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1 ｨｨｨｬｨ ｨｪｨｺｨｨｨｪｨ ﾁ ｨ ｨｪｨｺｨｰ-0302ｨｰ0208ｨ ｨｮ080009ｨｺｨ ｨｨ01ｨｨｨ ｨｰ08ｨｨ ﾂ0209ｨｺｨ 07 ｨ 0605ｨｹｨｪｨｨ02ｨ 011 ｨｨｨｬ02ｨｪｨｨ ｨ ｨｴ02ｨｪｨｺ06 08ｨｪｨ 05ｨｨ04ｨｨ08ｨｮ02ｨｰ ｨｬ02ｨｪｨｪｨ 07 05ｨｨｨｰ0208ｨ ｨｰｨｮ08ｨ, ｨｴ02ｨｪｨｪｨ ｨｪｨｪ06ｨｬｨｮ ｨｨ 0708ｨｨ06ｨ 0802ｨｰ02ｨｪｨｪ06ｨｬｨｮ 09ｨｨｨｪ010806ｨｬｨｮ 0908ｨｮ00ｨ 01ｨ, 0708ｨｨ090601ｨｨｨｰ ｨ 09ｨｰ0902ｨｪｨｪ0602 ｨｪｨ ｨ ｨｪｨｨ ｨｨ06ｨ 0802ｨｰ02ｨｪｨｪ ｨｨｨｪ010806ｨｬｨ 0908ｨｮ00ｨ 01ｨ ｨｮ ｨ 0605ｨｹｨｪ06ｨｦ 0709ｨｨ01ｨｨｨ ｨｰ08ｨｨ ﾂ0209ｨｺ06ｨｦ ｨ 0605ｨｹｨｪｨｨ ﾂ ｨ : 09ｨｨｨｪ010806ｨｬ 0908ｨｮ00ｨ 01ｨ, ｨｺｨｰ0806ｨｺｨ 0801ｨｨ060008ｨ 00ｨｨ07, ｨｮ0106 ﾂｨｺ0609ｨ 07 ｨｰｨ 01ｨｨｨｺｨ 0801ｨｨ07, 09ｨｨｨｪｨｺ0607ｨ 05ｨｹｨｪ ｨｰ0607ｨｪｨｨ07, 09ｨｪ0204ｨ 07ｨｪｨ 07 09ｨｬ0208ｨｰｨｹ, 0709ｨｨ0106ｨｰ080607ｨｪ ｨ 08ｨ ｨｰ04. The up-to-date literature data on hereditary and acquired Brugada syndrome are analyzed; the case report is presented of acquired Brugada syndrome in a female psychiatric patient observed by the authors. Key words: Brugada syndrome, electrocardiography, ventricular tachycardia, syncope, sudden death, psychoactive drugs ｨ 0502ｨｬ02 ｨ ｨ 09ｨｪ0609ｨｰｨｨ 0709ｨｨ0106ｨｰ080607ｨｪ06ｨｦ ｨｰ0208ｨ 07ｨｨｨｨ 09 ｨｪｨ 09ｨｰ0607ｨｴ ｨｬ07 ｨｮ ｨｰ0907 ｨ 0605ｨｹ ｨｪｨｨｨｬｨ ｨｪｨｨ02 [1-9]. ﾁｨ 09ｨｰ06ｨｰｨ ｨｪ0200ｨ ｨｰｨｨ09ｨｪ0401 ｨｺｨ 0801ｨｨ0609ｨ 09ｨｺｨｮ050708ｨｪ ｨｺｨｰ ｨｨ ﾂ02ｨｪｨｨｨｨ ｨｪ02ｨｦ ｨｰｨｨｨｺｨ ｨｬｨｨ, ｨ ｨｪｨｰｨｨ ｨ ｨｪｨｰｨ ｨｬｨｨ, ｨ ｨｪｨｰｨｨｨｺ06ｨｪ09ｨｮ05ｨｹ09ｨ ｨｪｨｰｨ ｨｬｨｨ, ｨｪ0608ｨｬ06ｨｰｨｨｨｬｨｨｨｺｨ ｨｬｨｨ ｨｰｨｨ00ｨ 02ｨｰ 75% [2, 3]. 0309ｨｨ01ｨｨ ﾂ0209ｨｺｨｨ ｨ 0605ｨｹｨｪ0402 ｨｨｨｬ0206ｨｰ ｨｰ ｨｪ06 ｨ ｨｺｨｨｨｦ 08ｨｨ09ｨｺ 09ｨｪ0204ｨ 07ｨｪ06ｨｦ 09ｨｬ0208ｨｰｨｨ (0005). 06ｨ ｨｺ, ｨ 09ｨｪｨｨｨｰ0205ｨｹｨｪ06ｨｬ ｨｨ ｨ ｨｪｨｨｨｨ (Herxheimer A. et Healy D., ) 0706ｨｺｨ 04ｨ ｨｪ ｨｺ08ｨ ｨｰｨｪ0602 ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ02 ﾂｨ 09ｨｰ06ｨｰ ｨｮ 07ｨ 02ｨｨ02ｨｪｨｰ ｨｨ ｨｪｨｨ02ｨｦ ｨ 09ｨｪ02ｨｪｨｨｨｨ ｨｮｨｬ ｨｮ00ｨｨｨｬｨｨ 0008ｨｮ0707ｨ ｨｬｨｨ (ｨ 0605ｨｹｨｪ ｨ ｨｮｨｺ06ｨｬ06ｨｦ ｨｨ ｨｨｨ 0406ｨｬ) [5]. 04ｨｨ09ｨｺ ｨｨｨｪ01ｨｨ09ｨｨ010609, 0708ｨｨｨｪｨｨｨｬｨ 06ｨｴｨｨ01 ｨｰｨｨ07ｨｨ ﾂｨｪ0402 ｨ ｨｪｨｰｨｨ0709ｨｨ0106ｨｰｨｨｨｺｨｨ, 09 2,39 08ｨ 04ｨ [6], ｨ ｨ ｨｰｨｨ07ｨｨ ﾂｨｪ ,5 08ｨ 04ｨ [7] ｨ 02ｨｰ ｨｰｨ ｨｺ060906ｨｦ ｨｮ ｨｰ0201, ｨｺｨｰ06 ｨｪ ｨｮ ﾂｨ 02ｨｰ 05ｨｰｨｨ ｨ 08ｨ ｨｰ04. 08ｨｬ0208ｨｨｨｺｨ ｨｪ09ｨｺ0602 ｨ 0002ｨｪｨｰ09ｨｰ ｨｺ06ｨｪｨｰ ｨ ｨｮｨｺｨｰｨ ｨｬｨｨ 07ｨｨｨｰｨ ｨｪｨｨ07 ｨｨ 0502ｨｺｨ 0809ｨｰ09ｨ ｨｬｨｨ (US1 7DA) c0606ｨ ｨｴｨｨ ｨｮ 06ｨ 1,6-1,7-ｨｺ08ｨ ｨｰｨｪ06ｨｬ ｨｪｨｨｨｨ 08ｨｨ09ｨｺｨ ｨｨ ｨｨ ｨｹ040609ｨ ｨｪｨｨｨｨ ｨｬ02ｨｪｨｪ0401 ｨ ｨｪｨｰｨｨ0709ｨｨ0106ｨｰｨｨ ﾂ0209ｨｺｨｨ ｨ 08ｨ ｨｰ0609 [9]. 0201ｨｪｨｨｨｬ ｨｨ ｨｨｨｺｨｰ ﾂｨｨｨｰｨ 06ｨｰ 09ｨｨｨｪ010806ｨｬ 0908ｨｮ00ｨ 01ｨ (0509), ｨｴｨｨｨｦ ｨｨ ﾂｨｨｨｪ06ｨｦ 09ｨｬ0208ｨｰｨｨ 4% ｨｮ ﾂｨ ｨｨ 20% 0905ｨｮ ﾂｨ ｨｮ 05ｨｨ ｨｰ08ｨｮｨｺｨｰｨｮ08ｨ 05ｨｹｨｪ06 ｨｪ02ｨｨ04ｨｬ02ｨｪ00ｨｪｨｪ04ｨｬ ｨｬ [10] ｨｮ ｨｨ0907ｨ ｨｪ09ｨｺｨｨ02 ｨｺｨ 0801ｨｨ ｨｨ ｨｨ ｨｮ00ｨ 01ｨ 0607ｨｮｨ 05ｨｨｨｺ0609ｨ 05ｨｨ ｨｪｨ ｨ ｨｪｨｨ02 04ｨ 8 07ｨ 02ｨｨ02ｨｪｨｰｨ ｨｬｨｨ (6 ｨｬｨｮ03 ﾂｨｨｨｪ ｨｨ ｨｪｨｴｨｨｨｪ04) ｨｨ040601ｨ ｨｬｨｨ ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺ06ｨｦ 09ｨｬ0208ｨｰｨｨ 09 ｨ ｨｪｨ ｨｬｨｪ [11]. 06ｨｪ09ｨｰ08ｨｮｨｬ02ｨｪｨｰｨ 05ｨｹｨｪ0402 ｨｬ02ｨｰ ｨｨ ｨ ｨｪｨｨ07 (050106ｨｺｨ 0801ｨｨ060008ｨ 00ｨｨ07, ｨ ｨｪ00ｨｨ060008ｨ 00ｨｨ07, ｨｺｨｰ080600ｨｨ04ｨｨ ｨｨ ﾂ0209ｨｺ0602 ｨｨ ｨ ｨｪｨｨ02, ｨ ｨｨ060709ｨｨ07 ｨｬｨｨ06ｨｺｨ 0801ｨ ｨｮ 4 07ｨ 02ｨｨ02ｨｪｨｰ0609) ｨｪ ｨｨ05ｨｨ ｨｺｨ ｨｺ ｨｨｨ ｨ ｨｪｨｨ ﾂ0209ｨｺ ｨ ｨ ｨ ｨｪｨｨ ｨ. 0301ｨｨｨｪ09ｨｰ0902ｨｪｨｪ06ｨｦ ｨ 02ｨｪｨｪ0609ｨｰｨｹ06 ｨｮ 05ｨｰｨｨ01 07ｨ 02ｨｨ02ｨｪｨｰ0609 ｨ ｨｪｨ 05ｨｨ ﾂｨｨ02 ｨｪｨ ｨ 06ｨｦ ｨｬ04 ｨ 0506ｨｺｨ ｨ 0906ｨｦ ｨｪ0603ｨｺｨｨ 07ｨｮ ﾂｨｺｨ 01ｨｨ09ｨ ( ) ｨｲ00ｨｬ06ｨｬ ｨｬ02ｨｪｨｰｨ ST. 05ｨｨｨｪｨｺ0607ｨ 05ｨｹｨｪ ｨｰ0607ｨｪｨｨ ｨ 05ｨｨ09ｨｹ ｨｨ09ｨｰ08ｨ 02ｨｨ02ｨｦ ｨｪｨ ｨｨｨｬ060800ｨｪ06ｨｦ ｨｮ0106 ﾂｨｺ060906ｨｦ ｨｰｨ 01ｨｨｨｺｨ 0801ｨｨｨｨ 00torsade de pointes03 (TdeP), ｨｪｨｨｨｺｨ ｨｦ ｨ ｨｪｨｪｨｨ01 07ｨ 08ｨｪ ｨｮ0106 ﾂｨｺ ｨｺ09ｨｰ08ｨ 09ｨｨ09ｨｰ0605 ｨｨ 0708ｨｨ ｨ ｨｬｨｬｨｨ080609ｨ ｨｪｨｪ06ｨｦ 09ｨｰｨｨｨｬｨｮ050702ｨｨｨｨ ｨ 05ｨｹｨｪ02ｨｦ0302ｨｬ 4 07ｨ 02ｨｨ02ｨｪｨｰｨ ｨｬ ｨｨｨｬ0705ｨ ｨｪｨｰｨｨ080609ｨ 05ｨｨ ｨｺｨ 0801ｨｨ ｨｰ ｨｨｨ 08ｨｨ050507ｨｰ060804, ｨｮ 2 ｨｪｨ 08ｨｮ0302ｨｪｨｨ07 08ｨｨｨｰｨｬｨ ｨｨ09 ﾂ020405ｨｨ ｨｪｨ 0006ｨｪ ｨｨ00ｨｬｨ ｨ 02ｨｰｨ -ｨ 0506ｨｺｨ ｨｰ , ｨｹｨｬ06ｨｦ 07ｨ 02ｨｨ02ｨｪｨｰ 0708ｨｨｨｪｨｨｨｬｨ 05 ｨ ｨｬｨｨ0601ｨ 0806ｨｪ ｨｨ 01ｨｨ0002ｨｪｨｨ0500ｨｨ01ｨ ｨｪｨｰ06ｨｨｨｪ (01ｨｨ0002ｨｪｨｨｨｪ) ｨｪｨ 0006ｨｪ ｨｺｨｰ0806ｨｺｨ 0801ｨｨ0609ｨｰｨｨｨｬｨｮ050702ｨｨｨｨ ｨｨｨｬ02 VVI, ｨｹｨｬ06ｨｦ 07ｨ 02ｨｨ02ｨｪｨｰ ｨｪ020603ｨｨ01ｨ ｨｪｨｪ06 09ｨｺ06ｨｪ- ﾂｨ ｨｬ07 ｨｨｨｬ0705ｨ ｨｪｨｰｨ 02ｨｨｨｨ ｨｺｨ 0801ｨｨ0609ｨｰｨｨｨｬｨｮ0507ｨｰ0608ｨ. 06ｨ ｨｺｨｨｨｬ 06ｨ 08ｨ 0406ｨｬ, ｨ 08ｨ ｨｰｨｹ ｨｮ00ｨ 01ｨ ｨ ｨｪ ｨｨ09ｨ ｨｨｨｬｨ ｨｪｨｺｨｨｨｪｨ 05ｨｨ 01ｨ 08ｨ ｨｺｨｰ0208ｨｪ04ｨｦ 07ｨ ｨｰｨｰ0208ｨｪ , ｨｴｨｨｨｦ ｨｨｨｰｨｹ ｨｺｨｨｨｦ 08ｨｨ09ｨｺ ｨｪｨｨｨｺｨｪ060902ｨｪｨｨ07 03ｨｨ04ｨｪ02ｨｮ ｨ 06ｨｴｨｨ ｨｮ0106 ﾂｨｺ ｨ 08ｨｨｨｰｨｬｨｨｨｦ ｨｮ 05ｨｨ02 ｨ ｨ ｨｪｨｨ ﾂ0209ｨｺ06ｨｦ 07ｨ ｨｰ ｨｨｨｨ ｨ. 00 ｨｪｨ 09ｨｰ0607ｨｴ ｨｬ ｨｰ06 ｨｺ05ｨｨｨｪｨｨｨｺ ｨｺｨｰ0806ｨｺｨ 0801ｨｨ060008ｨ 00ｨｨ ﾂ0209ｨｺｨｨｨｦ 09ｨｨｨｪ010806ｨｬ, 01ｨ 08ｨ ｨｺｨｰ0208ｨｨ04ｨｮ06ｨｴｨｨｨｦ ｨｨｨｪｨｺ0607ｨ 05ｨｹｨｪ04ｨｬｨｨ ｨｰ0607ｨｪｨｨ07ｨｬｨｨ ｨｨ 0507ｨｨ040601ｨ ｨｬｨｨ 0005 ｨｮ 07ｨ 02ｨｨ02ｨｪｨｰ0609 ｨ ｨ ｨｪｨｨ ﾂ0209ｨｺｨｨ01 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨｨｦ ｨ ｨｨ ｨｴｨｨｨｦ0907 ｨｪｨ ｨｰ0607ｨｪｨｪ06ｨｦ ｨｨ05ｨｨ ｨｰ08ｨ ｨｪ04ｨｨｨｰ0608ｨｪ06ｨｦ ｨｲ00ｨｬ06ｨｬ ｨｬ02ｨｪｨｰｨ ST ｨ ｨｮ01ｨｪ ｨｰ ｨｪｨｨ0701 (V1-V3) ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺ06ｨｦ ｨｺｨ 08ｨｰｨｨｨｪ02 08ｨ 0405ｨｨ ﾂｨ 06ｨｰ 09ｨｨｨｬ07ｨｰ06ｨｬｨｪ04ｨｦ (09ｨｨｨｪｨｺ0607ｨ 05ｨｹｨｪ04ｨｦ) ｨｨ ｨ ｨｨｨｬ07ｨｰ06ｨｬｨｪ04ｨｦ (ｨ ｨｨｨｪｨｺ0607ｨ 05ｨｹｨｪ04ｨｦ) 09ｨ 08ｨｨｨ ｨｪｨｰ 0509, ｨ 0302ｨｪｨｪ0609ｨｰｨｨ ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨｨｦ ｨｪｨ ｨｺ05ｨ 0909ｨｨ ﾂ0209ｨｺｨｨｨｦ (0709ｨｪ04ｨｦ), ｨｨｨｪｨｰ0208ｨｬｨｨｨｰｨｰｨｨ08ｨｮ06ｨｴｨｨｨｦ ｨｨ 05ｨ ｨｰ02ｨｪｨｰｨｪ04ｨｦ (09ｨｺ0804ｨｰ04ｨｦ) ｨｨ0102ｨｬｨｨ ｨｨ ｨｨ04ｨｮ ﾂ02ｨｪｨ ｨｪ ｨｰｨ ｨｰ06 ﾂｨｪ ｨｪ06ｨｦ 09ｨｰ060806ｨｪ04, ｨｨ 09 ｨｪ0201ｨ 09ｨｪｨｨｨｬ 0607ｨｨ09ｨ ｨｪｨｨ02ｨｬ 09ｨｨｨｪ010806ｨｬｨ 05ｨｨ03ｨｹ ｨｪ02ｨｬｨｪ0600ｨｨ02 ｨｺｨ 0801ｨｨ ｨｨ ｨｪｨ 06ｨｰ ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺｨｨ ｨｪｨｨ07, ｨ ｨｮ0006ｨｦ 09ｨｰ060806ｨｪ04, 01ｨｨｨ 00ｨｪ0609ｨｰｨｨｨｺｨ ｨ ｨｰ08ｨｮ01ｨｪ0702ｨｰ0907 ｨｪｨ 05ｨｨ ﾂｨｨ02ｨｬ ｨｨｨｪｨｰ0208ｨｬｨｨｨｰｨｰｨｨ08ｨｮ06ｨｴｨｨ01 ｨｨ 09ｨｺ0804ｨｰ ｨｬ 09ｨｨｨｪ010806ｨｬｨ ｨｨ ｨｬｨ ｨｪｨｨ000209ｨｰｨ 02ｨｨ02ｨｦ ｨｨ ﾂｨｨｨｰｨ 02ｨｰ0907, ﾂｨｰ06 ｨｮ ｨｬｨｮ03 ﾂｨｨｨｪ ｨｰ0802 ﾂｨ 02ｨｰ ｨ 04 ﾂｨ ｨｴ02, ﾂ02ｨｬ ｨｮ 0302ｨｪｨｴｨｨｨｪ [12], ｨｨ 08ｨｨ09ｨｺ ,5 08ｨ 04 [13] ｨ ｨｪｨｪ04ｨｬ 08ｨ 0405ｨｨ ﾂｨｪ0401 ｨｨ ｨ ｨｪｨｨｨｦ, 08ｨ ｨｰ08ｨ ｨｪ00ｨｪｨｪ0609ｨｰｨｹ ｨｨ04ｨｪｨ ｨｺ ｨｰｨ ｨｰ 06ｨｰ ｨｪｨ ﾂ ｨｺ [13], ｨｨ 03ｨｨｨｰ020502ｨｦ ｨｪｨ ﾂ ｨｺ ｨｰ08ｨ ｨｪｨ ｨｰ06 ﾂｨｪ06ｨｦ 0804ｨｨｨｨ ｨｨ ｨｪｨｨｨｨ 08ｨ ｨｰ08ｨ ｨｪ00ｨｪｨｪ0609ｨｰｨｹ ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ ｨ ｨｪｨｪ06ｨｬ ｨｨ06ｨｪ02 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ06 08ｨ ｨｰ08ｨ ｨｪ02ｨｪ ｨｮ ﾂｨ ｨｨ 09ｨｪ0204ｨ 07ｨｪ06ｨｦ ｨｪ06 ﾂｨｪ06ｨｦ 09ｨｬ0208ｨｰｨｨ 09 ｨｬ ｨｬ ｨ 09ｨｰ02 ( ｨｰ ｨｮ ﾂｨ 0209 ｨｪｨ ｨｨｨｰ020502ｨｦ, 09 ｨｰ06ｨｬ ﾂｨｨ ｨ ｨｮ ﾂｨ ｨｦ ｨｪｨ ｨｨｨｰ020502ｨｦ; 09 06ｨ ｨｨ05ｨ ｨｪ ｨｪｨ ｨｨｨｰ020502ｨｦ) ｨ 0604ｨｪｨ ﾂ02ｨｪｨｨ ｨｦ, ｨｮｨｬ020803ｨｨ ｨｪ02, 09 05ｨｰｨｨ01 09ｨｰ08ｨ ｨｪｨ 01 01ｨ ｨｮｨｴ0209ｨｰ09ｨｮ06ｨｰ ｨｨｨ 05ｨｹｨｪ0402 ｨｪｨ 0409ｨ ｨｪｨｨ07: ｨ ｨ ｨｪ00ｨｮｨｪ00ｨｮｨｰ (0009ｨｰ06ｨｪｨｮｨｴｨｨｨｦ ｨｪ0203) ｨｪｨ 08ｨｨ05ｨｨ0707ｨｨｨｪｨ 01, 0706ｨｺｨｺｨｮ08ｨｨ ｨｪｨｨｨｨ, 05ｨ ｨｨ ｨｰｨ ｨｨ (0009ｨｬ0208ｨｰｨｹ ｨｪ0203) 09 06ｨ ｨｨ05ｨ ｨｪ ｨｮｨｴ0209ｨｰ09ｨｮ02ｨｰ ｨｬｨｪ02ｨｪｨｨ02, ﾂｨｰ % 0905ｨｮ ﾂｨ ｨｨ 07ｨ 02ｨｨ02ｨｪｨｰ0609 ｨ ｨ ｨｪｨｨ ﾂ0209ｨｺｨｨ ｨ 0302ｨｪｨｨｨｦ ｨ 09 05ｨｰ06ｨｬ ｨｨ06ｨｪ02 ｨｬ060302ｨｰ ｨ 04ｨｰｨｹ ｨ ｨｪ [14]. 06ｨｪｨｰ ｨｪ06, ﾂｨｰ ｨｪ ｨｨ09ｨｰ08ｨｨ08ｨｮ02ｨｰ0907 ｨｮ ｨ ｨ ｨｬ0208ｨｨｨｺｨ ｨｪ020209, ｨｮ0006ｨｦ 09ｨｰ060806ｨｪ04, ﾂｨ ｨｴ ｨｰ0907 ｨｮ ｨｰｨ 09ｨｨｨｰ020502ｨｦ 00ｨｺｨ 09ｨｺｨ 0409ｨｺ ｨｰｨｪｨｨ ﾂ0209ｨｺ ｨｰｨｨ07ｨ ｨｨ ｨｨ04 09ｨｰ08ｨ ｨｪ ｨｰ06 ﾂｨｪ06ｨｦ ｨｨ01ｨｨｨｬ06ｨｬｨｮ, ｨｮ02ｨｰ 0603ｨｨ01ｨ ｨｰｨｹ ｨｰｨ ｨｰ06 ﾂｨｪ ｨｺ06ｨｦ 08ｨ ｨｰ08ｨ ｨｪ00ｨｪｨｪ0609ｨｰｨｨ ｨｨｨｦ09ｨｺ06ｨｦ ｨｮ050702ｨｨｨｨ.

2 ｨｪｨ 09ｨｰ0607ｨｴ ｨｬ ﾂｨｨｨｰｨ 02ｨｰ ｨｨ ﾂｨｪ06ｨｦ ｨｺｨｰ08ｨｨ ﾂ0209ｨｺ06ｨｦ03 ｨ ｨｪｨｹ ｨ [10, 15, 16], 08ｨ 0409ｨｨ09ｨ 06ｨｴ02ｨｦ ｨｰ09ｨｨ02 ｨ ｨｪ06ｨｬｨ 05ｨｹｨｪ06ｨｦ ｨｺｨｰ080600ｨｨ04ｨｨ ｨｨ ﾂ0209ｨｺ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 0507ｨｨｨｺｨ 0801ｨ 0708ｨ ｨｮ0106 ﾂｨｺｨ 09 06ｨ 05ｨ 09ｨｰｨｨ 0904ｨｪ060907ｨｴ ｨｰ08ｨ ｨｺｨｰｨ. 0102ｨｪ02ｨｰｨｨ ﾂ0209ｨｺ06ｨｦ 0609ｨｪ060906ｨｦ ｨｰ0907 ｨｬｨｮｨｰｨ 02ｨｨ ｨｪｨ SCN5A ｨｪｨ ｨｺ060806ｨｰｨｺ06ｨｬ ﾂ02 3-ｨｦ ｨｬ060906ｨｬ04 3p21-24 [16, 17]. 06ｨｰ06ｨｰ 0002ｨｪ ｨｺ0601ｨｨ08ｨｮ02ｨｰ 09ｨｰ08ｨｮｨｺｨｰｨｮ08ｨｮ ｨ 0205ｨｺｨ ｨ 05ｨｹ00ｨ 09ｨｮｨ ｨｲ0201ｨｨｨｪｨｨ0204 ｨｪｨ ｨｰ08ｨｨ ｨｺｨ ｨｪｨ , ｨｺ06ｨｰ ｨ ﾂｨｨ09ｨ 06ｨｰ ｨｪｨ ｨｰ08ｨｨ020904ｨｦ ｨｰ06ｨｺ 0706ｨｰ02ｨｪ02ｨｨｨ 05ｨ 0102ｨｦ09ｨｰ09ｨｨ07 [18]. 06ｨｰ06ｨｰ ｨｪ ｨ 0300ｨｪ 0708ｨｨ ｨｰ0802ｨｰｨｹ02ｨｬ ｨｬ060502ｨｺｨｮ050708ｨｪ ｨｪ02ｨｰｨｨ ﾂ0209ｨｺ06ｨｬ 09ｨ 08ｨｨｨ ｨｪｨｰ02 09ｨｨｨｪ010806ｨｬｨ ｨｮ0105ｨｨｨｪ00ｨｪｨｪ ｨｨｨｪｨｰ020809ｨ 05ｨ QT (LQT3) ｨｨ 0708ｨｨ 09ｨｨｨｪ010806ｨｬ ｨｪ020008ｨ, ｨｰｨ ｨｺ0302 ｨ ｨｨｨｨ080609ｨ ｨｪｨｪ ｨｺｨｨｨｬ 08ｨｨ09ｨｺ06ｨｬ 09ｨｪ0204ｨ 07ｨｪ06ｨｦ ｨ 08ｨｨｨｰｨｬ060002ｨｪｨｪ06ｨｦ 09ｨｬ0208ｨｰｨｨ. 01ｨ 09 ﾂｨｨｨｰ0409ｨ 02ｨｰ0907 ｨ ｨｬ0603ｨｪ0401 ｨｬｨｮｨｰｨ 02ｨｨｨｦ 0002ｨｪｨ SCN5A ｨ ｨｪｨｨ ｨｪ0609ｨ 08ｨｨｨ ｨｪｨｰ ｨｺｨ 04ｨ 05ｨｨ, ﾂｨｰ06 ｨｪｨ 08ｨｮ0302ｨｪｨｨ07 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨｨ080609ｨ ｨｪｨｨ07 ｨｪｨ ｨｰ08ｨｨ ｨｺｨ ｨｪｨ ｨｨ ｨｰ ｨｰ09ｨｨ02 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ07 ｨｮ080609ｨｪ07 05ｨｺ ｨｨｨｨ 0002ｨｪｨ, ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ ｨｹｨｰｨ 03 - ｨｨ ｨｬ0704ｨ 09ｨｨ09ｨｨｨｬ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ, ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ ｨｨ 0802ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ, ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ ｨｬ02ｨｪｨｨ ｨｪｨｨ07 ｨｪｨ ｨｰ08ｨｨ ｨｺｨ ｨｪｨ ｨｰ0607ｨｪｨｨ ｨｬ0203ｨｮｨｰ06 ﾂｨｪ06ｨｦ ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ ｨｨ ｨｮ09ｨｺ060802ｨｪｨｪ06ｨｦ ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ ｨｺｨ ｨｪｨ [13]. 