CLINICAL STUDY 2011 Double blind, randomized, cross over, controlled clinical trial of Symbosial (NaCl + Chitosan 3%) vs NaCl on high blood pressure p
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1 CLINICAL STUDY 2011 Double blind, randomized, cross over, controlled clinical trial of Symbosial (NaCl + Chitosan 3%) vs NaCl on high blood pressure parameters during the diet and lifestyle improvement period before an eventual prescription of an antihypertensive treatment Anti-Hypertension Salt
2 Making the Earth Safe and Mankind Healthy ECHO BUSINESS PARTNER OBJECTIVES
3 POPULATION Patients characteristics' at inclusion visit Patients' demographic characteristics Age MV Anova: p-value: Sex % 66.7% % 33.3% Khi²: p-value:
4 Making the Earth Safe and Mankind Healthy ECHO BUSINESS PARTNER BMI MV Anova: 3.59 p-value: = 79.5 ± 22.2 Kg = 69.6 ± 14.3 Kg = ± 9.9 cm = ± 7.6 cm = 92.9 ± 16.3 cm = 89.1 ± 14.2 cm = 99.2 ± 9.4 cm = 96.6 ± 9.2 cm Anova: p-value: Anova: p-value: Anova: p-value: Anova: p-value: Cardiovalscular context % 33.3% 33.3% 25. Ficher: p-value: % 2 5.6% % 95. Ficher: p-value: Tabagism Diabete
5 Cardiovalscular context MV % 62.3% Ficher: p-value: Anova: p-value: % 21.1% 10.5% 11.1% 5.3% Dyslipidemia MV Anova: p-value: MV Anova: p-value: MV Anova: p-value:
6 Making the Earth Safe and Mankind Healthy ECHO BUSINESS PARTNER Patients evolution during first period (-) 90 A(n=18) B(n=20) ± ± 21.6 (w0-w8)=0.3 ± 2.3 p= p= Anova p= ± ± 14.1 (w0-w8)=-0.3 ± Blood pressure parameters evolution between and 160 A(n=18) B(n=20) ± ± ± 7.4 (w0-w8)=-6.2 ± ± 9.7 (w0-w8)=-13.2 ± p= p= Anova p=
7 100 A(n=18) B(n=20) ± ± ± 7.6 (w0-w8)=-6.1 ± p= ± 7.8 (w0-w8)=-11.4 ± 7.6 p= Anova p= Khi²: p-value: Khi²: p-value: % % A(n=18) SBP<140mmHg SBP<140mmHg and DBP<90mmHg B(n=20) 90 A(n=18) B(n=19) ± ± ± 9.2 (w0-w8)=0.1 ± ± 8.6 (w0-w8)=-1.3 ± p= p= Anova p=0.5014
8 Making the Earth Safe and Mankind Healthy ECHO BUSINESS PARTNER Biologics parameters evolution between and : blood ionogram 160 A(n=18) B(n=19) ± ± ± 1.8 (w0-w8)=0.3 ± ± 1.4 (w0-w8)=0.3 ± p= p= Anova p= A(n=17) B(n=19) ± ± ± 0.4 (w0-w8)=0.2 ± ± 0.3 (w0-w8)=-0.1 ± p= p= Anova p= A(n=16) B(n=18) ± ± ± 2.3 (w0-w8)=-0.8 ± ± 3.0 (w0-w8)=-0.6 ± p= p= Anova p=0.6726
9 35 A(n=11) B(n=14) ± ± ± 2.9 (w0-w8)=0.6 ± ± 2.0 (w0-w8)=0.8 ± p= p= Anova p= A(n=15) B(n=18) ± ± ± 0.8 (w0-w8)=-0.1 ± ± 1.4 (w0-w8)=-0.5 ± p= p= Anova p= Biologics parameters evolution between and : urinary ionogram ± ± 49.9 p= ± 93.2 (w0-w8)=33.6 ± ± 69.9 (w0-w8)=24.8 ± 69.3 p= Anova p= A(n=14) B(n=18)
10 Making the Earth Safe and Mankind Healthy ECHO BUSINESS PARTNER Biologics parameters evolution between and : blood ionogram 80 A(n=14) B(n=18) ± ± ± 33.2 (w0-w8)=5.7 ± ± 34.7 (w0-w8)=6.0 ± p= p= Anova p= ± ± 45.1 p= p= ± 86.3 (w0-w8)=45.8 ± ± 59.9 (w0-w8)=45.8 ± 50.6 Anova p= A(n=8) B(n=11) Any secondary effect was observed during first period MV Anova: p-value:
11 Crossover analysis A : -6.2 ± 7.3 B: ± 11.1 Anova p= B : -3.6 ± 8.4 A: 0.2 ± 8.2 Anova p= ± 4.7 p= A B t-test vs W ± 7.4 : p= ± ± 11.5 p= ± ± 9.7 Anova W10 p= Anova W18 p= ± ± 11.6 t-test vs W10 : p= w10 w18 B A A : -6.1 ± 7.1 B: ± 7.6 Anova p= B : -2.5 ± 6.0 A: -0.5 ± 5.1 Anova p= ± 3.5 p= A B t-test vs W ± 7.6 : p= ± ± 9.2 p= ± ± 7.8 Anova W10 p= Anova W18 p= ± ± 9.3 t-test vs W10 : p= B A w10 w18 The cross over analysis
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2011 Vol.60 No.4 p.332 338 Usefulness of regional education program for dietary salt reduction: Self-monitoring of urinary salt excretion Kenichiro YASUTAKE[1] Kayoko SAWANO[1] Shoko YAMAGUCHI[1] Hiroko
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Background : There have not been any informations available of whether diuretics may enhance renoprotective effects of ACEI and ARB. Methods Post-hoc analysis of the results of COOPERATE trial, asking
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Title 泌尿器科領域に於ける17-Ketosteroidの研究 17-Ketosteroidの臨床的研究 第 III 篇 : 尿 Author(s) 卜部, 敏入 Citation 泌尿器科紀要 (1958), 4(1): 3-31 Issue Date 1958-01 URL http://hdl.handle.net/2433/111559 Right Type Departmental Bulletin
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