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46 17 RI 16 H16.3 H12.10 H8.4 S54.4 H15.4 H12.4 H17.5 H12.12 H16.9 H17.4 H17.4 H17.5 H17.10 H18.2 DNA PCRDNA MALDI-TOF/TOF

47 DNA

48 2 (2005 )

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56 RI Jr

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59 ; 600 ; DNA Zeiss Beckman Beckman TOMY Beckman BIORAD GenePulser CCD Zeiss CCD Zeiss Zeiss Lumat BIORAD PDS-1000DNA ABI373AABI310ABI3100 Procise clc GE Typhoon Affimetrix Becton DickinsonHPLC

60 1 FACS FACS 1FACS Calibur 2 3 2RI RI

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76 RI RI

77 RNA in vitro RNA I sirna CYP3A H The Replication Fork Protection Complex Drexel University College of Medicine H H H Vibrio furnissii Vibrio cholerae Rochester

78 Gateway DNA l ND1000 Miniscope TM1000 DNA BZ8000 ZOOM IPG SSH

79 DNA 1 I

80 DNA 1,753 m 2 RI RI P1 P2 P3 DNA 233 DNA RI MRC DNA Dr. David Loakes (MRC, Laboratory of Molecular Biology, Cambridge, UK)

81 DNA DNA DNA SSP 40 in vitro DNA II III MATE DNA

82 RI DNA 15 DNA 2 DNA DNA

83 CCD ( ) ( )

84 GeneChip technology ( ) DNA DNA PCR 4.RNA 5.RT-PCR 6. 7.DNA ( ) (1) (2) DNA (3) DNA (1) (2) DNA (3)

85 ( ) D Jr. 1 2 DNA 3RFLP 4PCR 5 DNA 6RT-PCR ( )

86 DNA

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88 Hara, K., Okamoto, M., Aki, T., Yagita, H., Tanaka, H., Mizukami, Y., Nakamura, H., Tomoda, A., Hamasaki, N., Kang, D., Synergistic enhancement of TRIL- and tumor necrosis factor a-induced cell death by a phenoxazine derivative, Mol. Cancer Ther.4 (7), (2005) Aki, T., and Mizukami, Y., Regulation of Cardiomyocyte functions by distinct phosphoinositide 3-kinase, Molecular Mechanisms of Heart diseases, (Edits Mizukami, Y. and Ohkusa, T.) Publisher Research Signport, (2005) Kimura, Y, and Mizukami, Y.,and Matsuzaki, M., Orphan G protein-coupled receptor and ischemia, Molecular Mechanisms of Heart diseases, (Edits Mizukami, Y. and Ohkusa, T.) Publisher Research Signport, (2005)

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96 RI DNA P2 P3 DNA DNA DNA DNA C TOF-MS 3130 Avant

97 in DNA type III

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113 FSRC 2 ( ) RNA P3 DNA 4 1 RI -80 CCD TOF PCR [450 ] /

114 DNA DNA / /1 370 PCR46 TOF DNA L5 FL () 8 4 DNA (3 ) (9 )

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44 4 I (1) ( ) (10 15 ) ( 17 ) ( 3 1 ) (2)

44 4 I (1) ( ) (10 15 ) ( 17 ) ( 3 1 ) (2) (1) I 44 II 45 III 47 IV 52 44 4 I (1) ( ) 1945 8 9 (10 15 ) ( 17 ) ( 3 1 ) (2) 45 II 1 (3) 511 ( 451 1 ) ( ) 365 1 2 512 1 2 365 1 2 363 2 ( ) 3 ( ) ( 451 2 ( 314 1 ) ( 339 1 4 ) 337 2 3 ) 363 (4) 46

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