00ｨｮｨｰｨ 02ｨｨｨｨ 0002ｨｪｨ SCN5A 06ｨ ｨｪｨ 08ｨｮ03ｨｨ09ｨ 06ｨｰ0907 ｨｮ 18-30% 07ｨ 02ｨｨ02ｨｪｨｰ , ｨ 0605ｨｹ ｨｨ 0902ｨｬ02ｨｦｨｪ ｨｮ ﾂｨ 0701 [19] ｨｺ 0002ｨｪｨ SCN5A ｨｨｨｬ0202ｨｰ ｨ 0605ｨｹ03ｨｨ02 08ｨ 04ｨｬ (2016 ｨ ｨｬｨｨｨｪ06ｨｺｨｨ090506ｨｰ), ｨｨ 05ｨｰ06 09ｨｮｨｴ0209ｨｰ0902ｨｪｨｪ ｨｪ0702ｨｰ ｨｪ02ｨｰｨｨ ﾂ0209ｨｺｨｨ02 ｨｨ ｨ ｨｪｨｨ ｨｬｨｪ02ｨｪｨｪ06, ｨ 02ｨｰ ｨ ｨｰ ｨｨ ﾂ0209ｨｺｨｨｨｬｨｨ 09ｨ 08ｨｨｨ ｨｪｨｰｨ ｨｬｨｨ ｨｨ 0108ｨｮ00ｨｨ ｨｪ0609, 06ｨｰ0902ｨｰ09ｨｰ0902ｨｪｨｪ ｨ ｨｺ0601ｨｨ080609ｨ ｨｪｨｨ02 ｨｺｨ ｨｪｨ ｨｨ ｨ 0205ｨｺ0609 ｨｨ06ｨｪｨｪ ｨｰ08ｨ ｨｪ ｨｰｨ [20]. 01ｨ 0708ｨｨｨｬ0208, ｨｨｨｬ0202ｨｰ ｨｨ09ｨ ｨｪｨｨ02 ｨ ｨｨｨｬ07ｨｰ06ｨｬｨｪ ｨ 08ｨｨｨ ｨｪｨｰｨ ｨｨ ｨｬｨｮｨｰｨ 02ｨｨｨｨ, 0708ｨｨ ｨｴ02ｨｦ ｨｺ ｨｪｨ 08ｨｮ0302ｨｪｨｨ ｨｨ ｨｺｨ 05ｨｹｨｬ0601ｨｮ05ｨｨｨｪｨ 09 ｨｪｨ ｨｰ08ｨｨ020904ｨｬ ｨｺｨ ｨｪｨ 0506ｨｬ ｨｨ ｨｺ ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ07ｨｬ ｨｬ0601ｨｮ050702ｨｨｨｨ 08ｨ ｨ 06ｨｰ04 ｨｪｨ ｨｰ08ｨｨ ｨｺｨ ｨｪｨ 05ｨ ｨｨ06ｨｪｨ ｨｬｨｨ ｨｺｨ 05ｨｹ02ｨｨ07 [21] ｨｪｨ ｨｮ02ｨｰ ｨ ｨｮｨｰ060906ｨｬｨｪ ｨｬｨｨｨｪｨ ｨｪｨｰｨｪ06ｨｬｨｮ ｨｰｨｨ07ｨｮ [14, 15]. 0606ｨｪｨｪ04ｨｬ ｨｬ0201ｨ ｨｪｨｨ04ｨｬ06ｨｬ ｨｨ ｨｬｨｮｨｰｨ 02ｨｨｨｨ 0002ｨｪｨ SCN5A ｨｰ0907 ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨ02 ｨｺ0605ｨｨ ﾂ0209ｨｰ09ｨ ｨｨ05ｨｨ ｨｮ09ｨｺ060802ｨｪｨｪｨ 07 ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ07 ｨｪｨ ｨｰ08ｨｨ ｨｺｨ ｨｪｨ ｨｺ0502ｨｰｨｺｨ ｨｨｨｺｨ 0801ｨ 0708ｨ ｨｮ0106 ﾂｨｺｨ, 0708ｨｨ ｨｴｨｨ02 ｨｺ ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨ ｨｰｨｪ0609ｨｰｨｨ 0706ｨｰ06ｨｺｨ ｨｪｨ ｨｰ08ｨｨ07 ｨｨ ｨｬ02ｨｪｨｪ06ｨｦ ｨｨ04ｨ 02ｨｨｨｨ 0507ｨｨｨｺｨ 0801ｨ [20]. 08ｨｮｨｪｨｺ02ｨｨ07 ｨｪｨ ｨｰ08ｨｨ ｨｺｨ ｨｪｨ ｨｪｨ 08ｨｮ03ｨ 02ｨｰ0907 ｨｰｨ ｨｺ ｨｰ09ｨｨ ｨｬ02ｨｴ02ｨｪｨｨ07 ｨｨ ｨｪ0609ｨｰｨｨ ｨｺ0502ｨｰ06ｨｺ 09 05ｨｪ ｨ 04ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺｨｨｨｦ 0802ｨｰｨｨｨｺｨｮ05ｨｮｨｬ [22]. 0306ｨｰ ｨｨｨｪ ｨｰ02ｨｪ02ｨｨｨ 05ｨ 0102ｨｦ09ｨｰ09ｨｨ07 (0302) 09 01ｨ 08ｨ ｨｺｨｰ0208ｨｪ06ｨｦ ｨｺ06ｨｦ03 09 ｨｪｨ ﾂｨ ｨ ｨ ｨｰ06 ｨｪｨ ｨｪ02ｨｺ06ｨｰ ｨｮ ﾂｨ 09ｨｰｨｺｨ ｨｨｨｺｨ 0801ｨ 0708ｨｨ ｨｰ06ｨｬ, ﾂｨｰ ｨｪ0106ｨｺｨ ｨｨｨｬ0202ｨｰ ｨｪ0608ｨｬｨ 05ｨｹｨｪｨｮ ｨｨ ﾂｨｨｨｪｨｮ, ｨ 00ｨｰ 01ｨｨ ｨｨ ｨｨ04ｨ 02ｨｨｨｨ 09ｨｰ02ｨｪｨｺｨｨ ｨｮ0106 ﾂｨｺｨ ｨｨ ｨｰ08ｨ ｨｪ09ｨｬｨｮ08ｨ 05ｨｹｨｪ04ｨｦ 0008ｨ 01ｨｨ02ｨｪｨｰ ｨｪｨ ｨｪｨｨ07, ﾂｨｰ06 ｨｪｨ ｨｰ ｨｲ00ｨｬ06ｨｬ ｨｬ02ｨｪｨｰｨ ST (ｨｰ06 ﾂｨｺｨｨ J) [23] ｨｪｨ ｨｨ04ｨ 02ｨｨｨｨ ｨｰ ｨｰ ｨｨｨｪ04 ｨｨ05ｨｨ ｨｺｨｮ070605ｨ 0302 (09 04ｨ 09ｨｨ09ｨｨｨｬ0609ｨｰｨｨ 06ｨｰ 08ｨ 04ｨｪｨｨ ｨｬ02ｨｪｨｨ ｨｨ04ｨ 02ｨｨｨｨ 05ｨｪ0106ｨｺｨ 0801ｨ ｨｨ 0507ｨｨｨｺｨ 0801ｨ ). 0308ｨｨ 04ｨ ｨｺ ｨｨ04ｨ 02ｨｨｨｨ 0507ｨｨｨｺｨ 0801ｨ ｨｪｨ ｨｰ ｨｰ08ｨｨ02ｨ ｨｰ0205ｨｹｨｪ04ｨｦ 04ｨｮｨ ｨｬ02ｨｪ02ｨｪｨｨ ｨｰｨｨ07ｨｮ ｨｨ ｨ ｨｪ ｨ ｨｪｨｪ02ｨｦ ｨｨ04ｨ 02ｨｨ02ｨｦ, ｨｪ06 ｨｪ ｨ ｨｺ06ｨｦ ｨｪｨｨ07 ｨｨｨｬ07ｨｮ05ｨｹ09ｨ ｨｨ09ｨｰ02ｨｬ02 01ｨｨ09ｨ - 03ｨｮ08ｨｺｨｨｨｪｨｹ ｨ 09ｨｰｨ ｨｪｨｨ ｨ 01ｨｨ02ｨｪｨｰｨ ｨｬ020301ｨｮ 05ｨｪ0106ｨｺｨ ｨｬ ｨｨ 0507ｨｨｨｺｨ ｨｬ, ｨｺ060001ｨ ｨｪｨ 08ｨ 0405ｨｨ ﾂｨｪ0401 ｨｮ ﾂｨ 09ｨｰｨｺｨ ｨｨｨｺｨ 0801ｨ ｨｨ04ｨ 02ｨｨ07 ｨｨ0100ｨｰ 09 08ｨ 04ｨｪ06ｨｦ 09ｨｺ ｨｰｨｹ06, 0708ｨｨ090601ｨｨｨｰ ｨｺ ｨ 0302ｨｪｨｪ06ｨｦ 01ｨｨ ｨｨｨｨ ｨｨ04ｨ 02ｨｨｨｨ ｨｨ ｨ ｨｺｨｰ0208ｨｪ0609ｨｰｨｨ ｨｬ020301ｨｮ 0507ｨｨｨｺｨ ｨｬ ｨｨ 05ｨｪ0106ｨｺｨ ｨｬ ｨｨ 06ｨ 08ｨ ｨ ｨｪｨｨ06 00ｨｮ070409ｨｨｨｬ ｨｺｨｪｨ 03, ｨ ｨｺ06ｨｰ ｨｺ09ｨｰ08ｨ 09ｨｨ09ｨｰ0605ｨ ｨｬ060302ｨｰ ｨ ｨｰｨｹ ｨ 08ｨｨｨｰｨｬｨｨ ｨｬ0201ｨ ｨｪｨｨ04ｨｬｨｮ re-entry ｨｨ04 ｨｰ0201 ｨｬ0209ｨｰ, ｨｪ ｨｰ02ｨｺｨ 02ｨｰ ｨ 0409ｨｰ080202, ｨｨｨｰ0907 ｨｺ ｨｬ0209ｨｰｨ ｨｬ, ｨ 08ｨ ｨ ｨｪｨｨ02 04ｨ ｨｨ09ｨ 02ｨｰ0907, ｨｨ ｨｪｨｨｨｺｨ 02ｨｰ ｨｪｨｨｨｰ0205ｨｹｨｪ ｨ ｨｮ030102ｨｪｨｨ ｨｰｨｨ07ｨｮ ｨｰ0608ｨｪ ｨ ｨｮ06 00ｨ 04ｨｮ ｨｴｨｨ ｨｰ09ｨｨ02 05ｨｰ ｨ ｨｪｨｪｨｨ02 05ｨｺ09ｨｰ08ｨ 09ｨｨ09ｨｰ ｨ 01ｨ 06ｨｰ 09 00ｨｮ070409ｨｨｨｬ ｨｺｨｪ0603 ｨｨ 04ｨ 07ｨｮ09ｨｺｨ 06ｨｰ ｨｮ0106 ﾂｨｺ0609ｨｮ06 ｨｰｨ 01ｨｨｨｺｨ 0801ｨｨ06 ｨｨ/ｨｨ05ｨｨ 00ｨｨｨ 08ｨｨ ｨｨ ｨｮ0106 ﾂｨｺ0609 (0804) [24] ｨ 00ｨ 02ｨｰ0907, ﾂｨｰ06, 0706ｨｬｨｨｨｬ ｨｪ02ｨｰｨｨ ﾂ0209ｨｺｨｨ01 ｨｪｨ 08ｨｮ0302ｨｪｨｨｨｦ, ｨ 0605ｨｹ ｨｪｨ ﾂ02ｨｪｨｨ ｨ 0409ｨｨｨｰｨｨｨｨ ｨｨ ｨｨ 0509 ｨｨｨｬ0202ｨｰ ｨ 09ｨｰ06ｨｪ06ｨｬｨｪｨ 07 ｨｪ020809ｨｪｨ 07 09ｨｨ09ｨｰ02ｨｬｨ ｨｨ ｨ ｨｪｨｨｨｦ 0706ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ06 ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ07 07ｨ 08ｨ 09ｨｨｨｬ07ｨ ｨｰｨｨ ﾂ0209ｨｺ06ｨｦ ｨｨ05ｨｨ ｨｰ0608ｨｬ060302ｨｪｨｨ02 09ｨｨｨｬ07ｨ ｨｰｨｨ ﾂ0209ｨｺ06ｨｦ ｨｪ020809ｨｪ06ｨｦ 09ｨｨ09ｨｰ02ｨｬ04 ｨｮ09ｨｨ05ｨｨ09ｨ 02ｨｰ ｨ 08ｨｨｨｰｨｬ060002ｨｪ0204 [25, 26]. 