table 2 C. trachomatis 17 C. trachomatis 15 C. trachomatis Ureaplasma parvum C. trachomatis Ureaplasma urealyticum 1 M. genitalium 4 M. genitalium 3 M. genitalium U. urealyticum 1 C. trachomatis M. genitalium C. trachomatis M. genitalium U. parvum Table % 19/22 C. trachomatis M. genitalium C. trachomatis M. genitalium 94.1% 16/ % 2/4 100% 1/1 3 P % 18/22 Table 4 C. trachomatis M. genitalium C. trachomatis M. genitalium82.4% 14/ % 3/4 100% 1/1 P Table % 20/22 C. trachomatis M. genitalium C. trachomatis M. genitalium 100% 17/ % 2/4 100% 1/1 M. genitalium P % 21/22 C. trachomatis M. genitalium C. trachomatis M. genitalium 100% 17/ % 3/4 Table Table 4.

8 THE JAPANESE JOURNAL OF ANTIBIOTICS 65 6 Dec Table Table % 1/1 P III. C. trachomatis M. genitalium LVFX 500 mg 1 1 C. trachomatis % 16/17 100% 17/17 C. trachomatis LVFX 500 mg S. TAKAHASHI 6 M. genitalium % 2/4 50.0% 2/4 C. trachomatis M. genitalium C. trachomatis M. genitalium M. genitalium 7 LVFX 100 mg 3 / M. genitalium % 4/ % 8/16 8 LVFX M. genitalium

9 Dec THE JAPANESE JOURNAL OF ANTIBIOTICS mg 1 1 M. genitalium LVFX MIC g/ml % C. trachomatis 1 C. trachomatis 2 4 C. trachomatis PCR C. trachomatis 2 4 PCR PCR M. genitalium 2 M. genitalium M. genitalium 2 4 M. genitalium LVFX 500 mg mg 500 mg 22 LVFX 500 mg % 482/29, % 203/ 16, LVFX 500 mg1 1 C. trachomatis LVFX 500 mg M. genitalium 4 LVFX : 57 60, Levo oxacin 500 mg S-2 : 34 46, ZHANG, Y. Y.; H. H. HUANG, Z. Y. REN, et al.: Clinical evaluation of oral levo oxacin 500 mg once-daily dosage for treatment of lower respiratory tract infections and urinary tract infections: a prospective multicenter study in China. J. Infect. Chemother. 15: , YOSHIDA, T.; S. MAEDA, T. DEGUCHI, et al.: Phylogeny-based rapid identification of Mycoplasma and Ureaplasma from urethritis. J. Clin. Microbiol. 40: ,

10 THE JAPANESE JOURNAL OF ANTIBIOTICS 65 6 Dec : , TAKAHASHI, S.; K. ICHIHARA, J. HASHIMOTO, et al.: Clinical ef cacy of levo oxacin 500 mg once daily for 7 days for patients with nongonococcal urethritis. J. Infect. Chemother. 17: , : , M. genitalium M. genitalium 12: 74 78, HAMASUNA, R.; J. S. JENSEN & Y. OSADA: Antimicrobial susceptibilities of Mycoplasma genitalium strains examined by broth dilution and quantitative PCR. Antimicrob. Agents Chemother. 53: , Polymerase Chain Reaction 13: 81 86, Levo oxacin 500 mg : , YAMAGUCHI, H.; H. KAWAI, T. MATSUMOTO, et al.: Post-marketing surveillance of the safety of levo oxacin in Japan. Chemotherapy 53: , 2007 Ef cacy and safety of levo oxacin to non-gonorrheal urethritis SHOICHI ONODERA Fuji City General Hospital YASUHIKO ONOE Miyamotocho Central Clinic TAKAHIDE HOSOBE Hosobe Clinic TETSURO KATO and MASAKI YOSHIDA Department of Infectious Diseases and Infection Control, The Jikei University School of Medicine We investigated the efficacy and safety of levofloxacin LVFX 500 mg once a day in patients with non-gonorrheal urethritis. Men, aged 20 years or older, with urethritis symptoms, and detection of Chlamydia trachomatis C. trachomatis or Mycoplasma genitalium M. genitalium by a microbiological examination were eligible for this study. Patients were administered LVFX 500 mg, orally, once a day and the dosage period was seven days. We assumed 22 patients for a safety and ef cacy analysis. In 22 patients, 17 patients had urethritis with C. trachomatis, 4 patients urethritis with M. genitalium, and one patient mixed infection of C. trachomatis and M. genitalium. In the clinial study, the primary endpoint was set as the bacteriological eradication rate at two to four weeks after completion of treatment. The

11 Dec THE JAPANESE JOURNAL OF ANTIBIOTICS bacterial eradication rate in the urethritis was 86.4% 19/22. The bacterial eradication rate in the urethritis with C. trachomatis, M. genitalium, and mixed infection of C. trachomatis and M. genitalium were 94.1% 16/17, 50.0% 2/4, 100% 1/1, respectively. A signi cant difference was not recognized among the three groups. The clinical efficacy at two to four weeks after completion of treatment was 90.9% 20/22. The clinical ef cacy rates in the urethritis with C. trachomatis, M. genitalium, and mixed infection of C. trachomatis and M. genitalium were 100% 17/17, 50.0% 2/4, 100% 1/1, respectively. The efficacy rate of urethritis with M. genitalium was signi cantly low. No adverse drug reactions were observed. These results suggest that once-a-day levofloxacin 500 mg is effective and safe treatment for non-gonorrheal urethritis.

366 12 THE JAPANESE JOURNAL OF ANTIBIOTICS 65 6 Dec. 2012 1 8 DNA 2,3 16 12 20 171 2008 12 2010 11 2 3,558 4.44% 1.65% 1.17% 90% 9 Escherichia coli -

366 12 THE JAPANESE JOURNAL OF ANTIBIOTICS 65 6 Dec. 2012 1 8 DNA 2,3 16 12 20 171 2008 12 2010 11 2 3,558 4.44% 1.65% 1.17% 90% 9 Escherichia coli - Dec. 2012 THE JAPANESE JOURNAL OF ANTIBIOTICS 65 6 365 11 sita oxacin 1 1 1 1 1 1 2 2 3 3 1 1 1 2 3 2012 9 14 sita oxacin STFX 50 mg 10% 2008 1 2008 12 2010 11 2 STFX 1,452 91.4% 1,235/1,351 95.9% 466/486

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