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9 1) i) Barber, M. et al.: Brit. Med J, 2, 565, 19'49. ii) Barber, M.F.G. J. Hayhoe and J. E. M. Whithead: Lancet, 1120 `1125, ) Bergey: Bergey's Manual of Determinative Bacteriology 7 th Ed: (1958).-3) Blair, J. E. M. Carr: J. Infectious Disease 93, 1, ) Bradie, J. et al.: Britli Med: 667, ) Clarke, S. K R. et al.: Lancet, 1, -1132, ) Elwood, J. S.: J. Path. Bact. 63 1, ) Felsen, J. Lupin. W. Wollarsky A.S. Well and 150 ~; J Disease Children 81, (1951).-0) Frick: Ann of Otol 40, 603 (1931).-11) i) Hinton, N. A. etal.: J. Lab. Clin. Med., 49, 566, ii) Hinton, N.A. & Orr. J. H.: J. Lab. Clin. Med., 49, 565, ) Hutchison, J. G. P. et al.: J. Clin.

10 The Staphylococcal Problem in the Otorhinolaryngological Clinic. Mitsuko TAGUCHI Department of the Otorhinolaryngology, the Komagome Hospital (Director: Dr. Hyo Miyakawa) One thousand four hundred and sixty seven strains of Staphylococcus were isolated from lesions and anterior nare of patients, who visited the otorhinolaryngological clinic of the Komagome Hospital. These strains were biochemically investigated, their sensitivity against several antibiotics was tested, and the phagetyping of these strains was done, comparing with 205 strains of Staphylococcus isolated from nasal cultures of patients in the wards of infectious diseases and of newborns, and 94 strains of moteers and staffs of the obstetric wards. Results were as follows: 1) The incidence rate of Staphylococcus aureus was higher among strains from lesions and nasal cultures of otorhinolaryngological patients than those of the control group. 2) The rate of antibiotic-resistant strains was 71. 1% of strains from lesions of otorhinolaryhngological patients, 28. 3% of nasal cultures of these patients, 84. 4% of those in the wards of infectious diseases, and 88. 3% of those of those of newborns. Among resistant strains of the otorhinolaryngological source, Penicillin resistant strains were most frequently found, but, on the contrary, Tetracyclin resistant strains predominated the control group. 3) The percentage of phage-typed strains was especially high in strains from otorhinolaryngological lesions, and phage-typed strains which belonged to the second group, were most frequently detected. 4) There were many cases, in which the strain from lesion indicated the different paagetype than that of anterior nare. 5) By over two times repeated cultures of the same lesion, cases with the same

11 typed strains were less found than those with strains of differnt types. In conclusion, a strain of Staphylococcus, isolated from a lesion of otorhino laryngological patient, should not be immediately decided, to be a pathogenic organism for this lesion. It is indeed evident, that the nasal Staphylococcal flora has been influenced by the use of antibiotics, but its relations with organisms, isolated from otorhinolaryngical lesions, have not always been clear, therefore, it is difficult to decide, whether it may have a pathogenic significance or not.

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