0202ｨｦ09ｨｰ09ｨｨｨｰ0205ｨｹｨｪ06, 09 93,3% 0905ｨｮ ﾂｨ ｨｨｨｪｨｺ0607ｨ 05ｨｹｨｪ ｨｨ09ｨｰｨｮ ｨｨ ｨｪｨｨｨｺｨ 06ｨｰ ﾂ0208ｨｪ0202 ｨｨ ｨｪ06 ﾂｨｪ ｨｬ07 ( ﾂｨ ), 0708ｨｨ ﾂ00ｨｬ ﾂｨ ｨｴ ｨｰ060806ｨｦ ｨｨｨｪ02 ｨｪ06 ﾂｨｨ [27] ｨｬ02 ｨｰ060006, 09 07ｨ ｨｰ060002ｨｪ ｨｨ0008ｨ 02ｨｰ ｨｹ 01ｨｨ09ｨ ｨ 05ｨ ｨｪ09 ｨｬ020301ｨｮ ｦﾁ- ｨｨ ｦﾂ-ｨ ｨｪ020800ｨｨ ﾂ0209ｨｺ06ｨｦ 09ｨｰｨｨｨｬｨｮ050702ｨｨ02ｨｦ. 06ｨ ｨｺ, 0708ｨｨ ｨｪｨｨｨｨ 07ｨ 02ｨｨ02ｨｪｨｰｨ ｨｬ ｦﾁ-ｨ ｨｪ06ｨｬｨｨｨｬ02ｨｰｨｨｨｺ0609 ｨｨ05ｨｨ ｦﾂ-ｨ ｨｪ06ｨ 0506ｨｺｨ ｨｰ ｨｪｨ ｨ ｨ ｨｹ ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ ｨｲ00ｨｬｨ ｨｬ02ｨｪｨｰｨ ST, ｨ 0708ｨｨ ｨｪｨｨｨｨ ｦﾁ-ｨ ｨｪ06ｨ 0506ｨｺｨ ｨｰ ｨｨ ｦﾂ- ｨ ｨｪ06ｨｬｨｨｨｬ02ｨｰｨｨｨｺ ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨ02 [28]. 0209ｨｪ0609ｨｪ0402 ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺｨｨ ｨｨ04ｨｪｨ ｨｺｨｨ ｨｨｨｪｨｺ0607ｨ 05ｨｹｨｪ ｨｰ0607ｨｪｨｨ07 ｨｨ 0507ｨｨ ｨ 0302ｨｪｨｪ0609ｨｰｨｹ ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺｨｨ ｨｪｨｨｨｦ ｨｰ ｨｰ020702ｨｪｨｹ ｨｪｨｨ07 ｨｪｨ ｨｰ08ｨｨ ｨｺｨ ｨｪｨ : 0708ｨｨ ｨｪｨｨｨｨ ｨｬ02ｨｪ % ｨｺｨ ｨｪｨ ｨ ｨｰｨｰ0208ｨｪ ｨｨ ｨｪｨ 08ｨｮ0302ｨｪｨｨ07 08ｨｨｨｰｨｬｨ ｨｪｨ ｨ ｨ 06ｨｰ0907 ｨｰ0605ｨｹｨｺ ｨｪｨｨ07 ｨ 0506ｨｺｨ ｨｰ ｨｪｨ ｨｰ08ｨｨ ｨｺｨ ｨｪｨ , 0708ｨｨ ｨｮ090205ｨｨ ﾂ02ｨｪｨｨｨｨ ｨｺ0605ｨｨ ﾂ0209ｨｰ09ｨ ｨｪｨｪ0401 ｨｪｨ ｨｰ08ｨｨ ｨｺｨ ｨｪｨ % ｨｺ ｨ 09ｨｰｨ 02ｨｰ 08ｨｨ09ｨｺ ｨｨｨ 05ｨｨ04ｨｨｨｰ0205ｨｹｨｪ06 80% ｨ 0605ｨｹｨｪ0401, ｨｪ020903ｨｨ , ｨｰ ｨｨｨｬ0205ｨｨ 09 ｨ ｨｪｨ ｨｬｨｪ ｨ ｨｬ060806ｨｺｨｨ, 09 ｨｰ06ｨｬ ﾂｨｨ ｨｮ ｨ ｨｬｨｨ [29] ｨ 07ｨ 02ｨｨ02ｨｪｨｰ ｨｨ09ｨｰｨｮ ｨｰ02ｨｺｨ 06ｨｰ ｨ ｨｰ0208ｨｨ ｨｪｨ ｨｪｨｨ07, 09 09ｨｨ ｨｺ06ｨｦ 06ｨ ｨｴ02ｨｦ 0905ｨ ｨ 0609ｨｰｨｨ ｨｨ ｨ ｨ ｨ 06ｨｰ ｨ. 0207ｨｨ09ｨ ｨｪ04 08ｨ 0405ｨｨ ﾂｨｪ0402 ｨｪｨ 08ｨｮ0302ｨｪｨｨ07 08ｨｨｨｰｨｬｨ 0708ｨｨ 0509: 09ｨｮ0708ｨ 0902ｨｪｨｰ08ｨｨｨｺｨｮ050708ｨｪ0402 ｨ 08ｨｨｨｰｨｬｨｨｨｨ, 00ｨｨｨ 08ｨｨ ｨｨ ｨｨｨｦ, ｨ ｨｰ08ｨｨ060902ｨｪｨｰ08ｨｨｨｺｨｮ050708ｨｪｨ 07 ｨｮ ｨ 07 ｨｰｨ 01ｨｨｨｺｨ 0801ｨｨ07, 0601ｨｪｨ ｨｺ06 09ｨ ｨｬ04ｨｬｨｨ ﾂｨ 09ｨｰ04ｨｬｨｨ ｨｨ 03ｨｨ04ｨｪ020607ｨ 09ｨｪ04ｨｬｨｨ ｨｰ0907 TdeP ｨｨ 0804 [10]. 0209ｨｪ0609ｨｪ04ｨｬ 01ｨｨｨ 00ｨｪ0609ｨｰｨｨ ﾂ0209ｨｺｨｨｨｬ ｨｺ08ｨｨｨｰ0208ｨｨ02ｨｬ ｨｰ ｨ ｨｪｨ 08ｨｮ0302ｨｪｨｨ02 ｨｪｨ ｨｨ04ｨｪｨ ｨｺ ｨｲ00ｨｬ06ｨｬ ｨｬ02ｨｪｨｰｨ ST (ｨｰ06 ﾂｨｺｨｨ J) 09 06ｨｰ ｨｪｨｨ0701 V 1 -V 3 [10]. 06ｨ ｨｺ ｨｰｨｨ01 06ｨｰ ｨｪｨｨ0701 ｨｬ060302ｨｰ ｨｨ09ｨｰ08ｨｨ080609ｨ ｨｰｨｹ0907 ｨｨｨｪ090208ｨｰｨｨ080609ｨ ｨｪｨｪ04ｨｦ 04ｨｮｨ ｨｨ09ｨ ｨｪ ｨ ｨｰｨｨ07ｨ ｨｲ00ｨｬｨ ｨｬ02ｨｪｨｰｨ ST 0708ｨｨ 0509: 00saddle-back type03 ( ) ｨｨ 00coved type03 ( ) (09ｨｬ. 08ｨｨ09. 1) ｨｲ00ｨｬ 00coved type ｨｰ ｨｪ ｨ 05ｨ 01ｨ 02ｨｰ 0708ｨｨ 09ｨｨｨｬ07ｨｰ06ｨｬｨｪ ｨｬｨ , 09 TdeP ｨｨ ｨ ｨｪｨ ｨｬｨｪ020402, 09 ｨｰ ｨｬ07 ｨｺｨ ｨｺ 00saddle-back type03 ﾂｨ ｨｴ ｨｰ0802- ﾂｨ 02ｨｰ ｨｨ ｨ ｨｨｨｬ07ｨｰ06ｨｬｨｪ ｨｬｨ ｨｪｨ ｨｺ06 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ07 ｨｪｨ ｨｨ 0509 ｨｬ0600ｨｮｨｰ ｨｪ0609ｨｨｨｰｨｹ ｨｴｨｨｨｦ 01ｨ 08ｨ ｨｺｨｰ0208, ﾂｨｰ06 ｨｰ0802ｨ ｨｮ02ｨｰ 0706ｨｨ09ｨｺｨ ｨｪｨｨｨｰ0205ｨｹｨｪ0401 ｨｬ02ｨｰ ｨｨ00ｨｨｨｺｨ 02ｨｨｨｨ. 0102ｨｺ06ｨｰ ｨ 09ｨｰ ｨｨｨ 00ｨｪ0609ｨｰｨｨｨｺｨｨ ｨ 00ｨ 06ｨｰ ｨｨ ｨｹ040609ｨ ｨｰｨｹ ｨｺｨｨ02 (ｨｪｨ 1-2 ｨｬ ｨ 0208ｨｹ ) 0708ｨ ｨｮ01ｨｪ ｨｰ ｨｪｨｨ ｨｨ00ｨｨｨｺｨ 02ｨｨｨｨ 0509 ｨｨ ｨｹ04ｨｮ06ｨｰ ｨｰｨ ｨｺ0302 ｨｰ0209ｨｰ ｨｪｨｨ02ｨｬ ｨ 0506ｨｺｨ ｨｰ ｨｪｨ ｨｰ08ｨｨ ｨｺｨ ｨｪｨ (ｨ ｨｦｨｬｨ 05ｨｨｨｪ - 1 ｨｬ00/ｨｺ00 04ｨ 5 ｨｬｨｨｨｪ 09ｨｪｨｮｨｰ08ｨｨ0902ｨｪｨｪ06 ｨｨ05ｨｨ 400 ｨｬ ｨ 05ｨｹｨｪ06, ｨｪ060906ｨｺｨ ｨｨｨｪｨ ｨｬｨｨ01-10 ｨｬ00/ｨｺ00 04ｨ 10 ｨｬｨｨｨｪ 09ｨｪｨｮｨｰ08ｨｨ0902ｨｪｨｪ06, 07ｨｨ0509ｨｨｨｺｨ ｨｨｨｪｨｨ01-1 ｨｬ00/ｨｺ00 04ｨ 10 ｨｬｨｨｨｪ 09ｨｪｨｮｨｰ08ｨｨ0902ｨｪｨｪ06) [13] ｨｰ 09 ｨ 0506ｨｺｨ ｨｰ0608ｨ ｨｬｨｨ ｨｪｨ ｨｰ08ｨｨ ｨｺｨ ｨｪｨ ｨｨｨｰ ｨｮ ｨｨ ｨ ｨｪｨｨｨｬｨ 02ｨｨ06ｨｪｨｪ ｨｰ ｨｪｨｨ07, ｨｰｨ ｨｺ ｨｺｨ ｨｺ ｨｬ ｨｪｨｨ ｨｨｨｺｨ ｨｰｨｪ0609ｨｰｨｹ 08ｨ 0409ｨｨｨｰｨｨ07 TdeP ｨｨ ｨ ｨｰ ｨｨ04ｨｮ ﾂ02ｨｪｨｨ ｨｪｨ ｨｺ0607ｨｨ05ｨｨ09ｨｹ 01ｨ ｨｪｨｪ ｨｨ06ｨ 0802ｨｰ00ｨｪｨｪ06ｨｬ ｨｪｨ 09ｨｰ0607ｨｴ ｨｬ ｨｨ09ｨ ｨｪ ｨｮ06-

3 ｨｨ ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ ｨｨ 09ｨｨｨｪ010806ｨｬ ｨｮ00ｨ 01ｨ. 02ｨ ｨｲ0709ｨｪ02ｨｪｨｨ07 09 ｨｰ02ｨｺ09ｨｰ02. ｨｴｨｨ ｨｰ0607ｨｪｨｨ07 ｨｨ 04ｨ ｨ ｨ ｨｪｨｨ07, ｨ 06ｨｴｨｨe 0509 [10, 30-37]: 05ｨｨ010608ｨ 01ｨｺｨ, 00ｨｨ070208ｨｺｨ 05ｨｨ02ｨｬｨｨ07, 00ｨｨ070208ｨｺｨ 05ｨｹ02ｨｨ02ｨｬｨｨ07, ｨｨ02ｨｨｨｰ ｨｰｨｨｨ ｨｬｨｨｨｪｨ, 06ｨｰ08ｨ ｨｪｨｨ02 ｨｺ06ｨｺｨ ｨｨｨｪ06ｨｬ, 00ｨｨ ｨ 08ｨ ｨｰｨｨ080206ｨｨ01ｨｨ04ｨｬ, 00ｨｨ070208ｨｰ0209ｨｰ0609ｨｰ020806ｨｪ02ｨｬｨｨ07, 0607ｨｮ010605ｨｨ ｨｰ02ｨｪｨｨ07, ｨ 08ｨｨｨｰｨｬ060002ｨｪｨｪｨ 07 01ｨｨ090705ｨ 04ｨｨ ｨ ｨｮ0106 ﾂｨｺｨ, ｨｨｨｺｨ 0801ｨｨｨｰ, ｨｨｨｪ00ｨ 08ｨｺｨｰ ｨｬｨｨ06ｨｺｨ 0801ｨ, 09ｨｰ02ｨｪ06ｨｺｨ 0801ｨｨ ｨｨｨｪ02ｨｬ02ｨｰｨ 05ｨ, ｨｬ0201ｨ ｨｪｨｨ ﾂ0209ｨｺｨ 07 06ｨ 09ｨｰ08ｨｮｨｺ02ｨｨ ｨｴ ｨｰ08ｨ ｨｺｨｰｨ 0708ｨ ｨｮ0106 ﾂｨｺｨ 0607ｨｮ ｨｬｨｨ ｨｨ05ｨｨ 0708ｨｨ 0002ｨｬ ｨｨｨｺｨ , ｨｰ0806ｨｬｨ 0605ｨｬｨ 0605ｨｨ ﾂｨｪ06ｨｦ ｨ 08ｨｰ0208ｨｨｨｨ, 08ｨ ｨ ｨｨ09ｨ 06ｨｴｨ 07 ｨ ｨｪ020908ｨｨ04ｨｬｨ ｨ 0608ｨｰ04, 08ｨ 0405ｨｨ ﾂｨｪ0402 ｨ ｨｪ06ｨｬｨ 05ｨｨｨｨ 0202ｨｪｨｰ08ｨ 05ｨｹｨｪ06ｨｦ ｨｨ ｨｰｨ ｨｰｨｨ09ｨｪ06ｨｦ ｨｪ020809ｨｪ06ｨｦ 09ｨｨ09ｨｰ02ｨｬ04, ｨｬ ﾂｨｪｨ 07 01ｨｨ09ｨｰ080600ｨｨ ｨｪｨｪｨ, ｨ ｨｰｨ ｨｺ09ｨｨ ｨｨｨｺｨ. 0308ｨｨ00ｨｬ 0502ｨｺｨ 0809ｨｰ0902ｨｪｨｪ ｨ 08ｨ ｨｰ0609, ｨｨｨｪ00ｨｨｨ ｨｨ08ｨｮ06ｨｴｨｨ01 ｨｪｨ ｨｰ08ｨｨ ｨｺｨ ｨｪｨ 0504, ｨｰｨ ｨｺ0302 ｨｬ060302ｨｰ ｨ ｨｰｨｹ ｨｺｨ 0809ｨｰ0902ｨｪｨｪ06-ｨｨｨｪ01ｨｮ02ｨｨ080609ｨ ｨｪｨｪ04ｨｦ ｨｨ09ｨ ｨｪ 0708ｨｨ ﾂ02ｨｪｨｨｨｨ ｨｬ0209ｨ 05ｨ 04ｨｨｨｪ06ｨｬ, 09ｨ 0006ｨｰ06ｨｪｨｨ ﾂ0209ｨｺｨｨｨｬｨｨ ｨ 08ｨ ｨｰｨ ｨｬｨｨ, ｦﾁ- ｨ ｨｪ020800ｨｨ ﾂ0209ｨｺｨｨｨｬｨｨ ｨ 0006ｨｪｨｨ09ｨｰｨ ｨｬｨｨ, ｦﾂ-ｨ ｨｪ06ｨ 0506ｨｺｨ ｨｰ0608ｨ ｨｬｨｨ, ｨ ｨｪｨｰｨｨ00ｨｨ09ｨｰｨ ｨｬｨｨｨｪ060904ｨｬｨｨ ｨ 08ｨ ｨｰｨ ｨｬｨｨ ｨｺ060502ｨｪｨｨ07, ｨ ｨｪｨｰｨｨｨｬｨ ｨｨｨｦｨｪ04ｨｬｨｨ ｨｰ09ｨ ｨｬｨｨ, ｨ ｨｰｨｨ09ｨｪ04ｨｬｨｨ, ｨ ｨｪｨｰｨｨｨｺ06ｨｪ09ｨｮ05ｨｹ09ｨ ｨｪｨｰｨ ｨｬｨｨ, ｨｪ02ｨｦ ｨｰｨｨｨｺｨ ｨｬｨｨ, ｨｰ08ｨｨ- ｨｨ ｨｰ02ｨｰ08ｨ 02ｨｨｨｺ05ｨｨ ﾂ0209ｨｺｨｨｨｬｨｨ ｨ ｨｪｨｰｨｨ ｨ ｨｪｨｰｨ ｨｬｨｨ, ｨ 08ｨ ｨｰｨ ｨｬｨｨ 05ｨｨｨｰｨｨ07 [38-50] ｨ ｨｪｨｪ04ｨｬ 05ｨｺ ｨｨｨｬ02ｨｪｨｰ0609 in vitro ｨｨ in vivo, 0902ｨｺ02ｨｨ06ｨｪｨｪ0401 ｨｨ ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺｨｨ01 ｨｨ ｨ ｨｪｨｨｨｦ ｨ ｨｪｨｰｨｨｨｺ06ｨｪ09ｨｮ05ｨｹ09ｨ ｨｪｨｰ04, ｨ ｨｪｨｰｨｨ ｨ ｨｪｨｰ04, ｨｪ02ｨｦ ｨｰｨｨｨｺｨｨ, ｨ ｨｪｨｺ09ｨｨ0605ｨｨｨｰｨｨｨｺｨｨ ｨｨ ｨｪ0608ｨｬ06ｨｰｨｨｨｬｨｨｨｺｨｨ ｨ ｨｪ04 ｨ 0506ｨｺｨｨ080609ｨ ｨｰｨｹ ｨ 0409ｨｰ ｨｺｨ 05ｨｨ HERG-ｨｺｨ ｨｪｨ 0504, ｨｪｨ ｨｰ08ｨｨ ｨｺｨ ｨｪｨ 0504 ( ｨｰ09ｨｨ ｨｺｨｰｨ 0002ｨｪｨ SCN5A) ｨｨ ｨｺｨ 05ｨｹ02ｨｨ ｨｺｨ ｨｪｨ 0504 L-ｨｰｨｨ07ｨ, ｨ 07, ｨｰｨ ｨｺｨｨｨｬ 06ｨ 08ｨ 0406ｨｬ, 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪｨｮ06 ｨｪ ｨｰｨ ｨｰ06 ﾂｨｪ0609ｨｰｨｹ ｨｺｨ ｨｪｨ ｨ [51-56]. 06ｨｬ0206ｨｴｨｨ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺ06ｨｦ 05ｨｨｨｰ0208ｨ ｨｰｨｮ ｨ ｨｴ02ｨｪｨｨ , ｨｰ0209ｨｪ06 ｨ ｨｨｨｨ080609ｨ ｨｪｨｪ06ｨｬ ｨｨ- 00ｨｬ06ｨｬ 0709ｨｨ0106ｨｰ080607ｨｪ ｨ 08ｨ ｨｰ0609, ｨｺｨ 09ｨ 06ｨｰ0907, ｨｪ0609ｨｪ06ｨｬ, 09ｨｮｨｨ02ｨｨ010609, 0905ｨｮ ﾂｨ ｨｨ080609ｨｺｨｨ ｨｨ ｨｨｨｪｨｰ06ｨｺ09ｨｨｨｺｨ 02ｨｨｨｨ, ｨｰ ｨｰｨｹ 0708ｨｨ ｨｰ06ｨｺ09ｨｨ ﾂ0209ｨｺｨｨ ｨ ｨｺｨ 0809ｨｰ0902ｨｪｨｪ ｨｰ09 (overdose) [43, 45-48, 57-58] ｨｪ0209ｨｪ06ｨｦ 0708ｨ ｨｺｨｰｨｨ ﾂ0209ｨｺ06ｨｦ 08ｨ ｨ 06ｨｰ02 ｨｬ04 ｨｪｨ ｨ ｨ 02ｨｬ ｨｪｨｨ ｨｪ0206ｨ 04 ﾂｨｪ06ｨｦ ｨｬ04 (09 ｨｮｨｬ020802ｨｪｨｪ04ｨｬ ｨｲ00ｨｬ06ｨｬ ｨｬ02ｨｪｨｰｨ ST) ｨｺ06ｨｪ00ｨｨ00ｨｮ08ｨ 02ｨｨｨｨ 00saddle-back type03 ｨｮ 07ｨ 02ｨｨ02ｨｪｨｰ0609, 0708ｨｨｨｪｨｨｨｬｨ 06ｨｴｨｨ ｨｨ0106ｨｰ080607ｨｪ ｨ 08ｨ ｨｰ ｨ 01 ｨｰ0208ｨ ｨｰｨｨ ﾂ0209ｨｺ ｨｰｨ ｨｪ01ｨ 08ｨｰｨ. 0308ｨｨ 05ｨｰ06ｨｬ ｨｨ09ｨｰ08ｨ 02ｨｨ07 ｨｰｨ ｨｺｨｨ01 ｨ 08ｨｮ00ｨ ｨ ｨｪ0401 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨｨｦ ｨｪｨ ｨ 02ｨｰ ｨｮ01ｨｮ010302ｨｪｨｨ ｨｨ ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺ ｨｰ0607ｨｪｨｨ07 ｨ 0605ｨｹｨｪ ｨｰｨｨ07ｨｮ 00 ﾂ080204ｨｬ0208ｨｪ06ｨｦ ｨｰ08ｨ ｨｪｨｺ09ｨｨ05ｨｨ04ｨ 02ｨｨｨｨ03, 09 09ｨｨｨｬ07ｨｰ06ｨｬｨ ｨｬｨｨ 06ｨ ｨｴ02ｨｦ 0905ｨ ｨ 0609ｨｰｨｨ, 0906ｨｪ05ｨｨ090609ｨｰｨｨ, 00ｨｨ0706ｨｰ06ｨｪｨｨｨｨ, ｨ 08ｨ 01ｨｨｨｺｨ 0801ｨｨｨｨ, ﾂｨｰ06 ｨｪｨ 0706ｨｬｨｨｨｪｨ 02ｨｰ ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺｨｮ06 ｨｺｨ 08ｨｰｨｨｨｪｨｮ 0005ｨｮｨ 06ｨｺ06ｨｦ 00ｨｨ ｨ 02ｨｨｨｨ ｨｺ ｨｺ02ｨｨｨｨ ｨｰ0208ｨ 07ｨｨｨｨ ｨｨ05ｨｨ 06ｨｰｨｬ02ｨｪ ｨｨ0106ｨｰ080607ｨｪ ｨ 08ｨ ｨｰｨ ｨｪｨ ｨ ｨ 02ｨｰ0907 ｨ 0409ｨｰ08ｨ 07 06ｨ 08ｨ ｨｰｨｪｨ 07 01ｨｨｨｪｨ ｨｬｨｨｨｺｨ ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨｨｦ ｨ ｨｮ05ｨｮ ﾂ0302ｨｪｨｨ02ｨｬ ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺ ｨｰ0607ｨｪｨｨ07 ｨ 0605ｨｹｨｪ ｨｨ090601ｨｨｨｬ 0906ｨ 09ｨｰ0902ｨｪｨｪ0602 ｨｪｨ ｨ ｨｪｨｨ ｨｹｨｪｨ ｨｰ ｨｰｨｮ07ｨｨ05ｨ ｨｨ01ｨｨｨ ｨｰ08ｨｨ ﾂ0209ｨｺｨｮ06 ｨ 0605ｨｹｨｪｨｨ02ｨｮ 0706 ｨｪｨ 0708ｨ ｨｪｨｨ06 09ｨｺ060806ｨｦ 0709ｨｨ01ｨｨｨ ｨｰ08ｨｨ ﾂ0209ｨｺ06ｨｦ (050303) 0706ｨｬ06ｨｴｨｨ ｨｨｨ 00ｨｪ060406ｨｬ: ｨ ｨｪｨｨ ﾂ0209ｨｺ ｨ 0302ｨｪｨｨ ｨｪ ｨｬ060400ｨ ｨｨ01ｨｨ ﾂ0209ｨｺｨｨｨｬｨｨ ｨｪｨ 08ｨｮ0302ｨｪｨｨ07ｨｬｨｨ ｨ ｨｪｨ ｨｬｨｪ0204ｨ 04ｨ ｨ ｨ ｨｪｨｨ07: 09ｨｨ09ｨｰ02ｨｬｨ ｨｰｨｨ- ﾂ0209ｨｺｨｨ ｨ 05ｨｺ ｨｨ04ｨｨ080609ｨ 05ｨ 09ｨｹ 06ｨｺ ｨｰ, ｨｬｨｨ080609ｨ ｨ ｨ 09ｨｰｨｨｨｪ02ｨｪｨｰｨｪ04ｨｦ 09ｨｨｨｪ010806ｨｬ, 04ｨ 0706ｨｨ ｨｪ ｨｨ01ｨｨ- ﾂ0209ｨｺ ｨｰ0607ｨｪｨｨ02 ｨｮ01ｨｮ0103ｨｨ050609ｨｹ ｨｺｨ ｨ ｨ, ｨｪｨ 08ｨｮ03ｨｨ ｨｪ, ｨｨ ｨｰ08ｨ 01, ﾂｨｰ06 ｨｬ0600ｨｮｨｰ 04ｨ 0905ｨ 0102ｨｰｨｹ ｨｺ06ｨｬｨｪｨ ｨｰ06ｨｦ, ｨ 0200 ｨｮｨ ｨｨｨｰｨｹ, ｨ 05ｨ 03ｨ 00ｨｨ 09 ｨｺ0608ｨｨ , ｨｪ06- ﾂｨｹ06 ｨｺｨ 04ｨ ｨｹ, ﾂｨｰ06 ｨｺｨｰ06-ｨｰ ｨｺ080409ｨ 02ｨｰ ｨｹ 09 ｨｺ09ｨ 08ｨｰｨｨ08ｨｮ ｨｮ05ｨｮ ﾂ0302ｨｪｨｨ07 09ｨ ｨｬ06 ﾂｨｮ0909ｨｰ09ｨｨ07 ｨ 0605ｨｹｨｪｨ 07 09ｨｰｨ 05ｨ 09ｨｨ09ｨｰ02ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺｨｨ ｨｮ0706ｨｰ0802ｨ 0507ｨｰｨｹ ｨｺ060809ｨ (1 07ｨｮ ｨｺ ｨｪｨ ｨｨ00ｨｬｨ ) ﾂ020806ｨｬ 10 ｨｬｨ 07 ｨｮ09ｨｨ05ｨｨ050609ｨｹ ﾂｨｮ0909ｨｰ ｨｰ08ｨ 01ｨ, 09ｨｨ010205ｨ, ｨｺｨ ｨｺ ｨｺｨ ｨｺｨｨ02-ｨｰ ｨｨ ｨｪ060306ｨｬ 06ｨｰｨｺ080409ｨ 05ｨｨ ｨｹ 0200 ｨｺ09ｨ 08ｨｰｨｨ0804, ｨ 05ｨ, ｨｺｨ ｨｺ 06ｨｪｨｨ ｨ 08ｨｨ09ｨ 05ｨｨ09ｨｹ ｨｨ05ｨ, ﾂｨｰ ｨｬ0600ｨｮｨｰ ｨｮｨ ｨｨｨｰｨｹ, 09ｨｰｨ 05ｨ 09ｨｰｨｮ ﾂｨ ｨｰｨｹ 0706 ｨ ｨ ｨｰｨ ｨｬ, ｨｺ08ｨｨ ﾂｨ ｨｰｨｹ ｨｬｨｨ ｨ 0405ｨ ｨ ｨｪｨ ｨｬ06ｨｰ0802ｨｪｨ 0908ｨ ﾂ06ｨｬ 0708ｨｨ00ｨｬｨｪ ｨｺ ｨｪｨ ｨｪｨｨ02 ｨｪ ｨｬ08ｨ ﾂ02ｨｪ06, ｨｬ, 0608ｨｨ02ｨｪｨｰｨｨ080609ｨ ｨｪｨ ｨｪ06. 01ｨ 09ｨｰ080602ｨｪｨｨ02 09ｨｪｨｨ0302ｨｪ06, ｨｪ ｨｪ ｨ ﾂ02ｨｰ, ｨｰ ｨｪｨ, ｨｨｨｰ, ﾂｨｰ06 09ｨｨ010205ｨ ｨｦ, ｨｺ06ｨｰ ｨｰ0205ｨｨ 0200 ｨｮｨ ｨｨｨｰｨｹ ｨｨ 04ｨ 0905ｨ 0102ｨｰｨｹ ｨｺ09ｨ 08ｨｰｨｨ0806ｨｦ. 06ｨｪｨｰ ｨｺｨｰ 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ06 09ｨｪｨｨ0302ｨｪ. 0506ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺｨｨ: 0706ｨｪｨｨ0302ｨｪｨｪ ｨｨｨｰｨ ｨｪｨｨ07, ｨｺ00, ｨｰ ｨｬ. 0602ｨｬ070208ｨ ｨｰｨｮ08ｨ ｨｰ0205ｨ 36,5 縺 ｨｪ ｨｺ ｨｨ 09ｨｨ01ｨｨｨｬ ｨｨ04ｨｨ09ｨｰ0402 ｨ ｨｪ0402, ｨｪｨ 0907ｨｨｨｪ02, ｨｪ0701 ｨｨ 09 06ｨ 05ｨ 09ｨｰｨｨ 05ｨ ｨ 0909ｨ 01ｨｨｨｪ ｨｺ 0905ｨ 03ｨｪ04ｨｦ, ｨｪ02 06ｨ ｨｪ. 0606ｨｪ ｨ 0708ｨｨ0005ｨｮ0302ｨｪ04. 03ｨｮ05ｨｹ ｨｬｨｨｨｪｨｮｨｰｨｮ, ｨｪｨ ｨｪ02ｨｪｨｨ / 70 ｨｬｨｬ. 08ｨｰ.09ｨｰ ｨ ｨｪｨｨ ｨｨｨｺｨｮ050708ｨｪ0602, 0108ｨｨ ｨｪ02ｨｰ, ﾂｨ 09ｨｰ06ｨｰｨ ｨ ｨｰ0205ｨｹｨｪ ｨｨ0302ｨｪｨｨｨｦ ｨｬｨｨｨｪ. 04ｨｨ0906ｨｰ ｨｬ0700ｨｺｨｨｨｦ, ｨ 0204ｨ ｨｪ02ｨｪｨｪ04ｨｦ ﾂ02ｨｪｨｹ ｨｮ ｨｺ08ｨ ｨ 0208ｨｪ06ｨｦ 01ｨｮ00ｨｨ. 05ｨｰｨｮ05, 01ｨｨｨｮ ｨｪ0608ｨｬ ｨｨ ﾂ0209ｨｺｨｨｨｦ 09ｨｰｨ ｨｰｨｮ09: ﾂ ｨｪ0402 ｨｪ ｨ ﾂｨｺｨｨ d=s, 0006ｨｰ060802ｨ ｨｺ02ｨｨ07 04ｨ ｨｬ ｨｪｨ, ｨｺ ｨｪ02ｨｦ 05ｨｨｨｪｨｨｨｨ. 05ｨｪｨｨ0302ｨｪｨ ﾂｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｹ 09ｨｰ ｨｨ ｨｹｨ 02 ｨｪ02ｨｮ09ｨｰ06ｨｦ ﾂｨｨ09ｨ. 02ｨｨｨ 00ｨｪ0604: 0805ｨｺ ｨｨ04ｨｬ II-III 09ｨｰｨ 01ｨｨｨｨ. 0805ｨｺ ｨｹｨｪｨ 07 05ｨｪ020200ｨ ｨ ｨｰｨｨ07. 05ｨ ｨｰ0703ｨｪ06ｨｦ ｨ 05ｨｺ ｨｹｨｪ04ｨｦ 07ｨ 08ｨ ｨｪ06ｨｨ ｨｨ00ｨｬｨｪ06ｨｬ 0706ｨｺ0602: Sol. Seduxeni 0,5%-2,0 09ｨｪｨｮｨｰ08ｨｨｨｬ ﾂｨｪ ｨｰ ｨｪｨｨｨｨ: ｨｮ09ｨｨ0502ｨｪｨｪ0602 ｨｪｨ ｨ ｨｪｨｨ02, 06ｨ ｨ ｨｪｨｨ ｨｬ02, Sol. Seduxeni 0,5%- 4,0 09/ｨｬ ｨｪｨ ｨｪ06 ﾂｨｹ, Sol. Glucosae 40%-20,0 ｨｨ Sol. Acidi ascorbinici 5%-4,0 09ｨｪｨｮｨｰ08ｨｨ0902ｨｪｨｪ06 09ｨｰ08ｨｮｨｦｨｪ ｨｨ ｨｨ ﾂｨｪ06ｨｬ 0609ｨｬ06ｨｰ0802 ｨ ｨｪｨ ｨｬｨｪ ｨ 08ｨ ｨｰｨｹ ｨｪ ｨｬ0603ｨｪ06 ｨｨ04-04ｨ 06ｨｰ09ｨｮｨｰ09ｨｰ09ｨｨ ｨｮｨｺｨｰｨｨ09ｨｪ ｨｺ06ｨｪｨｰｨ ｨｺｨｰｨ 09 ｨ 0605ｨｹｨｪ06ｨｦ ｨｹｨｪｨ ｨｨｨｰ ｨｰ0205ｨｨ 09 04ｨ ｨｺ0804ｨｰ04ｨｬｨｨ 0005ｨ 04ｨ ｨｬｨｨ, ｨｪｨ ｨｪ02 06ｨｰ0902 ﾂｨ 02ｨｰ, ｨｪｨ ｨｨｨｬ07 ｨｪ02 06ｨｰｨｺ05ｨｨｨｺｨ 02ｨｰ ｨ 00ｨｨ08ｨｮ02ｨｰ ｨｪｨ ｨｨｨｪｨｰ02ｨｪ09ｨｨ09ｨｪ ｨ ｨ 03ｨｨｨｰ0205ｨｨ, 06ｨｰｨｺ080409ｨ 02ｨｰ 0005ｨ 04ｨ, ｨ 02ｨｰ ｨｪ ｨｪｨ 0708ｨ ｨｪｨｪ ｨｨ0302ｨｪｨｨ07 ｨｺ06ｨｪ02 ﾂｨｪ0609ｨｰ07ｨｬｨｨ, 00ｨｬ04 ﾂｨｨｨｰ03, ｨｨ04ｨ ｨｨ08ｨ ｨｰ0205ｨｹｨｪ ｨｪ0702ｨｰ ｨｰ0402 ｨｺ06ｨｬｨ ｨｪ ｨｰ020702ｨｪｨｹ ｨｪｨ 08ｨｮ0302ｨｪｨｨ ｨｪｨ ｨｪｨｨ07 ｨｬ0603ｨｪ ｨｪｨｨｨｰｨｹ ｨｺｨ ｨｺ 0005ｨｮｨ 06ｨｺ ｨｮ0302ｨｪｨｨ02 ( ) : ｨｰ0607ｨｪｨｨ ｨｪ02ｨｦ ｨｰ

4 13ｨ 43 ｨｰｨｨ. 05ｨｺ05ｨ ｨ 02ｨｰ ﾂｨ ｨｰ0502ｨｪｨｨ02, ﾂｨｰ06 ｨ 0605ｨｹｨｪｨ 07 ｨｬ0201ｨｨｨｺｨ ｨｬ02ｨｪｨｰ0604ｨｪ06 04ｨ 0008ｨｮ0302ｨｪｨ /70, PS ｨｬｨｨｨｪ, ｨｰ02ｨｬ070208ｨ ｨｰｨｮ08ｨ 35,8 紊 ｨｨ ﾂ0209ｨｺｨｨｨｦ 09ｨｰｨ ｨｰｨｮ09: ﾂ ｨｪ0402 ｨｪ d=s, 0006ｨｰ060802ｨ ｨｺ02ｨｨｨｨ , ｨ ｨｪｨｨ ﾂ02ｨｪｨｨｨｦ 0109ｨｨ0302ｨｪｨｨｨｦ 0005ｨ 04ｨｪ ｨ 0506ｨｺ ｨｪ ｨｰ0907, ｨｪ ｨｮｨ ｨｪ ｨｺ05ｨ 01ｨｺｨｨ 09ｨｨｨｬｨｬ02ｨｰ08ｨｨ ﾂｨｪ ｨｺ ｨｰｨｨ 08ｨｰｨ ｨｰｨ ｨｪｨｨ02 ｨｪ02 ｨｪｨ 08ｨｮ0302ｨｪ ﾂｨｹ 01ｨｨ04ｨ 08ｨｰ08ｨｨ ﾂｨｪｨ. 05ｨｮ010603ｨｨ05ｨｹｨｪ ｨｺ ｨｪｨｨ01 ｨｺ06ｨｪ02 ﾂｨｪ0609ｨｰ02ｨｦ ｨｪｨｨ04ｨｺｨｨ02 d=s, 09 ｨｪｨｨ03ｨｪｨｨ01 ｨｺ06ｨｪ02 ﾂｨｪ0609ｨｰ02ｨｦ 06ｨｰ09ｨｮｨｰ09ｨｰ09ｨｮ06ｨｰ, 07ｨ ｨｰ ｨｨ ﾂ0209ｨｺｨｨ01 ｨｪ02ｨｰ. 0809ｨｪ ｨ ｨｪ02ｨｰ ﾂｨｪ04ｨｦ ｨｰ06ｨｪｨｮ09 09ｨｨｨｬｨｬ02ｨｰ08ｨｨ ﾂｨｪ04ｨｦ, 01ｨｨ0000ｨｮ04ｨｪ06 ｨｮｨｬ020802ｨｪｨｪ06 09ｨｪｨｨ0302ｨｪ ｨｺ09ｨｰ08ｨ 07ｨｨ08ｨ ｨｬｨｨ01ｨｪ06ｨｬｨｮ ｨｰｨｨ07ｨｮ. 0002ｨｪｨｨｨｪ0002ｨ 05ｨｹｨｪ ｨｪｨ ｨｺ0609 ｨｪ02ｨｰ. 05ｨｪｨｨ0302ｨｪｨｨ02 ﾂｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｨ 09ｨｰ0607 ｨｨ ｨｪ02ｨｦ ｨ 05ｨ 09ｨｰｨｨ 05ｨ ｨ ｨｰｨｮｨｴｨ ｨｬｨ ｨｰ06ｨｬｨ ｨｨｨ 00ｨｪ0609ｨｰｨｨ ﾂ0209ｨｺ06ｨｦ ｨｹ ｨｪｨ 0506ｨｬｨ ｨ 05ｨｹｨｪｨ 07 07ｨｮｨｪｨｺ02ｨｨ07, ｨｮ ﾂ02ｨｪ ｨ ｨｰｨｪ04ｨｦ, ｨ ﾂｨｪ04ｨｦ 05ｨｨｨｺ ｨ ｨｪｨｨ02 05ｨｨｨｺ090608ｨ : 02ｨｨｨｰ0604 7/3, ｨ ｨｺ 0,254, 0802ｨ ｨｺ02ｨｨ ｨｪｨｪ ｨｹｨｰｨ ++, 0802ｨ ｨｺ02ｨｨ07 03ｨ ｨｪ01ｨｨ +, ｨｺ0604ｨ 3,7 ｨｬｨｬ0605ｨｹ/ ｨｨｨ 00ｨｪ0604: 0606ｨｺ09ｨｨ ﾂ0209ｨｺｨ 07 05ｨｪ020200ｨ ｨｨｨｪ ｨ ｨｰｨｨ ｨｨ ｨ ｨｪｨｨ ﾂ0209ｨｺｨｨｨｬ 09ｨｨｨｪ010806ｨｬ06ｨｬ ｨｨ 0109ｨｨ00ｨ ｨｰ0205ｨｹｨｪ04ｨｬｨｨ ｨｪｨ 08ｨｮ0302ｨｪｨｨ07ｨｬｨｨ ﾂ02ｨｪｨｨ02: Sol. Prednisoloni 60 mg, Sol. Vit Acidi ascorbinici 5%-10,0, Sol. Piracetami 20%-10,0, Sol. Glucose 5%-200,0 09ｨｪｨｮｨｰ08ｨｨ0902ｨｪｨｪ06 ｨｺｨ ｨｹｨｪ Sol. Reamberini 400,0 09ｨｪｨｮｨｰ08ｨｨ0902ｨｪｨｪ06 ｨｬ ｨｪｨｪ06. Sol. Vit B1 2,0 09/ｨｬ 2 08ｨ 04ｨ ｨｪｨｹ. Sol. Vit B ｨｬ00 09/ｨｬ ｨ ｨｰ (08ｨｨ09. 2ｨ ): 08ｨｨｨｰｨｬ 09ｨｨｨｪｨｮ ｨｦ 09 ﾂｨ 09ｨｰ06ｨｰ06ｨｦ ｨｬｨｨｨｪ. 0201ｨｨｨｪ06 ﾂｨｪｨ ｨｪｨ 07 05ｨｺ09ｨｰ08ｨ 09ｨｨ09ｨｰ0605ｨ ｨｪｨ 07 ｨ 0506ｨｺｨ 01ｨ 0708ｨ 0906ｨｦ ｨｪ0603ｨｺｨｨ 07ｨｮ ﾂｨｺｨ 01ｨｨ09ｨ ( ｨｲ00ｨｬ06ｨｬ ｨｰ06 ﾂｨｺｨｨ J) ｨｺ0604ｨ ｨｺ080609ｨｨ 6,7 ｨｬｨｬ0605ｨｹ/05, ｨ ｨｨ05ｨｨ08ｨｮｨ ｨｨｨｪ 06ｨ ｨｴｨｨｨｦ 7,87 ｨｬｨｺｨｬ0605ｨｹ/05, ｨ ｨｪｨ 05ｨｨ04 ｨｺ080609ｨｨ: 0002ｨｬ ｨ ｨｨｨｪ 105, 0508ｨｨｨｰ080602ｨｨｨｰ04 3,5, ｨｰ060906ｨｦ 0706ｨｺｨ 04ｨ ｨｰ0205ｨｹ 0,9, 0502ｨｦｨｺ0602ｨｨｨｰ04 5,2, 07ｨ 0506 ﾂｨｺ ｨｪ0402 4, ｨｬ02ｨｪｨｰ ｨｪ , ｨｨｨｪ0600ｨｨ0504 3, ｨ ｨ ｨｨ0504 1, 05ｨｨｨｬ000602ｨｨｨｰ04 27, ｨｬ06ｨｪ0602ｨｨｨｰ ｨｬｨｬ/ ﾂｨ 09, ｨｬ06ｨｰ0802ｨｪｨ ｨｰ0208ｨ ｨｰ06ｨｬ ｨ ｨｪｨ ｨｬｨｪ0204ｨ : ｨ ｨｰｨｨｨｰ ｨｮ. 02ｨｨｨ 00ｨｪ0604: 0606ｨｺ09ｨｨ ﾂ0209ｨｺｨ 07 ｨｬｨｨ06ｨｺｨ 0801ｨｨ0601ｨｨ09ｨｰ080600ｨｨ ｨｨ02ｨｨｨｰｨｪｨ 07 ｨ ｨｪ02ｨｬｨｨ07. 01ｨ 0006ｨｪ ｨｨｨｪｨｰ06ｨｺ09ｨｨｨｺｨ 02ｨｨ06ｨｪｨｪ06ｨｦ ｨｰ0208ｨ 07ｨｨｨｨ ｨｰ0607ｨｪｨｨ02 07ｨ 02ｨｨ02ｨｪｨｰｨｺｨｨ ｨｮ05ｨｮ ﾂ03ｨｨ050609ｨｹ. 01ｨ ｨｮ06ｨｴｨｨｨｦ 0102ｨｪｨｹ 0708ｨｨ 0609ｨｬ06ｨｰ ｨｮ08ｨｪ04ｨｬ 0908ｨ ﾂ06ｨｬ: 09ｨｨ01ｨｨｨｰ ｨｰ0205ｨｨ, ｨｮｨｰ0806ｨｬ 04ｨ 09ｨｰ08ｨ ｨｺｨ 05ｨ, 03ｨ 05ｨｮ02ｨｰ0907 ｨｪｨ ｨｺ08ｨｮ0302ｨｪｨｨ02, 0905ｨ ｨ 0609ｨｰｨｹ. 01ｨ ｨｰ (08ｨｨ09. 2ｨ ): 08ｨｨｨｰｨｬ 09ｨｨｨｪｨｮ ｨｦ ﾂｨ 09ｨｰ06ｨｰ06ｨｦ ｨｬｨｨｨｪ. 02ｨ 08ｨ ｨｰｨｪｨ 07 01ｨｨｨｪｨ ｨｬｨｨｨｺｨ 00ｨ 08ｨｮ00ｨ ｨ ｨｪ ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨｨｦ ｨｮ06ｨｴ02ｨｬ ｨ 0605ｨｹｨｪｨ 07 09ｨｰｨ 05ｨ ｨ ｨｺｨｰｨｨ09ｨｪ0202, ｨｪｨ 09ｨｰ080602ｨｪｨｨ ｨｪ ｨｹ, ｨｪｨ ﾂｨ 05ｨ ｨｴｨ ｨｰｨｹ ｨｮ05ｨｺｨｨ ｨｨ09ｨ ｨｪｨ 0106ｨｬ06ｨｦ 09 ｨｮ05ｨｮ ﾂ0302ｨｪｨｨ02ｨｬ, ｨ ｨｨ ｨｮｨｺｨｰｨｨ09ｨｪ06ｨｦ 09ｨｨｨｬ07ｨｰ06ｨｬｨ ｨｰｨｨｨｺｨｨ, ｨ ｨｨ09ｨｪ0401, 09ｨｮｨｨ02ｨｨ01ｨｪ0401 ｨｰ02ｨｪ0102ｨｪ02ｨｨｨｦ ﾂ02ｨｬｨｮ 09 ｨｮ ｨｨ ｨ 05ｨｹｨｪ ｨｨ01ｨｨｨ ｨｰ08ｨｨ ﾂ0209ｨｺ ｨｰｨ 02ｨｨ06ｨｪｨ 08ｨ ｨｮ ｨｪ02ｨｺ06ｨｰ ｨ 02ｨｨ02ｨｪｨｰ ﾂ02ｨｪｨｨ02 ｨｰ0208ｨ ｨｰｨｨ ﾂ0209ｨｺｨｨｨｬｨｨ ｨ ｨｬｨｨ ｨｪ02ｨｦ0806ｨｰ080607ｨｪ ｨ 08ｨ ｨｰ ｨｨ090601ｨｨｨｰ ｨｺ 0607ｨ 09ｨｪ04ｨｬ ｨｺｨ 0801ｨｨ06ｨｰ06ｨｺ09ｨｨ ﾂ0209ｨｺｨｨｨｬ ｨｨ 00ｨｨ ｨ ｨｰｨｨ09ｨｪ04ｨｬ ｨｺｨｰｨ ｨｬ? ｨｰｨｪ06, ﾂｨｰ06 04ｨ ｨ ｨｨ06ｨｰ08ｨ ｨｪ ｨｬｨ 02ｨｨ ｨｺｨ 0809ｨｰ0902ｨｪｨｪ ｨｰ ｨ ｨｪｨｨ04ｨｬ02 06ｨｰ0902ｨｰ09ｨｰ0902ｨｪｨｪ04: 09ｨｨ09ｨｰ02ｨｬｨ ｨｬｨｨｨｺ ｨｬｨ 05ｨｹｨｪ ｨｺｨｨ090502ｨｪｨｨ07 02ｨｨｨｰ ｨｬ (CYP), ｨｮ08ｨｨ01ｨｨｨｪ01ｨｨ ｨ ｨｰ ｨｺｨｮ0806ｨｪ0604ｨｨ05ｨｰ08ｨ ｨｪ ｨ 0404 (070106), ｨｨｨｺ ｨｰ02ｨｨｨｪ ｨｨ 0108ｨｮ00ｨｨ02 00ｨ 08ｨｬｨ ｨｺ0601ｨｨｨｪｨ ｨｬｨｨ ﾂ0209ｨｺｨｨ02 ｨｨ 00ｨ 08ｨｬｨ ｨｺ06ｨｺｨｨｨｪ02ｨｰｨｨ ﾂ0209ｨｺｨｨ02 00ｨ ｨｺｨｰ [59] ｨｬ02ｨｪｨｰ04 02ｨｨｨｰ ｨｬ ｨｺｨ 05ｨｨ04ｨｮ06ｨｰ ﾂ02ｨｪｨｨ, ｨｺｨｨ0302 ﾂｨｪｨｨｨｺ02, 0905ｨｨ04ｨｨ09ｨｰ ｨ ﾂｨｺｨ 01, ｨｺｨｨ01, 0706 ﾂｨｺｨ 01, ｨｪ06ｨｬ ｨｬ ｨｨ 09 ｨｺ ｨ ｨｺｨ ｨｦ ｨｬ02ｨｪｨｰ 0905ｨｨ0706ｨｰ 0002ｨｪ02ｨｰｨｨ ﾂ0209ｨｺｨｨ02, ｨｺ06ｨｪ09ｨｰｨｨｨｰｨｮ02ｨｨ06ｨｪｨ 05ｨｹｨｪ0402 ｨｨ ｨ ｨｺｨｰ [60] ｨｰ 4 09ｨｰｨ ｨｰｨｮ09ｨ 0002ｨｪ02ｨｰｨｨ ﾂ0209ｨｺｨｨ 0102ｨｰ0208ｨｬｨｨｨｪｨｨ080609ｨ ｨｪｨｪ ｨｬ02ｨｰｨ ｨ 0605ｨｨ ﾂ0209ｨｺ ｨｪ06ｨｰｨｨ07ｨ [61]: extensive (fast) metabolizers - ｨ 0409ｨｰ ｨｬ02ｨｰｨ ｨ 0605ｨｨ04ｨ ｨｪｨｰ04, ｨｨｨｬ0206ｨｴｨｨ ｨ ｨｺｨｰｨｨ09ｨｪ ｨｬ04 05ｨｪ04ｨｨｨｬ0609, 09 ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺ06ｨｬ ｨ ｨｺｨｰ02-05ｨｰ06 07ｨ 02ｨｨ02ｨｪｨｰ04 09ｨｰｨ ｨｪ01ｨ 08ｨｰｨｪ0401 ｨｰ0208ｨ ｨｰｨｨ ﾂ0209ｨｺｨｨ ; intermediate metabolizers ｨｬ0203ｨｮｨｰ06 ﾂｨｪ0402, ｨｨｨｬ0206ｨｴｨｨ ｨｪｨｮ ｨ ｨｺｨｰｨｨ09ｨｪｨｮ ｨｬｨｮ 05ｨｪ04ｨｨｨｬｨ ; poor (slow) metabolizers - ｨｬ ｨｪｨｪ0402 ｨｬ02ｨｰｨ ｨ 0605ｨｨ04ｨ ｨｪｨｰ04, ｨｪ02 ｨｨｨｬ0206ｨｴｨｨ02 ｨ ｨｺｨｰｨｨ09ｨｪ ｨｬ 05ｨｪ04ｨｨｨｬ0609, ｨｰ09ｨｨ02 ﾂ ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨ ｨ 08ｨ ｨｰｨ ｨ 04ｨｬ02 ｨｺ080609ｨｨ ｨｬ060302ｨｰ ｨ 09ｨｰｨ ｨｰｨｹ ｨ 04; ultra-extensive (rapid) metabolizers ｨｨｨｪｨｰ02ｨｪ09ｨｨ09ｨｪ0402 ｨｬ02ｨｰｨ ｨ 0605ｨｨ04ｨ ｨｪｨｰ04, ｨｨｨｬ0206ｨｴｨｨ02 ｨｰ08ｨｨ ｨｨ ｨ ｨｬ 05ｨｪ04ｨｨｨｬ0609 ｨｨ ｨｮ09ｨｺ060802ｨｪｨｪ04ｨｦ 0502ｨｺｨ 0809ｨｰ0902ｨｪｨｪ04ｨｦ ｨｬ02ｨｰｨ ｨ 0605ｨｨ04ｨｬ ｨｨ0506ｨｦ ｨ 09ｨｰ, 08ｨ 0405ｨｨ ﾂｨｪ ｨ ｨ ｨ ｨｪｨｨ ﾂ02ｨｪｨｨ ｨｨ 0706 ﾂ02ｨｺ 09ｨｪｨｨ03ｨ 06ｨｰ ｨｬ02ｨｰｨ ｨ 0605ｨｨ ﾂ0209ｨｺｨｨｨｦ 0002ｨｪ06ｨｰｨｨ ｨｰｨｹ 0106 poor (slow) metabolizers ｨｨｨｪｨｪｨ 0102ｨ ｨｰｨｨ ｨｨ ｨｰｨｪ ｨｬ02ｨｪｨｰ0609 CYP 09 ｨｬ02ｨｰｨ ｨ 0605ｨｨ04ｨｬ ｨｨ0106ｨｰ080607ｨｪ ｨ 08ｨ ｨｰ ｨ 03ｨｪｨｮ ｨｹ ｨｨ0008ｨ 06ｨｰ 0707ｨｰｨｹ: CYP1A2, CYP2C9, CYP2C19, CYP2D6 ｨｨ CYP3A4, 0708ｨｨ ﾂ00ｨｬ CYP3A4 06ｨｰ0902ｨｰ09ｨｰ0902ｨｪ02ｨｪ 04ｨ ｨｬ02ｨｰｨ ｨ 0605ｨｨ04ｨｬ ｨ % 0709ｨｨ0106ｨｰ080607ｨｪ ｨ 08ｨ ｨｰ0609, ｨ 06ｨｴｨｨ ｨ ｨｨ06ｨｰ08ｨ ｨｪ ｨｬｨ 02ｨｨｨｨ ﾂ02ｨｪｨｨ [59, 62]. 04ｨ 0405ｨｨ ﾂｨｪ ｨｺｨ 0809ｨｰ0902ｨｪｨｪ ｨｰ09ｨ (09 ｨｰ06ｨｬ ﾂｨｨ ｨｨ 09ｨ ｨｬｨｨ ｨｪ02ｨｦ0806ｨｰ080607ｨｪ0402), ｨｰ0607ｨｪｨｨ07 ｨｨ 07ｨｨｨｴ ｨｨ ｨ 0605ｨｹｨｪ06ｨｦ ｨｰ: ｨ - ｨｨ ｨｪ06, ｨ - ｨｪｨ 0006ｨｪ02 ｨｰ0208ｨ 07ｨｨｨｨ. 02ｨ ｨｲ0709ｨｪ02ｨｪｨｨ07 09 ｨｰ02ｨｺｨｰ02. ｨ

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A servey of sudden deth associated with the use of antipsychotics or antidepressant drugs: 49 cases in 1 7inland. // Acta Psychiatrica Scand, 1991; 84: DA issues public health advisory for antipsychotic drugs used for treatment of behavioral disorders in elderly patients (1 7DA talk Paper) Rochvill (MD): US 1 7ood and Drug Administration (2006) ｨｮｨｺｨｰ ｨｰ0907 ｨｨｨｪ00ｨｨｨ ｨｨｨｰ0608ｨ ｨｬｨｨ CYP ｨｨ 0708ｨｨ ｨｪｨｪ ｨｺｨ 0809ｨｰ0902ｨｪｨｪ0401 ｨｺ06ｨｬｨ ｨｨｨｪｨ 02ｨｨ0701 ｨｬ060302ｨｰ ｨｨｨｰｨｹ ｨｨｨｰｨｮｨ 02ｨｨ07, ｨｺ060001ｨ ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨ ｨｺｨ 0809ｨｰ0902ｨｪｨｪ ｨｰ09ｨ, ｨｬ02ｨｰｨ ｨ 0605ｨｨ04ｨｨ08ｨｮ02ｨｬ ｨｰ0906ｨｬ ｨｬ02ｨｪｨｰｨ CYP, ｨ 02ｨｰ0907 ｨｬｨｪ060006ｨｺ08ｨ ｨｰｨｪ06 ｨｨ04-04ｨ ｨｨｨｪ00ｨｨｨ ｨｨ080609ｨ ｨｪｨｨ07 05ｨｰ ｨｬ02ｨｪｨｰｨ 0108ｨｮ00ｨｨｨｬ, ｨｬ0209ｨｰｨｪ06 ｨｪｨ 04ｨｪｨ ﾂ02ｨｪｨｪ04ｨｬ ｨ 08ｨ ｨｰ06ｨｬ [63] ｨｨ ｨｨｨｺ ｨｰ02ｨｨｨｪ [64] 06ｨｰ0902ｨｰ09ｨｰ0902ｨｪｨｪ04 04ｨ ｨｬ02ｨｰｨ ｨ 0605ｨｨ04ｨｬ ｨｬｨｪ0600ｨｨ01 ｨ ｨｪｨｺ09ｨｨ0605ｨｨｨｰｨｨｨｺ0609, ｨ ｨｪｨｰｨｨ ｨ ｨｪｨｰ0609, ｨ ｨｪｨｰｨｨ0709ｨｨ0106ｨｰｨｨｨｺ0609, 09ｨｰｨ ｨ ｨｨ05ｨｨ04ｨ ｨｰ ｨｪｨ 09ｨｰ080602ｨｪｨｨ ｨｨ ｨｨｨｪ00ｨｨｨ ｨｨ080609ｨ ｨｪｨｨｨｨ 05ｨｰｨｨ01 09ｨｨ09ｨｰ02ｨｬ ｨｪ02ｨｺ06ｨｰ060804ｨｬｨｨ 0502ｨｺｨ 0809ｨｰ0902ｨｪｨｪ04ｨｬｨｨ ｨ 08ｨ ｨｰｨ ｨｬｨｨ 09ｨｺ05ｨ ｨ 02ｨｰ0907 ｨ ｨｪｨ ｨｨ ﾂｨｪｨ 07 CYP 09ｨｨｨｰｨｮｨ 02ｨｨ ｨｪｨｨ02ｨｬ ｨｰ0208ｨ ｨｰｨｨ ﾂ0209ｨｺｨｨ ｨｮ080609ｨｪ07 ｨｰ06ｨｺ09ｨｨ ﾂ0209ｨｺｨｨ ｨ 09ｨｪ06 ｨ ｨｨ09ｨ ｨｪ ｨｬ0201ｨ ｨｪｨｨ04ｨｬ 0904ｨ ｨｨｨｬ060102ｨｦ09ｨｰ09ｨｨ07, ｨｺｨ 09ｨ 06ｨｴｨｨｨｦ ｨ ｨｪｨｨ ｨｺｨ 0809ｨｰ0902ｨｪｨｪ ｨ 08ｨ ｨｰｨ ｨｪｨ ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｬ ｨｮ080609ｨｪ02-04ｨ 0109ｨ ｨｰ 05ｨｨ ｨｬｨ ｨｬｨｨ [65]. 08ｨｪｨｰｨｨ ｨ ｨｪｨｰ04 ｨｨ ｨｪ02ｨｦ ｨｰｨｨｨｺｨｨ 09 ﾂｨｨｨｰｨ 06ｨｰ ｨｪ0609ｨｪ04ｨｬｨｨ 05ｨｨ070600ｨｨ05ｨｹｨｪ04ｨｬｨｨ ｨｨｨｪ02ｨｪｨｨ07ｨｬｨｨ, ｨｺ06ｨｰ ｨｺ0502ｨｰｨｺ ｨｴｨ 06ｨｰ ｨｨ ｨｬｨ ｨｬｨｨ. 06ｨｺｨ ｨｪｨｨ ｨｰｨ ｨｺｨｨ ｨ ｨｪ0609, ｨｺｨ ｨｺ ｨｺｨｨ02, ﾂ02ｨｪｨｹ ｨｨ 0706 ﾂｨｺｨｨ, ｨ 0600ｨ ｨｰ04 05ｨｨ ｨｬｨ ｨｬｨｨ ｨｨ ｨ 0605ｨｹ ｨｮ00ｨｨ ｨ ｨｪｨｨ04ｨｬ ｨｴｨ 06ｨｰ 0502ｨｺｨ 0809ｨｰ0902ｨｪｨｪ ｨｴ0209ｨｰ09ｨ 09 05ｨｰｨｨｨｬ ｨｰｨｨ0706ｨｬ 08ｨ ｨｪｨｨ ｨ ｨｨｨｬｨｪ0602 ｨｨｨｪ00ｨｨｨ ｨｨ080609ｨ ｨｪｨｨ ｨ 04ｨ 0109ｨ ｨｰｨ 0502ｨｺｨ 0809ｨｰ0902ｨｪｨｪ ｨ 08ｨ ｨｰ ｨｨ ｨｬｨ ｨｬｨｨ 0708ｨｨ090601ｨｨｨｰ ｨｺ ｨｪｨｨ06 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ ｨｨ ｨ 04ｨｬ02 ｨｺ080609ｨｨ, ﾂｨｰ06 ｨ ｨｨ0702ｨｰ ｨｪｨ ｨｰｨｺｨ ｨｪｨｨ 09 ｨｪｨｨ04ｨｺ06ｨｦ ｨｰｨｪ0609ｨｰｨｹ06 05ｨｨ ｨｬ, ｨｪｨ 0708ｨｨｨｬ0208, ｨ, ｨｨ ｨ 02ｨｰ ｨｮ09ｨｨ0502ｨｪｨｨ02 ｨｺｨ 0801ｨｨ06ｨｰ06ｨｺ09ｨｨ ﾂ0209ｨｺ ｨｦ09ｨｰ09ｨｨ07. 06ｨｰｨｨ ｨｨ ｨｬｨｪ0600ｨｨ ｨｮ00ｨｨ02 00ｨ 08ｨｬｨ ｨｺ06ｨｺｨｨｨｪ02ｨｰｨｨ ﾂ0209ｨｺｨｨ02 00ｨ ｨｺｨｰ ｨｬ0600ｨｮｨｰ 06ｨ ｨｲ0709ｨｪｨｨｨｰｨｹ 0905ｨｮ ﾂｨ ｨｨ ｨｪ02ｨ 05ｨ ｨｨ07ｨｰｨｪ ｨ 06 ﾂｨｪ ｨｦ09ｨｰ09ｨｨｨｦ 0502ｨｺｨ 0809ｨｰ0902ｨｪｨｪ ｨ 08ｨ ｨｰ0609, ｨｪｨ 04ｨｪｨ ﾂ02ｨｪｨｪ ｨｪｨｨ ｨ 01, 09ｨｺ0506 ﾂｨ ｨｨ09ｨ ｨｪｨｪ ｨ ｨ ｨ 02ｨｬ0402 ｨｪｨ ｨｬｨｨ ｨｪｨ ｨ 08ｨｮ00ｨ ｨ ｨｪ0402 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ ｨｰ0802- ﾂｨ 05ｨｨ09ｨｹ, ｨｨｨｬｨｮｨｴ0209ｨｰ0902ｨｪｨｪ06, ｨｮ 07ｨ 02ｨｨ02ｨｪｨｰ ｨｪ ｨｨ ｨｨ ｨ 09ｨｰｨ, ｨｮｨｰ09ｨｰ09ｨｮ06ｨｴ02ｨｦ 0906ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺ06ｨｦ 07ｨ ｨｰ ｨｨ02ｨｦ, 0708ｨｨ 0502 ﾂ02ｨｪｨｨｨｨ ｨ ｨｪｨｰｨｨ ｨ ｨｪｨｰｨ ｨｬｨｨ (09 ｨｰ06ｨｬ ﾂｨｨ ｨ ｨｰｨｨ07ｨｨ ﾂｨｪ04ｨｬｨｨ, ｨｺｨｰｨｨ09ｨｪ04ｨｬｨｨ ｨｨｨｪ00ｨｨｨ ｨｨｨｰ0608ｨ ｨｬｨｨ 06ｨ 08ｨ ｨｰｨｪ ｨ 0109ｨ ｨｰｨ ｨｰ06ｨｪｨｨｨｪｨ ), ｨｪ02ｨｦ ｨｰｨｨｨｺｨ ｨｬｨｨ, ｨ ｨｪｨｰｨｨｨｺ06ｨｪ09ｨｮ05ｨｹ09ｨ ｨｪｨｰｨ ｨｬｨｨ ｨｨ ｨ 02ｨｪ040601ｨｨｨ ｨｨｨｪ060904ｨｬｨｨ ｨ ｨｪｨｺ09ｨｨ0605ｨｨｨｰｨｨｨｺｨ ｨｬｨｨ ｨｨ ｨ 05ｨｨ ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺｨｮ06 ｨｺｨ 08ｨｰｨｨｨｪｨｮ 0005ｨｮｨ 06ｨｺ06ｨｦ ｨｨ ｨｪ00ｨｨ080609ｨ ｨｪｨｪ06ｨｦ 00ｨｨ ｨ 02ｨｨｨｨ. 01ｨ ｨｪｨ , 0502 ﾂｨ ｨｴｨｨ ｨ ﾂｨｨ0709ｨｨ01ｨｨｨ ｨｰ ｨｪ04 ｨ 04ｨｰｨｹ ｨｬ0502ｨｪ ｨ 01 ｨ ｨ 09ｨｪ0609ｨｰｨｨ ｨｨ ｨｺｨ 0801ｨｨ06ｨｰ06ｨｺ09ｨｨ ﾂｨｪ0609ｨｰｨｨ ｨｪｨ 04ｨｪｨ ﾂｨ 02ｨｬ0401 ｨｨｨｬｨｨ ｨｪ02ｨｦ0806ｨｰ080607ｨｪ ｨｺｨ 0809ｨｰ0902ｨｪｨｪ ｨｰ ｨｰ 0008ｨｮ0707ｨｮ ｨｨｨｪ01ｨｨ09ｨｨ01ｨｮｨ 05ｨｹｨｪ ｨｨ09ｨｺｨ ｨｺｨ 0801ｨｨ0609ｨ 09ｨｺｨｮ050708ｨｪ ｨｪ02ｨｪｨｨｨｦ 0708ｨｨ 0502 ﾂ02ｨｪｨｨｨｨ 0709ｨｨ0106ｨｰ080607ｨｪ04ｨｬｨｨ ｨ 08ｨ ｨｰｨ ｨｬｨｨ. 06ｨｰ06 05ｨｨ02ｨ ｨｨ ｨ 09ｨｰｨ, 07ｨ 02ｨｨ02ｨｪｨｰ ﾂｨｪ ｨｮ01ｨｨ09ｨｰ06ｨｦ 07ｨ ｨｰ ｨｨ02ｨｦ (04ｨ ｨ ｨ ｨｪｨｨ ｨ, ｨ 08ｨｨｨｰｨｬｨｨｨｨ, ｨ 08ｨ 01ｨｨｨｺｨ 0801ｨｨ07 ｨｬ02ｨｪ ｨｮ01ｨ ｨｬｨｨｨｪｨｮｨｰｨｮ), 09 09ｨｨｨｪｨｺ0607ｨ 05ｨｹｨｪ04ｨｬｨｨ ｨｰ0607ｨｪｨｨ07ｨｬｨｨ 09 ｨ ｨｪｨ ｨｬｨｪ020402, 09 09ｨｨｨｪ010806ｨｬ06ｨｬ ｨｮ0105ｨｨｨｪ00ｨｪｨｪ ｨｨｨｪｨｰ020809ｨ 05ｨ QT ( ｨｪｨｪ04ｨｬ ｨｨ05ｨｨ 0708ｨｨ06ｨ 0802ｨｰ00ｨｪｨｪ04ｨｬ), ｨｺｨｰ080605ｨｨｨｰｨｪ04ｨｬ 01ｨｨ09ｨ ｨ 05ｨ ｨｪ0906ｨｬ (00ｨｨ0706ｨｺｨ 05ｨｨ02ｨｬｨｨ07, 00ｨｨ0706ｨｺｨ 05ｨｹ02ｨｨ02ｨｬｨｨ07, 00ｨｨ0706ｨｬｨ 00ｨｪ020402ｨｬｨｨ07, 00ｨｨ070602ｨｨｨｪｨｺ02ｨｬｨｨ07), 09 ｨｪｨｨ04ｨｺｨｨｨｬ ｨｮ080609ｨｪ02ｨｬ ｨｬ02ｨｰｨ ｨ 0605ｨｨ04ｨｬｨ, 09 01ｨｨ0900ｨｮｨｪｨｺ02ｨｨ02ｨｦ ｨ 09ｨｰ06ｨｪ06ｨｬｨｪ06ｨｦ ｨｪ020809ｨｪ06ｨｦ 09ｨｨ09ｨｰ02ｨｬ04, ｨ 0302ｨｪｨｪ04ｨｬｨｨ ｨｪｨ 08ｨｮ0302ｨｪｨｨ07ｨｬｨｨ 00ｨｮｨｪｨｺ02ｨｨｨｦ 0702 ﾂ02ｨｪｨｨ ｨｨ 0706 ﾂ02ｨｺ, ｨｮｨｰ09ｨｰ09ｨｮ06ｨｴ02ｨｦ ｨｰ0208ｨ 07ｨｨ02ｨｦ ｨ 08ｨ ｨｰｨ ｨｬｨｨ, ｨ 0506ｨｺｨｨ08ｨｮ06ｨｴｨｨｨｬｨｨ ｨｺｨ 05ｨｨ , ｨｪｨ ｨｰ08ｨｨ ｨｨ05ｨｨ ｨｺｨ 05ｨｹ02ｨｨ ｨｺｨ ｨｪｨ ｨ ｨｨ/ｨｨ05ｨｨ ｨｨｨｪ00ｨｨｨ ｨｨ08ｨｮ06ｨｴｨｨｨｬｨｨ CYP, ｨｨ ｨｨｨｺ ｨｰ02ｨｨｨｪ. 10. 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